{"id":"https://openalex.org/W3036499366","doi":"https://doi.org/10.3390/ijms21124414","title":"Immuno-Metabolism and Microenvironment in Cancer: Key Players for Immunotherapy","display_name":"Immuno-Metabolism and Microenvironment in Cancer: Key Players for Immunotherapy","publication_year":2020,"publication_date":"2020-06-21","ids":{"openalex":"https://openalex.org/W3036499366","doi":"https://doi.org/10.3390/ijms21124414","mag":"3036499366","pmid":"https://pubmed.ncbi.nlm.nih.gov/32575899","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7352562"},"language":"en","primary_location":{"id":"doi:10.3390/ijms21124414","doi":"https://doi.org/10.3390/ijms21124414","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/ijms21124414","pdf_url":"https://www.mdpi.com/1422-0067/21/12/4414/pdf?version=1593068217","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/21/12/4414/pdf?version=1593068217","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080241438","display_name":"Gaia Giannone","orcid":"https://orcid.org/0000-0003-1991-039X","observed_orcids":["https://orcid.org/0000-0003-1991-039X"]},"institutions":[{"id":"https://openalex.org/I4210151091","display_name":"Candiolo Cancer Institute","ror":"https://ror.org/04wadq306","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210151091","https://openalex.org/I4210153126","https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gaia Giannone","raw_affiliation_strings":["Candiolo Cancer Institute, FPO\u2014IRCCS, University of Turin, 10060 Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Candiolo Cancer Institute, FPO\u2014IRCCS, University of Turin, 10060 Torino, Italy","institution_ids":["https://openalex.org/I4210151091","https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083131544","display_name":"Eleonora Ghisoni","orcid":"https://orcid.org/0000-0003-1950-0315","observed_orcids":["https://orcid.org/0000-0003-1950-0315"]},"institutions":[{"id":"https://openalex.org/I4210151091","display_name":"Candiolo Cancer Institute","ror":"https://ror.org/04wadq306","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210151091","https://openalex.org/I4210153126","https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Eleonora Ghisoni","raw_affiliation_strings":["Candiolo Cancer Institute, FPO\u2014IRCCS, University of Turin, 10060 Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Candiolo Cancer Institute, FPO\u2014IRCCS, University of Turin, 10060 Torino, Italy","institution_ids":["https://openalex.org/I4210151091","https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050247782","display_name":"Sofia Genta","orcid":"https://orcid.org/0000-0001-8441-2456","observed_orcids":["https://orcid.org/0000-0001-8441-2456"]},"institutions":[{"id":"https://openalex.org/I4210151091","display_name":"Candiolo Cancer Institute","ror":"https://ror.org/04wadq306","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210151091","https://openalex.org/I4210153126","https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sofia Genta","raw_affiliation_strings":["Candiolo Cancer Institute, FPO\u2014IRCCS, University of Turin, 10060 Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Candiolo Cancer Institute, FPO\u2014IRCCS, University of Turin, 10060 Torino, Italy","institution_ids":["https://openalex.org/I4210151091","https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052567150","display_name":"Giulia Scotto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151091","display_name":"Candiolo Cancer Institute","ror":"https://ror.org/04wadq306","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210151091","https://openalex.org/I4210153126","https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giulia Scotto","raw_affiliation_strings":["Candiolo Cancer Institute, FPO\u2014IRCCS, University of Turin, 10060 Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Candiolo Cancer Institute, FPO\u2014IRCCS, University of Turin, 10060 Torino, Italy","institution_ids":["https://openalex.org/I4210151091","https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016952664","display_name":"Valentina Tuninetti","orcid":"https://orcid.org/0000-0002-7377-0888","observed_orcids":["https://orcid.org/0000-0002-7377-0888"]},"institutions":[{"id":"https://openalex.org/I4210151091","display_name":"Candiolo Cancer Institute","ror":"https://ror.org/04wadq306","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210151091","https://openalex.org/I4210153126","https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Valentina Tuninetti","raw_affiliation_strings":["Candiolo Cancer Institute, FPO\u2014IRCCS, University of Turin, 10060 Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Candiolo Cancer Institute, FPO\u2014IRCCS, University of Turin, 10060 Torino, Italy","institution_ids":["https://openalex.org/I4210151091","https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017195256","display_name":"Margherita Turinetto","orcid":"https://orcid.org/0000-0002-9419-8606","observed_orcids":["https://orcid.org/0000-0002-9419-8606"]},"institutions":[{"id":"https://openalex.org/I4210151091","display_name":"Candiolo Cancer Institute","ror":"https://ror.org/04wadq306","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210151091","https://openalex.org/I4210153126","https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Margherita