{"id":"https://openalex.org/W3036445708","doi":"https://doi.org/10.1101/2020.06.23.166603","title":"DGAT1 is a lipid metabolism oncoprotein that enables cancer cells to accumulate fatty acid while avoiding lipotoxicity","display_name":"DGAT1 is a lipid metabolism oncoprotein that enables cancer cells to accumulate fatty acid while avoiding lipotoxicity","publication_year":2020,"publication_date":"2020-06-24","ids":{"openalex":"https://openalex.org/W3036445708","doi":"https://doi.org/10.1101/2020.06.23.166603","mag":"3036445708"},"language":"en","primary_location":{"id":"doi:10.1101/2020.06.23.166603","doi":"https://doi.org/10.1101/2020.06.23.166603","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2020.06.23.166603","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2020/06/24/2020.06.23.166603.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"parent_works":[],"lineage":["https://openalex.org/W3036445708"],"child_works_count":0,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2020/06/24/2020.06.23.166603.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050941311","display_name":"Daniel J. Wilcock","orcid":"https://orcid.org/0000-0002-3183-5540","observed_orcids":["https://orcid.org/0000-0002-3183-5540"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Daniel J. Wilcock","raw_affiliation_strings":["Division of Cancer Studies, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PT, UK","Division of Cancer Studies, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M3 9PT, UK"],"raw_orcid":"https://orcid.org/0000-0002-3183-5540","affiliations":[{"raw_affiliation_string":"Division of Cancer Studies, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PT, UK","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"Division of Cancer Studies, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M3 9PT, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083144603","display_name":"Andrew P. Badrock","orcid":"https://orcid.org/0000-0003-3907-3285","observed_orcids":["https://orcid.org/0000-0003-3907-3285"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andrew P. Badrock","raw_affiliation_strings":["Division of Molecular & Cellular Function, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PT, UK"],"raw_orcid":"https://orcid.org/0000-0003-3907-3285","affiliations":[{"raw_affiliation_string":"Division of Molecular & Cellular Function, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PT, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024154526","display_name":"Rhys Owen","orcid":"https://orcid.org/0000-0001-8024-087X","observed_orcids":["https://orcid.org/0000-0001-8024-087X"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rhys Owen","raw_affiliation_strings":["Division of Cancer Studies, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PT, UK","Division of Cancer Studies, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M3 9PT, UK"],"raw_orcid":"https://orcid.org/0000-0001-8024-087X","affiliations":[{"raw_affiliation_string":"Division of Cancer Studies, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PT, UK","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"Division of Cancer Studies, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M3 9PT, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036997534","display_name":"Melissa Guerin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melissa Guerin","raw_affiliation_strings":["Program in Molecular Medicine, Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School (UMMS), Worcester, MA 01605, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Molecular Medicine, Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School (UMMS), Worcester, MA 01605, Massachusetts, USA","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025526658","display_name":"Andrew D. Southam","orcid":"https://orcid.org/0000-0003-3030-7663","observed_orcids":["https://orcid.org/0000-0003-3030-7663"]},"institutions":[{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andrew D. Southam","raw_affiliation_strings":["Phenome Centre Birmingham, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK","School of Biosciences, Edgbaston, University of Birmingham, Birmingham, B15 2TT, UK","Phenome Centre Birmingham, University of Birmingham, Edgbaston, Birmingham, B1 2TT, UK"],"raw_orcid":"https://orcid.org/0000-0003-3030-7663","affiliations":[{"raw_affiliation_string":"Phenome Centre Birmingham, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK","institution_ids":["https://openalex.org/I79619799"]},{"raw_affiliation_string":"School of Biosciences, Edgbaston, University of Birmingham, Birmingham, B15 2TT, UK","institution_ids":["https://openalex.org/I79619799"]},{"raw_affiliation_string":"Phenome Centre Birmingham, University of