{"id":"https://openalex.org/W3035259481","doi":"https://doi.org/10.1186/s13063-020-04390-3","title":"Less invasive surfactant administration versus endotracheal surfactant instillation followed by limited peak pressure ventilation in preterm infants with respiratory distress syndrome in China: study protocol for a randomized controlled trial","display_name":"Less invasive surfactant administration versus endotracheal surfactant instillation followed by limited peak pressure ventilation in preterm infants with respiratory distress syndrome in China: study protocol for a randomized controlled trial","publication_year":2020,"publication_date":"2020-06-11","ids":{"openalex":"https://openalex.org/W3035259481","doi":"https://doi.org/10.1186/s13063-020-04390-3","mag":"3035259481","pmid":"https://pubmed.ncbi.nlm.nih.gov/32527290","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7289227"},"language":"en","primary_location":{"id":"doi:10.1186/s13063-020-04390-3","doi":"https://doi.org/10.1186/s13063-020-04390-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13063-020-04390-3","pdf_url":"https://trialsjournal.biomedcentral.com/counter/pdf/10.1186/s13063-020-04390-3","source":{"id":"https://openalex.org/S109512841","display_name":"Trials","issn_l":"1745-6215","issn":["1745-6215"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trials","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://trialsjournal.biomedcentral.com/counter/pdf/10.1186/s13063-020-04390-3","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083820132","display_name":"Jiajun Zhu","orcid":"https://orcid.org/0000-0002-6474-7790","observed_orcids":["https://orcid.org/0000-0002-6474-7790"]},"institutions":[{"id":"https://openalex.org/I4210137217","display_name":"Women's Hospital, School of Medicine, Zhejiang University","ror":"https://ror.org/042t7yh44","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210137217"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jiajun Zhu","raw_affiliation_strings":["Women's Hospital, Zhejiang University, School of Medicine, Hangzhou, 310006, China. jiajunzhu@zju.edu.cn","Women\u2019s Hospital, Zhejiang University, School of Medicine, Hangzhou, 310006, China"],"raw_orcid":"https://orcid.org/0000-0002-6474-7790","affiliations":[{"raw_affiliation_string":"Women's Hospital, Zhejiang University, School of Medicine, Hangzhou, 310006, China. jiajunzhu@zju.edu.cn","institution_ids":["https://openalex.org/I4210137217","https://openalex.org/I76130692"]},{"raw_affiliation_string":"Women\u2019s Hospital, Zhejiang University, School of Medicine, Hangzhou, 310006, China","institution_ids":["https://openalex.org/I4210137217","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078289274","display_name":"Yingying Bao","orcid":"https://orcid.org/0000-0001-5496-5877","observed_orcids":["https://orcid.org/0000-0001-5496-5877"]},"institutions":[{"id":"https://openalex.org/I4210137217","display_name":"Women's Hospital, School of Medicine, Zhejiang University","ror":"https://ror.org/042t7yh44","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210137217"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yingying Bao","raw_affiliation_strings":["Women's Hospital, Zhejiang University, School of Medicine, Hangzhou, 310006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Women's Hospital, Zhejiang University, School of Medicine, Hangzhou, 310006, China","institution_ids":["https://openalex.org/I4210137217","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011601159","display_name":"Lizhong Du","orcid":"https://orcid.org/0000-0002-3181-810X","observed_orcids":["https://orcid.org/0000-0002-3181-810X"]},"institutions":[{"id":"https://openalex.org/I4210113495","display_name":"Children's Hospital of Zhejiang University","ror":"https://ror.org/025fyfd20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210113495"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lizhong Du","raw_affiliation_strings":["The Children's Hospital, Zhejiang University, School of Medicine, Hangzhou, 310052, China. dulizhong@zju.edu.cn","The Children\u2019s Hospital, Zhejiang University, School of Medicine, Hangzhou, 310052, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Children's Hospital, Zhejiang University, School of Medicine, Hangzhou, 310052, China. dulizhong@zju.edu.cn","institution_ids":["https://openalex.org/I4210113495","https://openalex.org/I76130692"]},{"raw_affiliation_string":"The Children\u2019s Hospital, Zhejiang University, School of Medicine, Hangzhou, 310052, China","institution_ids":["https://openalex.org/I4210113495","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053341303","display_name":"Huafei Huang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Huafei Huang","raw_affiliation_strings":["Jiaxing Maternity and Child Health Care Hospital, Jiaxing, 314051, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiaxing Maternity and Child Health Care Hospital, Jiaxing, 314051, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067009905","display_name":"Qin Lv","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qin