{"id":"https://openalex.org/W3034579040","doi":"https://doi.org/10.2337/db20-288-or","title":"288-OR: Myeloid-Specific Deletion of Alox15 Decreases Pancreatic Inflammation and Protects from Spontaneous Diabetes Development in Nonobese Diabetic (NOD) Mice","display_name":"288-OR: Myeloid-Specific Deletion of Alox15 Decreases Pancreatic Inflammation and Protects from Spontaneous Diabetes Development in Nonobese Diabetic (NOD) Mice","publication_year":2020,"publication_date":"2020-06-01","ids":{"openalex":"https://openalex.org/W3034579040","doi":"https://doi.org/10.2337/db20-288-or","mag":"3034579040"},"language":"en","primary_location":{"id":"doi:10.2337/db20-288-or","doi":"https://doi.org/10.2337/db20-288-or","is_oa":false,"landing_page_url":"https://doi.org/10.2337/db20-288-or","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027677376","display_name":"Annie Rocio Pi\u00f1eros","orcid":"https://orcid.org/0000-0003-0135-7549","observed_orcids":["https://orcid.org/0000-0003-0135-7549","https://orcid.org/0000-0002-3458-6543"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"ANNIE PINEROS","raw_affiliation_strings":["Indianapolis, IN, Charlottesville, VA, Norfolk, VA, Rockville, MD, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indianapolis, IN, Charlottesville, VA, Norfolk, VA, Rockville, MD, Chicago, IL","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137649800","display_name":"Abhishek Kulkarni","orcid":"https://orcid.org/0000-0001-6792-7183","observed_orcids":["https://orcid.org/0000-0001-6792-7183"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"ABHISHEK KULKARNI","raw_affiliation_strings":["Indianapolis, IN, Charlottesville, VA, Norfolk, VA, Rockville, MD, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indianapolis, IN, Charlottesville, VA, Norfolk, VA, Rockville, MD, Chicago, IL","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031301882","display_name":"Kara S. Orr","orcid":"https://orcid.org/0000-0002-1321-8581","observed_orcids":["https://orcid.org/0000-0002-1321-8581"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"KARA ORR","raw_affiliation_strings":["Indianapolis, IN, Charlottesville, VA, Norfolk, VA, Rockville, MD, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indianapolis, IN, Charlottesville, VA, Norfolk, VA, Rockville, MD, Chicago, IL","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054205518","display_name":"Lindsey M. Glenn","orcid":"https://orcid.org/0000-0002-8543-6684","observed_orcids":["https://orcid.org/0000-0002-8543-6684"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"LINDSEY GLENN","raw_affiliation_strings":["Indianapolis, IN, Charlottesville, VA, Norfolk, VA, Rockville, MD, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indianapolis, IN, Charlottesville, VA, Norfolk, VA, Rockville, MD, Chicago, IL","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003747950","display_name":"Christopher A. Reissaus","orcid":"https://orcid.org/0000-0002-3260-4525","observed_orcids":["https://orcid.org/0000-0002-3260-4525"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"CHRISTOPHER A. REISSAUS","raw_affiliation_strings":["Indianapolis, IN, Charlottesville, VA, Norfolk, VA, Rockville, MD, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indianapolis, IN, Charlottesville, VA, Norfolk, VA, Rockville, MD, Chicago, IL","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080139662","display_name":"Marimar Hern\u00e1ndez\u2010P\u00e9rez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"MARIMAR HERNANDEZ-PEREZ","raw_affiliation_strings":["Indianapolis, IN, Charlottesville, VA, Norfolk, VA, Rockville, MD, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indianapolis, IN, Charlottesville, VA, Norfolk, VA, Rockville, MD, Chicago, IL","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012810402","display_name":"MARCIA J. MCDUFFIE","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"MARCIA J. MCDUFFIE","raw_affiliation_strings":["Indianapolis, IN, Charlottesville, VA, Norfolk, VA, Rockville, MD, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indianapolis, IN, Charlottesville, VA, Norfolk, VA, Rockville, MD, Chicago, IL","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105351645","display_name":"Jerry L. Nadler","orcid":"https://orcid.org/0000-0002-4200-6991","observed_orcids":["https://orcid.org/0000-0002-4200-6991"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"JERRY