{"id":"https://openalex.org/W3034670637","doi":"https://doi.org/10.2337/db20-144-or","title":"144-OR: The Antirheumatic Drug Auranofin Improves the Metabolic Phenotype of Obesity","display_name":"144-OR: The Antirheumatic Drug Auranofin Improves the Metabolic Phenotype of Obesity","publication_year":2020,"publication_date":"2020-06-01","ids":{"openalex":"https://openalex.org/W3034670637","doi":"https://doi.org/10.2337/db20-144-or","mag":"3034670637"},"language":"en","primary_location":{"id":"doi:10.2337/db20-144-or","doi":"https://doi.org/10.2337/db20-144-or","is_oa":false,"landing_page_url":"https://doi.org/10.2337/db20-144-or","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075310097","display_name":"Aaron R. Cox","orcid":"https://orcid.org/0000-0002-3330-5746","observed_orcids":["https://orcid.org/0000-0002-3330-5746"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"AARON COX","raw_affiliation_strings":["Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Houston, TX","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072107591","display_name":"Peter M. Masschelin","orcid":"https://orcid.org/0000-0002-5236-9462","observed_orcids":["https://orcid.org/0000-0002-5236-9462"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"PETER M. MASSCHELIN","raw_affiliation_strings":["Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Houston, TX","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031675553","display_name":"Natasha Chernis","orcid":"https://orcid.org/0000-0001-5787-1710","observed_orcids":["https://orcid.org/0000-0001-5787-1710"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"NATASHA CHERNIS","raw_affiliation_strings":["Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Houston, TX","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101934676","display_name":"Pradip Saha","orcid":"https://orcid.org/0000-0002-8505-0917","observed_orcids":["https://orcid.org/0000-0002-8505-0917"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"PRADIP SAHA","raw_affiliation_strings":["Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Houston, TX","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040858666","display_name":"Zeqin Lian","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"ZEQIN LIAN","raw_affiliation_strings":["Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Houston, TX","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009927516","display_name":"Jessica B. Felix","orcid":"https://orcid.org/0000-0003-2586-6591","observed_orcids":["https://orcid.org/0000-0003-2586-6591"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"JESSICA B. FELIX","raw_affiliation_strings":["Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Houston, TX","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"KANGHO KIM","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"KANGHO KIM","raw_affiliation_strings":["Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Houston, TX","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057213122","display_name":"Huaizhu Wu","orcid":"https://orcid.org/0000-0001-6846-5531","observed_orcids":["https://orcid.org/0000-0001-6846-5531"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"HUAIZHU WU","raw_affiliation_strings":["Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Houston, TX","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065153594","display_name":"Sean Michael Hartig","orcid":"https://orcid.org/0000-0002-2695-2072","observed_orcids":["https://orcid.org/0000-0002-2695-2072"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"SEAN M. HARTIG","raw_affiliation_strings":["Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Houston, TX","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.08509564,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"69","issue":"Supplement_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12979","display_name":"Cardiovascular Disease and Adiposity","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/auranofin","display_name":"auranofin","score":1.0},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9459999799728394},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8939999938011169},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9819999933242798},{"id":"https://openalex.org/keywords/white-adipose-tissue-inflammation","display_name":"white adipose tissue inflammation","score":0.8529999852180481},{"id":"https://openalex.org/keywords/mir-30a","display_name":"miR-30a","score":0.902999997138977},{"id":"https://openalex.org/keywords/hepatic-steatosis","display_name":"hepatic steatosis","score":0.9480000138282776},{"id":"https://openalex.org/keywords/glucose-tolerance","display_name":"glucose tolerance","score":0.6539999842643738},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.847000002861023},{"id":"https://openalex.org/keywords/antirheumatic-drugs","display_name":"antirheumatic drugs","score":0.828000009059906},{"id":"https://openalex.org/keywords/chronic-low-grade-inflammation","display_name":"low-grade