{"id":"https://openalex.org/W3035483333","doi":"https://doi.org/10.15406/ghoa.2019.10.00393","title":"Aggressive periodontitis in a setting of established crohn\u2019s disease: a complex interplay of etiological factors affecting disease outcome","display_name":"Aggressive periodontitis in a setting of established crohn\u2019s disease: a complex interplay of etiological factors affecting disease outcome","publication_year":2019,"publication_date":"2019-10-26","ids":{"openalex":"https://openalex.org/W3035483333","doi":"https://doi.org/10.15406/ghoa.2019.10.00393","mag":"3035483333"},"language":"en","primary_location":{"id":"doi:10.15406/ghoa.2019.10.00393","doi":"https://doi.org/10.15406/ghoa.2019.10.00393","is_oa":true,"landing_page_url":"https://doi.org/10.15406/ghoa.2019.10.00393","pdf_url":"https://medcraveonline.com/GHOA/GHOA-10-00393.pdf","source":{"id":"https://openalex.org/S4210201128","display_name":"Gastroenterology & Hepatology Open Access","issn_l":"2373-6372","issn":["2373-6372"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320093","host_organization_name":"MedCrave Group","host_organization_lineage":["https://openalex.org/P4310320093"],"host_organization_lineage_names":["MedCrave Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology &amp; Hepatology: Open Access","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://medcraveonline.com/GHOA/GHOA-10-00393.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041290771","display_name":"Abhishek Singh Nayyar","orcid":"https://orcid.org/0000-0001-7107-7564","observed_orcids":["https://orcid.org/0000-0001-7107-7564"]},"institutions":[{"id":"https://openalex.org/I149766970","display_name":"Maharashtra University of Health Sciences","ror":"https://ror.org/04grkj883","country_code":"IN","type":"education","lineage":["https://openalex.org/I149766970"]},{"id":"https://openalex.org/I4210127890","display_name":"Saraswati Dental College and Hospital","ror":"https://ror.org/02r2tq059","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210127890"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Abhishek Singh Nayyar","raw_affiliation_strings":["Department of Oral Medicine and Radiology , Faculty of Dentistry , Maharashtra University of Health Sciences , Nashik , Maharashtra , India , Tel +91-98509 04067 ,","Department of Oral Medicine and Radiology, Saraswati Dhanwantari Dental College and Hospital, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Medicine and Radiology , Faculty of Dentistry , Maharashtra University of Health Sciences , Nashik , Maharashtra , India , Tel +91-98509 04067 ,","institution_ids":["https://openalex.org/I149766970"]},{"raw_affiliation_string":"Department of Oral Medicine and Radiology, Saraswati Dhanwantari Dental College and Hospital, India","institution_ids":["https://openalex.org/I4210127890"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101844993","display_name":"Sandeep A. Patel","orcid":"https://orcid.org/0000-0003-0843-7744","observed_orcids":["https://orcid.org/0000-0003-0843-7744"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sandeep Patel","raw_affiliation_strings":["Consultant Periodontist and Implantologist, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Consultant Periodontist and Implantologist, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114173244","display_name":"Hiral A. Parikh","orcid":"https://orcid.org/0000-0001-8715-4691","observed_orcids":["https://orcid.org/0000-0001-8715-4691"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiral Parikh","raw_affiliation_strings":["Department of Periodontology and Implantology, Narsinhbhai Patel Dental College and Hospital, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontology and Implantology, Narsinhbhai Patel Dental College and Hospital, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110692476","display_name":"Anita Gala Doshi","orcid":"https://orcid.org/0000-0001-8030-4546","observed_orcids":["https://orcid.org/0000-0001-8030-4546"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anita Doshi","raw_affiliation_strings":["Consultant Prosthodontist, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Consultant Prosthodontist, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050912707","display_name":"Barun