{"id":"https://openalex.org/W3036334165","doi":"https://doi.org/10.1186/s41232-020-00121-y","title":"Therapeutic potential of mesenchymal stem cells and their exosomes in severe novel coronavirus disease 2019 (COVID-19) cases","display_name":"Therapeutic potential of mesenchymal stem cells and their exosomes in severe novel coronavirus disease 2019 (COVID-19) cases","publication_year":2020,"publication_date":"2020-06-22","ids":{"openalex":"https://openalex.org/W3036334165","doi":"https://doi.org/10.1186/s41232-020-00121-y","mag":"3036334165","pmid":"https://pubmed.ncbi.nlm.nih.gov/32582401","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7306412"},"language":"en","primary_location":{"id":"doi:10.1186/s41232-020-00121-y","doi":"https://doi.org/10.1186/s41232-020-00121-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s41232-020-00121-y","pdf_url":null,"source":{"id":"https://openalex.org/S143716263","display_name":"Inflammation and Regeneration","issn_l":"1346-8022","issn":["1346-8022","1880-5795","1880-8190","1880-9693"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammation and Regeneration","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s41232-020-00121-y","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054383014","display_name":"Atsunori Tsuchiya","orcid":"https://orcid.org/0000-0002-9279-5917","observed_orcids":["https://orcid.org/0000-0002-9279-5917"]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Atsunori Tsuchiya","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043758198","display_name":"Suguru Takeuchi","orcid":"https://orcid.org/0000-0002-7346-4506","observed_orcids":["https://orcid.org/0000-0002-7346-4506"]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Suguru Takeuchi","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069229457","display_name":"Takahiro Iwasawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahiro Iwasawa","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113965173","display_name":"Masaru Kumagai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaru Kumagai","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101526414","display_name":"Takeki Sato","orcid":"https://orcid.org/0009-0005-8392-0623","observed_orcids":["https://orcid.org/0009-0005-8392-0623"]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takeki Sato","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002228109","display_name":"Satoko Motegi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoko Motegi","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021150259","display_name":"Yui Ishii","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yui Ishii","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012721078","display_name":"Youhei Koseki","orcid":"https://orcid.org/0000-0002-2338-0830","observed_orcids":["https://orcid.org/0000-0002-2338-0830"]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Youhei Koseki","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057568273","display_name":"Kei Tomiyoshi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kei Tomiyoshi","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010627734","display_name":"Kazuki Natsui","orcid":"https://orcid.org/0000-0003-1988-4144","observed_orcids":["https://orcid.org/0000-0003-1988-4144"]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuki Natsui","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009245595","display_name":"Nobutaka Takeda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobutaka Takeda","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082308125","display_name":"Yuki Yoshida","orcid":"https://orcid.org/0000-0002-0185-7554","observed_orcids":["https://orcid.org/0000-0002-0185-7554"]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuki Yoshida","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057818186","display_name":"Fusako Yamazaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Fusako Yamazaki","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001539195","display_name":"Yuichi Kojima","orcid":"https://orcid.org/0000-0001-8337-884X","observed_orcids":["https://orcid.org/0000-0001-8337-884X"]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuichi Kojima","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026624133","display_name":"Yusuke Watanabe","orcid":"https://orcid.org/0000-0001-7869-0409","observed_orcids":["https://orcid.org/0000-0001-7869-0409"]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yusuke Watanabe","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034419978","display_name":"Naruhiro Kimura","orcid":"https://orcid.org/0000-0001-6683-1219","observed_orcids":["https://orcid.org/0000-0001-6683-1219"]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naruhiro Kimura","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055854164","display_name":"Kentaro Tominaga","orcid":"https://orcid.org/0000-0001-6792-1005","observed_orcids":["https://orcid.org/0000-0001-6792-1005"]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kentaro Tominaga","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086343771","display_name":"Hiroteru Kamimura","orcid":"https://orcid.org/0000-0002-9135-3092","observed_orcids":["https://orcid.org/0000-0002-9135-3092"]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroteru