{"id":"https://openalex.org/W3036283153","doi":"https://doi.org/10.1177/0748233720925707","title":"Effect of titanium dioxide nanoparticles administered during pregnancy on depression-like behavior in forced swimming and tail suspension tests in offspring mice","display_name":"Effect of titanium dioxide nanoparticles administered during pregnancy on depression-like behavior in forced swimming and tail suspension tests in offspring mice","publication_year":2020,"publication_date":"2020-04-01","ids":{"openalex":"https://openalex.org/W3036283153","doi":"https://doi.org/10.1177/0748233720925707","mag":"3036283153","pmid":"https://pubmed.ncbi.nlm.nih.gov/32552541"},"language":"en","primary_location":{"id":"doi:10.1177/0748233720925707","doi":"https://doi.org/10.1177/0748233720925707","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0748233720925707","pdf_url":null,"source":{"id":"https://openalex.org/S6336342","display_name":"Toxicology and Industrial Health","issn_l":"0748-2337","issn":["0748-2337","1477-0393"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology and Industrial Health","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003380157","display_name":"Mitra Tarlan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166459259","display_name":"Shiraz University","ror":"https://ror.org/028qtbk54","country_code":"IR","type":"education","lineage":["https://openalex.org/I166459259"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mitra Tarlan","raw_affiliation_strings":["Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran","institution_ids":["https://openalex.org/I166459259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044838951","display_name":"Javad Sajedianfard","orcid":"https://orcid.org/0000-0001-6843-2983","observed_orcids":["https://orcid.org/0000-0001-6843-2983"]},"institutions":[{"id":"https://openalex.org/I166459259","display_name":"Shiraz University","ror":"https://ror.org/028qtbk54","country_code":"IR","type":"education","lineage":["https://openalex.org/I166459259"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Javad Sajedianfard","raw_affiliation_strings":["Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran"],"raw_orcid":"https://orcid.org/0000-0001-6843-2983","affiliations":[{"raw_affiliation_string":"Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran","institution_ids":["https://openalex.org/I166459259"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036427804","display_name":"Mazyar Fathi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166459259","display_name":"Shiraz University","ror":"https://ror.org/028qtbk54","country_code":"IR","type":"education","lineage":["https://openalex.org/I166459259"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mazyar Fathi","raw_affiliation_strings":["Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran","institution_ids":["https://openalex.org/I166459259"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5044838951"],"corresponding_institution_ids":["https://openalex.org/I166459259"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":1.1205,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.74509054,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"36","issue":"4","first_page":"297","last_page":"304"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":0.5336999893188477,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":0.5336999893188477,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10786","display_name":"Maternal Mental Health During Pregnancy and Postpartum","score":0.3158999979496002,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.033799998462200165,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/titanium-dioxide-nanoparticles","display_name":"titanium dioxide nanoparticles","score":1.0},{"id":"https://openalex.org/keywords/prenatal-exposure","display_name":"prenatal exposure","score":0.8640000224113464},{"id":"https://openalex.org/keywords/depression-like-behavior","display_name":"depression-like behavior","score":0.9869999885559082},{"id":"https://openalex.org/keywords/forced-swim-test","display_name":"forced swim test","score":0.8420000076293945},{"id":"https://openalex.org/keywords/tail-suspension-test","display_name":"tail suspension test","score":1.0},{"id":"https://openalex.org/keywords/immobility-time","display_name":"immobility time","score":0.8700000047683716},{"id":"https://openalex.org/keywords/offspring-behavior","display_name":"offspring behavior","score":0.48399999737739563},{"id":"https://openalex.org/keywords/second-generation-offspring","display_name":"second-generation offspring","score":0.7570000290870667},{"id":"https://openalex.org/keywords/nanoparticle-toxicity","display_name":"nanoparticle toxicity","score":0.6190000176429749},{"id":"https://openalex.org/keywords/developmental-neurotoxicity","display_name":"developmental neurotoxicity","score":0.6309999823570251}],"concepts":[{"id":"https://openalex.org/C112672928","wikidata":"https://www.wikidata.org/wiki/Q239526","display_name":"Offspring","level":3,"score":0.8363382816314697},{"id":"https://openalex.org/C136569192","wikidata":"https://www.wikidata.org/wiki/Q4880745","display_name":"Behavioural despair test","level":4,"score":0.7322531938552856},{"id":"https://openalex.org/C105341887","wikidata":"https://www.wikidata.org/wiki/Q1307987","display_name":"Suspension (topology)","level":3,"score":0.6115949153900146},{"id":"https://openalex.org/C2777593239","wikidata":"https://www.wikidata.org/wiki/Q193521","display_name":"Titanium dioxide","level":2,"score":0.5658236145973206},{"id":"https://openalex.org/C2781001258","wikidata":"https://www.wikidata.org/wiki/Q7676084","display_name":"Tail suspension