Birmingham, Edgbaston, Birmingham, B1 2TT, UK","institution_ids":["https://openalex.org/I79619799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052921511","display_name":"Hannah R. Johnston","orcid":"https://orcid.org/0009-0002-5133-891X","observed_orcids":["https://orcid.org/0009-0002-5133-891X"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Hannah Johnston","raw_affiliation_strings":["Division of Cancer Studies, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PT, UK","Division of Cancer Studies, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M3 9PT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cancer Studies, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PT, UK","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"Division of Cancer Studies, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M3 9PT, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004472397","display_name":"Samuel Ogden","orcid":"https://orcid.org/0000-0002-0217-881X","observed_orcids":["https://orcid.org/0000-0002-0217-881X"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Samuel Ogden","raw_affiliation_strings":["Division of Molecular & Cellular Function, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular & Cellular Function, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PT, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045700446","display_name":"Paul Fullwood","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paul Fullwood","raw_affiliation_strings":["Division of Molecular & Cellular Function, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular & Cellular Function, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PT, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006451258","display_name":"Joanne Watson","orcid":"https://orcid.org/0000-0002-7754-276X","observed_orcids":["https://orcid.org/0000-0002-7754-276X"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Joanne Watson","raw_affiliation_strings":["Division of Molecular & Cellular Function, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PT, UK"],"raw_orcid":"https://orcid.org/0000-0002-7754-276X","affiliations":[{"raw_affiliation_string":"Division of Molecular & Cellular Function, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PT, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084008040","display_name":"Harriet R. Ferguson","orcid":"https://orcid.org/0000-0002-0283-4629","observed_orcids":["https://orcid.org/0000-0002-0283-4629"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Harriet Ferguson","raw_affiliation_strings":["Division of Molecular & Cellular Function, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PT, UK"],"raw_orcid":"https://orcid.org/0000-0002-0283-4629","affiliations":[{"raw_affiliation_string":"Division of Molecular & Cellular Function, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PT, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103760846","display_name":"Jennifer Ferguson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jennifer Ferguson","raw_affiliation_strings":["Division of Molecular & Cellular Function, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular & Cellular Function, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PT, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050999610","display_name":"Daniel A. Richardson","orcid":"https://orcid.org/0000-0002-3474-5145","observed_orcids":["https://orcid.org/0000-0002-3474-5145"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Daniel A. Richardson","raw_affiliation_strings":["Division of Cancer Studies, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PT, UK","Division of Cancer Studies, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M3 9PT, UK"],"raw_orcid":"https://orcid.org/0000-0002-3474-5145","affiliations":[{"raw_affiliation_string":"Division of Cancer Studies, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PT, UK","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"Division of Cancer Studies, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M3 9PT, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025554672","display_name":"Gavin Rhys Lloyd","orcid":"https://orcid.org/0000-0001-7989-6695","observed_orcids":["https://orcid.org/0000-0001-7989-6695"]},"institutions":[{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gavin R. Lloyd","raw_affiliation_strings":["Phenome Centre Birmingham, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK","School of Biosciences, Edgbaston, University of Birmingham, Birmingham, B15 2TT, UK","Phenome Centre Birmingham, University of Birmingham, Edgbaston, Birmingham, B1 2TT, UK"],"raw_orcid":"https://orcid.org/0000-0001-7989-6695","affiliations":[{"raw_affiliation_string":"Phenome Centre