{"id":"https://openalex.org/W3035964337","doi":"https://doi.org/10.1158/0008-5472.can-19-3670","title":"Autocrine IL6-Mediated Activation of the STAT3\u2013DNMT Axis Silences the TNF\u03b1\u2013RIP1 Necroptosis Pathway to Sustain Survival and Accumulation of Myeloid-Derived Suppressor Cells","display_name":"Autocrine IL6-Mediated Activation of the STAT3\u2013DNMT Axis Silences the TNF\u03b1\u2013RIP1 Necroptosis Pathway to Sustain Survival and Accumulation of Myeloid-Derived Suppressor Cells","publication_year":2020,"publication_date":"2020-06-17","ids":{"openalex":"https://openalex.org/W3035964337","doi":"https://doi.org/10.1158/0008-5472.can-19-3670","mag":"3035964337","pmid":"https://pubmed.ncbi.nlm.nih.gov/32554751","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7416440"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.can-19-3670","doi":"https://doi.org/10.1158/0008-5472.can-19-3670","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-19-3670","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC7416440","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069398909","display_name":"Alyssa D. Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]},{"id":"https://openalex.org/I2799702486","display_name":"Charlie Norwood VA Medical Center","ror":"https://ror.org/01ng1yh19","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799702486","https://openalex.org/I2799886695","https://openalex.org/I4210131075"]},{"id":"https://openalex.org/I4210087454","display_name":"Augusta University Health","ror":"https://ror.org/007rawr89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alyssa D. Smith","raw_affiliation_strings":["1Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia","2Georgia Cancer Center, Medical College of Georgia, Augusta, Georgia","3Charlie Norwood VA Medical Center, Augusta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia","institution_ids":["https://openalex.org/I25041050"]},{"raw_affiliation_string":"2Georgia Cancer Center, Medical College of Georgia, Augusta, Georgia","institution_ids":["https://openalex.org/I25041050","https://openalex.org/I4210087454"]},{"raw_affiliation_string":"3Charlie Norwood VA Medical Center, Augusta, Georgia","institution_ids":["https://openalex.org/I2799702486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036361334","display_name":"Chunwan Lu","orcid":"https://orcid.org/0000-0002-3823-9434","observed_orcids":["https://orcid.org/0000-0002-3823-9434","https://orcid.org/0000-0001-6458-8462"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]},{"id":"https://openalex.org/I2799702486","display_name":"Charlie Norwood VA Medical Center","ror":"https://ror.org/01ng1yh19","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799702486","https://openalex.org/I2799886695","https://openalex.org/I4210131075"]},{"id":"https://openalex.org/I4210087454","display_name":"Augusta University Health","ror":"https://ror.org/007rawr89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chunwan Lu","raw_affiliation_strings":["1Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia","2Georgia Cancer Center, Medical College of Georgia, Augusta, Georgia","3Charlie Norwood VA Medical Center, Augusta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia","institution_ids":["https://openalex.org/I25041050"]},{"raw_affiliation_string":"2Georgia Cancer Center, Medical College of Georgia, Augusta, Georgia","institution_ids":["https://openalex.org/I25041050","https://openalex.org/I4210087454"]},{"raw_affiliation_string":"3Charlie Norwood VA Medical Center, Augusta, Georgia","institution_ids":["https://openalex.org/I2799702486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000095453","display_name":"Daniela Payne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]},{"id":"https://openalex.org/I4210087454","display_name":"Augusta University Health","ror":"https://ror.org/007rawr89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniela Payne","raw_affiliation_strings":["1Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia","2Georgia Cancer Center, Medical College of Georgia, Augusta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia","institution_ids":["https://openalex.org/I25041050"]},{"raw_affiliation_string":"2Georgia Cancer Center, Medical College of Georgia, Augusta, Georgia","institution_ids":["https://openalex.org/I25041050","https://openalex.org/I4210087454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063745052","display_name":"Amy V. Paschall","orcid":"https://orcid.org/0000-0001-9144-7534","observed_orcids":["https://orcid.org/0000-0001-9144-7534"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]},{"id":"https://openalex.org/I2799702486","display_name":"Charlie