Turinetto","raw_affiliation_strings":["Candiolo Cancer Institute, FPO\u2014IRCCS, University of Turin, 10060 Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Candiolo Cancer Institute, FPO\u2014IRCCS, University of Turin, 10060 Torino, Italy","institution_ids":["https://openalex.org/I4210151091","https://openalex.org/I55143463"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077405667","display_name":"Giorgio Valabrega","orcid":"https://orcid.org/0000-0001-5444-6305","observed_orcids":["https://orcid.org/0000-0001-5444-6305"]},"institutions":[{"id":"https://openalex.org/I4210151091","display_name":"Candiolo Cancer Institute","ror":"https://ror.org/04wadq306","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210151091","https://openalex.org/I4210153126","https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giorgio Valabrega","raw_affiliation_strings":["Candiolo Cancer Institute, FPO\u2014IRCCS, University of Turin, 10060 Torino, Italy"],"raw_orcid":"https://orcid.org/0000-0001-5444-6305","affiliations":[{"raw_affiliation_string":"Candiolo Cancer Institute, FPO\u2014IRCCS, University of Turin, 10060 Torino, Italy","institution_ids":["https://openalex.org/I4210151091","https://openalex.org/I55143463"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5083131544"],"corresponding_institution_ids":["https://openalex.org/I4210151091","https://openalex.org/I55143463"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2112},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2112},"fwci":2.9714,"has_fulltext":true,"cited_by_count":163,"citation_normalized_percentile":{"value":0.9418466,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"21","issue":"12","first_page":"4414","last_page":"4414"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9599999785423279},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.9909999966621399},{"id":"https://openalex.org/keywords/immunotherapy-resistance","display_name":"immunotherapy resistance","score":0.7870000004768372},{"id":"https://openalex.org/keywords/extracellular-adenosine","display_name":"extracellular adenosine","score":0.9440000057220459},{"id":"https://openalex.org/keywords/tryptophan-metabolism","display_name":"tryptophan metabolism","score":0.9229999780654907},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.953000009059906},{"id":"https://openalex.org/keywords/tumor-hypoxia","display_name":"tumor hypoxia","score":0.8500000238418579},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.8270000219345093},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9620000123977661},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9850000143051147},{"id":"https://openalex.org/keywords/tumor-associated-macrophages","display_name":"tumor-associated macrophages","score":0.9980000257492065},{"id":"https://openalex.org/keywords/microbiome","display_name":"microbiome","score":0.6710000038146973},{"id":"https://openalex.org/keywords/immune-related-adverse-events","display_name":"immune-related adverse events","score":0.9639999866485596},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9100000262260437},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":1.0},{"id":"https://openalex.org/keywords/fecal-microbiota-transplantation","display_name":"fecal microbiota transplantation","score":0.906000018119812}],"concepts":[{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.7158141136169434},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6804426908493042},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5869635939598083},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.5610302090644836},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5545258522033691},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.4939597249031067},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.4766198694705963},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.4732045531272888},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.47309067845344543},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4218611419200897},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.421433687210083},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41679200530052185},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3970463275909424},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.21214339137077332},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.1882602870464325},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1639459729194641},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.09121820330619812},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000084582","descriptor_name":"Tumor-Associated Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000084582","descriptor_name":"Tumor-Associated Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000084582","descriptor_name":"Tumor-Associated Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.3390/ijms21124414","doi":"https://doi.org/10.3390/ijms21124414","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/ijms21124414","pdf_url":"https://www.mdpi.com/1422-0067/21/12/4414/pdf?version=1593068217","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmid:32575899","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32575899","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7352562","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7352562/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmh:oai:iris.unito.it:2318/1751000","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2318/1751000","pdf_url":"https://iris.unito.it/bitstream/2318/1751000/1/ijms-21-04414.pdf","source":{"id":"https://openalex.org/S4306400637","display_name":"Institutional