Birmingham, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK","institution_ids":["https://openalex.org/I79619799"]},{"raw_affiliation_string":"School of Biosciences, Edgbaston, University of Birmingham, Birmingham, B15 2TT, UK","institution_ids":["https://openalex.org/I79619799"]},{"raw_affiliation_string":"Phenome Centre Birmingham, University of Birmingham, Edgbaston, Birmingham, B1 2TT, UK","institution_ids":["https://openalex.org/I79619799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069557561","display_name":"Andris Jankevics","orcid":"https://orcid.org/0000-0003-2095-6846","observed_orcids":["https://orcid.org/0000-0003-2095-6846"]},"institutions":[{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andris Jankevics","raw_affiliation_strings":["Phenome Centre Birmingham, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK","School of Biosciences, Edgbaston, University of Birmingham, Birmingham, B15 2TT, UK","Phenome Centre Birmingham, University of Birmingham, Edgbaston, Birmingham, B1 2TT, UK"],"raw_orcid":"https://orcid.org/0000-0003-2095-6846","affiliations":[{"raw_affiliation_string":"Phenome Centre Birmingham, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK","institution_ids":["https://openalex.org/I79619799"]},{"raw_affiliation_string":"School of Biosciences, Edgbaston, University of Birmingham, Birmingham, B15 2TT, UK","institution_ids":["https://openalex.org/I79619799"]},{"raw_affiliation_string":"Phenome Centre Birmingham, University of Birmingham, Edgbaston, Birmingham, B1 2TT, UK","institution_ids":["https://openalex.org/I79619799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091024912","display_name":"Warwick B. Dunn","orcid":"https://orcid.org/0000-0001-6924-0027","observed_orcids":["https://orcid.org/0000-0001-6924-0027"]},"institutions":[{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Warwick B. Dunn","raw_affiliation_strings":["Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK","Phenome Centre Birmingham, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK","School of Biosciences, Edgbaston, University of Birmingham, Birmingham, B15 2TT, UK","Phenome Centre Birmingham, University of Birmingham, Edgbaston, Birmingham, B1 2TT, UK"],"raw_orcid":"https://orcid.org/0000-0001-6924-0027","affiliations":[{"raw_affiliation_string":"Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK","institution_ids":["https://openalex.org/I79619799"]},{"raw_affiliation_string":"Phenome Centre Birmingham, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK","institution_ids":["https://openalex.org/I79619799"]},{"raw_affiliation_string":"School of Biosciences, Edgbaston, University of Birmingham, Birmingham, B15 2TT, UK","institution_ids":["https://openalex.org/I79619799"]},{"raw_affiliation_string":"Phenome Centre Birmingham, University of Birmingham, Edgbaston, Birmingham, B1 2TT, UK","institution_ids":["https://openalex.org/I79619799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082118845","display_name":"Claudia Wellbrock","orcid":"https://orcid.org/0000-0002-3825-6381","observed_orcids":["https://orcid.org/0000-0002-3825-6381"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Claudia Wellbrock","raw_affiliation_strings":["Division of Cancer Studies, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PT, UK","Division of Cancer Studies, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M3 9PT, UK"],"raw_orcid":"https://orcid.org/0000-0002-3825-6381","affiliations":[{"raw_affiliation_string":"Division of Cancer Studies, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PT, UK","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"Division of Cancer Studies, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M3 9PT, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069095893","display_name":"Paul C. Lorigan","orcid":"https://orcid.org/0000-0002-8875-2164","observed_orcids":["https://orcid.org/0000-0002-8875-2164"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]},{"id":"https://openalex.org/I4210133995","display_name":"The Christie NHS Foundation Trust","ror":"https://ror.org/03v9efr22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210133995"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paul Lorigan","raw_affiliation_strings":["Department of Medical Oncology, The Christie NHS Foundation Trust, Wilmslow Road, Withington, Manchester M20 4BX, UK","Division of Cancer Studies, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PT, UK","Division of Cancer Studies, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M3 9PT, UK"],"raw_orcid":"https://orcid.org/0000-0002-8875-2164","affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, The Christie NHS Foundation Trust, Wilmslow Road, Withington, Manchester M20 4BX, UK","institution_ids":["https://openalex.org/I4210133995"]},{"raw_affiliation_string":"Division