{"id":"https://openalex.org/W3035655320","doi":"https://doi.org/10.1177/0748730420923164","title":"Circadian Potency Spectrum with Extended Exposure to Polychromatic White LED Light under Workplace Conditions","display_name":"Circadian Potency Spectrum with Extended Exposure to Polychromatic White LED Light under Workplace Conditions","publication_year":2020,"publication_date":"2020-06-16","ids":{"openalex":"https://openalex.org/W3035655320","doi":"https://doi.org/10.1177/0748730420923164","mag":"3035655320","pmid":"https://pubmed.ncbi.nlm.nih.gov/32539484","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7343335"},"language":"en","primary_location":{"id":"doi:10.1177/0748730420923164","doi":"https://doi.org/10.1177/0748730420923164","is_oa":true,"landing_page_url":"https://doi.org/10.1177/0748730420923164","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/0748730420923164","source":{"id":"https://openalex.org/S192515372","display_name":"Journal of Biological Rhythms","issn_l":"0748-7304","issn":["0748-7304","1552-4531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Rhythms","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://journals.sagepub.com/doi/pdf/10.1177/0748730420923164","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015486616","display_name":"Martin C. Moore\u2010Ede","orcid":"https://orcid.org/0000-0002-9557-0609","observed_orcids":["https://orcid.org/0000-0002-9557-0609"]},"institutions":[{"id":"https://openalex.org/I4210138174","display_name":"Circadian (United States)","ror":"https://ror.org/03rqvr941","country_code":"US","type":"company","lineage":["https://openalex.org/I4210138174"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Martin Moore-Ede","raw_affiliation_strings":["Circadian Light Research Center, Circadian ZircLight, Inc., Stoneham, Massachusetts"],"raw_orcid":"https://orcid.org/0000-0002-9557-0609","affiliations":[{"raw_affiliation_string":"Circadian Light Research Center, Circadian ZircLight, Inc., Stoneham, Massachusetts","institution_ids":["https://openalex.org/I4210138174"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043360147","display_name":"Anneke Heitmann","orcid":"https://orcid.org/0000-0002-9560-2906","observed_orcids":["https://orcid.org/0000-0002-9560-2906"]},"institutions":[{"id":"https://openalex.org/I4210138174","display_name":"Circadian (United States)","ror":"https://ror.org/03rqvr941","country_code":"US","type":"company","lineage":["https://openalex.org/I4210138174"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anneke Heitmann","raw_affiliation_strings":["Circadian Light Research Center, Circadian ZircLight, Inc., Stoneham, Massachusetts","Data Analytics Department, Circadian Technologies, Inc., Stoneham, Massachusetts"],"raw_orcid":"https://orcid.org/0000-0002-9560-2906","affiliations":[{"raw_affiliation_string":"Circadian Light Research Center, Circadian ZircLight, Inc., Stoneham, Massachusetts","institution_ids":["https://openalex.org/I4210138174"]},{"raw_affiliation_string":"Data Analytics Department, Circadian Technologies, Inc., Stoneham, Massachusetts","institution_ids":["https://openalex.org/I4210138174"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069264435","display_name":"Rainer Guttkuhn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210138174","display_name":"Circadian (United States)","ror":"https://ror.org/03rqvr941","country_code":"US","type":"company","lineage":["https://openalex.org/I4210138174"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rainer Guttkuhn","raw_affiliation_strings":["Data Analytics Department, Circadian Technologies, Inc., Stoneham, Massachusetts","*Circadian Light Research Center, Circadian ZircLight, Inc., Stoneham, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Data Analytics Department, Circadian Technologies, Inc., Stoneham, Massachusetts","institution_ids":["https://openalex.org/I4210138174"]},{"raw_affiliation_string":"*Circadian Light Research Center, Circadian ZircLight, Inc., Stoneham, Massachusetts","institution_ids":["https://openalex.org/I4210138174"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5015486616"],"corresponding_institution_ids":["https://openalex.org/I4210138174"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":{"value":3000,"currency":"USD","value_usd":3000},"fwci":1.5396,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.79285357,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"35","issue":"4","first_page":"405","last_page":"415"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11963","display_name":"Impact of Light on Environment and Health","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2306","display_name":"Global and Planetary Change"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11268","display_name":"Light effects on plants","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/white-led-light","display_name":"white LED light","score":0.753000020980835},{"id":"https://openalex.org/keywords/light-at-night","display_name":"light