{"id":"https://openalex.org/W3035062397","doi":null,"title":"Role of epidermal vascular endothelial growth factor in melanosome transfer through upregulation of protease-activated receptor-2","display_name":"Role of epidermal vascular endothelial growth factor in melanosome transfer through upregulation of protease-activated receptor-2","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W3035062397","mag":"3035062397"},"language":"en","primary_location":{"id":"pmh:oai:ir.ymlib.yonsei.ac.kr:22282913/133583","doi":null,"is_oa":true,"landing_page_url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/133583","pdf_url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/133583","source":{"id":"https://openalex.org/S4306400691","display_name":"YUHSpace (Yonsei University Medical Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193775966","host_organization_name":"Yonsei University","host_organization_lineage":["https://openalex.org/I193775966"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/133583","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002592016","display_name":"\uc774\uc758\ud615","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"\uc774\uc758\ud615","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5002592016"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.8554999828338623,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.8554999828338623,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11172","display_name":"Dermatologic Treatments and Research","score":0.12070000171661377,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melasma","display_name":"melasma","score":0.9819999933242798},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.824999988079071},{"id":"https://openalex.org/keywords/protease-activated-receptor-2","display_name":"protease-activated receptor 2","score":0.9890000224113464},{"id":"https://openalex.org/keywords/melanosome-transfer","display_name":"melanosome transfer","score":0.9850000143051147},{"id":"https://openalex.org/keywords/keratinocytes","display_name":"keratinocytes","score":0.9129999876022339},{"id":"https://openalex.org/keywords/melanocytes","display_name":"melanocytes","score":0.949999988079071},{"id":"https://openalex.org/keywords/telangiectasia","display_name":"telangiectasia","score":0.8370000123977661},{"id":"https://openalex.org/keywords/vegf-signaling","display_name":"VEGF signaling","score":0.621999979019165},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.7649999856948853},{"id":"https://openalex.org/keywords/hyperpigmentation","display_name":"hyperpigmentation","score":0.625}],"concepts":[{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.751558244228363},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5740373134613037},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.5308376550674438},{"id":"https://openalex.org/C103041312","wikidata":"https://www.wikidata.org/wiki/Q7916457","display_name":"Vascular endothelial growth factor C","level":5,"score":0.4908366799354553},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.4806296229362488},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47554823756217957},{"id":"https://openalex.org/C94435474","wikidata":"https://www.wikidata.org/wiki/Q1065756","display_name":"Melanosome","level":3,"score":0.4735010266304016},{"id":"https://openalex.org/C125268873","wikidata":"https://www.wikidata.org/wiki/Q17918484","display_name":"Protease-activated receptor 