Norwood VA Medical Center","ror":"https://ror.org/01ng1yh19","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799702486","https://openalex.org/I2799886695","https://openalex.org/I4210131075"]},{"id":"https://openalex.org/I4210087454","display_name":"Augusta University Health","ror":"https://ror.org/007rawr89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy V. Paschall","raw_affiliation_strings":["1Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia","2Georgia Cancer Center, Medical College of Georgia, Augusta, Georgia","3Charlie Norwood VA Medical Center, Augusta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia","institution_ids":["https://openalex.org/I25041050"]},{"raw_affiliation_string":"2Georgia Cancer Center, Medical College of Georgia, Augusta, Georgia","institution_ids":["https://openalex.org/I25041050","https://openalex.org/I4210087454"]},{"raw_affiliation_string":"3Charlie Norwood VA Medical Center, Augusta, Georgia","institution_ids":["https://openalex.org/I2799702486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032490826","display_name":"John David Klement","orcid":"https://orcid.org/0000-0003-4334-4076","observed_orcids":["https://orcid.org/0000-0003-4334-4076"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]},{"id":"https://openalex.org/I2799702486","display_name":"Charlie Norwood VA Medical Center","ror":"https://ror.org/01ng1yh19","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799702486","https://openalex.org/I2799886695","https://openalex.org/I4210131075"]},{"id":"https://openalex.org/I4210087454","display_name":"Augusta University Health","ror":"https://ror.org/007rawr89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John D. Klement","raw_affiliation_strings":["1Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia","2Georgia Cancer Center, Medical College of Georgia, Augusta, Georgia","3Charlie Norwood VA Medical Center, Augusta, Georgia"],"raw_orcid":"https://orcid.org/0000-0003-4334-4076","affiliations":[{"raw_affiliation_string":"1Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia","institution_ids":["https://openalex.org/I25041050"]},{"raw_affiliation_string":"2Georgia Cancer Center, Medical College of Georgia, Augusta, Georgia","institution_ids":["https://openalex.org/I25041050","https://openalex.org/I4210087454"]},{"raw_affiliation_string":"3Charlie Norwood VA Medical Center, Augusta, Georgia","institution_ids":["https://openalex.org/I2799702486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112888178","display_name":"Priscilla S. Redd","orcid":"https://orcid.org/0009-0004-3231-1564","observed_orcids":["https://orcid.org/0009-0004-3231-1564"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]},{"id":"https://openalex.org/I2799702486","display_name":"Charlie Norwood VA Medical Center","ror":"https://ror.org/01ng1yh19","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799702486","https://openalex.org/I2799886695","https://openalex.org/I4210131075"]},{"id":"https://openalex.org/I4210087454","display_name":"Augusta University Health","ror":"https://ror.org/007rawr89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Priscilla S. Redd","raw_affiliation_strings":["1Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia","2Georgia Cancer Center, Medical College of Georgia, Augusta, Georgia","3Charlie Norwood VA Medical Center, Augusta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia","institution_ids":["https://openalex.org/I25041050"]},{"raw_affiliation_string":"2Georgia Cancer Center, Medical College of Georgia, Augusta, Georgia","institution_ids":["https://openalex.org/I25041050","https://openalex.org/I4210087454"]},{"raw_affiliation_string":"3Charlie Norwood VA Medical Center, Augusta, Georgia","institution_ids":["https://openalex.org/I2799702486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047808870","display_name":"Mohammed L. Ibrahim","orcid":"https://orcid.org/0000-0003-2482-6811","observed_orcids":["https://orcid.org/0000-0003-2482-6811"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]},{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]},{"id":"https://openalex.org/I4210087454","display_name":"Augusta University Health","ror":"https://ror.org/007rawr89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087454"]}],"countries":["EG","US"],"is_corresponding":false,"raw_author_name":"Mohammed L. Ibrahim","raw_affiliation_strings":["1Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia","2Georgia Cancer Center, Medical College of Georgia, Augusta, Georgia","4Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Cairo