{"id":"https://openalex.org/W3035536614","doi":"https://doi.org/10.1074/jbc.ra120.013047","title":"Effects of intron conversion in the human CYP11B2 gene on its transcription and blood pressure regulation in transgenic mice","display_name":"Effects of intron conversion in the human CYP11B2 gene on its transcription and blood pressure regulation in transgenic mice","publication_year":2020,"publication_date":"2020-06-16","ids":{"openalex":"https://openalex.org/W3035536614","doi":"https://doi.org/10.1074/jbc.ra120.013047","mag":"3035536614","pmid":"https://pubmed.ncbi.nlm.nih.gov/32540969","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7415971"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.ra120.013047","doi":"https://doi.org/10.1074/jbc.ra120.013047","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.ra120.013047","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.ra120.013047","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043952521","display_name":"Brahmaraju Mopidevi","orcid":"https://orcid.org/0000-0003-1231-7796","observed_orcids":["https://orcid.org/0000-0003-1231-7796"]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brahmaraju Mopidevi","raw_affiliation_strings":["Department of Pathology, New York Medical College, Valhalla, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, New York Medical College, Valhalla, New York, USA","institution_ids":["https://openalex.org/I181190671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079001847","display_name":"Indu Sivankutty","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Indu Sivankutty","raw_affiliation_strings":["Department of Pathology, New York Medical College, Valhalla, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, New York Medical College, Valhalla, New York, USA","institution_ids":["https://openalex.org/I181190671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069138474","display_name":"Shoujin Hao","orcid":"https://orcid.org/0000-0002-0748-3805","observed_orcids":["https://orcid.org/0000-0002-0748-3805"]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shoujin Hao","raw_affiliation_strings":["Department of Pharmacology, New York Medical College, Valhalla, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, New York Medical College, Valhalla, New York, USA","institution_ids":["https://openalex.org/I181190671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007408600","display_name":"Nicholas R. Ferreri","orcid":"https://orcid.org/0000-0001-5097-9956","observed_orcids":["https://orcid.org/0000-0001-5097-9956"]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas R. Ferreri","raw_affiliation_strings":["Department of Pharmacology, New York Medical College, Valhalla, New York, USA"],"raw_orcid":"https://orcid.org/0000-0001-5097-9956","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, New York Medical College, Valhalla, New York, USA","institution_ids":["https://openalex.org/I181190671"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063055723","display_name":"Ashok Kumar","orcid":"https://orcid.org/0000-0001-9002-6324","observed_orcids":["https://orcid.org/0000-0001-9002-6324"]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ashok Kumar","raw_affiliation_strings":["Department of Pathology, New York Medical College, Valhalla, New York, USA akumar5@nymc.edu","Department of Pathology, New York Medical College, Valhalla, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, New York Medical College, Valhalla, New York, USA akumar5@nymc.edu","institution_ids":["https://openalex.org/I181190671"]},{"raw_affiliation_string":"Department of Pathology, New York Medical College, Valhalla, New York, USA","institution_ids":["https://openalex.org/I181190671"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5063055723"],"corresponding_institution_ids":["https://openalex.org/I181190671"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":0.1885,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.52561409,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"295","issue":"32","first_page":"11068","last_page":"11081"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyp11b2","display_name":"CYP11B2","score":0.9819999933242798},{"id":"https://openalex.org/keywords/aldosterone-synthase","display_name":"aldosterone synthase","score":0.9919999837875366},{"id":"https://openalex.org/keywords/aldosterone-biosynthesis","display_name":"aldosterone biosynthesis","score":0.7960000038146973},{"id":"https://openalex.org/keywords/blood-pressure-regulation","display_name":"blood pressure