{"id":"https://openalex.org/W3036409010","doi":"https://doi.org/10.1158/2326-6066.cir-20-0181","title":"SRC-3 Functions as a Coactivator of T-bet by Regulating the Maturation and Antitumor Activity of Natural Killer Cells","display_name":"SRC-3 Functions as a Coactivator of T-bet by Regulating the Maturation and Antitumor Activity of Natural Killer Cells","publication_year":2020,"publication_date":"2020-06-19","ids":{"openalex":"https://openalex.org/W3036409010","doi":"https://doi.org/10.1158/2326-6066.cir-20-0181","mag":"3036409010","pmid":"https://pubmed.ncbi.nlm.nih.gov/32561537"},"language":"en","primary_location":{"id":"doi:10.1158/2326-6066.cir-20-0181","doi":"https://doi.org/10.1158/2326-6066.cir-20-0181","is_oa":false,"landing_page_url":"https://doi.org/10.1158/2326-6066.cir-20-0181","pdf_url":null,"source":{"id":"https://openalex.org/S2765010658","display_name":"Cancer Immunology Research","issn_l":"2326-6066","issn":["2326-6066","2326-6074"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Immunology Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064363137","display_name":"Mengjia Hu","orcid":"https://orcid.org/0000-0002-9447-6047","observed_orcids":["https://orcid.org/0000-0002-9447-6047"]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengjia Hu","raw_affiliation_strings":["1State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Chongqing, China","institution_ids":["https://openalex.org/I151075929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066228329","display_name":"Yukai Lu","orcid":"https://orcid.org/0000-0001-6239-3880","observed_orcids":["https://orcid.org/0000-0001-6239-3880"]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yukai Lu","raw_affiliation_strings":["1State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Chongqing, China","institution_ids":["https://openalex.org/I151075929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101862186","display_name":"Yan Qi","orcid":"https://orcid.org/0000-0002-8394-4466","observed_orcids":["https://orcid.org/0000-0002-8394-4466"]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Qi","raw_affiliation_strings":["1State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Chongqing, China","institution_ids":["https://openalex.org/I151075929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100404243","display_name":"Zihao Zhang","orcid":"https://orcid.org/0009-0004-1539-031X","observed_orcids":["https://orcid.org/0009-0004-1539-031X","https://orcid.org/0000-0003-0527-5049"]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zihao Zhang","raw_affiliation_strings":["1State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Chongqing, China","institution_ids":["https://openalex.org/I151075929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100326211","display_name":"Song Wang","orcid":"https://orcid.org/0000-0002-8351-6656","observed_orcids":["https://orcid.org/0000-0002-8351-6656","https://orcid.org/0009-0002-7244-1246"]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Song Wang","raw_affiliation_strings":["1State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Chongqing, China","institution_ids":["https://openalex.org/I151075929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100606301","display_name":"Yang Xu","orcid":"https://orcid.org/0000-0002-8083-6750","observed_orcids":["https://orcid.org/0000-0002-8083-6750"]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Xu","raw_affiliation_strings":["1State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Chongqing, China","institution_ids":["https://openalex.org/I151075929"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Fang Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fang Chen","raw_affiliation_strings":["1State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Chongqing, China","institution_ids":["https://openalex.org/I151075929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101995226","display_name":"Yong Tang","orcid":"https://orcid.org/0000-0002-4858-4012","observed_orcids":["https://orcid.org/0000-0002-4858-4012"]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yong Tang","raw_affiliation_strings":["1State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Chongqing, China","institution_ids":["https://openalex.org/I151075929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001629068","display_name":"Shilei Chen","orcid":"https://orcid.org/0000-0002-5281-8918","observed_orcids":["https://orcid.org/0000-0002-5281-8918"]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shilei Chen","raw_affiliation_strings":["1State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Chongqing, China","institution_ids":["https://openalex.org/I151075929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086221768","display_name":"Mo Chen","orcid":"https://orcid.org/0000-0001-7226-6789","observed_orcids":["https://orcid.org/0000-0001-7226-6789"]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mo Chen","raw_affiliation_strings":["1State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Chongqing, China","institution_ids":["https://openalex.org/I151075929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011426710","display_name":"Changhong Du","orcid":"https://orcid.org/0000-0002-1537-0325","observed_orcids":["https://orcid.org/0000-0002-1537-0325"]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Changhong Du","raw_affiliation_strings":["1State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Chongqing, China","institution_ids":["https://openalex.org/I151075929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108834494","display_name":"Mingqiang