{"id":"https://openalex.org/W3036334591","doi":"https://doi.org/10.1093/europace/euaa162.301","title":"73Hemoglobin a1c levels and the risk of ischemic stroke and mortality in individuals with diabetes mellitus and atrial fibrillation","display_name":"73Hemoglobin a1c levels and the risk of ischemic stroke and mortality in individuals with diabetes mellitus and atrial fibrillation","publication_year":2020,"publication_date":"2020-06-01","ids":{"openalex":"https://openalex.org/W3036334591","doi":"https://doi.org/10.1093/europace/euaa162.301","mag":"3036334591"},"language":"en","primary_location":{"id":"doi:10.1093/europace/euaa162.301","doi":"https://doi.org/10.1093/europace/euaa162.301","is_oa":true,"landing_page_url":"https://doi.org/10.1093/europace/euaa162.301","pdf_url":"https://academic.oup.com/europace/article-pdf/22/Supplement_1/euaa162.301/33548484/euaa162.301.pdf","source":{"id":"https://openalex.org/S46732370","display_name":"EP Europace","issn_l":"1099-5129","issn":["1099-5129","1532-2092"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EP Europace","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/europace/article-pdf/22/Supplement_1/euaa162.301/33548484/euaa162.301.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082563611","display_name":"Louise Kezerle","orcid":"https://orcid.org/0000-0002-7858-737X","observed_orcids":["https://orcid.org/0000-0002-7858-737X"]},"institutions":[{"id":"https://openalex.org/I2800633300","display_name":"Soroka Medical Center","ror":"https://ror.org/003sphj24","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2800633300","https://openalex.org/I64767286"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"L Kezerle","raw_affiliation_strings":["Soroka University Medical Center, Beer Sheva, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Soroka University Medical Center, Beer Sheva, Israel","institution_ids":["https://openalex.org/I2800633300"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039870075","display_name":"Meytal Avgil Tsadok","orcid":"https://orcid.org/0000-0001-5127-8609","observed_orcids":["https://orcid.org/0000-0001-5127-8609"]},"institutions":[{"id":"https://openalex.org/I64767286","display_name":"Clalit Health Services","ror":"https://ror.org/04zjvnp94","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I64767286"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"M A Tsadok","raw_affiliation_strings":["Clalit Health Research Institute, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clalit Health Research Institute, Tel Aviv, Israel","institution_ids":["https://openalex.org/I64767286"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061341276","display_name":"Amichay Akriv","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I64767286","display_name":"Clalit Health Services","ror":"https://ror.org/04zjvnp94","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I64767286"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"A Akriv","raw_affiliation_strings":["Clalit Health Research Institute, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clalit Health Research Institute, Tel Aviv, Israel","institution_ids":["https://openalex.org/I64767286"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091629822","display_name":"Becca Feldman","orcid":"https://orcid.org/0000-0002-9535-2249","observed_orcids":["https://orcid.org/0000-0002-9535-2249"]},"institutions":[{"id":"https://openalex.org/I64767286","display_name":"Clalit Health Services","ror":"https://ror.org/04zjvnp94","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I64767286"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"B Feldman","raw_affiliation_strings":["Clalit Health Research Institute, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clalit Health Research Institute, Tel Aviv, Israel","institution_ids":["https://openalex.org/I64767286"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047307940","display_name":"Maya Leventer\u2010Roberts","orcid":"https://orcid.org/0000-0001-5797-0786","observed_orcids":["https://orcid.org/0000-0001-5797-0786"]},"institutions":[{"id":"https://openalex.org/I64767286","display_name":"Clalit Health Services","ror":"https://ror.org/04zjvnp94","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I64767286"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"M Leventer-Roberts","raw_affiliation_strings":["Clalit Health Research Institute, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clalit Health Research Institute, Tel