at night","score":0.718999981880188},{"id":"https://openalex.org/keywords/circadian-rhythm-disruption","display_name":"circadian rhythm disruption","score":0.722000002861023},{"id":"https://openalex.org/keywords/salivary-melatonin","display_name":"salivary melatonin","score":0.8349999785423279},{"id":"https://openalex.org/keywords/iprgcs","display_name":"intrinsically photosensitive retinal ganglion cells","score":0.9580000042915344},{"id":"https://openalex.org/keywords/blue-light","display_name":"blue light","score":0.5149999856948853},{"id":"https://openalex.org/keywords/workplace-lighting","display_name":"workplace lighting","score":0.5860000252723694},{"id":"https://openalex.org/keywords/circadian-phototransduction","display_name":"circadian phototransduction","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.8556513786315918},{"id":"https://openalex.org/C3449773","wikidata":"https://www.wikidata.org/wiki/Q92594","display_name":"Melanopsin","level":4,"score":0.8105449676513672},{"id":"https://openalex.org/C2778182776","wikidata":"https://www.wikidata.org/wiki/Q180912","display_name":"Melatonin","level":2,"score":0.6591306924819946},{"id":"https://openalex.org/C60548495","wikidata":"https://www.wikidata.org/wiki/Q7575205","display_name":"Spectral sensitivity","level":3,"score":0.6318022012710571},{"id":"https://openalex.org/C63531555","wikidata":"https://www.wikidata.org/wiki/Q7180960","display_name":"Phase response curve","level":4,"score":0.5583298206329346},{"id":"https://openalex.org/C38137364","wikidata":"https://www.wikidata.org/wiki/Q934475","display_name":"Intrinsically photosensitive retinal ganglion cells","level":4,"score":0.5552164316177368},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.5295007228851318},{"id":"https://openalex.org/C40833965","wikidata":"https://www.wikidata.org/wiki/Q6901438","display_name":"Monochromatic color","level":2,"score":0.4770963788032532},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39170336723327637},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.38492411375045776},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3713846206665039},{"id":"https://openalex.org/C6260449","wikidata":"https://www.wikidata.org/wiki/Q41364","display_name":"Wavelength","level":2,"score":0.33359503746032715},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.27858537435531616},{"id":"https://openalex.org/C38606739","wikidata":"https://www.wikidata.org/wiki/Q5121352","display_name":"Circadian clock","level":3,"score":0.27385252714157104},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.22592389583587646},{"id":"https://openalex.org/C189780591","wikidata":"https://www.wikidata.org/wiki/Q7187882","display_name":"Photopigment","level":3,"score":0.128658264875412},{"id":"https://openalex.org/C2777624874","wikidata":"https://www.wikidata.org/wiki/Q927337","display_name":"Retinal ganglion cell","level":3,"score":0.10867494344711304}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008027","descriptor_name":"Light","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008029","descriptor_name":"Lighting","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008550","descriptor_name":"Melatonin","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D017132","descriptor_name":"Workplace","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1177/0748730420923164","doi":"https://doi.org/10.1177/0748730420923164","is_oa":true,"landing_page_url":"https://doi.org/10.1177/0748730420923164","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/0748730420923164","source":{"id":"https://openalex.org/S192515372","display_name":"Journal of Biological Rhythms","issn_l":"0748-7304","issn":["0748-7304","1552-4531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Rhythms","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7343335","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7343335","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Rhythms","raw_type":"Text"},{"id":"pmid:32539484","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32539484","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biological rhythms","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1177/0748730420923164","doi":"https://doi.org/10.1177/0748730420923164","is_oa":true,"landing_page_url":"https://doi.org/10.1177/0748730420923164","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/0748730420923164","source":{"id":"https://openalex.org/S192515372","display_name":"Journal of Biological Rhythms","issn_l":"0748-7304","issn":["0748-7304","1552-4531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Rhythms","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4289578474","display_name":"ZircLight: Spectrum-specific Lighting for Shift Work","funder_award_id":"R43HL110769","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G952964938","display_name":"ZircLight: Spectrum-specific lighting for shift