{"id":"https://openalex.org/W3035959634","doi":"https://doi.org/10.1158/1541-7786.mcr-20-0108","title":"NRF2-Driven KEAP1 Transcription in Human Lung Cancer","display_name":"NRF2-Driven KEAP1 Transcription in Human Lung Cancer","publication_year":2020,"publication_date":"2020-06-22","ids":{"openalex":"https://openalex.org/W3035959634","doi":"https://doi.org/10.1158/1541-7786.mcr-20-0108","mag":"3035959634","pmid":"https://pubmed.ncbi.nlm.nih.gov/32571982"},"language":"en","primary_location":{"id":"doi:10.1158/1541-7786.mcr-20-0108","doi":"https://doi.org/10.1158/1541-7786.mcr-20-0108","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1541-7786.mcr-20-0108","pdf_url":null,"source":{"id":"https://openalex.org/S192067876","display_name":"Molecular Cancer Research","issn_l":"1541-7786","issn":["1541-7786","1557-3125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055761984","display_name":"Yijun Tian","orcid":"https://orcid.org/0000-0003-3471-3685","observed_orcids":["https://orcid.org/0000-0003-3471-3685"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yijun Tian","raw_affiliation_strings":["1Department of Tumor Biology, Moffitt Cancer Center, Tampa, Florida"],"raw_orcid":"https://orcid.org/0000-0003-3471-3685","affiliations":[{"raw_affiliation_string":"1Department of Tumor Biology, Moffitt Cancer Center, Tampa, Florida","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100318550","display_name":"Qian Liu","orcid":"https://orcid.org/0000-0002-1937-0568","observed_orcids":["https://orcid.org/0000-0002-1937-0568","https://orcid.org/0000-0001-6076-2945"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qian Liu","raw_affiliation_strings":["1Department of Tumor Biology, Moffitt Cancer Center, Tampa, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Tumor Biology, Moffitt Cancer Center, Tampa, Florida","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102742679","display_name":"Shengnan Yu","orcid":"https://orcid.org/0000-0003-4046-3520","observed_orcids":["https://orcid.org/0000-0003-4046-3520"]},"institutions":[{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shengnan Yu","raw_affiliation_strings":["2Department of Oncology, Tongji Hospital of Tongji Medical College, Wuhan, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Oncology, Tongji Hospital of Tongji Medical College, Wuhan, P.R. China","institution_ids":["https://openalex.org/I4210160344"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103259700","display_name":"Qian Chu","orcid":"https://orcid.org/0000-0001-8192-7630","observed_orcids":["https://orcid.org/0000-0001-8192-7630","https://orcid.org/0009-0009-8730-4819"]},"institutions":[{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qian Chu","raw_affiliation_strings":["2Department of Oncology, Tongji Hospital of Tongji Medical College, Wuhan, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Oncology, Tongji Hospital of Tongji Medical College, Wuhan, P.R. China","institution_ids":["https://openalex.org/I4210160344"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100400882","display_name":"Yuan Chen","orcid":"https://orcid.org/0000-0001-8676-0913","observed_orcids":["https://orcid.org/0000-0001-8676-0913"]},"institutions":[{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan Chen","raw_affiliation_strings":["2Department of Oncology, Tongji Hospital of Tongji Medical College, Wuhan, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Oncology, Tongji Hospital of Tongji Medical College, Wuhan, P.R. China","institution_ids":["https://openalex.org/I4210160344"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044031959","display_name":"Kongming Wu","orcid":"https://orcid.org/0000-0003-2499-1032","observed_orcids":["https://orcid.org/0000-0003-2499-1032"]},"institutions":[{"id":"https://openalex.org/I4210143608","display_name":"Henan Cancer Hospital","ror":"https://ror.org/043ek5g31","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210143608"]},{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]},{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kongming Wu","raw_affiliation_strings":["2Department of Oncology, Tongji Hospital of Tongji Medical College, Wuhan, P.R. China","3Department of Oncology, The First Affiliated Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Oncology, Tongji Hospital of Tongji Medical College, Wuhan, P.R. China","institution_ids":["https://openalex.org/I4210160344"]},{"raw_affiliation_string":"3Department of Oncology, The First Affiliated Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, P.R. China","institution_ids":["https://openalex.org/I4210143608","https://openalex.org/I4210156804"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100456567","display_name":"Liang Wang","orcid":"https://orcid.org/0000-0002-9364-8572","observed_orcids":["https://orcid.org/0000-0002-9364-8572"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]},{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liang Wang","raw_affiliation_strings":["1Department of Tumor Biology, Moffitt Cancer Center, Tampa, Florida","4Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin"],"raw_orcid":"https://orcid.org/0000-0002-9364-8572","affiliations":[{"raw_affiliation_string":"1Department