University, Cairo, Egypt"],"raw_orcid":"https://orcid.org/0000-0003-2482-6811","affiliations":[{"raw_affiliation_string":"1Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia","institution_ids":["https://openalex.org/I25041050"]},{"raw_affiliation_string":"2Georgia Cancer Center, Medical College of Georgia, Augusta, Georgia","institution_ids":["https://openalex.org/I25041050","https://openalex.org/I4210087454"]},{"raw_affiliation_string":"4Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Cairo University, Cairo, Egypt","institution_ids":["https://openalex.org/I145487455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020584166","display_name":"Dafeng Yang","orcid":"https://orcid.org/0009-0008-7774-0847","observed_orcids":["https://orcid.org/0009-0008-7774-0847","https://orcid.org/0000-0002-8320-8215"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]},{"id":"https://openalex.org/I2799702486","display_name":"Charlie Norwood VA Medical Center","ror":"https://ror.org/01ng1yh19","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799702486","https://openalex.org/I2799886695","https://openalex.org/I4210131075"]},{"id":"https://openalex.org/I4210087454","display_name":"Augusta University Health","ror":"https://ror.org/007rawr89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dafeng Yang","raw_affiliation_strings":["1Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia","2Georgia Cancer Center, Medical College of Georgia, Augusta, Georgia","3Charlie Norwood VA Medical Center, Augusta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia","institution_ids":["https://openalex.org/I25041050"]},{"raw_affiliation_string":"2Georgia Cancer Center, Medical College of Georgia, Augusta, Georgia","institution_ids":["https://openalex.org/I25041050","https://openalex.org/I4210087454"]},{"raw_affiliation_string":"3Charlie Norwood VA Medical Center, Augusta, Georgia","institution_ids":["https://openalex.org/I2799702486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047252858","display_name":"Qimei Han","orcid":"https://orcid.org/0000-0003-4874-8862","observed_orcids":["https://orcid.org/0000-0003-4874-8862"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]},{"id":"https://openalex.org/I4210087454","display_name":"Augusta University Health","ror":"https://ror.org/007rawr89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qimei Han","raw_affiliation_strings":["2Georgia Cancer Center, Medical College of Georgia, Augusta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Georgia Cancer Center, Medical College of Georgia, Augusta, Georgia","institution_ids":["https://openalex.org/I25041050","https://openalex.org/I4210087454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109375638","display_name":"Zhuoqi Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]},{"id":"https://openalex.org/I4210087454","display_name":"Augusta University Health","ror":"https://ror.org/007rawr89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhuoqi Liu","raw_affiliation_strings":["2Georgia Cancer Center, Medical College of Georgia, Augusta, Georgia"],"raw_orcid":"https://orcid.org/0000-0003-1965-7240","affiliations":[{"raw_affiliation_string":"2Georgia Cancer Center, Medical College of Georgia, Augusta, Georgia","institution_ids":["https://openalex.org/I25041050","https://openalex.org/I4210087454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061372791","display_name":"Huidong Shi","orcid":"https://orcid.org/0000-0003-1137-3390","observed_orcids":["https://orcid.org/0000-0003-1137-3390"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]},{"id":"https://openalex.org/I4210087454","display_name":"Augusta University Health","ror":"https://ror.org/007rawr89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huidong Shi","raw_affiliation_strings":["2Georgia Cancer Center, Medical College of Georgia, Augusta, Georgia"],"raw_orcid":"https://orcid.org/0000-0003-1137-3390","affiliations":[{"raw_affiliation_string":"2Georgia Cancer Center, Medical College of Georgia, Augusta, Georgia","institution_ids":["https://openalex.org/I25041050","https://openalex.org/I4210087454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014969282","display_name":"Thomas J. Hartney","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799702486","display_name":"Charlie Norwood VA Medical Center","ror":"https://ror.org/01ng1yh19","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799702486","https://openalex.org/I2799886695","https://openalex.org/I4210131075"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas J. Hartney","raw_affiliation_strings":["3Charlie Norwood VA Medical Center, Augusta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Charlie