{"id":"https://openalex.org/W3036166111","doi":"https://doi.org/10.1088/1742-6596/1563/1/012024","title":"In silico anti-inflammatory activity evaluation of some bioactive compound from ficus religiosa through molecular docking approach","display_name":"In silico anti-inflammatory activity evaluation of some bioactive compound from ficus religiosa through molecular docking approach","publication_year":2020,"publication_date":"2020-06-01","ids":{"openalex":"https://openalex.org/W3036166111","doi":"https://doi.org/10.1088/1742-6596/1563/1/012024","mag":"3036166111"},"language":"en","primary_location":{"id":"doi:10.1088/1742-6596/1563/1/012024","doi":"https://doi.org/10.1088/1742-6596/1563/1/012024","is_oa":true,"landing_page_url":"https://doi.org/10.1088/1742-6596/1563/1/012024","pdf_url":"https://iopscience.iop.org/article/10.1088/1742-6596/1563/1/012024/pdf","source":{"id":"https://openalex.org/S4210187594","display_name":"Journal of Physics Conference Series","issn_l":"1742-6588","issn":["1742-6588","1742-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","jufo-1","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320083","host_organization_name":"IOP Publishing","host_organization_lineage":["https://openalex.org/P4310320083","https://openalex.org/P4310311669"],"host_organization_lineage_names":["IOP Publishing","Institute of Physics"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Physics: Conference Series","raw_type":"journal-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://iopscience.iop.org/article/10.1088/1742-6596/1563/1/012024/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009090751","display_name":"Wiji Utami","orcid":"https://orcid.org/0000-0002-1906-3613","observed_orcids":["https://orcid.org/0000-0002-1906-3613"]},"institutions":[{"id":"https://openalex.org/I4405257675","display_name":"Universitas Islam Negeri Sulthan Thaha Saifuddin Jambi","ror":"https://ror.org/05j8ejf75","country_code":"ID","type":"education","lineage":["https://openalex.org/I4405257675"]}],"countries":["ID"],"is_corresponding":true,"raw_author_name":"W Utami","raw_affiliation_strings":["Chemistry Department, Faculty of Science and Technology, UIN Sulthan Thaha Saifuddin, Jambi, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry Department, Faculty of Science and Technology, UIN Sulthan Thaha Saifuddin, Jambi, Indonesia","institution_ids":["https://openalex.org/I4405257675"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072209553","display_name":"Hafiz Aji Aziz","orcid":"https://orcid.org/0000-0002-6825-4539","observed_orcids":["https://orcid.org/0000-0002-6825-4539"]},"institutions":[{"id":"https://openalex.org/I165230279","display_name":"Universitas Gadjah Mada","ror":"https://ror.org/03ke6d638","country_code":"ID","type":"education","lineage":["https://openalex.org/I165230279"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"H A Aziz","raw_affiliation_strings":["Austrian-Indonesian Centre (AIC) for Computational Chemistry, Universitas Gadjah Mada, Sekip Utara, Yogyakarta, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Austrian-Indonesian Centre (AIC) for Computational Chemistry, Universitas Gadjah Mada, Sekip Utara, Yogyakarta, Indonesia","institution_ids":["https://openalex.org/I165230279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112348037","display_name":"Ika Nur Fitriani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092172","display_name":"Walisongo State Islamic University","ror":"https://ror.org/00gq7p328","country_code":"ID","type":"education","lineage":["https://openalex.org/I4210092172"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"I N Fitriani","raw_affiliation_strings":["Chemistry Department, Faculty of Science and Technology, Walisongo State Islamic University, Semarang, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry Department, Faculty of Science and Technology, Walisongo State Islamic University, Semarang, Indonesia","institution_ids":["https://openalex.org/I4210092172"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010604810","display_name":"Adi Tiara Zikri","orcid":"https://orcid.org/0000-0001-6564-5115","observed_orcids":["https://orcid.org/0000-0001-6564-5115"]},"institutions":[{"id":"https://openalex.org/I165230279","display_name":"Universitas Gadjah Mada","ror":"https://ror.org/03ke6d638","country_code":"ID","type":"education","lineage":["https://openalex.org/I165230279"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"A T Zikri","raw_affiliation_strings":["Austrian-Indonesian Centre (AIC) for Computational Chemistry, Universitas Gadjah Mada, Sekip Utara, Yogyakarta, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Austrian-Indonesian Centre (AIC) for Computational Chemistry, Universitas Gadjah Mada, Sekip Utara, Yogyakarta, Indonesia","institution_ids":["https://openalex.org/I165230279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023981976","display_name":"Adean Mayasri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210101654","display_name":"Universitas Islam Negeri Ar-Raniry","ror":"https://ror.org/01aa12z17","country_code":"ID","type":"education","lineage":["https://openalex.org/I4210101654"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"A Mayasri","raw_affiliation_strings":["Chemistry Education Department, Tarbiyah and Teacher Training Faculty, UIN Ar-raniry, Banda Aceh, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry Education Department, Tarbiyah and Teacher Training Faculty, UIN Ar-raniry, Banda Aceh, Indonesia","institution_ids":["https://openalex.org/I4210101654"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054920628","display_name":"Dindin Nasrudin","orcid":"https://orcid.org/0000-0002-9977-1790","observed_orcids":["https://orcid.org/0000-0002-9977-1790"]},"institutions":[{"id":"https://openalex.org/I4210107902","display_name":"Sunan Gunung Djati State Islamic University Bandung","ror":"https://ror.org/01j33fx63","country_code":"ID","type":"education","lineage":["https://openalex.org/I4210107902"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"D Nasrudin","raw_affiliation_strings":["Department of Physics Education, UIN Sunan Gunung Djati, Bandung, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics Education, UIN Sunan Gunung Djati, Bandung, Indonesia","institution_ids":["https://openalex.org/I4210107902"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5009090751"],"corresponding_institution_ids":["https://openalex.org/I4405257675"],"apc_list":null,"apc_paid":null,"fwci":6.9869,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.97016781,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"1563","issue":"1","first_page":"012024","last_page":"012024"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13422","display_name":"Phytochemistry and biological activities of Ficus species","score":0.9096999764442444,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13422","display_name":"Phytochemistry and biological activities of Ficus species","score":0.9096999764442444,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.08730000257492065,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ficus-religiosa","display_name":"Ficus religiosa","score":1.0},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.9670000076293945},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.8799999952316284},{"id":"https://openalex.org/keywords/cox-2-inhibition","display_name":"COX-2 inhibition","score":0.9700000286102295},{"id":"https://openalex.org/keywords/bioactive-compounds","display_name":"bioactive compounds","score":0.8140000104904175},{"id":"https://openalex.org/keywords/campesterol","display_name":"campesterol","score":0.9169999957084656},{"id":"https://openalex.org/keywords/kaempferol","display_name":"kaempferol","score":1.0},{"id":"https://openalex.org/keywords/binding-energy","display_name":"binding energy","score":0.8230000138282776},{"id":"https://openalex.org/keywords/traditional-medicine","display_name":"traditional medicine","score":0.7319999933242798},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.48399999737739563}],"concepts":[{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.7497575283050537},{"id":"https://openalex.org/C2779362140","wikidata":"https://www.wikidata.org/wiki/Q1938846","display_name":"Ficus","level":2,"score":0.7427409291267395},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5778217911720276},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5099359750747681},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4936100244522095},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26065367460250854},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25855061411857605},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.15442731976509094},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08324983716011047},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1088/1742-6596/1563/1/012024","doi":"https://doi.org/10.1088/1742-6596/1563/1/012024","is_oa":true,"landing_page_url":"https://doi.org/10.1088/1742-6596/1563/1/012024","pdf_url":"https://iopscience.iop.org/article/10.1088/1742-6596/1563/1/012024/pdf","source":{"id":"https://openalex.org/S4210187594","display_name":"Journal of Physics Conference Series","issn_l":"1742-6588","issn":["1742-6588","1742-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","jufo-1","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320083","host_organization_name":"IOP