regulation","score":0.8019999861717224},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6959999799728394},{"id":"https://openalex.org/keywords/p300","display_name":"P300","score":0.8240000009536743},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.8640000224113464},{"id":"https://openalex.org/keywords/c-ebpalpha","display_name":"C/EBP\u03b1","score":0.8420000076293945},{"id":"https://openalex.org/keywords/open-chromatin","display_name":"open chromatin","score":0.6930000185966492},{"id":"https://openalex.org/keywords/cyp11b1","display_name":"CYP11B1","score":0.8259999752044678},{"id":"https://openalex.org/keywords/humanized-transgenic-mice","display_name":"humanized transgenic mice","score":0.847000002861023}],"concepts":[{"id":"https://openalex.org/C94671646","wikidata":"https://www.wikidata.org/wiki/Q207551","display_name":"Intron","level":3,"score":0.7236822247505188},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.6368521451950073},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5834513902664185},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.5757654905319214},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.5632456541061401},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5539179444313049},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.43019387125968933},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35993894934654236},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000450","descriptor_name":"Aldosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000450","descriptor_name":"Aldosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000450","descriptor_name":"Aldosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007438","descriptor_name":"Introns","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007438","descriptor_name":"Introns","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007438","descriptor_name":"Introns","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019405","descriptor_name":"Cytochrome P-450 CYP11B2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019405","descriptor_name":"Cytochrome P-450 CYP11B2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019405","descriptor_name":"Cytochrome P-450 CYP11B2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019405","descriptor_name":"Cytochrome P-450 CYP11B2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019405","descriptor_name":"Cytochrome P-450 CYP11B2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019405","descriptor_name":"Cytochrome P-450 CYP11B2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.ra120.013047","doi":"https://doi.org/10.1074/jbc.ra120.013047","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.ra120.013047","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7415971","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7415971","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:32540969","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32540969","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:touroscholar.touro.edu:nymc_fac_pubs-3839","doi":null,"is_oa":false,"landing_page_url":"https://touroscholar.touro.edu/nymc_fac_pubs/2885","pdf_url":null,"source":{"id":"https://openalex.org/S4377196437","display_name":"Touro Scholar (Touro College)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I200437953","host_organization_name":"Touro College","host_organization_lineage":["https://openalex.org/I200437953"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NYMC Faculty Publications","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1074/jbc.ra120.013047","doi":"https://doi.org/10.1074/jbc.ra120.013047","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.ra120.013047","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5199999809265137}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1346412078","display_name":null,"funder_award_id":"RO1 HL 122742","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2038981980","display_name":"Non-Coding Variants of Angiotensinogen Gene and Hypertension","funder_award_id":"R01HL130344","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7653894263","display_name":null,"funder_award_id":"RO1 HL 130344","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7830509667","display_name":"Aldosterone Synthase & Hypertension","funder_award_id":"R01HL122742","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000859653","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA023108","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W15815035","https://openalex.org/W1518176291","https://openalex.org/W1974940487","https://openalex.org/W1980496342","https://openalex.org/W1985770217","https://openalex.org/W1993887819","https://openalex.org/W1995360148","https://openalex.org/W2002548814","https://openalex.org/W2022293803","https://openalex.org/W2024885055","https://openalex.org/W2026161101","https://openalex.org/W2042603198","https://openalex.org/W2049642674","https://openalex.org/W2053351931","https://openalex.org/W2057263483","https://openalex.org/W2059846045","https://openalex.org/W2074074092","https://openalex.org/W2084160423","https://openalex.org/W2092416602","https://openalex.org/W2099370101","https://openalex.org/W2099735579","https://openalex.org/W2105933951","https://openalex.org/W2107999636","https://openalex.org/W2108103924","https://openalex.org/W2111847103","https://openalex.org/W2114004604","https://openalex.org/W2120539803","https://openalex.org/W2123978721","https://openalex.org/W2126107947","https://openalex.org/W2129265683","https://openalex.org/W2129950671","https://openalex.org/W2135207001","https://openalex.org/W2138232712","https://openalex.org/W2138649633","https://openalex.org/W2144360877","https://openalex.org/W2145366887","https://openalex.org/W2147457015","https://openalex.org/W2156497356","https://openalex.org/W2159655200","https://openalex.org/W2161212879","https://openalex.org/W2161781851","https://openalex.org/W2163707326","https://openalex.org/W2164490909","https://openalex.org/W2166161383","https://openalex.org/W2168492733","https://openalex.org/W2259938310","https://openalex.org/W2320846957","https://openalex.org/W2581452190","https://openalex.org/W2603800604","https://openalex.org/W2883415719","https://openalex.org/W4296981502","https://openalex.org/W6600628402"],"related_works":["https://openalex.org/W2749950165","https://openalex.org/W2138232712","https://openalex.org/W2904897670","https://openalex.org/W2729213489","https://openalex.org/W2134555657","https://openalex.org/W1985770217","https://openalex.org/W2124108262","https://openalex.org/W2057477110","https://openalex.org/W2029758149","https://openalex.org/W2148252556"],"abstract_inverted_index":{"The":[0,39],"human":[1],"cytochrome":[2],"P450":[3],"family":[4],"11":[5],"subfamily":[6],"B":[7],"member":[8],"2":[9,54],"(":[10,158,165,175],"hCYP11B2":[11,28,56,137,169,231],")":[12,160,167,177],"gene":[13,138],"encodes":[14],"aldosterone":[15,163],"synthase,":[16],"the":[17,21,48,58,62,69,84,101,127,136,141,154,199,205],"rate-limiting":[18],"enzyme":[19],"in":[20,74,111,230,237],"biosynthesis":[22],"of":[23,47,50,55,61,135,190,201,227],"aldosterone.":[24],"In":[25],"some":[26],"humans,":[27],"undergoes":[29],"a":[30,45,159,191,224,234],"unique":[31],"intron":[32,40,53,70,102,117,142,146,155,187,206,219,228],"conversion":[33,41,71,103,143,156,207,229],"whose":[34],"function":[35],"is":[36,42,72],"largely":[37],"unclear.":[38],"formed":[43],"by":[44],"replacement":[46],"segment":[49],"DNA":[51],"within":[52],"with":[57,115,182],"corresponding":[59],"region":[60],"hCYP11B1":[63],"gene.":[64],"We":[65,119,148],"show":[66],"here":[67],"that":[68,150,195],"located":[73],"an":[75],"open":[76],"chromatin":[77,196],"form":[78],"and":[79,92,130,132,171,174,214,232],"binds":[80,208],"more":[81,209],"strongly":[82,210],"to":[83,211,217],"transcriptional":[85],"regulators":[86],"histone":[87],"acetyltransferase":[88],"P300":[89],"(p300),":[90],"NF\u03baB,":[91,213],"CCAAT":[93],"enhancer\u2013binding":[94],"protein":[95,172],"\u03b1":[96],"(CEBP\u03b1).":[97],"Reporter":[98],"constructs":[99],"containing":[100,125,139,153,185,204],"had":[104],"increased":[105,161,168,178],"promoter":[106],"activity":[107],"on":[108],"transient":[109],"transfection":[110],"H295R":[112],"cells":[113],"compared":[114,181],"WT":[116,145,186,218],"2.":[118,147,188,220],"generated":[120],"humanized":[121],"transgenic":[122],"(TG)":[123],"mice":[124,152,184,203],"all":[126],"introns,":[128],"exons,":[129],"5\u2032-":[131],"3\u2032-flanking":[133],"regions":[134],"either":[140],"or":[144],"found":[149],"TG":[151,183,202],"have":[157],"plasma":[162],"levels,":[164,173],"b":[166],"mRNA":[170],"c":[176],"blood":[179,238],"pressure":[180,239],"Results":[189],"ChIP":[192],"assay":[193],"showed":[194],"obtained":[197],"from":[198],"adrenals":[200],"p300,":[212],"CEBP\u03b1":[215],"than":[216],"These":[221],"results":[222],"uncover":[223],"functional":[225],"role":[226],"suggest":[233],"new":[235],"paradigm":[236],"regulation.":[240]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2020-06-19T00:00:00"}