NADLER","raw_affiliation_strings":["Indianapolis, IN, Charlottesville, VA, Norfolk, VA, Rockville, MD, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indianapolis, IN, Charlottesville, VA, Norfolk, VA, Rockville, MD, Chicago, IL","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102802719","display_name":"MARGARET A. MORRIS","orcid":"https://orcid.org/0000-0003-2399-6552","observed_orcids":["https://orcid.org/0000-0003-2399-6552"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"MARGARET A. MORRIS","raw_affiliation_strings":["Indianapolis, IN, Charlottesville, VA, Norfolk, VA, Rockville, MD, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indianapolis, IN, Charlottesville, VA, Norfolk, VA, Rockville, MD, Chicago, IL","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031560696","display_name":"Raghavendra G. Mirmira","orcid":"https://orcid.org/0000-0002-5013-6075","observed_orcids":["https://orcid.org/0000-0002-5013-6075","https://orcid.org/0000-0003-3638-8409"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"RAGHAVENDRA MIRMIRA","raw_affiliation_strings":["Indianapolis, IN, Charlottesville, VA, Norfolk, VA, Rockville, MD, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indianapolis, IN, Charlottesville, VA, Norfolk, VA, Rockville, MD, Chicago, IL","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102940395","display_name":"Sarah A. Tersey","orcid":"https://orcid.org/0000-0003-0667-2361","observed_orcids":["https://orcid.org/0000-0003-0667-2361"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"SARAH A. TERSEY","raw_affiliation_strings":["Indianapolis, IN, Charlottesville, VA, Norfolk, VA, Rockville, MD, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indianapolis, IN, Charlottesville, VA, Norfolk, VA, Rockville, MD, Chicago, IL","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"69","issue":"Supplement_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.8569999933242798},{"id":"https://openalex.org/keywords/12-15-lipoxygenase","display_name":"12/15-lipoxygenase","score":0.9760000109672546},{"id":"https://openalex.org/keywords/alox15","display_name":"ALOX15","score":0.9990000128746033},{"id":"https://openalex.org/keywords/myeloid-specific-knockout-mice","display_name":"myeloid-specific knockout","score":0.843999981880188},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8069999814033508},{"id":"https://openalex.org/keywords/pancreatitis","display_name":"pancreatitis","score":0.8220000267028809},{"id":"https://openalex.org/keywords/insulitis","display_name":"insulitis","score":0.9459999799728394},{"id":"https://openalex.org/keywords/beta-cell-destruction","display_name":"beta cell destruction","score":0.7099999785423279},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.7170000076293945},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9369999766349792},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.746999979019165},{"id":"https://openalex.org/keywords/pancreatic-lymph-nodes","display_name":"pancreatic lymph nodes","score":0.75},{"id":"https://openalex.org/keywords/nod-mice","display_name":"NOD mice","score":0.6579999923706055},{"id":"https://openalex.org/keywords/arachidonic-acid-metabolism","display_name":"arachidonic acid metabolism","score":0.8790000081062317},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.7379999756813049},{"id":"https://openalex.org/keywords/pdx1","display_name":"PDX1","score":0.7990000247955322}],"concepts":[{"id":"https://openalex.org/C2778013207","wikidata":"https://www.wikidata.org/wiki/Q1961243","display_name":"NOD mice","level":4,"score":0.8032791614532471},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.759932279586792},{"id":"https://openalex.org/C2779511750","wikidata":"https://www.wikidata.org/wiki/Q922215","display_name":"Insulitis","level":4,"score":0.6594862937927246},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6113173961639404},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5757245421409607},{"id":"https://openalex.org/C55851684","wikidata":"https://www.wikidata.org/wiki/Q518390","display_name":"Nod","level":3,"score":0.5234407782554626},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.46885356307029724},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.44667574763298035},{"id":"https://openalex.org/C2779919695","wikidata":"https://www.wikidata.org/wiki/Q4201963","display_name":"CD11c","level":4,"score":0.4281196892261505},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40573498606681824},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.40459612011909485},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4036577641963959},