Kamimura","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010895501","display_name":"Masaaki Takamura","orcid":"https://orcid.org/0000-0001-6773-4613","observed_orcids":["https://orcid.org/0000-0001-6773-4613"]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaaki Takamura","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021394925","display_name":"Shuji Terai","orcid":"https://orcid.org/0000-0002-5439-635X","observed_orcids":["https://orcid.org/0000-0002-5439-635X"]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Shuji Terai","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan","institution_ids":["https://openalex.org/I71395657"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5021394925","https://openalex.org/A5054383014"],"corresponding_institution_ids":["https://openalex.org/I71395657"],"apc_list":{"value":1230,"currency":"USD","value_usd":1230},"apc_paid":{"value":1230,"currency":"USD","value_usd":1230},"fwci":1.7417,"has_fulltext":true,"cited_by_count":78,"citation_normalized_percentile":{"value":0.87355405,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"40","issue":"1","first_page":"14","last_page":"14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9589999914169312,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9589999914169312,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.02500000037252903,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9879999756813049},{"id":"https://openalex.org/keywords/exosomes","display_name":"exosomes","score":0.9819999933242798},{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9670000076293945},{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.996999979019165},{"id":"https://openalex.org/keywords/cytokine-storm","display_name":"cytokine storm","score":0.8669999837875366},{"id":"https://openalex.org/keywords/acute-respiratory-distress-syndrome","display_name":"acute respiratory distress syndrome","score":1.0},{"id":"https://openalex.org/keywords/multiple-organ-failure","display_name":"multiple organ failure","score":0.9150000214576721},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.8569999933242798},{"id":"https://openalex.org/keywords/anti-inflammatory-macrophages","display_name":"anti-inflammatory macrophages","score":0.8149999976158142},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.925000011920929},{"id":"https://openalex.org/keywords/clinical-trials","display_name":"clinical trials","score":0.5659999847412109},{"id":"https://openalex.org/keywords/stem-cell-therapy","display_name":"stem cell therapy","score":0.7580000162124634}],"concepts":[{"id":"https://openalex.org/C2779559532","wikidata":"https://www.wikidata.org/wiki/Q1076369","display_name":"Cytokine storm","level":5,"score":0.8221909403800964},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.7757954597473145},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.7387956976890564},{"id":"https://openalex.org/C2776348555","wikidata":"https://www.wikidata.org/wiki/Q344873","display_name":"ARDS","level":3,"score":0.7119091749191284},{"id":"https://openalex.org/C2781261824","wikidata":"https://www.wikidata.org/wiki/Q903634","display_name":"Exosome","level":5,"score":0.694922685623169},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6634002327919006},{"id":"https://openalex.org/C2777648638","wikidata":"https://www.wikidata.org/wiki/Q57751738","display_name":"Coronavirus","level":5,"score":0.5643631815910339},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5235433578491211},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5158704519271851},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4793027937412262},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.45761388540267944},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.21386292576789856},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1905081570148468},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.18102341890335083},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.13356292247772217},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1277470588684082},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.12234723567962646},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10832011699676514},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1186/s41232-020-00121-y","doi":"https://doi.org/10.1186/s41232-020-00121-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s41232-020-00121-y","pdf_url":null,"source":{"id":"https://openalex.org/S143716263","display_name":"Inflammation and Regeneration","issn_l":"1346-8022","issn":["1346-8022","1880-5795","1880-8190","1880-9693"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammation and Regeneration","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7306412","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7306412/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7306412/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflamm Regen","raw_type":"Text"},{"id":"pmid:32582401","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32582401","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammation and regeneration","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:08e8189e496c4fbf8d3fd3404291ec0a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/08e8189e496c4fbf8d3fd3404291ec0a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Inflammation and Regeneration, Vol 40, Iss 1, Pp 1-6 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s41232-020-00121-y","doi":"https://doi.org/10.1186/s41232-020-00121-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s41232-020-00121-y","pdf_url":null,"source":{"id":"https://openalex.org/S143716263","display_name":"Inflammation and Regeneration","issn_l":"1346-8022","issn":["1346-8022","1880-5795","1880-8190","1880-9693"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammation and Regeneration","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2283612345","display_name":"Development of novel anti-inflammatory therapy using mesenchymal stem cells","funder_award_id":"18K07903","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3036334165.pdf","grobid_xml":"https://content.openalex.org/works/W3036334165.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W2025371271","https://openalex.org/W2234004612","https://openalex.org/W2513841600","https://openalex.org/W2610356532","https://openalex.org/W2727272993","https://openalex.org/W2735330142","https://openalex.org/W2887348504","https://openalex.org/W2900422864","https://openalex.org/W2900756811","https://openalex.org/W2909460623","https://openalex.org/W2942732217","https://openalex.org/W2965521594","https://openalex.org/W2965732197","https://openalex.org/W2968489197","https://openalex.org/W2972860306","https://openalex.org/W2974844443","https://openalex.org/W2987862763","https://openalex.org/W3001118548","https://openalex.org/W3002108456","https://openalex.org/W3004280078","https://openalex.org/W3005079553","https://openalex.org/W3007940623","https://openalex.org/W3008385380","https://openalex.org/W3008827533","https://openalex.org/W3009859788","https://openalex.org/W3009885589","https://openalex.org/W3010233963","https://openalex.org/W3010456711","https://openalex.org/W3011152298","https://openalex.org/W3011568661","https://openalex.org/W3012421327","https://openalex.org/W3012492786","https://openalex.org/W3013058647","https://openalex.org/W3014001472","https://openalex.org/W3014249633","https://openalex.org/W3015228903","https://openalex.org/W3016075808","https://openalex.org/W3016263512","https://openalex.org/W3016535995","https://openalex.org/W3016846376","https://openalex.org/W3022970339","https://openalex.org/W3025192101","https://openalex.org/W3163226127"],"related_works":["https://openalex.org/W4395112367","https://openalex.org/W3089093329","https://openalex.org/W3048652302","https://openalex.org/W3108125581","https://openalex.org/W3187158205","https://openalex.org/W4394850891","https://openalex.org/W3134043545","https://openalex.org/W4387940601","https://openalex.org/W3211336183","https://openalex.org/W3135624637"],"abstract_inverted_index":{"The":[0,24],"novel":[1],"coronavirus":[2,7,15],"severe":[3,116,128,168],"acute":[4,53],"respiratory":[5,54],"syndrome":[6,56],"2":[8],"(SARS-CoV-2)":[9],"is":[10],"the":[11,20,27,125,160],"causative":[12],"agent":[13],"of":[14,26,41,115,118,127,130,136,138,162,170,179],"disease":[16],"2019":[17],"(COVID-19)":[18],"and":[19,39,58,68,82,95,98,102,134,140,143,146,152,164,183],"ensuing":[21],"worldwide":[22],"pandemic.":[23],"spread":[25],"virus":[28],"has":[29],"had":[30],"global":[31],"effects":[32],"such":[33],"as":[34,74,76],"activity":[35],"restriction,":[36],"economic":[37],"stagnation,":[38],"collapse":[40],"healthcare":[42],"infrastructure.":[43],"Severe":[44],"SARS-CoV-2":[45],"infection":[46],"induces":[47],"a":[48],"cytokine":[49],"storm,":[50],"leading":[51],"to":[52],"distress":[55],"(ARDS)":[57],"multiple":[59],"organ":[60],"failure,":[61],"which":[62],"are":[63,109],"very":[64],"serious":[65],"health":[66],"conditions":[67],"must":[69],"be":[70],"mitigated":[71],"or":[72,175],"resolved":[73],"soon":[75],"possible.":[77],"Mesenchymal":[78],"stem":[79],"cells":[80,88],"(MSCs)":[81],"their":[83,141],"exosomes":[84,153,184],"can":[85,103],"affect":[86],"immune":[87],"by":[89],"inducing":[90],"anti-inflammatory":[91],"macrophages,":[92],"regulatory":[93,99],"T":[94,105],"B":[96],"cells,":[97,101],"dendritic":[100],"inactivate":[104],"cells.":[106],"Hence,":[107],"they":[108],"potential":[110,161],"candidate":[111],"agents":[112],"for":[113,154],"treatment":[114],"cases":[117,129,169],"COVID-19.":[119],"In":[120],"this":[121],"review,":[122],"we":[123,158],"report":[124,159],"background":[126],"COVID-19,":[131],"basic":[132,145],"aspects":[133],"mechanisms":[135],"action":[137],"MSCs":[139,151,180],"exosomes,":[142],"discuss":[144],"clinical":[147,177],"studies":[148],"based":[149],"on":[150,191],"influenza-induced":[155],"ARDS.":[156],"Finally,":[157],"MSC":[163],"exosome":[165],"therapy":[166],"in":[167,172,188],"COVID-19":[171],"recently":[173],"initiated":[174],"planned":[176],"trials":[178],"(33":[181],"trials)":[182],"(1":[185],"trial)":[186],"registered":[187],"13":[189],"countries":[190],"ClinicalTrials.gov.":[192]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":36},{"year":2020,"cited_by_count":18},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2020-06-25T00:00:00"}