Publishing","host_organization_lineage":["https://openalex.org/P4310320083","https://openalex.org/P4310311669"],"host_organization_lineage_names":["IOP Publishing","Institute of Physics"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Physics: Conference Series","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1088/1742-6596/1563/1/012024","doi":"https://doi.org/10.1088/1742-6596/1563/1/012024","is_oa":true,"landing_page_url":"https://doi.org/10.1088/1742-6596/1563/1/012024","pdf_url":"https://iopscience.iop.org/article/10.1088/1742-6596/1563/1/012024/pdf","source":{"id":"https://openalex.org/S4210187594","display_name":"Journal of Physics Conference Series","issn_l":"1742-6588","issn":["1742-6588","1742-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","jufo-1","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320083","host_organization_name":"IOP Publishing","host_organization_lineage":["https://openalex.org/P4310320083","https://openalex.org/P4310311669"],"host_organization_lineage_names":["IOP Publishing","Institute of Physics"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Physics: Conference Series","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3036166111.pdf","grobid_xml":"https://content.openalex.org/works/W3036166111.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1965709374","https://openalex.org/W2023783584","https://openalex.org/W2042180286","https://openalex.org/W2059859378","https://openalex.org/W2073397664","https://openalex.org/W2077251773","https://openalex.org/W2080436113","https://openalex.org/W2111134372","https://openalex.org/W2181349688","https://openalex.org/W2271454856","https://openalex.org/W2401866878","https://openalex.org/W2419071470","https://openalex.org/W2563626714","https://openalex.org/W2643738657","https://openalex.org/W2753384153","https://openalex.org/W2781503388","https://openalex.org/W2787971200","https://openalex.org/W2791584627","https://openalex.org/W2898451135","https://openalex.org/W2899460209","https://openalex.org/W2913167134","https://openalex.org/W2928653222","https://openalex.org/W2931826438","https://openalex.org/W2973531015","https://openalex.org/W2979142401","https://openalex.org/W2980993564","https://openalex.org/W2991054906","https://openalex.org/W3088676335","https://openalex.org/W3092483528","https://openalex.org/W6771769698","https://openalex.org/W6784789945"],"related_works":["https://openalex.org/W3155456948","https://openalex.org/W4387866312","https://openalex.org/W4307865156","https://openalex.org/W2463202224","https://openalex.org/W7138869562","https://openalex.org/W4406166376","https://openalex.org/W4407416618","https://openalex.org/W7164255305","https://openalex.org/W4415247286","https://openalex.org/W4407292651"],"abstract_inverted_index":{"Abstract":[0],"This":[1,37,140],"tree":[2],"generally":[3],"is":[4,142,159],"used":[5],"as":[6,55,137,152],"traditional":[7],"medicine":[8],"for":[9,71],"several":[10],"ailments.":[11],"In":[12,16],"this":[13],"research,":[14],"the":[15,29,33,42,48,65,88,104,120,128,135,145,170],"Silico":[17],"approach":[18],"using":[19,64,93],"molecular":[20,66],"docking":[21,67],"has":[22],"been":[23],"applied":[24],"to":[25,32,40,108,115,134,161,168],"11":[26,45,72],"compounds":[27,46,73,123,146],"from":[28,47,147,165],"Ficus":[30,49,148,166],"religiosa":[31,50,149,167],"cyclooxygenase-2":[34],"(COX-2)":[35],"receptor.":[36,121],"study":[38],"aimed":[39],"predict":[41],"ability":[43],"of":[44,87,119],"in":[51,79],"inhibition":[52],"COX-2":[53],"enzyme":[54],"a":[56],"prostaglandin":[57],"source.":[58],"The":[59,83,122],"detailed":[60],"information":[61],"was":[62,74,90,99,113],"obtained":[63],"approach.":[68],"Docking":[69],"simulation":[70],"executed":[75],"through":[76],"AutodockVina":[77],"embedded":[78],"MGL":[80],"Tools":[81],"1.5.6.":[82],"lowest":[84,105,129],"binding":[85,106,130],"energy":[86,107],"complexes":[89],"visualized":[91],"by":[92],"Discovery":[94],"Studio":[95],"(Biova)":[96],"software.":[97],"It":[98],"found":[100],"that":[101,144],"campesterol":[102],"provided":[103],"COX-2,":[109],"while":[110],"kaempferol":[111],"strongly":[112],"tied":[114],"TYR385":[116],"and":[117,132],"SER530":[118],"containing":[124],"anti-inflammatory":[125,154],"effect":[126],"have":[127,150],"energy,":[131],"binds":[133],"residue":[136],"native":[138],"ligands.":[139],"result":[141],"indicated":[143],"potency":[151],"an":[153],"agent.":[155],"Still,":[156],"advanced":[157],"research":[158],"needed":[160],"examine":[162],"more":[163],"ligands":[164],"isolate":[169],"best":[171],"conformation.":[172]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2020-06-25T00:00:00"}