Norwood VA Medical Center, Augusta, Georgia","institution_ids":["https://openalex.org/I2799702486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077226478","display_name":"Asha Nayak-Kapoor","orcid":"https://orcid.org/0000-0003-1635-7197","observed_orcids":["https://orcid.org/0000-0003-1635-7197"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]},{"id":"https://openalex.org/I2799702486","display_name":"Charlie Norwood VA Medical Center","ror":"https://ror.org/01ng1yh19","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799702486","https://openalex.org/I2799886695","https://openalex.org/I4210131075"]},{"id":"https://openalex.org/I4210087454","display_name":"Augusta University Health","ror":"https://ror.org/007rawr89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Asha Nayak-Kapoor","raw_affiliation_strings":["2Georgia Cancer Center, Medical College of Georgia, Augusta, Georgia","3Charlie Norwood VA Medical Center, Augusta, Georgia"],"raw_orcid":"https://orcid.org/0000-0003-1635-7197","affiliations":[{"raw_affiliation_string":"2Georgia Cancer Center, Medical College of Georgia, Augusta, Georgia","institution_ids":["https://openalex.org/I25041050","https://openalex.org/I4210087454"]},{"raw_affiliation_string":"3Charlie Norwood VA Medical Center, Augusta, Georgia","institution_ids":["https://openalex.org/I2799702486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016580028","display_name":"Kebin Liu","orcid":"https://orcid.org/0000-0003-1965-7240","observed_orcids":["https://orcid.org/0000-0003-1965-7240"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]},{"id":"https://openalex.org/I2799702486","display_name":"Charlie Norwood VA Medical Center","ror":"https://ror.org/01ng1yh19","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799702486","https://openalex.org/I2799886695","https://openalex.org/I4210131075"]},{"id":"https://openalex.org/I4210087454","display_name":"Augusta University Health","ror":"https://ror.org/007rawr89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kebin Liu","raw_affiliation_strings":["1Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia","2Georgia Cancer Center, Medical College of Georgia, Augusta, Georgia","3Charlie Norwood VA Medical Center, Augusta, Georgia"],"raw_orcid":"https://orcid.org/0000-0003-1965-7240","affiliations":[{"raw_affiliation_string":"1Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia","institution_ids":["https://openalex.org/I25041050"]},{"raw_affiliation_string":"2Georgia Cancer Center, Medical College of Georgia, Augusta, Georgia","institution_ids":["https://openalex.org/I25041050","https://openalex.org/I4210087454"]},{"raw_affiliation_string":"3Charlie Norwood VA Medical Center, Augusta, Georgia","institution_ids":["https://openalex.org/I2799702486"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.4234,"has_fulltext":false,"cited_by_count":80,"citation_normalized_percentile":{"value":0.9436985,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"80","issue":"15","first_page":"3145","last_page":"3156"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12672","display_name":"Phagocytosis and Immune Regulation","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myeloid-derived-suppressor-cells","display_name":"myeloid-derived suppressor cells","score":1.0},{"id":"https://openalex.org/keywords/necroptosis","display_name":"necroptosis","score":0.7689999938011169},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.7459999918937683},{"id":"https://openalex.org/keywords/ripk1","display_name":"RIPK1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.777999997138977},{"id":"https://openalex.org/keywords/dna-methyltransferases","display_name":"DNA methyltransferases","score":0.8270000219345093},{"id":"https://openalex.org/keywords/decitabine","display_name":"decitabine","score":0.8289999961853027},{"id":"https://openalex.org/keywords/irf8","display_name":"IRF8","score":0.8790000081062317},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.8479999899864197},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8539999723434448},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8889999985694885},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.6750591993331909},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6082923412322998},{"id":"https://openalex.org/C94030615","wikidata":"https://www.wikidata.org/wiki/Q3346925","display_name":"Necroptosis","level":4,"score":0.5973711609840393},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5945807099342346},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.5458120107650757},{"id":"https://openalex.org/C117705580","wikidata":"https://www.wikidata.org/wiki/Q18027494","display_name":"IRF8","level":4,"score":0.4797819256782532},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46923381090164185},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.44533517956733704},{"id":"https://openalex.org/C55721878","wikidata":"https://www.wikidata.org/wiki/Q15220362","display_name":"Myeloid-derived