{"id":"https://openalex.org/W3035535580","doi":"https://doi.org/10.2337/db20-1960-p","title":"1960-P: A Novel Nitric Oxide Releasing Nanomatrix Gel Prevents High-Fat Diet-Induced Obesity and Insulin Resistance","display_name":"1960-P: A Novel Nitric Oxide Releasing Nanomatrix Gel Prevents High-Fat Diet-Induced Obesity and Insulin Resistance","publication_year":2020,"publication_date":"2020-06-01","ids":{"openalex":"https://openalex.org/W3035535580","doi":"https://doi.org/10.2337/db20-1960-p","mag":"3035535580"},"language":"en","primary_location":{"id":"doi:10.2337/db20-1960-p","doi":"https://doi.org/10.2337/db20-1960-p","is_oa":false,"landing_page_url":"https://doi.org/10.2337/db20-1960-p","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091066153","display_name":"Guang Ren","orcid":"https://orcid.org/0000-0001-7871-2110","observed_orcids":["https://orcid.org/0000-0001-7871-2110"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"GUANG REN","raw_affiliation_strings":["Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Birmingham, AL","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049030356","display_name":"AUBREY L. SHAW","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"AUBREY L. SHAW","raw_affiliation_strings":["Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Birmingham, AL","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051453414","display_name":"Patrick T.J. Hwang","orcid":"https://orcid.org/0000-0001-6457-1812","observed_orcids":["https://orcid.org/0000-0001-6457-1812"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"PATRICK HWANG","raw_affiliation_strings":["Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Birmingham, AL","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056475460","display_name":"R. Carl Millican","orcid":"https://orcid.org/0000-0002-3144-2835","observed_orcids":["https://orcid.org/0000-0002-3144-2835"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"REID C. MILLICAN","raw_affiliation_strings":["Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Birmingham, AL","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026338916","display_name":"Ho\u2010Wook Jun","orcid":"https://orcid.org/0000-0001-9150-7189","observed_orcids":["https://orcid.org/0000-0001-9150-7189"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"HO-WOOK JUN","raw_affiliation_strings":["Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Birmingham, AL","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023858699","display_name":"Jeong\u2010a Kim","orcid":"https://orcid.org/0000-0003-4674-4606","observed_orcids":["https://orcid.org/0000-0003-4674-4606"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"JEONGA KIM","raw_affiliation_strings":["Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Birmingham, AL","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.08645078,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"69","issue":"Supplement_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.8895999789237976,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.8895999789237976,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.07119999825954437,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9380000233650208},{"id":"https://openalex.org/keywords/amphiphilic-peptides","display_name":"peptide amphiphiles","score":0.8619999885559082},{"id":"https://openalex.org/keywords/brown-adipose-tissue-browning","display_name":"brown adipose tissue browning","score":0.8579999804496765},{"id":"https://openalex.org/keywords/high-fat-diet-induced-obesity","display_name":"high-fat diet-induced obesity","score":0.9470000267028809},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":1.0},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.8899999856948853},{"id":"https://openalex.org/keywords/ucp1","display_name":"UCP1","score":0.777999997138977},{"id":"https://openalex.org/keywords/glucose-tolerance","display_name":"glucose tolerance","score":0.656000018119812},{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":0.5680000185966492},{"id":"https://openalex.org/keywords/adipose-tissue-inflammation","display_name":"adipose tissue inflammation","score":0.7649999856948853},{"id":"https://openalex.org/keywords/mitochondrial-biogenesis","display_name":"mitochondrial biogenesis","score":0.6759999990463257},{"id":"https://openalex.org/keywords/obesity-treatment","display_name":"obesity