{"id":"https://openalex.org/W3035396106","doi":"https://doi.org/10.2337/db20-1259-p","title":"1259-P: Dyslipidemia of Insulin Resistance Is Associated with Subclinical Inflammation in Youth with Type 2 Diabetes","display_name":"1259-P: Dyslipidemia of Insulin Resistance Is Associated with Subclinical Inflammation in Youth with Type 2 Diabetes","publication_year":2020,"publication_date":"2020-06-01","ids":{"openalex":"https://openalex.org/W3035396106","doi":"https://doi.org/10.2337/db20-1259-p","mag":"3035396106"},"language":"en","primary_location":{"id":"doi:10.2337/db20-1259-p","doi":"https://doi.org/10.2337/db20-1259-p","is_oa":false,"landing_page_url":"https://doi.org/10.2337/db20-1259-p","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044564796","display_name":"ALFREDO VILLALOBOS-PEREZ","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"ALFREDO VILLALOBOS-PEREZ","raw_affiliation_strings":["Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bethesda, MD","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023964948","display_name":"Celeste K. L. Cravalho","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"CELESTE K. CRAVALHO","raw_affiliation_strings":["Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bethesda, MD","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025888749","display_name":"Samantha T. Matta","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"SAMANTHA MATTA","raw_affiliation_strings":["Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bethesda, MD","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073459077","display_name":"Abby G. Meyers","orcid":"https://orcid.org/0000-0002-3297-194X","observed_orcids":["https://orcid.org/0000-0002-3297-194X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"ABBY MEYERS","raw_affiliation_strings":["Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bethesda, MD","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090900196","display_name":"Lilian S. Mabundo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"LILIAN MABUNDO","raw_affiliation_strings":["Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bethesda, MD","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042569302","display_name":"Maureen L. Sampson","orcid":"https://orcid.org/0000-0003-0885-250X","observed_orcids":["https://orcid.org/0000-0003-0885-250X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"MAUREEN L. SAMPSON","raw_affiliation_strings":["Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bethesda, MD","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083340348","display_name":"Mary F. Walter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"MARY WALTER","raw_affiliation_strings":["Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bethesda, MD","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045776561","display_name":"Amber B. Courville","orcid":"https://orcid.org/0000-0002-1419-3937","observed_orcids":["https://orcid.org/0000-0002-1419-3937"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"AMBER B. COURVILLE","raw_affiliation_strings":["Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bethesda, MD","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005673337","display_name":"Stephanie Therese Chung","orcid":"https://orcid.org/0000-0001-6989-0417","observed_orcids":["https://orcid.org/0000-0001-6989-0417"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"STEPHANIE T. CHUNG","raw_affiliation_strings":["Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bethesda, MD","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.11124793,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"69","issue":"Supplement_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.8817999958992004,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.8817999958992004,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.07100000232458115,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.0284000001847744,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-2-diabetes-in-youth","display_name":"type 2 diabetes in youth","score":0.8360000252723694},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9710000157356262},{"id":"https://openalex.org/keywords/dyslipidemia","display_name":"dyslipidemia","score":0.9959999918937683},{"id":"https://openalex.org/keywords/subclinical-inflammation","display_name":"subclinical inflammation","score":0.925000011920929},{"id":"https://openalex.org/keywords/small-dense-ldl","display_name":"small dense LDL","score":0.5040000081062317},{"id":"https://openalex.org/keywords/triglyceride-rich-lipoproteins","display_name":"triglyceride-rich lipoproteins","score":0.9879999756813049},{"id":"https://openalex.org/keywords/apolipoprotein-b","display_name":"apolipoprotein B","score":0.9319999814033508},{"id":"https://openalex.org/keywords/glycated-albumin","display_name":"glycated albumin","score":0.6949999928474426},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.7960000038146973},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.5870000123977661},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.5979999899864197},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.7409999966621399},{"id":"https://openalex.org/keywords/matsuda-index","display_name":"Matsuda index","score":0.7310000061988831},{"id":"https://openalex.org/keywords/atherosclerotic-cardiovascular-disease-risk","display_name":"atherosclerotic cardiovascular disease risk","score":0.8629999756813049},{"id":"https://openalex.org/keywords/lipoprotein-size","display_name":"lipoprotein