Kumar","orcid":"https://orcid.org/0000-0002-2562-1714","observed_orcids":["https://orcid.org/0000-0002-2562-1714"]},"institutions":[{"id":"https://openalex.org/I887998513","display_name":"Bharati Vidyapeeth (Deemed to be University)","ror":"https://ror.org/0052mmx10","country_code":"IN","type":"education","lineage":["https://openalex.org/I887998513"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Barun Kumar","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Bharati Vidyapeeth (Deemed to be University) Dental College and Hospital, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Bharati Vidyapeeth (Deemed to be University) Dental College and Hospital, India","institution_ids":["https://openalex.org/I887998513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110520684","display_name":"Thatapudi Shankar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thatapudi A Shankar","raw_affiliation_strings":["Department of Prosthodontics and Crown and Bridge, Kalinga Institute of Dental Sciences, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Prosthodontics and Crown and Bridge, Kalinga Institute of Dental Sciences, India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":95},"biblio":{"volume":"10","issue":"5","first_page":"262","last_page":"266"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9297000169754028,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9297000169754028,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10359","display_name":"Dental Implant Techniques and Outcomes","score":0.021700000390410423,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aggressive-periodontitis","display_name":"aggressive periodontitis","score":1.0},{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":0.996999979019165},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.9860000014305115},{"id":"https://openalex.org/keywords/periodontal-disease","display_name":"periodontal disease","score":0.7390000224113464},{"id":"https://openalex.org/keywords/gut-dysbiosis","display_name":"gut dysbiosis","score":0.8159999847412109},{"id":"https://openalex.org/keywords/oral-microbiota","display_name":"oral microbiota","score":0.7680000066757202},{"id":"https://openalex.org/keywords/intestinal-epithelial-barrier","display_name":"intestinal epithelial barrier","score":0.7250000238418579},{"id":"https://openalex.org/keywords/implant-therapy","display_name":"implant treatment","score":0.6539999842643738},{"id":"https://openalex.org/keywords/osseointegration","display_name":"osseointegration","score":0.9670000076293945}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7830647230148315},{"id":"https://openalex.org/C2780385504","wikidata":"https://www.wikidata.org/wiki/Q520127","display_name":"Periodontitis","level":2,"score":0.7646447420120239},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.7369189858436584},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.6321446895599365},{"id":"https://openalex.org/C2779280984","wikidata":"https://www.wikidata.org/wiki/Q1472","display_name":"Crohn's disease","level":3,"score":0.6035818457603455},{"id":"https://openalex.org/C137627325","wikidata":"https://www.wikidata.org/wiki/Q156318","display_name":"Etiology","level":2,"score":0.5754193067550659},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.482255756855011},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4491814374923706},{"id":"https://openalex.org/C2777165150","wikidata":"https://www.wikidata.org/wiki/Q269334","display_name":"Dysbiosis","level":3,"score":0.44293367862701416},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2899981141090393},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2699478268623352}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.15406/ghoa.2019.10.00393","doi":"https://doi.org/10.15406/ghoa.2019.10.00393","is_oa":true,"landing_page_url":"https://doi.org/10.15406/ghoa.2019.10.00393","pdf_url":"https://medcraveonline.com/GHOA/GHOA-10-00393.pdf","source":{"id":"https://openalex.org/S4210201128","display_name":"Gastroenterology & Hepatology Open Access","issn_l":"2373-6372","issn":["2373-6372"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320093","host_organization_name":"MedCrave Group","host_organization_lineage":["https://openalex.org/P4310320093"],"host_organization_lineage_names":["MedCrave Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology &amp; Hepatology: Open Access","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.15406/ghoa.2019.10.00393","doi":"https://doi.org/10.15406/ghoa.2019.10.00393","is_oa":true,"landing_page_url":"https://doi.org/10.15406/ghoa.2019.10.00393","pdf_url":"https://medcraveonline.com/GHOA/GHOA-10-00393.pdf","source":{"id":"https://openalex.org/S4210201128","display_name":"Gastroenterology & Hepatology Open Access","issn_l":"2373-6372","issn":["2373-6372"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320093","host_organization_name":"MedCrave Group","host_organization_lineage":["https://openalex.org/P4310320093"],"host_organization_lineage_names":["MedCrave Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology &amp; Hepatology: Open Access","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3035483333.pdf","grobid_xml":"https://content.openalex.org/works/W3035483333.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1205330300","https://openalex.org/W1594433044","https://openalex.org/W1768674173","https://openalex.org/W1977527961","https://openalex.org/W1978739533","https://openalex.org/W1978889683","https://openalex.org/W1983736281","https://openalex.org/W1984210507","https://openalex.org/W1986079650","https://openalex.org/W1989840100","https://openalex.org/W2024346860","https://openalex.org/W2047547853","https://openalex.org/W2052988287","https://openalex.org/W2073646248","https://openalex.org/W2078621117","https://openalex.org/W2099941232","https://openalex.org/W2103817331","https://openalex.org/W2112635226","https://openalex.org/W2120741277","https://openalex.org/W2122591280","https://openalex.org/W2127048170","https://openalex.org/W2153547726","https://openalex.org/W2157368712","https://openalex.org/W2159325000","https://openalex.org/W2169890771","https://openalex.org/W2343323917","https://openalex.org/W2466404883","https://openalex.org/W2527386006","https://openalex.org/W2899142686","https://openalex.org/W2953134042","https://openalex.org/W4230633180","https://openalex.org/W4251548628","https://openalex.org/W6980782794"],"related_works":["https://openalex.org/W3209980423","https://openalex.org/W2953843795","https://openalex.org/W4410211709","https://openalex.org/W4390602759","https://openalex.org/W4399430324","https://openalex.org/W4402111185","https://openalex.org/W4296029824","https://openalex.org/W4206749273","https://openalex.org/W3003977194","https://openalex.org/W1546703593"],"abstract_inverted_index":{"The":[0],"prevalence":[1],"of":[2,18,41,64,89,105,118,123,138],"periodontal":[3],"disease":[4,14,36,91,96,125,147],"seems":[5,20],"to":[6,21,50],"be":[7],"increased":[8],"in":[9,23,33,62,67,130,141],"patients":[10,69],"with":[11,144,150],"inflammatory":[12,47],"bowel":[13],"(IBD).Moreover,":[15],"the":[16,39,42,46,51,59,74,77,86,114,119],"induction":[17],"periodontitis":[19,68,140],"result":[22],"gut":[24,28],"dysbiosis":[25],"and":[26,44,108],"altered":[27],"epithelial":[29],"cell":[30],"barrier":[31],"function":[32],"which":[34,126],"one":[35,117],"might":[37,72],"alter":[38],"composition":[40],"microbiota":[43],"increase":[45],"response":[48],"related":[49],"other":[52],"disease.Such":[53],"systemic":[54],"conditions":[55],"might,":[56],"also,":[57],"influence":[58],"clinical":[60],"outcome":[61],"case":[63,133,137],"implant":[65,151],"therapy":[66],"as":[70,82,84],"they":[71],"affect":[73,85],"soft":[75],"tissues,":[76],"general":[78],"trabecular":[79],"bone":[80],"pattern":[81],"well":[83],"successful":[87],"outcomes":[88],"osseo-integration.Crohn's":[90],"is":[92,116],"a":[93,109,136,142],"chronic":[94],"granulomatous":[95,106],"process":[97],"characterized":[98],"by":[99],"persistent":[100],"intestinal":[101],"inflammation,":[102],"ulceration,":[103],"formation":[104],"lesions":[107],"generalized":[110],"trans-mural":[111],"inflammation":[112],"throughout":[113],"intestines.Periodontitis":[115],"common":[120],"oral":[121],"manifestations":[122],"Crohn's":[124,146],"was":[127],"first":[128],"described":[129],"1969.The":[131],"present":[132],"report":[134],"describes":[135],"aggressive":[139],"patient":[143],"established":[145],"successfully":[148],"managed":[149],"therapy.":[152]},"counts_by_year":[{"year":2024,"cited_by_count":2}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2020-06-19T00:00:00"}