of Cancer Studies, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PT, UK","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"Division of Cancer Studies, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M3 9PT, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034685016","display_name":"Craig J. Ceol","orcid":"https://orcid.org/0000-0002-7188-7580","observed_orcids":["https://orcid.org/0000-0002-7188-7580"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Craig Ceol","raw_affiliation_strings":["Program in Molecular Medicine, Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School (UMMS), Worcester, MA 01605, Massachusetts, USA"],"raw_orcid":"https://orcid.org/0000-0002-7188-7580","affiliations":[{"raw_affiliation_string":"Program in Molecular Medicine, Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School (UMMS), Worcester, MA 01605, Massachusetts, USA","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012450757","display_name":"Chiara Francavilla","orcid":"https://orcid.org/0000-0003-1775-3386","observed_orcids":["https://orcid.org/0000-0003-1775-3386"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Chiara Francavilla","raw_affiliation_strings":["Division of Molecular & Cellular Function, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PT, UK"],"raw_orcid":"https://orcid.org/0000-0003-1775-3386","affiliations":[{"raw_affiliation_string":"Division of Molecular & Cellular Function, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PT, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051175106","display_name":"Michael P. Smith","orcid":"https://orcid.org/0000-0002-5980-7840","observed_orcids":["https://orcid.org/0000-0002-5980-7840"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Michael P. Smith","raw_affiliation_strings":["Division of Molecular & Cellular Function, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PT, UK"],"raw_orcid":"https://orcid.org/0000-0002-5980-7840","affiliations":[{"raw_affiliation_string":"Division of Molecular & Cellular Function, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PT, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054179421","display_name":"Adam F. L. Hurlstone","orcid":"https://orcid.org/0000-0001-5260-9457","observed_orcids":["https://orcid.org/0000-0001-5260-9457"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Adam F. L. Hurlstone","raw_affiliation_strings":["Division of Infection Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PT, UK","Lydia Becker Institute of Immunology, The University of Manchester, Manchester, M13 9PT, UK","Lydia Becker Institute of Immunology, The University of Manchester, Manchester, M13 PT, UK"],"raw_orcid":"https://orcid.org/0000-0001-5260-9457","affiliations":[{"raw_affiliation_string":"Division of Infection Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PT, UK","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"Lydia Becker Institute of Immunology, The University of Manchester, Manchester, M13 9PT, UK","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"Lydia Becker Institute of Immunology, The University of Manchester, Manchester, M13 PT, UK","institution_ids":["https://openalex.org/I28407311"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5051175106","https://openalex.org/A5054179421"],"corresponding_institution_ids":["https://openalex.org/I28407311"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dgat1","display_name":"DGAT1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/diacylglycerol-o-acyltransferase-1","display_name":"diacylglycerol O-acyltransferase 1","score":0.9380000233650208},{"id":"https://openalex.org/keywords/oncoprotein","display_name":"oncoprotein","score":0.9309999942779541},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.7379999756813049},{"id":"https://openalex.org/keywords/lipotoxicity","display_name":"lipotoxicity","score":0.9739999771118164},{"id":"https://openalex.org/keywords/fatty-acid-oxidation","display_name":"fatty acid oxidation","score":0.9390000104904175},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.7170000076293945},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8740000128746033},{"id":"https://openalex.org/keywords/lipid-droplets","display_name":"lipid droplets","score":0.828000009059906},{"id":"https://openalex.org/keywords/braf","display_name":"BRAF","score":0.8939999938011169},{"id":"https://openalex.org/keywords/nras","display_name":"NRAS","score":0.9950000047683716},{"id":"https://openalex.org/keywords/tumor-metabolism","display_name":"cancer