lv","raw_affiliation_strings":["Ningbo Maternal and Children Hospital, Ningbo, 315012, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ningbo Maternal and Children Hospital, Ningbo, 315012, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056096697","display_name":"Yejun Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108140","display_name":"Shaoxing City Women and Children Hospital","ror":"https://ror.org/01hvjym56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210108140"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yejun Jiang","raw_affiliation_strings":["Shao Xing Maternity and Child Health Care Hospital, Shaoxing, 312000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shao Xing Maternity and Child Health Care Hospital, Shaoxing, 312000, China","institution_ids":["https://openalex.org/I4210108140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033489584","display_name":"Yuxuan Dai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162045","display_name":"Jinhua Central Hospital","ror":"https://ror.org/04z13ha89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162045"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuxuan Dai","raw_affiliation_strings":["Central Hospital of Jinhua, Jinghua, 321000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Hospital of Jinhua, Jinghua, 321000, China","institution_ids":["https://openalex.org/I4210162045"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100739496","display_name":"Zhijun Chen","orcid":"https://orcid.org/0000-0001-7203-5788","observed_orcids":["https://orcid.org/0000-0001-7203-5788"]},"institutions":[{"id":"https://openalex.org/I4210140936","display_name":"Boai Hospital of Zhongshan","ror":"https://ror.org/0440kgc56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140936"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhijun Chen","raw_affiliation_strings":["Boai Hospital of Zhongshan, Zhongshan, 528400, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boai Hospital of Zhongshan, Zhongshan, 528400, China","institution_ids":["https://openalex.org/I4210140936"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101699772","display_name":"Jingyun Shi","orcid":"https://orcid.org/0000-0002-2196-930X","observed_orcids":["https://orcid.org/0000-0002-2196-930X"]},"institutions":[{"id":"https://openalex.org/I4210118272","display_name":"Gansu Provincial Maternal and Child Health Hospital","ror":"https://ror.org/02n9as466","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210118272"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingyun Shi","raw_affiliation_strings":["Gansu Provincial Maternity and Child-Care Hospital, Lanzhou, 730050, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gansu Provincial Maternity and Child-Care Hospital, Lanzhou, 730050, China","institution_ids":["https://openalex.org/I4210118272"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060810072","display_name":"Yongyan Shi","orcid":"https://orcid.org/0000-0002-7933-3806","observed_orcids":["https://orcid.org/0000-0002-7933-3806"]},"institutions":[{"id":"https://openalex.org/I2800370534","display_name":"Sheng Jing Hospital","ror":"https://ror.org/0202bj006","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800370534"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongyan Shi","raw_affiliation_strings":["Shengjing Hospital of China Medical University, Shenyang, 110004, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shengjing Hospital of China Medical University, Shenyang, 110004, China","institution_ids":["https://openalex.org/I2800370534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056156060","display_name":"Chuangzhong Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104539","display_name":"Shenzhen Maternity and Child Healthcare Hospital","ror":"https://ror.org/01me2d674","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210104539"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chuangzhong Yang","raw_affiliation_strings":["Affiliated Shenzhen Maternity& Child Healthcare Hospital, Southern Medical University, Shenzhen, 518028, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affiliated Shenzhen Maternity& Child Healthcare Hospital, Southern Medical University, Shenzhen, 518028, China","institution_ids":["https://openalex.org/I4210104539","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111203423","display_name":"Hua Mei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44673925","display_name":"Inner Mongolia Medical University","ror":"https://ror.org/01mtxmr84","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I44673925"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hua Mei","raw_affiliation_strings":["Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010050, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010050, China","institution_ids":["https://openalex.org/I44673925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100754993","display_name":"Hong Jiang","orcid":"https://orcid.org/0000-0001-7188-5713","observed_orcids":["https://orcid.org/0000-0001-7188-5713"]},"institutions":[{"id":"https://openalex.org/I4210089311","display_name":"Yanan