Research Information System University of Turin (University of Turin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55143463","host_organization_name":"University of Turin","host_organization_lineage":["https://openalex.org/I55143463"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:8aa2d7653b6348459783460aea9193c6","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8aa2d7653b6348459783460aea9193c6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, Vol 21, Iss 4414, p 4414 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ijms21124414","doi":"https://doi.org/10.3390/ijms21124414","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/ijms21124414","pdf_url":"https://www.mdpi.com/1422-0067/21/12/4414/pdf?version=1593068217","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307105","display_name":"Amgen","ror":"https://ror.org/03g03ge92"},{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320327811","display_name":"PharmaMar","ror":"https://ror.org/02h694m69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3036499366.pdf","grobid_xml":"https://content.openalex.org/works/W3036499366.grobid-xml"},"referenced_works_count":162,"referenced_works":["https://openalex.org/W1525326448","https://openalex.org/W1554937135","https://openalex.org/W1581040284","https://openalex.org/W1848588865","https://openalex.org/W1889084531","https://openalex.org/W1971620413","https://openalex.org/W1980040544","https://openalex.org/W1986913755","https://openalex.org/W1987534017","https://openalex.org/W1990423632","https://openalex.org/W1991058406","https://openalex.org/W1993467048","https://openalex.org/W1998554884","https://openalex.org/W2002558089","https://openalex.org/W2003635644","https://openalex.org/W2010378562","https://openalex.org/W2015260577","https://openalex.org/W2016804396","https://openalex.org/W2036977806","https://openalex.org/W2049601932","https://openalex.org/W2056154638","https://openalex.org/W2057370954","https://openalex.org/W2059476255","https://openalex.org/W2060469376","https://openalex.org/W2065308992","https://openalex.org/W2067933166","https://openalex.org/W2068234766","https://openalex.org/W2068912461","https://openalex.org/W2070825440","https://openalex.org/W2076743146","https://openalex.org/W2077620347","https://openalex.org/W2077786296","https://openalex.org/W2082431132","https://openalex.org/W2085402245","https://openalex.org/W2090410108","https://openalex.org/W2090925778","https://openalex.org/W2092367583","https://openalex.org/W2095861825","https://openalex.org/W2100039832","https://openalex.org/W2100413206","https://openalex.org/W2105746949","https://openalex.org/W2110139358","https://openalex.org/W2114017759","https://openalex.org/W2114849434","https://openalex.org/W2116879609","https://openalex.org/W2121406067","https://openalex.org/W2121820529","https://openalex.org/W2126932404","https://openalex.org/W2127903252","https://openalex.org/W2142644858","https://openalex.org/W2144174481","https://openalex.org/W2145247311","https://openalex.org/W2156906256","https://openalex.org/W2160551785","https://openalex.org/W2165456770","https://openalex.org/W2168634451","https://openalex.org/W2169991956","https://openalex.org/W2185075416","https://openalex.org/W2196159484","https://openalex.org/W2201379305","https://openalex.org/W2224656683","https://openalex.org/W2275606382","https://openalex.org/W2275872217","https://openalex.org/W2317340981","https://openalex.org/W2335616547","https://openalex.org/W2359306646","https://openalex.org/W2465860350","https://openalex.org/W2469758901","https://openalex.org/W2482556255","https://openalex.org/W2518536270","https://openalex.org/W2519184848","https://openalex.org/W2520601585","https://openalex.org/W2529373149","https://openalex.org/W2529904548","https://openalex.org/W2559382297","https://openalex.org/W2570766240","https://openalex.org/W2595109242","https://openalex.org/W2598253740","https://openalex.org/W2601055810","https://openalex.org/W2611694282","https://openalex.org/W2611933383","https://openalex.org/W2623680111","https://openalex.org/W2728594144","https://openalex.org/W2743307239","https://openalex.org/W2755951643","https://openalex.org/W2758407040","https://openalex.org/W2761750001","https://openalex.org/W2765132620","https://openalex.org/W2765212591","https://openalex.org/W2765314233","https://openalex.org/W2765672396","https://openalex.org/W2766903152","https://openalex.org/W2772677509","https://openalex.org/W2774712455","https://openalex.org/W2782333299","https://openalex.org/W2788621395","https://openalex.org/W2789566036","https://openalex.org/W2791328450","https://openalex.org/W2791850181","https://openalex.org/W2794419219","https://openalex.org/W2794690279","https://openalex.org/W2795186863","https://openalex.org/W2801375800","https://openalex.org/W2801780797","https://openalex.org/W2803437699","https://openalex