2","level":4,"score":0.4642795920372009},{"id":"https://openalex.org/C130287650","wikidata":"https://www.wikidata.org/wiki/Q17091190","display_name":"Growth factor receptor inhibitor","level":4,"score":0.4213562607765198},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.4115743339061737},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3723779320716858},{"id":"https://openalex.org/C146285616","wikidata":"https://www.wikidata.org/wiki/Q7916455","display_name":"Vascular endothelial growth factor A","level":4,"score":0.33055436611175537},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.30540192127227783},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2612525224685669},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.184195876121521},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15635082125663757},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.05526244640350342},{"id":"https://openalex.org/C75184817","wikidata":"https://www.wikidata.org/wiki/Q5381540","display_name":"Enzyme-linked receptor","level":3,"score":0.05224296450614929},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C107538193","wikidata":"https://www.wikidata.org/wiki/Q187526","display_name":"Melanin","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:ir.ymlib.yonsei.ac.kr:22282913/133583","doi":null,"is_oa":true,"landing_page_url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/133583","pdf_url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/133583","source":{"id":"https://openalex.org/S4306400691","display_name":"YUHSpace (Yonsei University Medical Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193775966","host_organization_name":"Yonsei University","host_organization_lineage":["https://openalex.org/I193775966"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:3035062397","doi":null,"is_oa":false,"landing_page_url":"https://ir.ymlib.yonsei.ac.kr/bitstream/22282913/133583/1/T011825.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:ir.ymlib.yonsei.ac.kr:22282913/133583","doi":null,"is_oa":true,"landing_page_url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/133583","pdf_url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/133583","source":{"id":"https://openalex.org/S4306400691","display_name":"YUHSpace (Yonsei University Medical Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193775966","host_organization_name":"Yonsei University","host_organization_lineage":["https://openalex.org/I193775966"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3035062397.pdf","grobid_xml":"https://content.openalex.org/works/W3035062397.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W250723341","https://openalex.org/W1537712767","https://openalex.org/W1588182076","https://openalex.org/W1763622072","https://openalex.org/W1963938486","https://openalex.org/W1985375673","https://openalex.org/W1985712533","https://openalex.org/W1986133342","https://openalex.org/W1991202990","https://openalex.org/W2004127276","https://openalex.org/W2013038209","https://openalex.org/W2022490022","https://openalex.org/W2022767495","https://openalex.org/W2031525727","https://openalex.org/W2031843235","https://openalex.org/W2033837699","https://openalex.org/W2040089666","https://openalex.org/W2041560508","https://openalex.org/W2052197231","https://openalex.org/W2052327891","https://openalex.org/W2061645708","https://openalex.org/W2064016804","https://openalex.org/W2069413718","https://openalex.org/W2073549690","https://openalex.org/W2077861409","https://openalex.org/W2081753893","https://openalex.org/W2082158969","