Aviv, Israel","institution_ids":["https://openalex.org/I64767286"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031898772","display_name":"Reut Ohana","orcid":"https://orcid.org/0009-0001-1216-5625","observed_orcids":["https://orcid.org/0009-0001-1216-5625"]},"institutions":[{"id":"https://openalex.org/I64767286","display_name":"Clalit Health Services","ror":"https://ror.org/04zjvnp94","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I64767286"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"R Ohana","raw_affiliation_strings":["Clalit Health Research Institute, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clalit Health Research Institute, Tel Aviv, Israel","institution_ids":["https://openalex.org/I64767286"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041877269","display_name":"Moti Haim","orcid":"https://orcid.org/0000-0001-6673-0506","observed_orcids":["https://orcid.org/0000-0001-6673-0506"]},"institutions":[{"id":"https://openalex.org/I2800633300","display_name":"Soroka Medical Center","ror":"https://ror.org/003sphj24","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2800633300","https://openalex.org/I64767286"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"M Haim","raw_affiliation_strings":["Soroka University Medical Center, Beer Sheva, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Soroka University Medical Center, Beer Sheva, Israel","institution_ids":["https://openalex.org/I2800633300"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4344,"currency":"EUR","value_usd":4909},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"22","issue":"Supplement_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.843999981880188},{"id":"https://openalex.org/keywords/glycemic-control","display_name":"glycemic control","score":0.8569999933242798},{"id":"https://openalex.org/keywords/non-valvular-atrial-fibrillation","display_name":"non-valvular atrial fibrillation","score":0.9470000267028809},{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.847000002861023},{"id":"https://openalex.org/keywords/stroke-risk","display_name":"stroke risk","score":0.7110000252723694},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.8859999775886536},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.9929999709129333},{"id":"https://openalex.org/keywords/embolic-complications","display_name":"embolic complications","score":0.5899999737739563},{"id":"https://openalex.org/keywords/oral-anticoagulants","display_name":"oral anticoagulants","score":0.7730000019073486},{"id":"https://openalex.org/keywords/cha2ds2-vasc-score","display_name":"CHA2DS2-VASc score","score":0.8949999809265137},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.6320000290870667},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.4749999940395355},{"id":"https://openalex.org/keywords/tel-aviv","display_name":"Tel Aviv","score":0.3149999976158142}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9818552732467651},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.8344784379005432},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.7525361776351929},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.7367339134216309},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6666032075881958},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.6590214371681213},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.6446046829223633},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.5046237707138062},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.502626895904541},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4371187388896942},{"id":"https://openalex.org/C144301174","wikidata":"https://www.wikidata.org/wiki/Q7893852","display_name":"Univariate analysis","level":3,"score":0.4337582290172577},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3628422021865845},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.35028183460235596},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.20677873492240906},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.10227897763252258},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/europace/euaa162.301","doi":"https://doi.org/10.1093/europace/euaa162.301","is_oa":true,"landing_page_url":"https://doi.org/10.1093/europace/euaa162.301","pdf_url":"https://academic.oup.com/europace/article-pdf/22/Supplement_1/euaa162.301/33548484/euaa162.301.pdf","source":{"id":"https://openalex.org/S46732370","display_name":"EP Europace","issn_l":"1099-5129","issn":["1099-5129","1532-2092"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EP Europace","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1093/europace/euaa162.301","doi":"https://doi.org/10.1093/europace/euaa162.301","is_oa":true,"landing_page_url":"https://doi.org/10.1093/europace/euaa162.301","pdf_url":"https://academic.oup.com/europace/article-pdf/22/Supplement_1/euaa162.301/33548484/euaa162.301.pdf","source":{"id":"https://openalex.org/S46732370","display_name":"EP Europace","issn_l":"1099-5129","issn":["1099-5129","1532-2092"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EP Europace","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W3036334591.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4220999201","https://openalex.org/W2286769709","https://openalex.org/W2809021408","https://openalex.org/W7165568539","https://openalex.org/W3119603452","https://openalex.org/W2888590090","https://openalex.org/W4404381617","https://openalex.org/W2045388469","https://openalex.org/W4210832175","https://openalex.org/W2905002467"],"abstract_inverted_index":{"Abstract":[0,335],"Funding":[1],"Acknowledgements":[2],"Pfizer":[3],"Israel":[4],"Background":[5],"Diabetes":[6],"mellitus":[7],"(DM)":[8],"is":[9,39],"associated":[10,216,311],"with":[11,47,96,190,202,217,224,232,277,301,312],"increased":[12,219,314],"risk":[13,24,57,220,259,267,315,328],"of":[14,25,37,58,100,115,128,137,149,171,176,213,221,263,299,316],"embolic":[15],"complications":[16],"in":[17,27,181,188,194,200,281,318,332],"non-valvular":[18],"atrial":[19,306],"fibrillation":[20],"(NVAF).":[21],"Whether":[22],"the":[23,31,34,53,76,135,174,182,195,282],"stroke":[26,60,177,222,317,331],"AF":[28,48,138],"patients":[29,120,129,189,300],"remains":[30],"same":[32],"among":[33],"wide":[35],"spectrum":[36],"disease":[38],"yet":[40],"to":[41,51,106,131,230],"be":[42],"determined.":[43],"Aim":[44],"Among":[45,118],"individuals":[46,231],"and":[49,56,61,110,143,162,198,208,247,261],"DM,":[50],"assess":[52],"incidence":[54,175],"rates":[55],"ischemic":[59],"mortality":[62,270],"by":[63],"baseline":[64],"HbA1C":[65],"levels.":[66],"Methods":[67],"We":[68],"conducted":[69],"a":[70,97,111,167,225,278,319],"prospective,":[71],"historical":[72],"cohort":[73,298],"study":[74,86,184],"using":[75],"Clalit":[77],"Health":[78],"Services":[79],"(CHS)":[80],"electronic":[81],"medical":[82],"records":[83],"database.":[84],"The":[85,154,266],"population":[87],"included":[88],"all":[89],"CHS":[90],"members":[91],"\u2265":[92,144],"21":[93],"years":[94,159],"old,":[95],"first":[98],"diagnosis":[99],"NVAF":[101],"between":[102,141,245,275],"January":[103],"1,":[104],"2010":[105],"December":[107],"31,":[108],"2016":[109],"minimal":[112],"follow-up":[113],"period":[114],"1":[116],"year.":[117],"those":[119,201],"identified":[121],"as":[122],"diabetics,":[123],"we":[124],"compared":[125,223,229],"three":[126,183],"groups":[127,185],"according":[130],"HBA1C":[132,191,203,214,233,283,308],"levels":[133,212,244,309],"at":[134],"time":[136],"diagnosis:":[139],"<7.0%,":[140],"7-9%":[142,246],"9%.":[145],"Results":[146],"A":[147],"total":[148],"44,451":[150],"cases":[151],"were":[152,164,215,310],"identified.":[153],"median":[155],"age":[156],"was":[157],"75":[158],"(IQR":[160],"65-83)":[161],"52.5%":[163],"women.":[165],"During":[166],"mean":[168],"follow":[169],"up":[170],"38":[172],"months,":[173],"per":[178],"100":[179],"person-years":[180],"was:":[186],"1.9":[187],"<7%,":[192],"2.37":[193],"intermediary":[196],"group":[197,285],"2.72":[199],">9%.":[204],"In":[205,295],"both":[206],"univariate":[207],"multivariate":[209],"analyses,":[210],"higher":[211],"an":[218,313],"dose-dependent":[226,320],"response":[227],"when":[228],"<7%":[234],"(Adjusted":[235],"Hazard":[236],"Ratio":[237],"(AHR)":[238],"=":[239,290],"1.32":[240],"{95%":[241,250],"CI":[242,251],"1.12-1.55}for":[243],"AHR":[248],"1.64":[249],"1.28-2.09})":[252],"even":[253,322],"after":[254,286,323],"adjusting":[255],"for":[256,268,325,330,338],"CHA2DS2-VASC":[257],"individual":[258],"factors":[260,329],"use":[262],"oral":[264],"anti-coagulants.":[265],"overall":[269],"did":[271],"not":[272],"differ":[273],"significantly":[274],"groups,":[276],"slight":[279],"elevation":[280],">9%":[284],"adjusted":[287],"analysis":[288],"{aHR":[289],"1.17":[291],"(1.07-":[292],"1.28)}":[293],"Conclusion:":[294],"this":[296,333],"observational":[297],"incident":[302],"newly":[303],"diagnosed":[304],"nonvalvular":[305],"fibrillation,":[307],"manner":[321],"accounting":[324],"other":[326],"recognized":[327],"population.":[334],"Figure.":[336],"Kaplan-Meier":[337],"stroke-free":[339],"survival":[340]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2020-06-25T00:00:00"}