Suppressor Cell","level":4,"score":0.4295230805873871},{"id":"https://openalex.org/C14077384","wikidata":"https://www.wikidata.org/wiki/Q18033186","display_name":"Suppressor of cytokine signaling 1","level":4,"score":0.41174572706222534},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34695929288864136},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.34302660822868347},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3016771674156189},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.26299747824668884},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.22959205508232117},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.22644349932670593},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.1821177899837494},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.13793513178825378},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.11533921957015991},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072737","descriptor_name":"Myeloid-Derived Suppressor Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000072737","descriptor_name":"Myeloid-Derived Suppressor Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000076123","descriptor_name":"DNA (Cytosine-5-)-Methyltransferase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000079302","descriptor_name":"Necroptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000079302","descriptor_name":"Necroptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000097584","descriptor_name":"DNA Methyltransferase 3B","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004248","descriptor_name":"DNA (Cytosine-5-)-Methyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019898","descriptor_name":"Autocrine Communication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053422","descriptor_name":"Receptor-Interacting Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1158/0008-5472.can-19-3670","doi":"https://doi.org/10.1158/0008-5472.can-19-3670","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-19-3670","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmid:32554751","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32554751","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:6756748","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC7416440","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:7416440","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7416440","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cancer Res","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:6756748","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC7416440","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1142816981","display_name":"Role of IRF8 in Tumor Rejection and Suppression","funder_award_id":"R01CA133085","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2818600542","display_name":"Function of IRF8 in MDSC and T Cell Differentiation","funder_award_id":"F31AI120487","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3501426187","display_name":null,"funder_award_id":"I01 CX001364","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G5918385109","display_name":"Function of IRF8 in T cell activation and immune tolerance","funder_award_id":"F30CA236436","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7205884179","display_name":"TUMOR SPECIFIC DELIVERY OF VERTICILLIN A OVERCOMES EPIGENETIC SILENCING RESPONSIBLE FOR DRUG RESISTANCE","funder_award_id":"R01CA227433","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7370439360","display_name":"Role of NF-kB in Fas-mediated Apoptosis and Tumor Suppression","funder_award_id":"R01CA182518","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1529595331","https://openalex.org/W1625747271","https://openalex.org/W1971426748","https://openalex.org/W1989984706","https://openalex.org/W1995980060","https://openalex.org/W1997222174","https://openalex.org/W2005928313","https://openalex.org/W2008228521","https://openalex.org/W2011210685","https://openalex.org/W2020611733","https://openalex.org/W2023164440","https://openalex.org/W2023561138","https://openalex.org/W2029169197","https://openalex.org/W2046864536","https://openalex.org/W2057093003","https://openalex.org/W2060672294","https://openalex.org/W2069590345","https://openalex.org/W2070968699","https://openalex.org