https://openalex.org/W2101671042","https://openalex.org/W2118778583","https://openalex.org/W2125779675","https://openalex.org/W2135608710","https://openalex.org/W2141046053","https://openalex.org/W2142180341","https://openalex.org/W2150092296","https://openalex.org/W2169674426","https://openalex.org/W2395003662","https://openalex.org/W2412873861","https://openalex.org/W2418887810"],"related_works":["https://openalex.org/W2516126160","https://openalex.org/W2293973873","https://openalex.org/W4249995993","https://openalex.org/W7055961757","https://openalex.org/W2054524504","https://openalex.org/W2169674426","https://openalex.org/W4251156253","https://openalex.org/W2091901535","https://openalex.org/W3030748442","https://openalex.org/W2045850284"],"abstract_inverted_index":{"Melasma":[0],"is":[1,69,116,133,142,205],"a":[2,99,298],"common":[3],"acquired":[4],"symmetrical":[5],"hypermelanosis":[6],"characterized":[7],"by":[8,125,207],"irregular":[9],"light":[10],"to":[11,52,93,144,164],"dark":[12],"brown":[13],"macules":[14],"and":[15,29,61,83,97,105,141,184,220,225,248,258,270,292],"patches":[16],"on":[17],"sun-exposed":[18],"areas":[19],"of":[20,36,67,102,111,149,200,232,238,251,265,282,286,305],"the":[21,34,37,65,109,130,154,165,198,203,217,221,283,287],"skin.":[22,43,177,194,240],"Histologically,":[23],"melanosomes":[24],"are":[25,48,86,123],"increased":[26,87,234,246,262,293],"in":[27,33,88,108,135,139,146,191,202,216,267,290,300],"number":[28],"more":[30,159,169],"widely":[31],"dispersed":[32],"keratinocytes":[35,204,226],"lesional":[38,90,176,193],"skin":[39,91,96],"than":[40],"perilesional":[41,94],"normal":[42,95],"The":[44],"major":[45],"etiological":[46],"factors":[47],"genetic":[49],"background,":[50],"exposure":[51],"ultraviolet":[53],"radiation,":[54],"pregnancy,":[55],"hormonal":[56],"therapies,":[57],"cosmetics,":[58],"phototoxic":[59],"drugs,":[60],"antiseizure":[62],"medications,":[63],"although":[64],"pathogenesis":[66,110],"melasma":[68,89,155,175,192],"not":[70,138],"fully":[71],"understood.":[72],"Recent":[73],"studies":[74],"found":[75],"that":[76,122],"epidermal":[77,106,275,294],"vascular":[78],"endothelial":[79],"growth":[80],"factor":[81],"(VEGF)":[82],"dermal":[84,103],"vessels":[85,104],"compared":[92],"suggested":[98],"possible":[100],"role":[101,299],"VEGF":[107,185,214,233,244,259,276,295,352],"melasma.":[112],"Protease-activated":[113,368],"receptor-2":[114,369],"(PAR-2)":[115],"seven":[117,371],"transmembrane":[118,372],"G":[119,373],"protein-coupled":[120,374],"receptors":[121],"activated":[124],"serine":[126],"protease":[127],"cleavage.":[128],"In":[129,151,178,241,253],"epidermis,":[131],"PAR-2":[132,171,183,201,209,235,255,288,306,438,486,533],"expressed":[134],"keratinocytes,":[136],"but":[137],"melanocytes,":[140],"shown":[143],"involve":[145],"melanosome":[147,263,301],"phagocytosis":[148],"keratinocytes.":[150,271],"our":[152],"study,":[153],"patient,":[156],"who":[157],"showed":[158,168],"prominent":[160],"telangiectatic":[161],"erythema":[162],"confined":[163],"hyperpigmented":[166],"lesion,":[167],"intense":[170],"staining":[172,186],"intensity":[173,187],"at":[174,227],"addition,":[179,254],"positive":[180],"correlation":[181],"between":[182],"was":[188,211],"also":[189,261],"observed":[190],"To":[195],"determine":[196],"whether":[197],"expression":[199,210,289],"regulated":[206],"VEGF,":[208],"measured":[212],"after":[213],"treatment":[215,245,260],"mouse":[218,239],"model":[219],"cocultures":[222],"using":[223],"melanocytes":[224,269],"1:10":[228],"ratio.":[229],"Intradermal":[230],"injection":[231],"mRNA":[236,247,511],"level":[237],"cocultured":[242,268],"cells,":[243],"protein":[249],"levels":[250],"PAR-2.":[252],"agonist":[256],"peptide":[257],"content":[264],"keratinocyte":[266],"From":[272],"these":[273],"results,":[274],"could":[277],"be":[278],"considered":[279],"as":[280],"one":[281],"regulating":[284],"molecule":[285],"epidermis":[291],"may":[296],"have":[297],"transfer":[302],"through":[303],"upregulation":[304],"signaling.":[307],"\\n\\n\\n\\n[\ud55c\uae00]\\n\\n\uae30\ubbf8\ub294":[308],"\uc8fc\ub85c":[309],"\uc5ec\uc131\uc758":[310],"\uc77c\uad11":[311],"\ub178\ucd9c\ubd80\uc704\uc5d0":[312],"\ud6c4\ucc9c\uc801\uc73c\ub85c":[313],"\ubc1c\uc0dd\ud558\ub294":[314],"\uacfc\uc0c9\uc18c\uc131":[315],"\uc9c8\ud658\uc73c\ub85c":[316],"\uc870\uc9c1\ud559\uc801\uc73c\ub85c":[317],"\uac01\uc9c8\ud615\uc131\uc138\ud3ec\uc758":[318],"\uba5c\ub77c\ub2cc":[319,414,463,566,620],"\uc0c9\uc18c":[320],"\uc99d\uac00":[321],"\uc18c\uacac\uc774":[322],"\ud45c\ud53c\uc758":[323,351,403,608],"\ubaa8\ub4e0":[324],"\uce35\uc5d0\uc11c":[325],"\uad00\ucc30\ub41c\ub2e4.":[326],"\uae30\ubbf8\uc758":[327,361],"\ubc1c\uc0dd\uacfc":[328],"\uad00\ud558\uc5ec":[329],"\uc720\uc804\uc801":[330],"\uc694\uc778,":[331],"\uc790\uc678\uc120,":[332],"\ud638\ub974\ubaac":[333],"\ub4f1\uc758":[334],"\uc694\uc778\ub4e4\uc774":[335],"\uc6d0\uc778\uc73c\ub85c":[336],"\uc5b8\uae09\ub418\uace0":[337],"\uc788\uc73c\ub098":[338],"\uc815\ud655\ud55c":[339],"\uae30\uc804\uc5d0":[340],"\ub300\ud574\uc11c\ub294":[341],"\uc544\uc9c1":[342],"\ubc1d\ud600\uc9c0\uc9c0":[343],"\uc54a\uc558\ub2e4.":[344],"\ucd5c\uadfc":[345],"\uae30\ubbf8":[346,430,445],"\ubcd1\ubcc0\uc774":[347],"\uc8fc\ubcc0\uc758":[348],"\ube44\ubcd1\ubcc0\uc5d0":[349],"\ube44\ud574":[350,496,514,537,548],"\ubc1c\ud604\uacfc":[353,450],"\uc9c4\ud53c\uc758":[354],"\ud608\uad00\uc774":[355],"\uc99d\uac00\ub418\uc5b4":[356,441],"\uc788\uc74c\uc774":[357],"\ubcf4\uace0\ub418\uc5c8\uc73c\uba70":[358],"\uc774\ub7ec\ud55c":[359,605],"\ud604\uc0c1\uc774":[360],"\ubc1c\uc0dd\uc5d0":[362],"\uad00\ub828\uc774":[363],"\uc788\uc744":[364],"\uac83\uc73c\ub85c":[365,391,398,419],"\uc0dd\uac01\ub418\uace0":[366],"\uc788\ub2e4.":[367,401],"(PAR-2)\ub294":[370],"receptor\ub85c":[375],"\uc138\ub9b0":[376],"\ub2e8\ubc31\ubd84\ud574\ud6a8\uc18c\uc5d0":[377],"\uc758\ud574":[378],"\ud65c\uc131\ud654\ub418\uc5b4":[379],"\uc138\ud3ec":[380,582,600],"\ub0b4\ubd80\ub85c":[381],"\uc2e0\ud638\ub97c":[382],"\uc804\ub2ec\ud558\uac8c":[383],"\ub41c\ub2e4.":[384],"PAR-2\ub294":[385,406],"\ub2e4\uc591\ud55c":[386,395,470],"\uc7a5\uae30":[387],"\ubc0f":[388,472,591],"\uc138\ud3ec\uc5d0":[389],"\uc874\uc7ac\ud558\ub294":[390,405],"\uc54c\ub824\uc84c\uc73c\uba70":[392],"\uac01":[393],"\uc7a5\uae30\uc5d0\uc11c":[394],"\uc5ed\ud560\uc744":[396],"\ud558\ub294":[397],"\ubcf4\uace0":[399],"\ub418\uace0":[400],"\ud2b9\ud788":[402,539],"\uac01\uc9c8\ud615\uc131\uc138\ud3ec\uc5d0":[404],"\ud53c\ubd80":[407],"\ud22c\uacfc":[408],"\uc7a5\ubcbd\uc758":[409],"\ud56d\uc0c1\uc131":[410],"\uc870\uc808\ubfd0\ub9cc":[411],"\uc544\ub2c8\ub77c":[412],"\uba5c\ub77c\ub2cc\uc758":[413],"\uc138\ud3ec\uc5d0\uc11c":[415],"\uac01\uc9c8\ud615\uc131\uc138\ud3ec\ub85c\uc758":[416,559,622],"\uc774\ub3d9\uc744":[417],"\uc870\uc808\ud558\ub294":[418],"\uc54c\ub824\uc838":[420],"\uc788\ub2e4.