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.38011765480041504},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3059534430503845},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2337/db20-288-or","doi":"https://doi.org/10.2337/db20-288-or","is_oa":false,"landing_page_url":"https://doi.org/10.2337/db20-288-or","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2948080039","https://openalex.org/W1982038380","https://openalex.org/W3035227746","https://openalex.org/W11189207","https://openalex.org/W2101055038","https://openalex.org/W4283705101","https://openalex.org/W3166080163","https://openalex.org/W4387362534","https://openalex.org/W2748632281","https://openalex.org/W2170550355"],"abstract_inverted_index":{"The":[0],"pathogenesis":[1],"of":[2,10,37,55,66,115,121,135,172,204,240,246,271,335],"type":[3,206],"1":[4,207],"diabetes":[5,44,108,208],"(T1D)":[6],"involves":[7],"the":[8,11,38,46,64,69,89,98,146,202,235,263],"interaction":[9],"immune":[12,94,257],"system":[13],"with":[14,175],"\u03b2":[15,31],"cells.":[16,178],"12/15-lipoxygenase":[17],"(12/15-LOX),":[18],"an":[19],"enzyme":[20],"involved":[21],"in":[22,29,45,68,101,110,145,157,181,201,218,228,234,244,262],"arachidonic":[23],"acid":[24],"metabolism,":[25],"is":[26],"highly":[27],"expressed":[28],"both":[30],"cells":[32,143,159,189],"and":[33,61,92,100,141,225,242,260,269,304,327],"macrophages.":[34,193],"Global":[35],"deletion":[36,180,217],"gene":[39],"encoding":[40],"12/15-LOX":[41,67],"(Alox15)":[42],"prevents":[43],"NOD":[47,90],"mouse":[48],"(animal":[49],"model":[50],"for":[51],"T1D)":[52],"via":[53],"reduction":[54],"proinflammatory":[56,161],"cytokines":[57,162],"produced":[58,137],"by":[59,138,164],"macrophages":[60,70,139,174,182,219],"islets.":[62],"However,":[63],"role":[65],"during":[71],"T1D":[72],"development":[73,270],"remains":[74],"unclear.":[75],"To":[76,153],"address":[77],"this":[78],"issue,":[79],"we":[80,167],"generated":[81],"myeloid":[82,158],"lineage-specific":[83],"Alox15":[84,156,179,216,255],"knockout":[85],"mice":[86,117,129,196,213],"(Alox15\u2206myel)":[87],"on":[88],"background":[91],"evaluated":[93],"cell":[95,258],"infiltration":[96,123,259],"into":[97],"pancreas":[99,264],"pancreatic":[102],"lymph":[103],"nodes,":[104],"as":[105,107],"well":[106],"outcome":[109],"these":[111,250],"animals.":[112],"Pancreas":[113],"sections":[114],"Alox15\u2206Myel":[116,128,195,247],"showed":[118,131,197,237],"a":[119,132,169,198],"decrease":[120,200],"lymphocyte":[122],"compared":[124,149,190,210],"to":[125,150,191,211,221,266,339],"control":[126,151,212],"littermates.":[127],"also":[130],"decreased":[133,226],"frequency":[134],"IL-1\u03b2":[136],"(F480+IL1\u03b2+)":[140],"dendritic":[142],"(CD11c+IL1\u03b2+)":[144],"pLNs":[147],"when":[148],"mice.":[152,230,248],"clarify":[154],"if":[155],"mediates":[160],"production":[163,185],"T":[165,177,188],"cells,":[166],"performed":[168],"co-culture":[170],"assay":[171],"Alox15-/-":[173],"na\u00efve":[176],"impaired":[183],"IFN-\u03b3":[184],"from":[186],"CD4+":[187],"WT":[192],"Furthermore,":[194],"significant":[199],"incidence":[203],"spontaneous":[205],"(<10%)":[209],"(80%)":[214],"(P<0.05).":[215],"led":[220],"increased":[222,238],"\u03b2-cell":[223,267],"mass":[224],"insulitis":[227],"nondiabetic":[229],"Gene":[231],"expression":[232,239],"analysis":[233],"islets":[236,245],"Pdx1":[241],"Il-10":[243],"Together,":[249],"data":[251],"suggest":[252],"that":[253],"myeloid-derived":[254],"promotes":[256],"inflammation":[261],"leading":[265],"destruction":[268],"T1D.":[272],"Disclosure":[273],"A.":[274,277],"Pineros:":[275],"None.":[276,279,282,285,288,291,294,297,331],"Kulkarni:":[278],"K.":[280],"Orr:":[281],"L.":[283],"Glenn:":[284],"C.A.":[286],"Reissaus:":[287],"M.":[289],"Hernandez-Perez:":[290],"M.J.":[292],"McDuffie:":[293],"J.":[295],"Nadler:":[296],"M.A.":[298],"Morris:":[299],"Stock/Shareholder;":[300],"Spouse/Partner;":[301,324],"Becton,":[302],"Dickinson":[303],"Company,":[305],"Bristol-Myers":[306],"Squibb,":[307],"Johnson":[308],"&":[309],"Johnson,":[310],"Medtronic,":[311],"Sanofi.":[312],"R.":[313],"Mirmira:":[314],"Advisory":[315],"Panel;":[316],"Self;":[317],"Hibercell,":[318],"Sigilon":[319],"Therapeutics,":[320],"Veralox":[321],"Therapeutics.":[322],"Employee;":[323],"Eli":[325],"Lilly":[326],"Company.":[328],"S.A.":[329],"Tersey:":[330],"Funding":[332],"National":[333],"Institutes":[334],"Health":[336],"(R01DK105588,":[337],"P30DK097512":[338],"R.M.)":[340]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2020-06-19T00:00:00"}