Shen","orcid":"https://orcid.org/0000-0002-6925-5613","observed_orcids":["https://orcid.org/0000-0002-6925-5613"]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingqiang Shen","raw_affiliation_strings":["1State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Chongqing, China","institution_ids":["https://openalex.org/I151075929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100776333","display_name":"Fengchao Wang","orcid":"https://orcid.org/0000-0003-0766-2173","observed_orcids":["https://orcid.org/0000-0003-0766-2173","https://orcid.org/0000-0002-7410-6620"]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fengchao Wang","raw_affiliation_strings":["1State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Chongqing, China","institution_ids":["https://openalex.org/I151075929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110366856","display_name":"Yongping Su","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongping Su","raw_affiliation_strings":["1State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Chongqing, China","institution_ids":["https://openalex.org/I151075929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063989151","display_name":"Youcai Deng","orcid":"https://orcid.org/0000-0001-5488-8576","observed_orcids":["https://orcid.org/0000-0001-5488-8576"]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Youcai Deng","raw_affiliation_strings":["2Institute of Materia Medica, College of Pharmacy, Third Military Medical University, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Institute of Materia Medica, College of Pharmacy, Third Military Medical University, Chongqing, China","institution_ids":["https://openalex.org/I151075929"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100670730","display_name":"Junping Wang","orcid":"https://orcid.org/0000-0001-5905-0940","observed_orcids":["https://orcid.org/0000-0001-5905-0940"]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junping Wang","raw_affiliation_strings":["1State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Chongqing, China","institution_ids":["https://openalex.org/I151075929"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I151075929"],"apc_list":null,"apc_paid":null,"fwci":0.5165,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.56896749,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"8","issue":"9","first_page":"1150","last_page":"1162"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/src-3","display_name":"SRC-3","score":0.9629999995231628},{"id":"https://openalex.org/keywords/t-bet","display_name":"T-bet","score":0.972000002861023},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.9850000143051147},{"id":"https://openalex.org/keywords/nk-cell-maturation","display_name":"NK cell maturation","score":0.8130000233650208},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.7979999780654907},{"id":"https://openalex.org/keywords/transcriptional-coactivation","display_name":"transcriptional coactivation","score":0.7860000133514404},{"id":"https://openalex.org/keywords/zeb2","display_name":"ZEB2","score":0.9269999861717224},{"id":"https://openalex.org/keywords/blimp-1","display_name":"Blimp-1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/s1pr5","display_name":"S1PR5","score":0.9909999966621399},{"id":"https://openalex.org/keywords/nuclear-translocation","display_name":"nuclear translocation","score":0.8460000157356262},{"id":"https://openalex.org/keywords/tumor-surveillance","display_name":"tumor surveillance","score":0.8220000267028809},{"id":"https://openalex.org/keywords/steroid-receptor-coactivators","display_name":"steroid receptor coactivators","score":0.5120000243186951}],"concepts":[{"id":"https://openalex.org/C77445288","wikidata":"https://www.wikidata.org/wiki/Q637488","display_name":"Coactivator","level":4,"score":0.7302058935165405},{"id":"https://openalex.org/C2776608160","wikidata":"https://www.wikidata.org/wiki/Q4785462","display_name":"Natural (archaeology)","level":2,"score":0.49704626202583313},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4789986312389374},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.4528714418411255},{"id":"https://openalex.org/C108636557","wikidata":"https://www.wikidata.org/wiki/Q21109354","display_name":"Proto-oncogene tyrosine-protein kinase Src","level":3,"score":0.4397931694984436},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4276278018951416},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35076987743377686},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3222130835056305},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.2257538139820099},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.18494713306427002},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1367000937461853},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11543673276901245},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.10954806208610535},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008546","descriptor_name":"Melanoma, Experimental","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056921","descriptor_name":"Nuclear Receptor Coactivator 3","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D056921","descriptor_name":"Nuclear Receptor Coactivator 