work","funder_award_id":"R44HL110769","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3035655320.pdf"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W46523259","https://openalex.org/W1482178272","https://openalex.org/W1622456520","https://openalex.org/W1918503161","https://openalex.org/W1964863578","https://openalex.org/W1968786793","https://openalex.org/W2004825358","https://openalex.org/W2023126912","https://openalex.org/W2046289352","https://openalex.org/W2070946727","https://openalex.org/W2083933443","https://openalex.org/W2090740247","https://openalex.org/W2103987983","https://openalex.org/W2106496774","https://openalex.org/W2112778345","https://openalex.org/W2115908598","https://openalex.org/W2133026008","https://openalex.org/W2136149869","https://openalex.org/W2159200188","https://openalex.org/W2163034057","https://openalex.org/W2163521873","https://openalex.org/W2221935254","https://openalex.org/W2233039400","https://openalex.org/W2320338248","https://openalex.org/W2389771398","https://openalex.org/W2551231535","https://openalex.org/W2555865797","https://openalex.org/W2560751806","https://openalex.org/W2600843354","https://openalex.org/W2782864368","https://openalex.org/W2868533733","https://openalex.org/W2916740450","https://openalex.org/W2969965946","https://openalex.org/W2993172100","https://openalex.org/W3142424074","https://openalex.org/W4298413076","https://openalex.org/W4317524127"],"related_works":["https://openalex.org/W4366082987","https://openalex.org/W4417048997","https://openalex.org/W2152075431","https://openalex.org/W2037925413","https://openalex.org/W2161404195","https://openalex.org/W2168712252","https://openalex.org/W2920341888","https://openalex.org/W2946852268","https://openalex.org/W2936456066","https://openalex.org/W2796768776"],"abstract_inverted_index":{"Electric":[0],"light":[1,10,67,138,177,247,259,274,281],"has":[2],"enabled":[3],"humans":[4],"to":[5,55,95,97,106,111,122,170,192,231,249],"conquer":[6],"the":[7,16,39,57,132,142,145,197,202,241,255],"night,":[8],"but":[9],"exposure":[11,260],"at":[12,184,222,261],"night":[13,262],"can":[14],"disrupt":[15],"circadian":[17,41,48,58,89,147,251,271,278],"timing":[18,42],"system":[19],"and":[20,109,118,225,253,276],"is":[21,51],"associated":[22],"with":[23,179,219],"a":[24,44,155,210,220,226],"diverse":[25,180],"range":[26],"of":[27,47,83,136,165,188,201,229,243,258],"health":[28,256],"disorders.":[29],"To":[30,140],"provide":[31],"adequate":[32],"lighting":[33],"for":[34],"visual":[35],"tasks":[36],"without":[37],"disrupting":[38],"human":[40,71,146,168,213],"system,":[43],"precise":[45],"definition":[46],"spectral":[49,59,90,148,181,216,238],"sensitivity":[50,60,91,149,217,239],"required.":[52],"Prior":[53],"attempts":[54],"define":[56],"curve":[61,200,218],"have":[62,154],"used":[63,161],"short":[64],"(\u226490-min)":[65],"monochromatic":[66],"exposures":[68,164],"in":[69,74,93,150,263],"dark-adapted":[70,76,88],"subjects":[72,169],"or":[73,79],"vitro":[75],"isolated":[77],"retina":[78],"melanopsin.":[80],"Several":[81],"lines":[82],"evidence":[84],"suggest":[85],"that":[86,144],"these":[87],"curves,":[92],"addition":[94],"430-":[96],"499-nm":[98],"(blue)":[99],"wavelength":[100],"sensitivity,":[101,159],"may":[102,153],"include":[103],"transient":[104],"400-":[105],"429-nm":[107],"(violet)":[108],"500-":[110],"560-nm":[112],"(green)":[113],"components":[114],"mediated":[115],"by":[116,267],"cone-":[117],"rod-originated":[119],"extrinsic":[120],"inputs":[121],"intrinsically":[123],"photosensitive":[124],"retinal":[125],"ganglion":[126],"cells":[127],"(ipRGCs),":[128],"which":[129],"decay":[130],"over":[131],"first":[133],"2":[134],"h":[135],"extended":[137],"exposure.":[139],"test":[141],"hypothesis":[143],"light-adapted":[151,166,235],"conditions":[152],"narrower,":[156],"predominantly":[157],"blue,":[158],"we":[160],"12-h":[162],"continuous":[163],"healthy":[167],"6":[171],"polychromatic":[172],"white":[173,273,280],"light-emitting":[174],"diode":[175],"(LED)":[176],"sources":[178,248],"power":[182],"distributions":[183],"recommended":[185],"workplace":[186],"levels":[187],"illumination":[189],"(540":[190],"lux)":[191],"determine":[193],"their":[194],"effect":[195],"on":[196],"area":[198],"under":[199],"overnight":[203],"(2000-0800":[204],"h)":[205],"salivary":[206],"melatonin.":[207],"We":[208],"derived":[209],"narrow":[211],"steady-state":[212],"Circadian":[214,236],"Potency":[215,237],"peak":[221],"477":[223],"nm":[224],"full-width":[227],"half-maximum":[228],"438":[230],"493":[232],"nm.":[233],"This":[234],"permits":[240],"development":[242],"spectrally":[244],"engineered":[245],"LED":[246],"minimize":[250],"disruption":[252],"address":[254],"risks":[257],"our":[264],"24/7":[265],"society,":[266],"alternating":[268],"between":[269],"daytime":[270],"stimulatory":[272],"spectra":[275],"nocturnal":[277],"protective":[279],"spectra.":[282]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-06-19T00:00:00"}