\\n\\n\uae30\ubbf8":[421],"\ud658\uc790\ub97c":[422],"\ub300\uc0c1\uc73c\ub85c":[423],"\ud6c4\ud5a5\uc801\uc73c\ub85c":[424],"\uc9c4\ud589\ud55c":[425],"\uc5f0\uad6c\uc5d0\uc11c":[426],"\ubaa8\uc138\ud608\uad00\ud655\uc7a5\uc744":[427],"\ub3d9\ubc18\ud55c":[428],"\ud64d\ubc18\uc774":[429],"\ubcd1\ubcc0":[431,436,447],"\uc8fc\ubcc0\uc5d0":[432],"\ub69c\ub837\ud558\uac8c":[433],"\ub098\ud0c0\ub098\ub294":[434],"\ud658\uc790\uc5d0\uc11c\uae30\ubbf8":[435],"\uc870\uc9c1\uc758":[437],"\ubc1c\ud604\uc774":[439,512,535],"\uc0c1\ub300\uc801\uc73c\ub85c":[440],"\uc788\uc74c\uc744":[442],"\ud655\uc778\ud558\uc600\ub2e4.":[443],"\ub610\ud55c":[444,502],"\ud658\uc790\uc758":[446],"\uc870\uc9c1\uc5d0\uc11c":[448],"PAR-2\uc758":[449,477,510,556,574,592,612],"\ud608\uad00\ub0b4\ud53c":[451,456,468,490,505,554,589],"\uc131\uc7a5\uc778\uc790\uc758":[452],"\ubc1c\ud604\uac04\uc5d0":[453],"\uc0c1\uad00\uc131\uc774":[454],"\uad00\ucc30\ub418\uc5c8\ub2e4.":[455],"\uc131\uc7a5\uc778\uc790\uc640":[457,555,573],"PAR-2\uac04\uc758":[458],"\uad00\ub828\uc131\uc744":[459],"\uc54c\uae30":[460],"\uc704\ud574":[461],"\uac01\uc9c8\ud615\uc131\uc138\ud3ec\uc640":[462,565],"\uc138\ud3ec\ub85c":[464,567],"\uad6c\uc131\ub41c":[465,568],"\uacf5\uc870":[466,569],"\ubc30\uc591\uc5d0":[467,570],"\uc131\uc7a5\uc778\uc790\ub97c":[469,526,544],"\ub18d\ub3c4":[471],"\uae30\uac04":[473],"\ub3d9\uc548":[474],"\ucc98\ub9ac\ud55c":[475,577,595],"\ud6c4":[476,578],"mRNA\uc640":[478],"\ub2e8\ubc31\uc9c8":[479],"\uc591\uc744":[480],"RT-PCR\uacfc":[481],"western":[482],"blot\uc744":[483],"\ud1b5\ud558\uc5ec":[484,618],"\uce21\uc815\ud558\uc600\ub2e4.":[485,586],"mRNA\uc758":[487,534],"\ubc1c\ud604\uc740":[488],"100nM\uc758":[489],"\uc131\uc7a5\uc778\uc790":[491,506,590],"3\uc2dc\uac04":[492],"\ucc98\ub9ac":[493,508],"\uad70\uc5d0\uc11c":[494,509,596],"\ub300\uc870\uad70\uc5d0":[495,513,536,547,597],"\ud1b5\uacc4\uc801\uc73c\ub85c":[497,515,549],"\uc758\ubbf8":[498,516,550],"\uc788\ub294":[499,517,551],"\uc99d\uac00\ub97c":[500,518,552],"\ubcf4\uc600\ub2e4.":[501,519,553],"100nM\uacfc":[503],"200nM\uc758":[504],"24\uc2dc\uac04":[507],"\uc950\ub97c":[520],"\ud1b5\ud55c":[521],"\ub3d9\ubb3c":[522],"\uc2e4\ud5d8\uc5d0\uc11c":[523],"\ud608\uad00":[524,542,571],"\ub0b4\ud53c":[525,543,572],"\uc9c4\ud53c":[527],"\ub0b4\uc5d0":[528],"\uc8fc\uc0ac\ud558\uc600\uc744":[529],"\ub54c":[530,546],"\uc950":[531],"\ud53c\ubd80\uc758":[532],"\uc99d\uac00\ud558\uc600\uc73c\uba70":[538],"4\u03bcM\uacfc":[540],"10\u03bcM\uc758":[541],"\ucc98\ub9ac\ud558\uc600\uc744":[545],"\ud65c\uc131\ud654\uac00":[557],"\uba5c\ub77c\ub178\uc880\uc758":[558,584,619],"\uc774\ub3d9\uc5d0":[560,623],"\ubbf8\uce58\ub294":[561],"\uc601\ud5a5\uc744":[562,615,624],"\ud655\uc778\ud558\uae30":[563],"\uc704\ud574\uc11c":[564],"\ud65c\uc131\ud654":[575,593],"\ud3a9\ud0c0\uc774\ub4dc\ub97c":[576,594],"\uc804\uc790\ud604\ubbf8\uacbd\uc744":[579],"\ud1b5\ud574":[580],"\uac01\uc9c8\ud615\uc131":[581,599,610],"\ub0b4\ubd80\uc758":[583],"\uc218\ub97c":[585],"\uc774":[587],"\uacb0\uacfc":[588],"\ube44\ud558\uc5ec":[598],"\uc548\uc758":[601],"\uba5c\ub77c\ub178\uc880":[602],"\uc218\uac00":[603],"\uc99d\uac00\ud558\uc600\ub2e4.":[604],"\uacb0\uacfc\ub97c":[606],"\ud1a0\ub300\ub85c":[607],"\ud608\uad00\ub0b4\ud53c\uc778\uc790\uac00":[609],"\uc138\ud3ec\uc758":[611],"\ubc1c\ud604":[613],"\uc99d\uac00\uc5d0":[614],"\uc8fc\uba70,":[616],"\uc774\ub97c":[617],"\uc138\ud3ec\ub85c\ubd80\ud130":[621],"\uc904":[625],"\uac83\uc774\ub77c\uace0":[626],"\ucd94\uc815\ud574":[627],"\ubcfc":[628],"\uc218":[629],"\uc788\uaca0\ub2e4.":[630]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2020-06-19T00:00:00"}