{"id":"https://openalex.org/W3034659596","doi":"https://doi.org/10.1101/2020.06.15.20131987","title":"Can the protection be among us? Previous viral contacts and prevalent HLA alleles avoiding an even more disseminated COVID-19 pandemic","display_name":"Can the protection be among us? Previous viral contacts and prevalent HLA alleles avoiding an even more disseminated COVID-19 pandemic","publication_year":2020,"publication_date":"2020-06-17","ids":{"openalex":"https://openalex.org/W3034659596","doi":"https://doi.org/10.1101/2020.06.15.20131987","mag":"3034659596"},"language":"en","primary_location":{"id":"doi:10.1101/2020.06.15.20131987","doi":"https://doi.org/10.1101/2020.06.15.20131987","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2020.06.15.20131987","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2020/08/25/2020.06.15.20131987.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2020/08/25/2020.06.15.20131987.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042932762","display_name":"Eduardo Cheuiche Antonio","orcid":"https://orcid.org/0000-0003-1125-2978","observed_orcids":["https://orcid.org/0000-0003-1125-2978"]},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Eduardo Cheuiche Antonio","raw_affiliation_strings":["Post Graduation Program in Genetics and Molecular Biology - Universidade Federal do Rio Grande do Sul - Brazil"],"raw_orcid":"https://orcid.org/0000-0003-1125-2978","affiliations":[{"raw_affiliation_string":"Post Graduation Program in Genetics and Molecular Biology - Universidade Federal do Rio Grande do Sul - Brazil","institution_ids":["https://openalex.org/I130442723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008382489","display_name":"Mariana Rost Meireles","orcid":"https://orcid.org/0000-0002-2024-2846","observed_orcids":["https://orcid.org/0000-0002-2024-2846"]},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Mariana Rost Meireles","raw_affiliation_strings":["Post Graduation Program in Genetics and Molecular Biology - Universidade Federal do Rio Grande do Sul - Brazil"],"raw_orcid":"https://orcid.org/0000-0002-2024-2846","affiliations":[{"raw_affiliation_string":"Post Graduation Program in Genetics and Molecular Biology - Universidade Federal do Rio Grande do Sul - Brazil","institution_ids":["https://openalex.org/I130442723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000579280","display_name":"Marcelo Alves de Souza Bragatte","orcid":"https://orcid.org/0000-0001-6031-4755","observed_orcids":["https://orcid.org/0000-0001-6031-4755"]},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marcelo Alves de Souza Bragatte","raw_affiliation_strings":["Post Graduation Program in Genetics and Molecular Biology - Universidade Federal do Rio Grande do Sul - Brazil"],"raw_orcid":"https://orcid.org/0000-0001-6031-4755","affiliations":[{"raw_affiliation_string":"Post Graduation Program in Genetics and Molecular Biology - Universidade Federal do Rio Grande do Sul - Brazil","institution_ids":["https://openalex.org/I130442723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079866895","display_name":"Gustavo Fioravanti Vieira","orcid":"https://orcid.org/0000-0002-2380-8059","observed_orcids":["https://orcid.org/0000-0002-2380-8059"]},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]},{"id":"https://openalex.org/I4210102413","display_name":"Universidade La Salle","ror":"https://ror.org/01dzqrq04","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210102413"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Gustavo Fioravanti Vieira","raw_affiliation_strings":["Post Graduation Program in Genetics and Molecular Biology - Universidade Federal do Rio Grande do Sul - Brazil","Post Graduation Program in Health and Human Development - Universidade La Salle Canoas - Brazil"],"raw_orcid":"https://orcid.org/0000-0002-2380-8059","affiliations":[{"raw_affiliation_string":"Post Graduation Program in Genetics and Molecular Biology - Universidade Federal do Rio Grande do Sul - Brazil","institution_ids":["https://openalex.org/I130442723"]},{"raw_affiliation_string":"Post Graduation Program in Health and Human Development - Universidade La Salle Canoas - Brazil","institution_ids":["https://openalex.org/I4210102413"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5079866895"],"corresponding_institution_ids":["https://openalex.org/I130442723","https://openalex.org/I4210102413"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.7329000234603882,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.7329000234603882,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.25369998812675476,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9660000205039978},{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.9819999933242798},{"id":"https://openalex.org/keywords/hla-alleles","display_name":"HLA alleles","score":0.9309999942779541},{"id":"https://openalex.org/keywords/major-histocompatibility-complex","display_name":"major histocompatibility complex","score":0.7009999752044678},{"id":"https://openalex.org/keywords/covid-19-severity","display_name":"COVID-19 severity","score":0.8669999837875366},{"id":"https://openalex.org/keywords/immunological-cross-reactivity","display_name":"immunological cross-reactivity","score":0.7870000004768372},{"id":"https://openalex.org/keywords/t-cell-epitopes","display_name":"T cell epitopes","score":0.8840000033378601},{"id":"https://openalex.org/keywords/hla-a-0201","display_name":"HLA-A*0201","score":0.9559999704360962},{"id":"https://openalex.org/keywords/sars-cov-1","display_name":"SARS-CoV-1","score":0.8510000109672546},{"id":"https://openalex.org/keywords/human-coronaviruses","display_name":"human coronaviruses","score":0.6299999952316284},{"id":"https://openalex.org/keywords/hcov-229e","display_name":"HCoV-229E","score":0.8339999914169312},{"id":"https://openalex.org/keywords/hcov-oc43","display_name":"HCoV-OC43","score":0.9919999837875366},{"id":"https://openalex.org/keywords/herd-immunity","display_name":"herd immunity","score":0.5370000004768372},{"id":"https://openalex.org/keywords/vaccine-development","display_name":"vaccine development","score":0.7900000214576721},{"id":"https://openalex.org/keywords/hla-typing","display_name":"HLA typing","score":0.6850000023841858},{"id":"https://openalex.org/keywords/disease-prognosis","display_name":"disease prognosis","score":0.4359999895095825}],"concepts":[{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.717708170413971},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.6912879347801208},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.6516874432563782},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6023197174072266},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5899678468704224},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5525253415107727},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5285771489143372},{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.5222062468528748},{"id":"https://openalex.org/C89623803","wikidata":"https://www.wikidata.org/wiki/Q12184","display_name":"Pandemic","level":5,"score":0.516834557056427},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.4644797742366791},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.42060425877571106},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.38604238629341125},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3398503065109253},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.3380504846572876},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.329248309135437},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.2328384816646576},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19894269108772278},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.16368693113327026},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.1425779163837433},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10385438799858093},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/2020.06.15.20131987","doi":"https://doi.org/10.1101/2020.06.15.20131987","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2020.06.15.20131987","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2020/08/25/2020.06.15.20131987.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/2020.06.15.20131987","doi":"https://doi.org/10.1101/2020.06.15.20131987","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2020.06.15.20131987","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2020/08/25/2020.06.15.20131987.