University Affiliated Hospital","ror":"https://ror.org/006992e45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089311"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong Jiang","raw_affiliation_strings":["Yan'an University Affiliated Hospital, Yan'an, 716000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yan'an University Affiliated Hospital, Yan'an, 716000, China","institution_ids":["https://openalex.org/I4210089311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100297349","display_name":"Yanhui Sun","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yanhui Sun","raw_affiliation_strings":["Chongqing Health Center for Women and Children, Chongqing, 400021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chongqing Health Center for Women and Children, Chongqing, 400021, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100575851","display_name":"Xuemei Sun","orcid":"https://orcid.org/0000-0002-9145-6171","observed_orcids":["https://orcid.org/0000-0002-9145-6171"]},"institutions":[{"id":"https://openalex.org/I4210097945","display_name":"Linyi People's Hospital","ror":"https://ror.org/011r8ce56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097945"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuemei Sun","raw_affiliation_strings":["Linyi People's Hospital, Linyi, 276003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Linyi People's Hospital, Linyi, 276003, China","institution_ids":["https://openalex.org/I4210097945"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5011601159","https://openalex.org/A5083820132"],"corresponding_institution_ids":["https://openalex.org/I4210113495","https://openalex.org/I4210137217","https://openalex.org/I76130692"],"apc_list":{"value":2190,"currency":"USD","value_usd":2190},"apc_paid":{"value":2190,"currency":"USD","value_usd":2190},"fwci":0.5796,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.69125939,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"21","issue":"1","first_page":"516","last_page":"516"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11060","display_name":"Infant Development and Preterm Care","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/less-invasive-surfactant-administration","display_name":"less invasive surfactant administration","score":0.9990000128746033},{"id":"https://openalex.org/keywords/preterm-infants","display_name":"preterm infants","score":0.7870000004768372},{"id":"https://openalex.org/keywords/respiratory-distress-syndrome","display_name":"respiratory distress syndrome","score":0.9729999899864197},{"id":"https://openalex.org/keywords/bronchopulmonary-dysplasia","display_name":"bronchopulmonary dysplasia","score":0.9950000047683716},{"id":"https://openalex.org/keywords/surfactant-replacement-therapy","display_name":"surfactant therapy","score":0.8740000128746033},{"id":"https://openalex.org/keywords/mechanical-ventilation","display_name":"mechanical ventilation","score":0.7360000014305115},{"id":"https://openalex.org/keywords/continuous-positive-airway-pressure","display_name":"continuous positive airway pressure","score":0.8199999928474426},{"id":"https://openalex.org/keywords/intubation-complications","display_name":"intubation complications","score":0.6620000004768372},{"id":"https://openalex.org/keywords/retinopathy-of-prematurity","display_name":"retinopathy of prematurity","score":0.7699999809265137},{"id":"https://openalex.org/keywords/necrotizing-enterocolitis","display_name":"necrotizing enterocolitis","score":0.9359999895095825},{"id":"https://openalex.org/keywords/intraventricular-hemorrhage","display_name":"intraventricular hemorrhage","score":0.968999981880188}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9308856725692749},{"id":"https://openalex.org/C2778721537","wikidata":"https://www.wikidata.org/wiki/Q922640","display_name":"Bronchopulmonary dysplasia","level":4,"score":0.8973313570022583},{"id":"https://openalex.org/C2779303187","wikidata":"https://www.wikidata.org/wiki/Q10859678","display_name":"Necrotizing enterocolitis","level":2,"score":0.7794727087020874},{"id":"https://openalex.org/C2779918416","wikidata":"https://www.wikidata.org/wiki/Q1423087","display_name":"Retinopathy of prematurity","level":4,"score":0.7275921106338501},{"id":"https://openalex.org/C141983124","wikidata":"https://www.wikidata.org/wiki/Q188008","display_name":"Respiratory distress","level":2,"score":0.6840251684188843},{"id":"https://openalex.org/C2779252433","wikidata":"https://www.wikidata.org/wiki/Q6058597","display_name":"Intraventricular hemorrhage","level":4,"score":0.6172463297843933},{"id":"https://openalex.org/C2777080012","wikidata":"https://www.wikidata.org/wiki/Q3766250","display_name":"Mechanical ventilation","level":2,"score":0.5738255977630615},{"id":"https://openalex.org/C2779547634","wikidata":"https://www.wikidata.org/wiki/Q5165502","display_name":"Continuous positive airway pressure","level":3,"score":0.5531314611434937},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5500400066375732},{"id":"https://openalex.org/C2778376644","wikidata":"https://www.wikidata.org/wiki/Q2253111","display_name":"Gestational