3","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1158/2326-6066.cir-20-0181","doi":"https://doi.org/10.1158/2326-6066.cir-20-0181","is_oa":false,"landing_page_url":"https://doi.org/10.1158/2326-6066.cir-20-0181","pdf_url":null,"source":{"id":"https://openalex.org/S2765010658","display_name":"Cancer Immunology Research","issn_l":"2326-6066","issn":["2326-6066","2326-6074"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Immunology Research","raw_type":"journal-article"},{"id":"pmid:32561537","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32561537","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer immunology research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1800724462","display_name":null,"funder_award_id":"81573084","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G579715080","display_name":"\u7535\u79bb\u8f90\u5c04\u81f4\u9aa8\u9ad3\u9020\u8840\u6162\u6027\u635f\u4f24\u7684\u6548\u5e94\u4e0e\u673a\u5236\u7814\u7a76","funder_award_id":"81930090","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6109347227","display_name":null,"funder_award_id":"AWS16J014","funder_id":"https://openalex.org/F4320332856","funder_display_name":"Public Library Association"},{"id":"https://openalex.org/G6458950741","display_name":null,"funder_award_id":"81500087","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8605986815","display_name":null,"funder_award_id":"81725019","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320332856","display_name":"Public Library Association","ror":"https://ror.org/03eg6ys02"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1500703461","https://openalex.org/W1528382674","https://openalex.org/W1825871879","https://openalex.org/W1866358952","https://openalex.org/W1966315835","https://openalex.org/W1977027014","https://openalex.org/W1980393439","https://openalex.org/W2006120252","https://openalex.org/W2022069273","https://openalex.org/W2033457677","https://openalex.org/W2037001386","https://openalex.org/W2044723012","https://openalex.org/W2065201368","https://openalex.org/W2067518787","https://openalex.org/W2073300038","https://openalex.org/W2077772422","https://openalex.org/W2091744080","https://openalex.org/W2092705670","https://openalex.org/W2097134216","https://openalex.org/W2105910944","https://openalex.org/W2127334297","https://openalex.org/W2127944870","https://openalex.org/W2137835860","https://openalex.org/W2145704789","https://openalex.org/W2148093274","https://openalex.org/W2151463503","https://openalex.org/W2157586986","https://openalex.org/W2168405751","https://openalex.org/W2235808789","https://openalex.org/W2248268226","https://openalex.org/W2308713192","https://openalex.org/W2345615811","https://openalex.org/W2398473974","https://openalex.org/W2471767420","https://openalex.org/W2536673977","https://openalex.org/W2587933500","https://openalex.org/W2624710712","https://openalex.org/W2766566645","https://openalex.org/W2785341808","https://openalex.org/W2792405992","https://openalex.org/W2804095578","https://openalex.org/W2804122556","https://openalex.org/W2810696819","https://openalex.org/W2891599740","https://openalex.org/W2901501609","https://openalex.org/W2903803003","https://openalex.org/W2944276385","https://openalex.org/W2947619927"],"related_works":["https://openalex.org/W2335580378","https://openalex.org/W2770812810","https://openalex.org/W2588664945","https://openalex.org/W2037001386","https://openalex.org/W1995282122","https://openalex.org/W1975832952","https://openalex.org/W7148649602","https://openalex.org/W4283807025","https://openalex.org/W4378781758","https://openalex.org/W2295269397"],"abstract_inverted_index":{"Abstract":[0],"Natural":[1],"killer":[2],"(NK)\u2013cell":[3],"development":[4],"and":[5,23,47,60,87,111,146],"maturation":[6],"is":[7,17,32],"a":[8,18,106,132,139,153],"well-organized":[9],"process.":[10],"The":[11,76],"steroid":[12],"receptor":[13],"coactivator":[14,140],"3":[15],"(SRC-3)":[16],"regulator":[19],"of":[20,54,78,102,124,136,141,162],"the":[21,100,122,125,158],"hematopoietic":[22],"immune":[24],"systems;":[25],"however,":[26],"its":[27],"role":[28,135],"in":[29,41,96,99,143],"NK":[30,42,97,163],"cells":[31,43,98],"poorly":[33],"understood.":[34],"Here,":[35],"SRC-3":[36,55,64,110,115,137,150],"displayed":[37],"increased":[38],"nuclear":[39],"translocation":[40],"during":[44],"terminal":[45],"differentiation":[46],"upon":[48],"inflammatory":[49],"cytokine":[50],"stimulation.":[51],"Targeted":[52],"deletion":[53],"altered":[56],"normal":[57],"NK-cell":[58,62,70,144],"distribution":[59],"compromised":[61],"maturation.":[63],"deficiency":[65],"led":[66],"to":[67,120,156],"significantly":[68],"impaired":[69],"functions,":[71],"especially":[72],"their":[73],"antitumor":[74],"activity.":[75],"expression":[77],"several":[79],"critical":[80],"T-bet":[81,91,112,119,142],"target":[82],"genes,":[83],"including":[84],"Zeb2,":[85],"Prdm1,":[86],"S1pr5,":[88],"but":[89],"not":[90],"itself,":[92],"was":[93,105,116],"markedly":[94],"decreased":[95],"absence":[101],"SRC-3.":[103],"There":[104],"physiologic":[107],"interaction":[108],"between":[109],"proteins,":[113],"where":[114],"recruited":[117],"by":[118],"regulate":[121],"transcription":[123],"aforementioned":[126],"genes.":[127],"Collectively,":[128],"our":[129],"findings":[130],"unmask":[131],"previously":[133],"unrecognized":[134],"as":[138],"biology":[145],"indicate":[147],"that":[148],"targeting":[149],"may":[151],"be":[152],"promising":[154],"strategy":[155],"increase":[157],"tumor":[159],"surveillance":[160],"function":[161],"cells.":[164]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2020-06-25T00:00:00"}