.org/W2804772768","https://openalex.org/W2804812017","https://openalex.org/W2805302875","https://openalex.org/W2805354595","https://openalex.org/W2807434325","https://openalex.org/W2883024704","https://openalex.org/W2885907209","https://openalex.org/W2886389565","https://openalex.org/W2887449433","https://openalex.org/W2888059202","https://openalex.org/W2888578355","https://openalex.org/W2890642520","https://openalex.org/W2891418171","https://openalex.org/W2892380094","https://openalex.org/W2894313087","https://openalex.org/W2895311113","https://openalex.org/W2898631010","https://openalex.org/W2899044337","https://openalex.org/W2900832038","https://openalex.org/W2901242178","https://openalex.org/W2905243010","https://openalex.org/W2907028960","https://openalex.org/W2912501325","https://openalex.org/W2912593557","https://openalex.org/W2914335731","https://openalex.org/W2919663648","https://openalex.org/W2922163396","https://openalex.org/W2924289105","https://openalex.org/W2943887705","https://openalex.org/W2944336209","https://openalex.org/W2945653463","https://openalex.org/W2947495476","https://openalex.org/W2947747173","https://openalex.org/W2947825849","https://openalex.org/W2948936033","https://openalex.org/W2949375297","https://openalex.org/W2954833581","https://openalex.org/W2957105318","https://openalex.org/W2967744297","https://openalex.org/W2968303346","https://openalex.org/W2969738919","https://openalex.org/W2971904552","https://openalex.org/W2980659545","https://openalex.org/W2988620928","https://openalex.org/W2989673251","https://openalex.org/W2990862758","https://openalex.org/W2995899912","https://openalex.org/W2997965122","https://openalex.org/W3000696551","https://openalex.org/W3001577527","https://openalex.org/W3010374411","https://openalex.org/W3015470279","https://openalex.org/W3025022288","https://openalex.org/W3082943961","https://openalex.org/W3147176276","https://openalex.org/W3149531407","https://openalex.org/W4211245409"],"related_works":["https://openalex.org/W7204540436","https://openalex.org/W3045007983","https://openalex.org/W3122953246","https://openalex.org/W3212277766","https://openalex.org/W4211001418","https://openalex.org/W3035999666","https://openalex.org/W4386864831","https://openalex.org/W4226210606","https://openalex.org/W4411673283","https://openalex.org/W7171815833"],"abstract_inverted_index":{"Immune":[0],"checkpoint":[1],"inhibitors":[2],"(ICIs)":[3],"have":[4],"changed":[5],"therapeutic":[6],"algorithms":[7],"in":[8,32,155],"several":[9],"malignancies,":[10],"although":[11],"intrinsic":[12],"and":[13,37,52,76,104,118,140,170,183,205],"secondary":[14],"resistance":[15],"is":[16,151],"still":[17],"an":[18,63,84],"issue.":[19],"In":[20,42],"this":[21,43],"context,":[22],"the":[23,33,39,47,60,72,80,88,111,125,130,138,141,152,165,174,201,206],"dysregulation":[24],"of":[25,66,74,79,143,167,176],"immuno-metabolism":[26],"plays":[27],"a":[28,96],"leading":[29],"role":[30],"both":[31,137],"tumor":[34,106],"microenvironment":[35],"(TME)":[36],"at":[38],"host":[40],"level.":[41],"review,":[44],"we":[45],"summarize":[46],"most":[48,158],"important":[49],"immune-metabolic":[50],"factors":[51,114],"how":[53],"they":[54],"could":[55],"be":[56],"exploited":[57],"therapeutically.":[58],"At":[59],"cellular":[61],"level,":[62],"increased":[64],"concentration":[65],"extracellular":[67],"adenosine":[68,202],"as":[69,71,116],"well":[70],"depletion":[73],"tryptophan":[75,190],"uncontrolled":[77],"activation":[78],"PI3K/AKT":[81],"pathway":[82,191],"induces":[83,95],"immune-tolerant":[85],"TME,":[86],"reducing":[87],"response":[89,126,139],"to":[90,123,127,161],"ICIs.":[91],"Moreover,":[92],"aberrant":[93],"angiogenesis":[94],"hypoxic":[97],"environment":[98],"by":[99],"recruiting":[100],"VEGF,":[101],"Treg":[102],"cells":[103],"immune-suppressive":[105],"associated":[107],"macrophages":[108],"(TAMs).":[109],"On":[110],"other":[112],"hand,":[113],"such":[115],"gender":[117],"body":[119],"mass":[120],"index":[121],"seem":[122],"affect":[124],"ICIs,":[128,171],"while":[129,187],"microbiome":[131,210],"composition":[132],"(and":[133],"its":[134],"alterations)":[135],"modulates":[136],"development":[142],"immune-related":[144],"adverse":[145],"events.":[146],"Exploiting":[147],"these":[148],"complex":[149],"mechanisms":[150],"next":[153],"goal":[154],"immunotherapy.":[156],"The":[157],"successful":[159],"strategy":[160],"date":[162],"has":[163],"been":[164],"combination":[166],"antiangiogenic":[168],"drugs":[169],"which":[172],"prolonged":[173],"survival":[175],"patients":[177],"with":[178,208],"non-small-cell":[179],"lung":[180],"cancer":[181],"(NSCLC)":[182],"hepatocellular":[184],"carcinoma":[185],"(HCC),":[186],"results":[188],"from":[189],"inhibition":[192],"studies":[193],"are":[194],"inconclusive.":[195],"New":[196],"exciting":[197],"strategies":[198],"include":[199],"targeting":[200],"pathway,":[203],"TAMs":[204],"microbiota":[207],"fecal":[209],"transplantation.":[211]},"counts_by_year":[{"year":2026,"cited_by_count":16},{"year":2025,"cited_by_count":18},{"year":2024,"cited_by_count":28},{"year":2023,"cited_by_count":27},{"year":2022,"cited_by_count":52},{"year":2021,"cited_by_count":18},{"year":2020,"cited_by_count":4}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2020-06-25T00:00:00"}