/W2082626794","https://openalex.org/W2106084333","https://openalex.org/W2114111935","https://openalex.org/W2114262474","https://openalex.org/W2115970169","https://openalex.org/W2116609506","https://openalex.org/W2117409731","https://openalex.org/W2153232526","https://openalex.org/W2153570621","https://openalex.org/W2160229573","https://openalex.org/W2164388264","https://openalex.org/W2283137583","https://openalex.org/W2285354269","https://openalex.org/W2432310654","https://openalex.org/W2471500324","https://openalex.org/W2537146822","https://openalex.org/W2537220355","https://openalex.org/W2554914186","https://openalex.org/W2564668537","https://openalex.org/W2572813173","https://openalex.org/W2578575431","https://openalex.org/W2604922424","https://openalex.org/W2794842946","https://openalex.org/W2806675488","https://openalex.org/W2808004437","https://openalex.org/W2809626459","https://openalex.org/W2902849689","https://openalex.org/W2919041616","https://openalex.org/W2936706033","https://openalex.org/W2945950379","https://openalex.org/W2954317599","https://openalex.org/W2956987968","https://openalex.org/W2972398989"],"related_works":["https://openalex.org/W4313373773","https://openalex.org/W2147374892","https://openalex.org/W4313355025","https://openalex.org/W2160229573","https://openalex.org/W1995462306","https://openalex.org/W2463132144","https://openalex.org/W2783633531","https://openalex.org/W2336653050","https://openalex.org/W4246858537","https://openalex.org/W4308630773"],"abstract_inverted_index":{"Abstract":[0],"Although":[1],"accumulation":[2,18,33,52,65,86,106,152,257],"of":[3,11,16,34,41,56,70,115,118,192,199],"myeloid-derived":[4],"suppressor":[5],"cells":[6,194],"(MDSC)":[7],"is":[8],"a":[9,168,213],"hallmark":[10],"cancer,":[12],"the":[13,20,44,71,126,259],"underlying":[14],"mechanism":[15],"this":[17],"within":[19],"tumor":[21,154,260],"microenvironment":[22],"remains":[23],"incompletely":[24],"understood.":[25],"We":[26],"report":[27],"here":[28],"that":[29,91,125,210,242],"TNF\u03b1\u2013RIP1\u2013mediated":[30],"necroptosis":[31,232],"regulates":[32],"MDSCs.":[35,79],"In":[36,188],"tumor-bearing":[37,157,180],"mice,":[38,89],"pharmacologic":[39],"inhibition":[40],"DNMT":[42],"with":[43,67,184],"DNA":[45,92,113,121],"methyltransferease":[46],"inhibitor":[47],"decitabine":[48],"(DAC)":[49],"decreased":[50,104,228],"MDSC":[51,64,96,105,143,151,164,254],"and":[53,146,153,170,182,201,203,230,236,256],"increased":[54,68,139,150,197],"activation":[55],"antigen-specific":[57],"cytotoxic":[58],"T":[59],"lymphocytes.":[60],"DAC-induced":[61],"decreases":[62],"in":[63,78,87,131,134,142,144,156,159,167,177,179,227,258],"correlated":[66],"expression":[69,198,245],"myeloid":[72],"cell":[73,85,109,165],"lineage-specific":[74],"transcription":[75],"factor":[76],"IRF8":[77],"However,":[80],"DAC":[81,103,136],"also":[82],"suppressed":[83],"MDSC-like":[84,193],"IRF8-deficient":[88],"indicating":[90],"methylation":[93,114],"may":[94],"regulate":[95],"survival":[97,235,255],"through":[98],"an":[99],"IRF8-independent":[100],"mechanism.":[101],"Instead,":[102],"by":[107,218],"increasing":[108],"death":[110,166],"via":[111],"disrupting":[112],"RIP1-dependent":[116,171,231],"targets":[117],"necroptosis.":[119],"Genome-wide":[120],"bisulfite":[122],"sequencing":[123],"revealed":[124],"Tnf":[127],"promoter":[128],"was":[129,174],"hypermethylated":[130],"tumor-induced":[132],"MDSCs":[133,178,211],"vivo.":[135,160],"treatment":[137,191],"dramatically":[138],"TNF\u03b1":[140,148,162,223],"levels":[141],"vitro,":[145,189],"neutralizing":[147],"significantly":[149],"growth":[155],"mice":[158,181],"Recombinant":[161],"induced":[163],"dose-":[169],"manner.":[172],"IL6":[173,190,244],"abundantly":[175],"expressed":[176],"patients":[183],"human":[185],"colorectal":[186],"cancer.":[187],"activated":[195],"STAT3,":[196],"DNMT1":[200],"DNMT3b,":[202],"enhanced":[204],"survival.":[205],"Overall,":[206],"our":[207],"findings":[208,240],"reveal":[209],"establish":[212],"STAT3\u2013DNMT":[214],"epigenetic":[215],"axis,":[216],"regulated":[217],"autocrine":[219],"IL6,":[220],"to":[221,233,252],"silence":[222],"expression.":[224],"This":[225],"results":[226],"TNF\u03b1-induced":[229],"sustain":[234],"accumulation.":[237],"Significance:":[238],"These":[239],"demonstrate":[241],"targeting":[243],"or":[246],"function":[247],"represent":[248],"potentially":[249],"effective":[250],"approaches":[251],"suppress":[253],"microenvironment.":[261]},"counts_by_year":[{"year":2026,"cited_by_count":13},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":20},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2020-06-25T00:00:00"}