inflammation","score":0.5860000252723694}],"concepts":[{"id":"https://openalex.org/C2776243873","wikidata":"https://www.wikidata.org/wiki/Q421230","display_name":"Auranofin","level":3,"score":0.8469883799552917},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.7890870571136475},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6804047226905823},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6552364826202393},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6544126272201538},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6235324740409851},{"id":"https://openalex.org/C2776175330","wikidata":"https://www.wikidata.org/wiki/Q1365091","display_name":"Steatosis","level":2,"score":0.5099693536758423},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.5069715976715088},{"id":"https://openalex.org/C97037327","wikidata":"https://www.wikidata.org/wiki/Q5334291","display_name":"Ectopic expression","level":3,"score":0.454056054353714},{"id":"https://openalex.org/C2780988686","wikidata":"https://www.wikidata.org/wiki/Q14375936","display_name":"Hyperinsulinemia","level":4,"score":0.42316633462905884},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.4221261143684387},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.4212483763694763},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.4198876619338989},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.38870617747306824},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.34541141986846924},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.3395754098892212},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2556050419807434},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2337/db20-144-or","doi":"https://doi.org/10.2337/db20-144-or","is_oa":false,"landing_page_url":"https://doi.org/10.2337/db20-144-or","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2944808964","https://openalex.org/W4306194614","https://openalex.org/W3198915344","https://openalex.org/W2834915452","https://openalex.org/W3034338372","https://openalex.org/W2948412530","https://openalex.org/W3002131183","https://openalex.org/W4411046575","https://openalex.org/W7125650542","https://openalex.org/W2953695244"],"abstract_inverted_index":{"Obesity":[0],"is":[1],"associated":[2],"with":[3,75,162],"chronic":[4],"low-grade":[5,199],"inflammation,":[6],"reflecting":[7],"significant":[8],"alterations":[9],"in":[10,19,59,80,108,146,201],"the":[11,31,40,56,60,81,90,124,153],"composition":[12],"of":[13,34,55,64,95,132,142,159,187,214,265],"immune":[14],"cell":[15],"populations":[16],"that":[17,43,92,97,135,141,217],"reside":[18],"white":[20],"adipose":[21],"tissue":[22],"(WAT).":[23],"The":[24],"ensuing":[25],"pro-inflammatory":[26],"environment":[27],"likely":[28,193],"impinges":[29],"on":[30],"metabolic":[32,212],"functions":[33],"adipocytes":[35],"and":[36,71,83,117,167,182,189,203,226],"may":[37,218],"partially":[38],"explain":[39],"insulin":[41,69,115,165,181,224],"resistance":[42,116,225],"characterizes":[44],"type":[45],"2":[46],"diabetes":[47],"mellitus":[48],"(T2DM).":[49],"We":[50,87],"recently":[51],"demonstrated":[52],"ectopic":[53,77,105,204],"expression":[54,101,107,145],"microRNA":[57],"miR-30a":[58,106,144],"subcutaneous":[61],"fat":[62,78,206],"pad":[63],"diabetic":[65],"mice":[66,161],"coupled":[67],"improved":[68,164],"sensitivity":[70,166],"increased":[72],"energy":[73],"expenditure":[74],"decreased":[76],"deposition":[79],"liver":[82,205],"reduced":[84],"WAT":[85,109,202],"inflammation.":[86],"subsequently":[88],"pursued":[89],"notion":[91],"pharmacological":[93],"inhibitors":[94],"inflammation":[96,200],"exhibit":[98],"a":[99,130,185],"gene":[100],"profile":[102],"similar":[103,139],"to":[104,128,140,261],"should":[110],"represent":[111],"new":[112],"drugs":[113],"for":[114,223],"T2DM.":[118,227],"To":[119],"this":[120,149],"end,":[121],"we":[122,151],"used":[123],"Broad":[125],"Connectivity":[126],"Map":[127],"analyze":[129],"library":[131],"small":[133],"molecules":[134],"induce":[136],"mRNA":[137],"profiles":[138],"exogenous":[143],"WAT.":[147],"Through":[148],"process,":[150],"nominated":[152],"rheumatoid":[154],"arthritis":[155],"compound":[156],"auranofin.":[157],"Treatment":[158],"obese":[160],"auranofin":[163,192],"glucose":[168],"tolerance.":[169],"Auranofin":[170],"treatment":[171],"also":[172],"normalized":[173],"other":[174],"obesity-associated":[175],"abnormalities,":[176],"including":[177],"hepatic":[178],"steatosis,":[179],"serum":[180],"leptin.":[183],"Mechanistically,":[184],"combination":[186],"proteomics":[188],"immunophenotyping":[190],"established":[191],"exerts":[194],"antidiabetic":[195],"activities":[196],"by":[197],"opposing":[198],"accumulation.":[207],"These":[208],"studies":[209],"reveal":[210],"important":[211],"properties":[213],"anti-inflammatory":[215],"treatments":[216],"be":[219],"re-purposed":[220],"as":[221],"therapies":[222],"Disclosure":[228],"A.":[229],"Cox:":[230],"None.":[231,234,237,240,243,246,249,252,255],"P.M.":[232],"Masschelin:":[233],"N.":[235],"Chernis:":[236],"P.":[238],"Saha:":[239],"Z.":[241],"Lian:":[242],"J.B.":[244],"Felix:":[245],"K.":[247],"Kim:":[248],"H.":[250],"Wu:":[251],"S.M.":[253],"Hartig:":[254],"Funding":[256],"American":[257],"Diabetes":[258],"Association":[259],"(1-18-IBS-105":[260],"S.M.H.);":[262],"National":[263],"Institutes":[264],"Health":[266],"(R01DK114356)":[267]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-06-19T00:00:00"}