treatment","score":0.7649999856948853}],"concepts":[{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.8676584959030151},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8367979526519775},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8346059322357178},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.721897542476654},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.6182777285575867},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6066750288009644},{"id":"https://openalex.org/C151955695","wikidata":"https://www.wikidata.org/wiki/Q654528","display_name":"White adipose tissue","level":3,"score":0.5829599499702454},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.4648282527923584},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.396582692861557},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39219430088996887}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2337/db20-1960-p","doi":"https://doi.org/10.2337/db20-1960-p","is_oa":false,"landing_page_url":"https://doi.org/10.2337/db20-1960-p","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7099999785423279}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4224324753","https://openalex.org/W2093187404","https://openalex.org/W67369149","https://openalex.org/W2034310187","https://openalex.org/W2980494944","https://openalex.org/W4205485486","https://openalex.org/W2102663850","https://openalex.org/W2977307942","https://openalex.org/W2078821762","https://openalex.org/W71626438"],"abstract_inverted_index":{"Endothelial":[0],"dysfunction":[1],"is":[2,14],"characterized":[3],"by":[4,54,214],"reduction":[5],"of":[6,9,42,56,164,176,216,225,259],"the":[7,61,111,127,151,157,162,174,191,196,201],"bioavailability":[8],"nitric":[10,203],"oxide":[11,204],"(NO),":[12],"and":[13,27,51,89,139,145,173,184,211,234],"associated":[15],"with":[16,72,119,130],"metabolic":[17],"syndrome":[18],"including,":[19],"obesity,":[20],"insulin":[21,52,140,144,212,235],"resistance,":[22],"hypertension,":[23],"coronary":[24],"heart":[25],"disease,":[26],"aging.":[28],"Because":[29],"NO":[30,43,68],"plays":[31],"important":[32],"roles":[33],"in":[34,150,167,180,190],"mitochondrial":[35],"biogenesis,":[36],"we":[37,64],"hypothesize":[38],"that":[39,223],"exogenous":[40],"application":[41],"may":[44],"prevent":[45],"high":[46],"fat":[47,169],"diet":[48],"(HFD)-induced":[49],"obesity":[50,210,233],"resistance":[53,213],"promotion":[55,215],"adipose":[57,101,182,186,217],"tissue":[58,102,170,183,187,218],"browning.":[59,219],"In":[60],"current":[62],"study,":[63],"developed":[65],"a":[66,229],"novel":[67,202,230],"releasing":[69,205],"nanomatrix":[70,206],"gel":[71,207],"natural":[73],"peptide":[74],"amphiphiles":[75],"(PANO).":[76],"8":[77],"week":[78],"old":[79],"male":[80],"C57BL/6":[81],"mice":[82,112,117,128,134,154,193],"were":[83,113,148],"randomly":[84],"divided":[85],"into":[86,99],"2":[87,105],"groups,":[88],"then":[90],"either":[91],"vehicle":[92,158,197],"(PA)":[93],"or":[94],"PANO":[95,120,132,152,226],"was":[96,171,188],"subcutaneously":[97],"injected":[98,118,129,133,153,159,198],"brown":[100,181],"area":[103],"every":[104],"weeks":[106,109],"for":[107,232],"11":[108],"while":[110],"fed":[114],"HFD.":[115],"The":[116,220],"gained":[121],"less":[122],"body":[123],"weight":[124],"compared":[125,155,194],"to":[126,156,195],"vehicle.":[131],"demonstrated":[135],"improved":[136],"glucose":[137],"tolerance":[138],"tolerance.":[141],"Fasting":[142],"glucose,":[143],"leptin":[146],"levels":[147],"lower":[149],"mice.":[160,199],"Furthermore,":[161],"expression":[163,175],"pro-inflammatory":[165],"genes":[166],"epididymal":[168],"lower,":[172],"uncoupled":[177],"protein":[178],"(UCP1)":[179],"inguinal":[185],"higher":[189],"PANO-injected":[192],"Thus,":[200],"ameliorated":[208],"HFD-induced":[209],"results":[221],"suggest":[222],"injection":[224],"can":[227],"be":[228],"therapeutic":[231],"resistance.":[236],"Disclosure":[237],"G.":[238],"Ren:":[239],"None.":[240,243,246,249,252,255],"A.L.":[241],"Shaw:":[242],"P.":[244],"Hwang:":[245],"R.C.":[247],"Millican:":[248],"H.":[250],"Jun:":[251],"J.":[253],"Kim:":[254],"Funding":[256],"National":[257],"Institutes":[258],"Health":[260],"(1R01HL125391-01)":[261]},"counts_by_year":[],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2020-06-19T00:00:00"}