age","level":3,"score":0.5369645357131958},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5309020280838013},{"id":"https://openalex.org/C2780807750","wikidata":"https://www.wikidata.org/wiki/Q5477511","display_name":"Fraction of inspired oxygen","level":3,"score":0.5292760133743286},{"id":"https://openalex.org/C2777050789","wikidata":"https://www.wikidata.org/wiki/Q7259529","display_name":"Pulmonary hemorrhage","level":3,"score":0.4619354009628296},{"id":"https://openalex.org/C2780395437","wikidata":"https://www.wikidata.org/wiki/Q754348","display_name":"Neonatal respiratory distress syndrome","level":4,"score":0.4453222155570984},{"id":"https://openalex.org/C2776953283","wikidata":"https://www.wikidata.org/wiki/Q17125052","display_name":"Surfactant therapy","level":4,"score":0.4173886179924011},{"id":"https://openalex.org/C200457457","wikidata":"https://www.wikidata.org/wiki/Q584049","display_name":"Ventilation (architecture)","level":2,"score":0.4104744791984558},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.2692347764968872},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.24840062856674194},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.21258369088172913},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18112581968307495},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.10033047199249268},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C2776006263","wikidata":"https://www.wikidata.org/wiki/Q16606552","display_name":"Obstructive sleep apnea","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007234","descriptor_name":"Infant, Premature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007442","descriptor_name":"Intubation, Intratracheal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011663","descriptor_name":"Pulmonary Surfactants","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D012121","descriptor_name":"Respiration, Artificial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012127","descriptor_name":"Respiratory Distress Syndrome, Newborn","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012127","descriptor_name":"Respiratory Distress Syndrome, Newborn","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015337","descriptor_name":"Multicenter Studies as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045422","descriptor_name":"Continuous Positive Airway Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s13063-020-04390-3","doi":"https://doi.org/10.1186/s13063-020-04390-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13063-020-04390-3","pdf_url":"https://trialsjournal.biomedcentral.com/counter/pdf/10.1186/s13063-020-04390-3","source":{"id":"https://openalex.org/S109512841","display_name":"Trials","issn_l":"1745-6215","issn":["1745-6215"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trials","raw_type":"journal-article"},{"id":"pmid:32527290","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32527290","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trials","raw_type":"Clinical Trial Protocol"},{"id":"pmh:oai:pubmedcentral.nih.gov:7289227","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7289227/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trials","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:1f4c1e04d4f14f04bb3e8ca2668c26ef","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/1f4c1e04d4f14f04bb3e8ca2668c26ef","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Trials, Vol 21, Iss 1, Pp 1-9 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s13063-020-04390-3","doi":"https://doi.org/10.1186/s13063-020-04390-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13063-020-04390-3","pdf_url":"https://trialsjournal.biomedcentral.com/counter/pdf/10.1186/s13063-020-04390-3","source":{"id":"https://openalex.org/S109512841","display_name":"Trials","issn_l":"1745-6215","issn":["1745-6215"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trials","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Study Protocol","id":"https://openalex.org/study-designs/study-protocol"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320317451","display_name":"Inner Mongolia Medical University","ror":"https://ror.org/01mtxmr84"},{"id":"https://openalex.org/F4320322927","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884"},{"id":"https://openalex.org/F4320324301","display_name":"China Medical University","ror":"https://ror.org/032d4f246"},{"id":"https://openalex.org/F4320326228","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39"},{"id":"https://openalex.org/F4320336313","display_name":"Shengjing Hospital","ror":"https://ror.org/0202bj006"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3035259481.pdf","grobid_xml":"https://content.openalex.org/works/W3035259481.