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3034659596.pdf","grobid_xml":"https://content.openalex.org/works/W3034659596.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W793398751","https://openalex.org/W1842363969","https://openalex.org/W2000305183","https://openalex.org/W2004583429","https://openalex.org/W2008808963","https://openalex.org/W2010188496","https://openalex.org/W2044518292","https://openalex.org/W2102303272","https://openalex.org/W2122691845","https://openalex.org/W2133707124","https://openalex.org/W2138594452","https://openalex.org/W2157973714","https://openalex.org/W2166593999","https://openalex.org/W2168766701","https://openalex.org/W2399366904","https://openalex.org/W2486229810","https://openalex.org/W2506181858","https://openalex.org/W2762030706","https://openalex.org/W2783905681","https://openalex.org/W2874904637","https://openalex.org/W2982242904","https://openalex.org/W2984055282","https://openalex.org/W3003217347","https://openalex.org/W3004280078","https://openalex.org/W3008443627","https://openalex.org/W3009912996","https://openalex.org/W3011127849","https://openalex.org/W3011488280","https://openalex.org/W3012565918","https://openalex.org/W3017304088","https://openalex.org/W3045971896","https://openalex.org/W3047288835"],"related_works":["https://openalex.org/W3017304088","https://openalex.org/W4362582199","https://openalex.org/W3191104213","https://openalex.org/W4386753033","https://openalex.org/W4284680099","https://openalex.org/W4317697895","https://openalex.org/W4380992133","https://openalex.org/W3111377329","https://openalex.org/W4405471517","https://openalex.org/W3028496098"],"abstract_inverted_index":{"Abstract":[0],"COVID-19":[1,51,172],"is":[2],"bringing":[3],"scenes":[4],"of":[5,27,31,47,56,86,135,144,163,180],"sci-fi":[6],"movies":[7],"into":[8],"real":[9],"life,":[10],"and":[11,33,60,94,131,148,153,190],"it":[12],"seems":[13],"to":[14],"be":[15],"far":[16],"from":[17,92,137],"over.":[18],"Infected":[19],"individuals":[20],"exhibit":[21],"variable":[22],"severity,":[23,52],"suggesting":[24],"the":[25,28,39,45,53,100,113,142,184],"involvement":[26],"genetic":[29],"constitution":[30],"populations":[32],"previous":[34,181],"cross-reactive":[35],"immune":[36],"contacts":[37],"in":[38,50,80,146,157,171],"individuals\u2019":[40],"disease":[41],"outcome.":[42],"To":[43,75],"investigate":[44],"participation":[46],"MHC":[48],"alleles":[49],"combined":[54],"use":[55],"HLA-B*07,":[57],"HLA-B*44,":[58],"HLA-DRB1*03,":[59],"HLA-DRB1*04":[61],"grouped":[62],"affected":[63],"countries":[64],"presenting":[65],"similar":[66],"death":[67],"rates,":[68],"based":[69],"only":[70],"on":[71],"their":[72],"allele":[73],"frequencies.":[74],"prospect":[76],"T":[77,119],"cell":[78,120],"targets":[79],"SARS-CoV-2,":[81],"we":[82],"modeled":[83],"3D":[84],"structures":[85,123],"HLA-A*02:01":[87],"complexed":[88],"with":[89,97,127,132,165],"immunogenic":[90],"epitopes":[91,136],"SAR-CoV-1":[93],"compared":[95,126],"them":[96],"models":[98],"containing":[99],"corresponding":[101,114],"SARS-CoV-2":[102],"peptides.":[103,167],"It":[104],"reveals":[105],"molecular":[106],"conservation":[107],"between":[108],"SARS-CoV":[109,166],"peptides,":[110],"evidencing":[111],"that":[112],"current":[115],"sequences":[116],"are":[117],"putative":[118],"epitopes.":[121],"These":[122],"were":[124],"also":[125],"other":[128],"HCoVs":[129],"sequences,":[130],"a":[133],"panel":[134],"unrelated":[138],"viruses,":[139],"looking":[140],"for":[141,186],"triggers":[143,182],"cross-protection":[145],"asymptomatic":[147],"uninfected":[149],"individuals.":[150],"229E,":[151],"OC43,":[152],"impressively,":[154],"viruses":[155],"involved":[156],"endemic":[158],"human":[159],"infections":[160],"share":[161],"fingerprints":[162],"immunogenicity":[164],"Wide-scale":[168],"HLA":[169],"genotyping":[170],"patients":[173],"shall":[174],"improve":[175],"prognosis":[176],"prediction.":[177],"Structural":[178],"identification":[179],"paves":[183],"way":[185],"herd":[187],"immunity":[188],"examination":[189],"wide":[191],"spectrum":[192],"vaccine":[193],"development.":[194]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2020-06-19T00:00:00"}