{"id":"https://openalex.org/W3034642004","doi":"https://doi.org/10.1021/acsinfecdis.0c00091","title":"In Vitro and In Vivo Characterization of the Anti-Zika Virus Activity of ProTides of 2\u2032-C-\u03b2-Methylguanosine","display_name":"In Vitro and In Vivo Characterization of the Anti-Zika Virus Activity of ProTides of 2\u2032-C-\u03b2-Methylguanosine","publication_year":2020,"publication_date":"2020-06-11","ids":{"openalex":"https://openalex.org/W3034642004","doi":"https://doi.org/10.1021/acsinfecdis.0c00091","mag":"3034642004","pmid":"https://pubmed.ncbi.nlm.nih.gov/32525653"},"language":"en","primary_location":{"id":"doi:10.1021/acsinfecdis.0c00091","doi":"https://doi.org/10.1021/acsinfecdis.0c00091","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsinfecdis.0c00091","pdf_url":null,"source":{"id":"https://openalex.org/S2764646616","display_name":"ACS Infectious Diseases","issn_l":"2373-8227","issn":["2373-8227"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035710908","display_name":"Marcos Rom\u00e1rio Matos de Souza","orcid":"https://orcid.org/0000-0002-9365-3224","observed_orcids":["https://orcid.org/0000-0002-9365-3224"]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marcos\nRoma\u0301rio Matos de Souza","raw_affiliation_strings":["Universidade Federal do Rio de Janeiro , , ,","Departamento de Virologia, Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-9365-3224","affiliations":[{"raw_affiliation_string":"Universidade Federal do Rio de Janeiro , , ,","institution_ids":["https://openalex.org/I122140584"]},{"raw_affiliation_string":"Departamento de Virologia, Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil","institution_ids":["https://openalex.org/I122140584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022653431","display_name":"Marcela Sabino Cunha","orcid":"https://orcid.org/0009-0000-0913-1347","observed_orcids":["https://orcid.org/0009-0000-0913-1347"]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marcela Sabino Cunha","raw_affiliation_strings":["Universidade Federal do Rio de Janeiro , , ,","Departamento de Virologia, Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal do Rio de Janeiro , , ,","institution_ids":["https://openalex.org/I122140584"]},{"raw_affiliation_string":"Departamento de Virologia, Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil","institution_ids":["https://openalex.org/I122140584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040506728","display_name":"Aniekan M. Okon","orcid":"https://orcid.org/0000-0002-8960-4497","observed_orcids":["https://orcid.org/0000-0002-8960-4497"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aniekan Okon","raw_affiliation_strings":["University of Minnesota , , , ,","Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Minnesota , , , ,","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040573068","display_name":"F\u00e1bio Lu\u00eds Lima Monteiro","orcid":"https://orcid.org/0000-0002-9107-6865","observed_orcids":["https://orcid.org/0000-0002-9107-6865"]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Fa\u0301bio Lui\u0301s\nLima Monteiro","raw_affiliation_strings":["Universidade Federal do Rio de Janeiro , , ,","Departamento de Gen\u00e9tica, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal do Rio de Janeiro , , ,","institution_ids":["https://openalex.org/I122140584"]},{"raw_affiliation_string":"Departamento de Gen\u00e9tica, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil","institution_ids":["https://openalex.org/I122140584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076667202","display_name":"Loraine Campanati","orcid":"https://orcid.org/0000-0001-9172-1951","observed_orcids":["https://orcid.org/0000-0001-9172-1951"]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Loraine Campanati","raw_affiliation_strings":["Universidade Federal do Rio de Janeiro , , ,","Departamento de Gen\u00e9tica, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal do Rio de Janeiro , , ,","institution_ids":["https://openalex.org/I122140584"]},{"raw_affiliation_string":"Departamento de Gen\u00e9tica, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil","institution_ids":["https://openalex.org/I122140584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055669445","display_name":"Carston