{"id":"https://openalex.org/W3035965237","doi":"https://doi.org/10.1017/s0424820100158960","title":"Diethylnitrosamine-induced spongiosis hepatis in Medaka, Oryzias latipes","display_name":"Diethylnitrosamine-induced spongiosis hepatis in Medaka, Oryzias latipes","publication_year":1990,"publication_date":"1990-08-12","ids":{"openalex":"https://openalex.org/W3035965237","doi":"https://doi.org/10.1017/s0424820100158960","mag":"3035965237"},"language":"en","primary_location":{"id":"doi:10.1017/s0424820100158960","doi":"https://doi.org/10.1017/s0424820100158960","is_oa":false,"landing_page_url":"http://doi.org/10.1017/s0424820100158960","pdf_url":null,"source":{"id":"https://openalex.org/S4210239783","display_name":"Proceedings annual meeting Electron Microscopy Society of America","issn_l":"0424-8201","issn":["0424-8201","2690-1315"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings, annual meeting, Electron Microscopy Society of America","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110694024","display_name":"William N. Norton","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William N. Norton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108292865","display_name":"Hank Gardner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hank Gardner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"48","issue":"3","first_page":"282","last_page":"283"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14135","display_name":"Cancer and biochemical research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diethylnitrosamine","display_name":"diethylnitrosamine","score":0.9869999885559082},{"id":"https://openalex.org/keywords/medaka","display_name":"medaka","score":0.9319999814033508},{"id":"https://openalex.org/keywords/hepatocarcinogenesis","display_name":"hepatocarcinogenesis","score":0.8410000205039978},{"id":"https://openalex.org/keywords/liver-tumors","display_name":"liver tumors","score":0.7379999756813049},{"id":"https://openalex.org/keywords/embryonic-exposure","display_name":"embryonic exposure","score":0.4909999966621399}],"concepts":[{"id":"https://openalex.org/C2777289358","wikidata":"https://www.wikidata.org/wiki/Q2371293","display_name":"Oryzias","level":3,"score":0.9952177405357361},{"id":"https://openalex.org/C2780182102","wikidata":"https://www.wikidata.org/wiki/Q1679050","display_name":"Spongiosis","level":2,"score":0.9025965929031372},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.7539299726486206},{"id":"https://openalex.org/C2909208804","wikidata":"https://www.wikidata.org/wiki/Q127282","display_name":"Fish <Actinopterygii>","level":2,"score":0.6507009267807007},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5048869252204895},{"id":"https://openalex.org/C104488531","wikidata":"https://www.wikidata.org/wiki/Q864212","display_name":"Bioassay","level":2,"score":0.43545180559158325},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4276770353317261},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.37784552574157715},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2859879434108734},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16918042302131653},{"id":"https://openalex.org/C505870484","wikidata":"https://www.wikidata.org/wiki/Q180538","display_name":"Fishery","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1017/s0424820100158960","doi":"https://doi.org/10.1017/s0424820100158960","is_oa":false,"landing_page_url":"http://doi.org/10.1017/s0424820100158960","pdf_url":null,"source":{"id":"https://openalex.org/S4210239783","display_name":"Proceedings annual meeting Electron Microscopy Society of America","issn_l":"0424-8201","issn":["0424-8201","2690-1315"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings, annual meeting, Electron Microscopy Society of America","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W1933748924","https://openalex.org/W1978630371","https://openalex.org/W2067970777","https://openalex.org/W2087149293","https://openalex.org/W2407259870"],"related_works":["https://openalex.org/W2103966820","https://openalex.org/W3036899335","https://openalex.org/W2416837252","https://openalex.org/W3036821272","https://openalex.org/W7095611455","https://openalex.org/W2020046676","https://openalex.org/W2105467467","https://openalex.org/W2046633950","https://openalex.org/W2166917212","https://openalex.org/W2147836282"],"abstract_inverted_index":{"Investigators":[0],"representing":[1],"such":[2,118],"diverse":[3],"disciplines":[4],"as":[5,16,36,48,105],"biochemistry,":[6],"pathology,":[7],"genetics":[8],"and":[9,18,33,83,110],"environmental":[10],"toxicology":[11],"currently":[12],"employ":[13],"fish":[14,51,82],"models":[15],"routine":[17],"reliable":[19],"bioassay":[20],"testing":[21],"systems":[22],"for":[23,53,67,80],"the":[24,31,72,111,115],"detection":[25],"of":[26,39,57,71,76,117],"toxins":[27],"and/or":[28],"carcinogens":[29,109],"in":[30,102,121,126],"environment,":[32],"more":[34,73],"appropriately,":[35],"rapid":[37],"indicators":[38],"carcinogenicity.":[40],"The":[41],"Japanese":[42],"medaka,":[43],"Oryzias":[44],"latipes,":[45],"has":[46,98],"served":[47],"a":[49,63,88,119],"popular":[50],"model":[52],"carcinogenicity":[54],"studies,":[55],"many":[56],"which":[58],"have":[59],"included":[60],"diethylnitrosamine":[61],"(DENA),":[62],"site":[64],"specific":[65],"carcinogen":[66],"hepatic":[68,89,108],"neoplasms.":[69],"One":[70],"intriguing":[74],"manifestations":[75],"nitrosamine":[77],"exposure":[78],"reported":[79,101],"both":[81],"rats":[84],"is":[85,124],"spongiosis":[86],"hepatis,":[87],"lesion":[90,120],"characterized":[91],"by":[92],"multilocular":[93],"cyst-like":[94],"complexes.":[95],"Spongiosis":[96],"hepatis":[97],"not":[99],"been":[100],"medaka":[103,123],"exposed":[104],"embryos":[106],"to":[107],"single":[112],"article":[113],"indicating":[114],"presence":[116],"adult":[122],"limited":[125],"cytological":[127],"descriptions.":[128]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2020-06-25T00:00:00"}