test","level":5,"score":0.5016648769378662},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.4963398575782776},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.47099846601486206},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.4455582797527313},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3451518416404724},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.335033118724823},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3263469338417053},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.32121479511260986},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2618487775325775},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19986256957054138},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.14014267921447754},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.11051446199417114},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C5961521","wikidata":"https://www.wikidata.org/wiki/Q746083","display_name":"Homotopy","level":2,"score":0.0},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.0},{"id":"https://openalex.org/C202444582","wikidata":"https://www.wikidata.org/wiki/Q837863","display_name":"Pure mathematics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007492","descriptor_name":"Iran","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013550","descriptor_name":"Swimming","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014025","descriptor_name":"Titanium","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D018811","descriptor_name":"Maternal Exposure","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D019417","descriptor_name":"Hindlimb Suspension","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1177/0748233720925707","doi":"https://doi.org/10.1177/0748233720925707","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0748233720925707","pdf_url":null,"source":{"id":"https://openalex.org/S6336342","display_name":"Toxicology and Industrial Health","issn_l":"0748-2337","issn":["0748-2337","1477-0393"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology and Industrial Health","raw_type":"journal-article"},{"id":"pmid:32552541","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32552541","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology and industrial health","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311380","display_name":"School of Veterinary Science, Shiraz University","ror":"https://ror.org/028qtbk54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W55883933","https://openalex.org/W1591139950","https://openalex.org/W1621260886","https://openalex.org/W1966318343","https://openalex.org/W1969040530","https://openalex.org/W1987990233","https://openalex.org/W1997363723","https://openalex.org/W2005120531","https://openalex.org/W2013132604","https://openalex.org/W2017201333","https://openalex.org/W2026081258","https://openalex.org/W2029245044","https://openalex.org/W2031015267","https://openalex.org/W2040927330","https://openalex.org/W2043435297","https://openalex.org/W2050339045","https://openalex.org/W2051726387","https://openalex.org/W2060348273","https://openalex.org/W2070000758","https://openalex.org/W2073779348","https://openalex.org/W2081345968","https://openalex.org/W2089299823","https://openalex.org/W2102969320","https://openalex.org/W2105168029","https://openalex.org/W2111812837","https://openalex.org/W2114461027","https://openalex.org/W2120235566","https://openalex.org/W2121681651","https://openalex.org/W2130276206","https://openalex.org/W2131803478","https://openalex.org/W2147301250","https://openalex.org/W2152638739","https://openalex.org/W2157596197","https://openalex.org/W2169282855","https://openalex.org/W2891593735"],"related_works":["https://openalex.org/W2060348273","https://openalex.org/W3190782483","https://openalex.org/W2794134220","https://openalex.org/W2952347433","https://openalex.org/W3211484979","https://openalex.org/W2073779348","https://openalex.org/W2592805409","https://openalex.org/W1967740915","https://openalex.org/W3206998140","https://openalex.org/W2891593735"],"abstract_inverted_index":{"Introduction:":[0],"Applications":[1],"of":[2,29,37,82,90,123,136,165,170,208,230,242],"engineered":[3],"nanoparticles":[4,10],"are":[5,14],"rapidly":[6],"increasing.":[7],"Titanium":[8],"dioxide":[9],"(TiO":[11],"2":[12,44,69,138,172,210,246],"NPs)":[13],"used":[15],"in":[16,49,183,198,226,232,252],"many":[17],"products":[18],"including":[19],"those":[20],"produced":[21],"by":[22,79],"pigment":[23],"and":[24,52,57,128,133,148,160,167,188,205,220,237],"cosmetic":[25],"manufacturers.":[26],"The":[27,99],"objective":[28],"this":[30],"study":[31,100],"was":[32,196,215],"to":[33,42,76,85,96,244],"investigate":[34],"the":[35,50,92,107,118,180,184,227,233],"effects":[36],"maternal":[38],"exposure":[39,241],"during":[40],"pregnancy":[41],"TiO":[43,137,171,209,245],"NPs":[45,173,247],"on":[46,143,156],"depressive-like":[47],"behavior":[48,224,251],"first":[51,108],"second":[53,119,228],"generation":[54,229],"offspring.":[55,222],"Materials":[56],"Methods:":[58],"Forty":[59],"female":[60,221],"albino":[61],"mice":[62,93,231],"were":[63,73,94,102,154],"placed":[64],"into":[65,104],"four":[66,105],"groups":[67,101,126,202],"for":[68],"weeks.":[70],"Fertile":[71],"males":[72,84],"then":[74],"added":[75],"each":[77],"cage":[78],"a":[80],"ratio":[81],"two":[83],"five":[86],"females.":[87],"After":[88],"detection":[89],"pregnancy,":[91],"transferred":[95],"separate":[97],"cages.":[98],"divided":[103],"groups:":[106],"group,":[109],"served":[110],"as":[111],"control,":[112],"did":[113],"not":[114],"receive":[115],"any":[116],"treatment;":[117],"group":[120],"received":[121],"injections":[122,141],"normal":[124],"saline;":[125],"3":[127],"4":[129],"received,":[130],"respectively,":[131],"50":[132,166,204],"100":[134,168,206],"\u00b5l":[135,169,207],"NP":[139],"solution":[140],"subcutaneously":[142],"days":[144,158],"3,":[145],"7,":[146],"10,":[147],"14":[149],"after":[150],"mating.":[151],"Behavioral":[152],"tests":[153],"conducted":[155],"postnatal":[157],"21":[159],"40.":[161],"Findings:":[162],"Subcutaneous":[163],"injection":[164],"significantly":[174],"(":[175],"p":[176],"<":[177],"0.05)":[178],"increased":[179,225],"immobility":[181],"time":[182],"forced":[185,234],"swimming":[186],"test":[187,191,236],"tail":[189],"suspension":[190],"(TST).":[192],"No":[193,212],"significant":[194,213],"difference":[195,214],"observed":[197],"measured":[199],"variables":[200],"between":[201,218],"receiving":[203],"NPs.":[211],"also":[216],"found":[217],"male":[219],"Depression-like":[223],"swim":[235],"TST.":[238],"Conclusion:":[239],"Prenatal":[240],"mothers":[243],"would":[248],"increase":[249],"depression-like":[250],"neonatal":[253],"mice.":[254]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2020-06-25T00:00:00"}