R. Wagner","orcid":"https://orcid.org/0000-0001-7927-719X","observed_orcids":["https://orcid.org/0000-0001-7927-719X"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Carston R. Wagner","raw_affiliation_strings":["University of Minnesota , , , ,","Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States"],"raw_orcid":"https://orcid.org/0000-0001-7927-719X","affiliations":[{"raw_affiliation_string":"University of Minnesota , , , ,","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075475500","display_name":"Luciana Jesus da Costa","orcid":"https://orcid.org/0000-0002-9044-3387","observed_orcids":["https://orcid.org/0000-0002-9044-3387"]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Luciana Jesus da Costa","raw_affiliation_strings":["Universidade Federal do Rio de Janeiro , , ,","Departamento de Virologia, Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-9044-3387","affiliations":[{"raw_affiliation_string":"Universidade Federal do Rio de Janeiro , , ,","institution_ids":["https://openalex.org/I122140584"]},{"raw_affiliation_string":"Departamento de Virologia, Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil","institution_ids":["https://openalex.org/I122140584"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5055669445","https://openalex.org/A5075475500"],"corresponding_institution_ids":["https://openalex.org/I122140584","https://openalex.org/I130238516"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":0.3745,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.63165295,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"6","issue":"7","first_page":"1650","last_page":"1658"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.012199999764561653,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11748","display_name":"Organophosphorus compounds synthesis","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zika-virus","display_name":"Zika virus","score":0.921999990940094},{"id":"https://openalex.org/keywords/protide","display_name":"ProTide","score":0.8299999833106995},{"id":"https://openalex.org/keywords/hint1","display_name":"HINT1","score":0.734000027179718},{"id":"https://openalex.org/keywords/antiviral-nucleoside-analogues","display_name":"antiviral nucleosides","score":0.8730000257492065},{"id":"https://openalex.org/keywords/microvascular-endothelial-cells","display_name":"microvascular endothelial cells","score":0.7400000095367432},{"id":"https://openalex.org/keywords/neuroblastoma-cells","display_name":"neuroblastoma cells","score":0.9890000224113464},{"id":"https://openalex.org/keywords/antiviral-agents","display_name":"antiviral agents","score":0.5799999833106995}],"concepts":[{"id":"https://openalex.org/C2777053367","wikidata":"https://www.wikidata.org/wiki/Q202864","display_name":"Zika virus","level":3,"score":0.8981467485427856},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7011404633522034},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6797569394111633},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6152338981628418},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.43988317251205444},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39151543378829956},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3561137914657593},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3386734426021576},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14173418283462524},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.12051275372505188}],"mesh":[{"descriptor_ui":"D000071243","descriptor_name":"Zika Virus Infection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000071244","descriptor_name":"Zika Virus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006151","descriptor_name":"Guanosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009705","descriptor_name":"Nucleosides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acsinfecdis.0c00091","doi":"https://doi.org/10.1021/acsinfecdis.0c00091","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsinfecdis.0c00091","pdf_url":null,"source":{"id":"https://openalex.org/S2764646616","display_name":"ACS Infectious Diseases","issn_l":"2373-8227","issn":["2373-8227"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Infectious Diseases","raw_type":"journal-article"},{"id":"pmid:32525653","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32525653","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS infectious diseases","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.6800000071525574,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309636","display_name":"University of Minnesota","ror":"https://ror.org/03grvy078"},{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320322749","display_name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","ror":"https://ror.org/03kk0s825"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1500965038","https://openalex.org/W1964066906","https://openalex.org/W1970305894","https://openalex.org/W1973593491","https://openalex.org/W1984236050","https://openalex.org/W1987935503","https://openalex.org/W2015089921","https://openalex.org/W2016019565","https://openalex.org/W2020361084","https://openalex.org/W2045174016","https://openalex.org/W2062879499","https://openalex.org/W2065717236","https://openalex.org/W2077108587","https://openalex.org/W2079884831","https://openalex.org/W2100036957","https://openalex.org/W2107277218","https://openalex.org/W2122349387","https://openalex.org/W2147458973","https://openalex.org/W2165611390","https://openalex.org/W2168912424","https://openalex.org/W2392178457","https://openalex.org/W2402664383","https://openalex.org/W2552845139","https://openalex.org/W2572997664","https://openalex.org/W2607369158","https://openalex.org/W2691725800","https://openalex.org/W2732775333","https://openalex.org/W2746722788","https://openalex.org/W2752555298","https://openalex.org/W2756207857","https://openalex.org/W2763358936","https://openalex.org/W2793598447","https://openalex.org/W2803569593","https://openalex.org/W2806242691","https://openalex.org/W2911401325","https://openalex.org/W2952456408","https://openalex.org/W2975158828","https://openalex.org/W2996495947","https://openalex.org/W4254860060"],"related_works":["https://openalex.org/W2911401325","https://openalex.org/W7065660619","https://openalex.org/W7163736527","https://openalex.org/W4220924653","https://openalex.org/W2118217493","https://openalex.org/W2088611160","https://openalex.org/W2402664383","https://openalex.org/W2081994747","https://openalex.org/W2090627055","https://openalex.org/W4382936546"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"ProTide":[2,37,46],"approach":[3],"has":[4],"emerged":[5],"as":[6,161],"a":[7,40,49,117],"powerful":[8],"tool":[9],"to":[10,59,94],"improve":[11],"the":[12,26,60],"intracellular":[13,57,70],"delivery":[14],"of":[15,32,35,121,151],"nucleotide":[16,62,73],"analogs":[17],"with":[18,116,128,135],"antiviral":[19],"and":[20,45,90,106,109,130,139],"anticancer":[21],"activity.":[22],"Here,":[23],"we":[24],"characterized":[25],"anti-ZIKV":[27,162],"(ZIKV,":[28],"Zika":[29],"virus)":[30],"activity":[31],"two":[33],"ProTides":[34,150],"2\u2032-C-\u03b2-methylguanosine.":[36],"UMN-1001":[38,78,89,131],"is":[39,48,79,84],"2\u2032-C-\u03b2-methylguanosine":[41,99,129],"tryptamine":[42,51],"phosphoramidate":[43,52],"monoester,":[44],"UMN-1002":[47,54,91,136],"2-(methylthio)-ethyl-2\u2032-C-\u03b2-methylguanosine":[50],"diester.":[53],"undergoes":[55],"stepwise":[56],"activation":[58],"corresponding":[61],"monophosphate":[63],"followed":[64],"by":[65,69,81],"P\u2013N":[66],"bond":[67],"cleavage":[68],"histidine":[71],"triad":[72],"binding":[74],"protein":[75],"1":[76],"(Hint1).":[77],"activated":[80,149],"Hint1":[82],"but":[83],"less":[85],"cell-permeable":[86],"than":[87,98],"UMN-1002.":[88],"were":[92],"found":[93],"be":[95,155],"more":[96],"potent":[97],"against":[100],"ZIKV":[101,112,122,142],"in":[102,110],"human-derived":[103],"microvascular":[104],"endothelial":[105],"neuroblastoma":[107],"cells":[108],"reducing":[111],"RNA":[113],"replication.":[114],"Studies":[115],"newborn":[118],"mouse":[119],"model":[120],"infection":[123],"demonstrated":[124],"that,":[125],"while":[126],"treatment":[127,134],"was":[132,137],"lethal,":[133],"nontoxic":[138],"significantly":[140],"reduced":[141],"infection.":[143],"Our":[144],"data":[145],"suggests":[146],"that":[147],"anchimeric":[148],"2\u2032-C-\u03b2-methyl":[152],"nucleosides":[153],"should":[154],"further":[156],"investigated":[157],"for":[158],"their":[159],"potential":[160],"therapeutics.":[163]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-06-19T00:00:00"}