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W1978264421","https://openalex.org/W2022129249","https://openalex.org/W2041711947","https://openalex.org/W2046224781","https://openalex.org/W2093355370","https://openalex.org/W2124288768","https://openalex.org/W2150015019","https://openalex.org/W2172178605","https://openalex.org/W2209748026","https://openalex.org/W2340491018","https://openalex.org/W2554386859","https://openalex.org/W2559976192","https://openalex.org/W2590090896","https://openalex.org/W2790554076","https://openalex.org/W2801204649","https://openalex.org/W2807027117","https://openalex.org/W2909880430","https://openalex.org/W2916052842","https://openalex.org/W2936595371","https://openalex.org/W2960398430","https://openalex.org/W2970827569","https://openalex.org/W2971526079","https://openalex.org/W3147650584","https://openalex.org/W4248251600"],"related_works":["https://openalex.org/W2554386859","https://openalex.org/W2551687468","https://openalex.org/W2998037007","https://openalex.org/W4310774919","https://openalex.org/W3203277446","https://openalex.org/W3167955757","https://openalex.org/W2022129249","https://openalex.org/W2991407649","https://openalex.org/W4395068123","https://openalex.org/W3003391771"],"abstract_inverted_index":{"BACKGROUND:":[0],"Less":[1],"invasive":[2],"surfactant":[3,11,62,67,110,164,174,206,296,313,334],"administration":[4,45,68],"(LISA)":[5],"is":[6,112,245],"a":[7,88,228,250],"way":[8],"of":[9,25,44,58,61,91,119,125,138,145,148,151,156,178,182,205,212,233,273,285,325,341],"giving":[10],"without":[12],"endotracheal":[13,66,326],"intubation":[14,289,327],"and":[15,39,86,129,162,166,198,208,224,270,282,290,328,339],"has":[16],"shown":[17],"to":[18,54,103,169],"be":[19,94,101,216,349],"promising":[20],"in":[21,29,41,76,96,133,231,253,259,305],"reducing":[22,254],"the":[23,33,42,56,97,104,134,143,171,209,239,268,279,283,329],"incidence":[24,177],"bronchopulmonary":[26,120],"dysplasia":[27,121],"(BPD)":[28],"preterm":[30,77,234,260,342],"infants.":[31],"However,":[32,242],"mechanism":[34],"underlying":[35],"its":[36,48],"beneficial":[37],"effect":[38],"variations":[40],"technique":[43,214],"may":[46],"prevent":[47],"widespread":[49],"use.":[50],"This":[51],"trial":[52,320],"aims":[53],"evaluate":[55],"effects":[57],"two":[59],"methods":[60],"administration,":[63,165,207],"LISA":[64,105,240,248,280,345],"or":[65,106,346],"followed":[69],"by":[70,238,288],"low":[71],"peak":[72],"pressure":[73,277],"(LPPSA)":[74],"ventilation,":[75],"infants":[78,235,343],"with":[79,87,236],"respiratory":[80,153,255],"distress":[81],"syndrome":[82],"(RDS).":[83],"METHODS:":[84],"weeks":[85,124],"primary":[89],"diagnosis":[90],"RDS":[92,237],"will":[93,100,215,321,348],"involved":[95],"study.":[98],"Infants":[99],"randomized":[102,318],"LPPSA":[107,347],"group":[108],"when":[109],"therapy":[111],"indicated.":[113],"Primary":[114],"outcomes":[115,141,232],"include":[116,142],"mortality,":[117],"severity":[118],"at":[122],"36":[123],"postmenstrual":[126],"age":[127],"(PMA),":[128],"mechanical":[130],"ventilation":[131,294,310],"(MV)":[132],"first":[135],"72":[136],"h":[137,204],"life.":[139],"Secondary":[140],"days":[144],"MV,":[146],"duration":[147],"all":[149],"sorts":[150],"non-invasive":[152],"support,":[154],"fraction":[155],"inspired":[157],"oxygen,":[158],"oxygen":[159],"saturation":[160],"before":[161],"after":[163],"time":[167],"required":[168],"perform":[170],"procedure":[172,281],"for":[173],"administration.":[175,297,314,335],"The":[176,264,336],"comorbidities,":[179],"including":[180],"retinopathy":[181],"prematurity":[183],"(ROP),":[184],"necrotizing":[185],"enterocolitis":[186],"(NEC),":[187],"intraventricular":[188],"hemorrhage":[189,201],"(IVH),":[190],"hemodynamically":[191],"significant":[192],"patent":[193],"ductus":[194],"arteriosus":[195],"(hsPDA),":[196],"pneumothorax,":[197],"massive":[199],"pulmonary":[200],"within":[202],"48":[203],"failure":[210],"rates":[211],"each":[213],"determined.":[217],"DISCUSSION:":[218],"Data":[219],"from":[220],"recent":[221],"systematic":[222],"review":[223],"meta-analysis":[225],"have":[226],"suggested":[227],"possible":[229,265],"improvement":[230],"technique.":[241],"robust":[243],"evidence":[244],"lacking.":[246],"Why":[247],"plays":[249],"potential":[251],"role":[252],"morbidity,":[256],"mainly":[257,304],"BPD":[258],"infants,":[261],"remains":[262],"unclear.":[263],"explanations":[266],"are":[267],"active":[269],"uninterrupted":[271],"delivery":[272],"continuous":[274],"positive":[275,309],"airway":[276],"during":[278,332],"avoidance":[284],"complications":[286],"caused":[287],"relatively":[291,307],"high":[292],"pressure/volume":[293,330],"following":[295,312,344],"We":[298],"hypothesized":[299],"that":[300],"LISA's":[301],"effectiveness":[302],"lies":[303],"avoiding":[306],"high-pressure":[308],"immediately":[311],"Thus,":[315],"this":[316],"multicenter":[317],"controlled":[319],"focus":[322],"on":[323,359],"issues":[324],"used":[331],"conventional":[333],"effectiveness,":[337],"safety":[338],"comorbidities":[340],"evaluated.":[350],"TRIAL":[351],"REGISTRATION:":[352],"Chinese":[353],"Clinical":[354],"Trial":[355],"Registry:":[356],"ChiCTR1900020970.":[357],"Registered":[358],"23":[360],"January":[361],"2019.":[362]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-06-19T00:00:00"}