particle size","score":0.8149999976158142}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8506526947021484},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.7859757542610168},{"id":"https://openalex.org/C2778096610","wikidata":"https://www.wikidata.org/wiki/Q1476525","display_name":"Dyslipidemia","level":3,"score":0.7623307704925537},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7564524412155151},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.6362703442573547},{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.571800708770752},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5518853068351746},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5512253046035767},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.5009503364562988},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.45518749952316284},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.45074161887168884},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.3042701780796051}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2337/db20-1259-p","doi":"https://doi.org/10.2337/db20-1259-p","is_oa":false,"landing_page_url":"https://doi.org/10.2337/db20-1259-p","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3176395452","https://openalex.org/W4389958288","https://openalex.org/W2899635255","https://openalex.org/W2622955276","https://openalex.org/W4399685199","https://openalex.org/W4313889702","https://openalex.org/W2116241217","https://openalex.org/W3034714328","https://openalex.org/W2157137075","https://openalex.org/W4407196356"],"abstract_inverted_index":{"The":[0,245],"dyslipidemia":[1],"of":[2,48,53,74,113,248,313],"insulin":[3],"resistance":[4],"(IR),":[5],"characterized":[6],"by":[7,139],"high":[8],"triglyceride-rich":[9],"lipoproteins":[10,15,24],"(TRLP)":[11],"and":[12,26,50,63,103,108,180,203,225,231],"low":[13],"high-density":[14],"(HDL),":[16],"is":[17,56],"associated":[18,255],"with":[19,40,69,82,125,149,228,243,252,256],"systemic":[20],"inflammation,":[21,114,258],"small":[22,173,229],"low-density":[23],"(LDL)":[25],"are":[27],"important":[28],"risk":[29,279],"factors":[30],"for":[31,262],"atherosclerotic":[32],"disease":[33],"(ASCVD)":[34],"in":[35,38,66,212,219,250,270],"adults.":[36],"Yet,":[37],"youth":[39,68,81,251,272],"type":[41],"2":[42],"diabetes":[43],"(T2D)":[44],"the":[45,51,118,140,260],"natural":[46],"history":[47],"ASCVD":[49,278],"role":[52],"low-grade":[54],"inflammation":[55,269],"still":[57],"emerging.":[58],"We":[59],"compared":[60],"lipoprotein":[61,100],"profiles":[62],"inflammatory":[64,221],"markers":[65,122],"21":[67],"T2D,":[70,150,213],"within":[71],"5":[72],"years":[73],"diagnosis,":[75],"to":[76,265],"10":[77],"age/BMI":[78],"matched":[79],"control":[80],"normal":[83],"glucose":[84],"tolerance":[85],"(age:":[86],"15.8\u00b12.5":[87],"(10-23":[88],"y)":[89],"mean\u00b1SD":[90],"(range),":[91],"Tanner":[92],"Stage":[93],"IV-V,":[94],"BMI:":[95],"38.9\u00b16.9":[96],"(27.1-57.8":[97],"kg/m2).":[98],"Fasting":[99],"particle":[101,183],"size":[102],"number,":[104],"apolipoprotein":[105],"B":[106],"(apoB),":[107],"GlycA,":[109],"a":[110,144],"composite":[111],"marker":[112],"were":[115,123,192,210,216],"derived":[116],"from":[117],"NMR":[119],"LipoProfile\u00ae.":[120],"Pro-inflammatory":[121],"measured":[124],"multi-plex":[126],"ELISA":[127],"assays":[128],"(C-Reactive":[129],"Protein":[130],"(hsCRP),":[131],"IL-6,":[132],"IL-8,":[133],"IL-1\u03b2,":[134],"TNF-alpha).":[135],"IR":[136,249],"was":[137,254],"calculated":[138],"Matsuda":[141,159],"index":[142,160],"during":[143],"multi-sample":[145],"75g":[146],"OGTT.":[147],"Youth":[148],"had":[151],"higher":[152,165,181,211],"A1c":[153],"(7.2\u00b11.3":[154],"vs.":[155,162,168,176,186,199,206],"5.4\u00b10.3%,":[156],"P<0.01),":[157,164,171,240],"lower":[158],"(1.3\u00b11.2":[161],"2.8\u00b11.4,":[163],"ApoB":[166],"(75.8\u00b117.5":[167],"50.8\u00b19.2":[169],"mg/dL,":[170],"more":[172],"LDL":[174,230],"(903.4\u00b1413.3":[175],"575.8\u00b1146.4":[177],"nmol/L,":[178,188],"P=0.02)":[179],"TRLPs":[182],"concentrations":[184],"(121.3\u00b145":[185],"70.4\u00b130.9":[187],"P<0.01).":[189],"HDL":[190],"particles":[191],"not":[193,242],"different":[194],"between":[195],"groups.":[196],"GlycA":[197,224],"(439.7\u00b177.8":[198],"363.6\u00b146.7":[200],"\u03bcmol/L,":[201,208],"P=0.01)":[202,209],"hsCRP":[204,226],"(0.8\u00b10.9":[205],"0.2\u00b10.2":[207],"but":[214,241],"there":[215],"no":[217],"differences":[218],"other":[220],"markers.":[222],"Both":[223],"correlated":[227],"TRLP":[232],"(GlycA:":[233],"both":[234,238],"r=0.4,":[235],"P<0.05);":[236],"hsCRP:":[237],"r=0.5,":[239],"HDL.":[244],"dyslipidemic":[246],"profile":[247],"T2D":[253],"subclinical":[257],"supporting":[259],"need":[261],"longitudinal":[263],"studies":[264],"determine":[266],"whether":[267],"reducing":[268],"these":[271],"will":[273],"be":[274],"effective":[275],"as":[276],"an":[277],"reduction":[280],"strategy.":[281],"Disclosure":[282],"A.":[283,292],"Villalobos-Perez:":[284],"None.":[285,288,291,294,297,300,303,306,309],"C.K.":[286],"Cravalho:":[287],"S.":[289],"Matta:":[290],"Meyers:":[293],"L.":[295],"Mabundo:":[296],"M.L.":[298],"Sampson:":[299],"M.":[301],"Walter:":[302],"A.B.":[304],"Courville:":[305],"S.T.":[307],"Chung:":[308],"Funding":[310],"National":[311],"Institutes":[312],"Health":[314],"(to":[315],"S.T.C.,":[316],"L.M.,":[317],"A.B.C.)":[318]},"counts_by_year":[],"updated_date":"2026-10-09T09:14:12.587421","created_date":"2020-06-19T00:00:00"}