of Tumor Biology, Moffitt Cancer Center, Tampa, Florida","institution_ids":["https://openalex.org/I3019308854"]},{"raw_affiliation_string":"4Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin","institution_ids":["https://openalex.org/I204308271"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6495,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.62081745,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"18","issue":"10","first_page":"1465","last_page":"1476"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.9919999837875366},{"id":"https://openalex.org/keywords/keap1","display_name":"Keap1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.6320000290870667},{"id":"https://openalex.org/keywords/lung-squamous-cell-carcinoma","display_name":"lung squamous cell carcinoma","score":0.9169999957084656},{"id":"https://openalex.org/keywords/adenocarcinoma","display_name":"adenocarcinoma","score":0.7820000052452087},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8109999895095825},{"id":"https://openalex.org/keywords/gene-expression-ratio","display_name":"gene expression ratio","score":0.515999972820282},{"id":"https://openalex.org/keywords/survival-prediction","display_name":"survival prediction","score":0.5090000033378601}],"concepts":[{"id":"https://openalex.org/C2776529522","wikidata":"https://www.wikidata.org/wiki/Q18034700","display_name":"KEAP1","level":4,"score":0.7215717434883118},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.6315743327140808},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5836476683616638},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5537923574447632},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5419268608093262},{"id":"https://openalex.org/C134320426","wikidata":"https://www.wikidata.org/wiki/Q901026","display_name":"Chromatin immunoprecipitation","level":5,"score":0.5298317074775696},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4332853853702545},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.41236400604248047},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.40284422039985657},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.3781910538673401},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.367278516292572},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3389014005661011},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3177396059036255},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2269885540008545},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18051302433013916},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.14990565180778503}],"mesh":[{"descriptor_ui":"D000072019","descriptor_name":"Kelch-Like ECH-Associated Protein 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000072019","descriptor_name":"Kelch-Like ECH-Associated Protein 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000072019","descriptor_name":"Kelch-Like ECH-Associated Protein 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1158/1541-7786.mcr-20-0108","doi":"https://doi.org/10.1158/1541-7786.mcr-20-0108","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1541-7786.mcr-20-0108","pdf_url":null,"source":{"id":"https://openalex.org/S192067876","display_name":"Molecular Cancer Research","issn_l":"1541-7786","issn":["1541-7786","1557-3125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Research","raw_type":"journal-article"},{"id":"pmid:32571982","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32571982","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular cancer research : MCR","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8199999928474426}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6286570624","display_name":null,"funder_award_id":"81572608","funder_id":"https://openalex.org/F4320332587","funder_display_name":"Natural Science Foundation of Ningbo"},{"id":"https://openalex.org/G6306250871","display_name":null,"funder_award_id":"81874120","funder_id":"https://openalex.org/F4320332587","funder_display_name":"Natural Science Foundation of Ningbo"}],"funders":[{"id":"https://openalex.org/F4320332587","display_name":"Natural Science Foundation of Ningbo","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W1533811499","https://openalex.org/W1855392312","https://openalex.org/W1977709885","https://openalex.org/W1986241711","https://openalex.org/W1987024849","https://openalex.org/W1993204994","https://openalex.org/W1998560601","https://openalex.org/W2023784234","https://openalex.org/W2027287873","https://openalex.org/W2031100365","https://openalex.org/W2049553585","https://openalex.org/W2068427957","https://openalex.org/W2075425070","https://openalex.org/W2077999711","https://openalex.org/W2092286165","https://openalex.org/W2092482659","https://openalex.org/W2093146349","https://openalex.org/W2098462984","https://openalex.org/W2101540252","https://openalex.org/W2114586150","https://openalex.org/W2114843025","https://openalex.org/W2117054546","https://openalex.org/W2117800935","https://openalex.org/W2125435699","https://openalex.org/W2129726289","https