metabolism","score":0.7160000205039978}],"concepts":[{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.6222638487815857},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.5236653685569763},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5147445201873779},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.4948582053184509},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.48907238245010376},{"id":"https://openalex.org/C36020004","wikidata":"https://www.wikidata.org/wiki/Q106951674","display_name":"Diacylglycerol kinase","level":4,"score":0.46163344383239746},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4603523910045624},{"id":"https://openalex.org/C25095133","wikidata":"https://www.wikidata.org/wiki/Q573950","display_name":"Lipid droplet","level":2,"score":0.4563513398170471},{"id":"https://openalex.org/C44353895","wikidata":"https://www.wikidata.org/wiki/Q6556772","display_name":"Lipotoxicity","level":4,"score":0.4283924102783203},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4148011803627014},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40469881892204285},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.3919558525085449},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39119037985801697},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.37131160497665405},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.09255024790763855},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.07628625631332397},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1101/2020.06.23.166603","doi":"https://doi.org/10.1101/2020.06.23.166603","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2020.06.23.166603","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2020/06/24/2020.06.23.166603.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/b905f4d5-406c-4ae3-b9f4-0bbbab12879f","doi":null,"is_oa":false,"landing_page_url":"https://research.manchester.ac.uk/en/publications/b905f4d5-406c-4ae3-b9f4-0bbbab12879f","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Wilcock, D J, Badrock, A P, Owen, R, Guerin, M, Southam, A D, Johnston, H, Ogden, S, Fullwood, P, Watson, J, Ferguson, H, Ferguson, J, Richardson, D A, Lloyd, G R, Jankevics, A, Dunn, W B, Wellbrock, C, Lorigan, P, Ceol, C, Francavilla, C, Smith, M P & Hurlstone, A F L 2020, 'DGAT1 is a lipid metabolism oncoprotein that enables cancer cells to accumulate fatty acid while avoiding lipotoxicity', bioRxiv. https://doi.org/10.1101/2020.06.23.166603","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.atira.dk:studenttheses/132992eb-7386-42bd-9db5-6005f205e386","doi":null,"is_oa":false,"landing_page_url":"https://research.manchester.ac.uk/en/studentTheses/132992eb-7386-42bd-9db5-6005f205e386","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"synchronisedUnifiedStudentThesis","raw_type":"Phd"}],"best_oa_location":{"id":"doi:10.1101/2020.06.23.166603","doi":"https://doi.org/10.1101/2020.06.23.166603","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2020.06.23.166603","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2020/06/24/2020.06.23.166603.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G231238943","display_name":"Progression factors in melanoma leading to novel therapeutic targets","funder_award_id":"282059","funder_id":"https://openalex.org/F4320338352","funder_display_name":"FP7 Ideas: European Research Council"},{"id":"https://openalex.org/G2522048720","display_name":"Integrating innovative technologies for genotyping and phenotyping in stratified medicine","funder_award_id":"MR/M009157/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G3137453868","display_name":"Exploring how endocytic recycling of receptor tyrosine kinases specifies cellular responses.","funder_award_id":"107636/A/15/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G3442122185","display_name":"DGAT1 is a novel melanoma oncogene","funder_award_id":"610262","funder_id":"https://openalex.org/F4320308296","funder_display_name":"Melanoma Research Alliance"},{"id":"https://openalex.org/G6868616705","display_name":null,"funder_award_id":"/Z/15/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G792842285","display_name":null,"funder_award_id":"107636/ Z/15/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G8511167494","display_name":null,"funder_award_id":"A23251","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"}],"funders":[{"id":"https://openalex.org/F4320308296","display_name":"Melanoma Research Alliance","ror":"https://ror.org/025ck6r46"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320338352","display_name":"FP7 Ideas: European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3036445708.pdf","grobid_xml":"https://content.openalex.org/works/W3036445708.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W1516721515","https://openalex.org/W1550747483","https://openalex.org/W1977918192","https://openalex.org/W1986234170","https://openalex.org/W1997238838","https://openalex.org/W2007517413","https://openalex.org/W2011133384","https://openalex.org/W2013570209","https://openalex.org/W2014671368","https://openalex.org/W2024138646","https://openalex.org/W2035738326","https://openalex.org/W2041237929","https://openalex.org/W2042752102","https://openalex.org/W2056040807","https://openalex.org/W2061671067","https://openalex.org/W2070050178","https://openalex.org/W2074329146","https://openalex.org/W2098131661","https://openalex.org/W2114843025","https://openalex.org/W2121990555","https://openalex.org/W2127624416","https://openalex.org/W2128149258","https://openalex.org/W2157852151","https://openalex.org/W2170096200","https://openalex.org/W2275678839","https://openalex.org/W2395626624","https://openalex.org/W2409438593","https://openalex.org/W2560396365","https://openalex.org/W2583594489","https://openalex.org/W2593816418","https://openalex.org/W2604316693","https://openalex.org/W2622950952","https://openalex.org/W2725383737","https://openalex.org/W2729569907","https://openalex.org/W2737046088","https://openalex.org/W2761586844","https://openalex.org/W2767190680","https://openalex.org/W2770225202","https://openalex.org/W2771932126","https://openalex.org/W2772163503","https://openalex.org/W2773070885","https://openalex.org/W2781847477","https://openalex.org/W2792592939","https://openalex.org/W2793046629","https://openalex.org/W2796192631","https://openalex.org/W2808347790","https://openalex.org/W2885582506","https://openalex.org/W2888976073","https://openalex.org/W2891967018","https://openalex.org/W2905852219","https://openalex.org/W2913214687","https://openalex.org/W2919288354","https://openalex.org/W2928665623","https://openalex.org/W2942264351","https://openalex.org/W2971445256","https://openalex.org/W2978449399","https://openalex.org/W2979426601","https://openalex.org/W2988805363","https://openalex.org/W2992324722","https://openalex.org/W3001738994","https://openalex.org/W3005474073"],"related_works":["https://openalex.org/W6999730277","https://openalex.org/W4283258349","https://openalex.org/W3084116825","https://openalex.org/W2989423849","https://openalex.org/W3028888477","https://openalex.org/W2919288354","https://openalex.org/W2187229549","https://openalex.org/W4392919749","https://openalex.org/W3094645115"],"abstract_inverted_index":{"ABSTRACT":[0],"Dysregulated":[1],"cellular":[2],"metabolism":[3],"is":[4,154,185],"a":[5,86,155],"hallmark":[6,18],"of":[7,142,160,170],"cancer.":[8],"As":[9],"yet,":[10],"few":[11],"druggable":[12],"oncoproteins":[13],"directly":[14],"responsible":[15],"for":[16,113,188,193],"this":[17,60],"have":[19],"been":[20],"identified.":[21],"Increased":[22],"fatty":[23,39,96,136,175],"acid":[24,137,176],"acquisition":[25,177],"allows":[26],"cancer":[27,56,61,91],"cells":[28,92,180],"to":[29,78,93],"meet":[30],"their":[31],"membrane":[32],"biogenesis,":[33],"ATP,":[34],"and":[35,45,81,106,130,164],"signaling":[36,44,129],"needs.":[37],"Excess":[38],"acids":[40],"suppress":[41],"growth":[42,123],"factor":[43],"cause":[46],"oxidative":[47],"stress":[48],"in":[49,55,103],"non-transformed":[50],"cells,":[51],"but":[52],"surprisingly":[53],"not":[54],"cells.":[57],"Molecules":[58],"underlying":[59],"adaptation":[62],"may":[63],"provide":[64],"new":[65],"drug":[66],"targets.":[67],"Here,":[68],"we":[69],"identify":[70],"Diacylglycerol":[71],"O-acyltransferase":[72],"1":[73],"(DGAT1),":[74],"an":[75],"enzyme":[76],"integral":[77],"triacylglyceride":[79],"synthesis":[80],"lipid":[82,147],"droplet":[83],"formation,":[84],"as":[85],"frequently":[87],"up-regulated":[88],"oncoprotein":[89,158],"allowing":[90],"tolerate":[94],"excess":[95],"acids.":[97],"DGAT1":[98,119,153,172,184],"over-expression":[99],"alone":[100],"induced":[101],"melanoma":[102,116,121,162,179,194],"zebrafish":[104],"melanocytes,":[105],"co-operated":[107],"with":[108,166],"oncogenic":[109],"BRAF":[110],"or":[111],"NRAS":[112],"more":[114],"rapid":[115],"formation.":[117],"Mechanistically,":[118],"stimulated":[120],"cell":[122,132,195],"through":[124,181],"sustaining":[125],"mTOR":[126],"kinase\u2013S6":[127],"kinase":[128],"suppressed":[131],"death":[133],"by":[134,178],"tempering":[135],"oxidation,":[138],"thereby":[139],"preventing":[140],"accumulation":[141],"reactive":[143],"oxygen":[144],"species":[145],"including":[146],"peroxides.":[148],"SIGNIFICANCE":[149],"We":[150],"show":[151],"that":[152],"bona":[156],"fide":[157],"capable":[159],"inducing":[161],"formation":[163],"co-operating":[165],"other":[167],"known":[168],"drivers":[169],"melanoma.":[171],"facilitates":[173],"enhanced":[174],"suppressing":[182],"lipototoxicity.":[183],"also":[186],"critical":[187],"maintaining":[189],"S6K":[190],"activity":[191],"required":[192],"growth.":[196]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2020-06-25T00:00:00"}