://openalex.org/W2140452134","https://openalex.org/W2149441684","https://openalex.org/W2161446823","https://openalex.org/W2162371443","https://openalex.org/W2164442171","https://openalex.org/W2167803469","https://openalex.org/W2168106545","https://openalex.org/W2168152640","https://openalex.org/W2203433851","https://openalex.org/W2275877493","https://openalex.org/W2280934059","https://openalex.org/W2337969040","https://openalex.org/W2343285674","https://openalex.org/W2346530374","https://openalex.org/W2346937970","https://openalex.org/W2417535489","https://openalex.org/W2461013690","https://openalex.org/W2465125172","https://openalex.org/W2506418499","https://openalex.org/W2507289596","https://openalex.org/W2519030578","https://openalex.org/W2569171734","https://openalex.org/W2570401594","https://openalex.org/W2575837388","https://openalex.org/W2764232556","https://openalex.org/W2765185461","https://openalex.org/W2767826728","https://openalex.org/W2768204493","https://openalex.org/W2790282058","https://openalex.org/W2795505616","https://openalex.org/W2799554741","https://openalex.org/W2801988573","https://openalex.org/W2888569026","https://openalex.org/W2968887911","https://openalex.org/W2975424845","https://openalex.org/W2988716798","https://openalex.org/W6769944288"],"related_works":["https://openalex.org/W3082482616","https://openalex.org/W2945113757","https://openalex.org/W2161446823","https://openalex.org/W3183926312","https://openalex.org/W4402857881","https://openalex.org/W2379009576","https://openalex.org/W2521054508","https://openalex.org/W3025430486","https://openalex.org/W3037221486","https://openalex.org/W4365997892"],"abstract_inverted_index":{"Abstract":[0],"Constitutive":[1],"NRF2":[2,37,69,108,127,153,170,176,200,212,241,256,285],"activation":[3,55],"by":[4],"disrupted":[5],"KEAP1-NRF2":[6],"interaction":[7],"has":[8],"been":[9],"reported":[10],"in":[11,40,51,74,123,128,147,198,209,222,240,265],"a":[12,281],"variety":[13],"of":[14,58,97,284],"human":[15,25,42,75,150],"cancers.":[16,43,132],"However,":[17],"studies":[18],"focusing":[19],"on":[20],"NRF2-driven":[21,277],"KEAP1":[22,39,46,72,86,119,157,173,184,188,195,215,278],"expression":[23,34,104,121,249],"under":[24],"cancer":[26,143,273,297],"contexts":[27],"are":[28],"still":[29],"uncommon.":[30],"We":[31,44,60,77],"examined":[32],"mRNA":[33,47,90,120,158,189,196,207,220,248],"correlation":[35],"between":[36],"and":[38,48,81,89,159,165,182,187,217,299],"multiple":[41,129,269],"measured":[45],"protein":[49,160],"alterations":[50],"response":[52],"to":[53,67,71,84,106,172],"the":[54,98,246,258],"or":[56,214],"silencing":[57],"NRF2.":[59],"queried":[61],"chromatin":[62],"immunoprecipitation":[63],"sequencing":[64,166],"(ChIP-seq)":[65],"datasets":[66],"identify":[68],"binding":[70,177],"promoters":[73],"cells.":[76],"used":[78,102],"reporter":[79],"assay":[80],"CRISPR":[82],"editing":[83],"assess":[85],"promoter":[87,185],"activity":[88,186],"abundance":[91],"change.":[92],"To":[93],"determine":[94],"specimen":[95],"implication":[96],"feedback":[99],"pattern,":[100],"we":[101,203,232],"gene":[103],"ratio":[105,208,221],"predict":[107],"signal":[109],"disruption":[110],"as":[111,113],"well":[112],"patients'":[114],"prognosis.":[115],"Correlation":[116],"analysis":[117,267],"showed":[118,261],"was":[122],"positive":[124,134],"association":[125],"with":[126,211,224,237,254,268],"squamous":[130,140,270],"cell":[131,141,271],"The":[133],"correlations":[135],"were":[136],"consistent":[137,169],"across":[138],"all":[139],"lung":[142,151,272],"cohorts,":[144],"but":[145],"not":[146],"adenocarcinomas.":[148],"In":[149,228],"cells,":[152],"interventions":[154],"significantly":[155,179],"altered":[156],"expressions.":[161],"ChIP-quantitative":[162],"PCR":[163],"(ChIP-qPCR)":[164],"data":[167],"demonstrated":[168],"occupancy":[171],"promoter.":[174],"Deleting":[175],"site":[178],"reduced":[180],"baseline":[181],"inducible":[183],"expression.":[190],"By":[191],"incorporating":[192],"tumor":[193],"tissue":[194],"expressions":[197],"estimating":[199],"signaling":[201,286],"disruptions,":[202],"found":[204],"increased":[205],"TXN/KEAP1":[206],"cases":[210,223,236],"gain":[213],"loss":[216],"decreased":[218],"NRF2/KEAP1":[219],"NRF2\u2013KEAP1":[225],"somatic":[226],"mutations.":[227],"TCGA":[229],"PanCancer":[230],"datasets,":[231],"also":[233],"identified":[234],"that":[235],"loss-of-function":[238],"mutations":[239],"pathway":[242],"recurrently":[243],"appeared":[244],"above":[245],"NRF2-KEAP1":[247],"regression":[250],"lines.":[251],"Moreover,":[252],"compared":[253],"previous":[255],"signatures,":[257],"ratio-based":[259],"strategy":[260],"better":[262],"predictive":[263],"performance":[264],"survival":[266],"cohort":[274],"validations.":[275],"Implications:":[276],"transcription":[279],"is":[280],"crucial":[282],"component":[283],"modulation.":[287],"This":[288],"hidden":[289],"circuit":[290],"will":[291],"provide":[292],"in-depth":[293],"insight":[294],"into":[295],"novel":[296],"prevention":[298],"therapeutic":[300],"strategies.":[301]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2020-06-25T00:00:00"}