{"id":"https://openalex.org/W3034577051","doi":"https://doi.org/10.2337/db20-1864-p","title":"1864-P: Higher Relative Abundance of Bacteroidetes in Gut Microbiota Is Associated with Decreased Insulin Clearance and Insulin Sensitivity after a Short-Term High-Calorie, High-Fat Diet in Healthy Men","display_name":"1864-P: Higher Relative Abundance of Bacteroidetes in Gut Microbiota Is Associated with Decreased Insulin Clearance and Insulin Sensitivity after a Short-Term High-Calorie, High-Fat Diet in Healthy Men","publication_year":2020,"publication_date":"2020-06-01","ids":{"openalex":"https://openalex.org/W3034577051","doi":"https://doi.org/10.2337/db20-1864-p","mag":"3034577051"},"language":"en","primary_location":{"id":"doi:10.2337/db20-1864-p","doi":"https://doi.org/10.2337/db20-1864-p","is_oa":false,"landing_page_url":"https://doi.org/10.2337/db20-1864-p","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"SATOSHI KADOWAKI","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"SATOSHI KADOWAKI","raw_affiliation_strings":["Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokyo, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061830609","display_name":"Yoshifumi Tamura","orcid":"https://orcid.org/0000-0002-1685-7821","observed_orcids":["https://orcid.org/0000-0002-1685-7821"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"YOSHIFUMI TAMURA","raw_affiliation_strings":["Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokyo, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047679976","display_name":"Daisuke Sugimoto","orcid":"https://orcid.org/0000-0003-0943-0712","observed_orcids":["https://orcid.org/0000-0003-0943-0712"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"DAISUKE SUGIMOTO","raw_affiliation_strings":["Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokyo, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081559450","display_name":"Yuki Someya","orcid":"https://orcid.org/0000-0003-1657-3199","observed_orcids":["https://orcid.org/0000-0003-1657-3199"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"YUKI SOMEYA","raw_affiliation_strings":["Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokyo, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073891226","display_name":"Hideyoshi Kaga","orcid":"https://orcid.org/0000-0003-0579-2177","observed_orcids":["https://orcid.org/0000-0003-0579-2177"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"HIDEYOSHI KAGA","raw_affiliation_strings":["Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokyo, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112498743","display_name":"Ruriko Suzuki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"RURIKO SUZUKI","raw_affiliation_strings":["Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokyo, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022222261","display_name":"Saori Kakehi","orcid":"https://orcid.org/0000-0002-1280-2882","observed_orcids":["https://orcid.org/0000-0002-1280-2882"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"SAORI KAKEHI","raw_affiliation_strings":["Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokyo, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015606339","display_name":"Nozomu Yamasaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"NOZOMU YAMASAKI","raw_affiliation_strings":["Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokyo, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108201469","display_name":"Motonori Sato","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"MOTONORI SATO","raw_affiliation_strings":["Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokyo, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051450792","display_name":"Akio Kanazawa","orcid":"https://orcid.org/0000-0003-2292-395X","observed_orcids":["https://orcid.org/0000-0003-2292-395X","https://orcid.org/0009-0005-4607-478X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"AKIO KANAZAWA","raw_affiliation_strings":["Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokyo, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032317621","display_name":"Ryuzo Kawamori","orcid":"https://orcid.org/0000-0002-9686-9098","observed_orcids":["https://orcid.org/0000-0002-9686-9098"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"RYUZO KAWAMORI","raw_affiliation_strings":["Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokyo, Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043895658","display_name":"Hirotaka Watada","orcid":"https://orcid.org/0000-0001-5961-1816","observed_orcids":["https://orcid.org/0000-0001-5961-1816"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"HIROTAKA WATADA","raw_affiliation_strings":["Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokyo, Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1407,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.38624439,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"69","issue":"Supplement_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12964","display_name":"Diet, Metabolism, and Disease","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bacteroidetes","display_name":"Bacteroidetes","score":0.890999972820282},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9990000128746033},{"id":"https://openalex.org/keywords/insulin-clearance","display_name":"insulin clearance","score":0.8970000147819519},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.9039999842643738},{"id":"https://openalex.org/keywords/hyperinsulinemia","display_name":"hyperinsulinemia","score":0.8769999742507935},{"id":"https://openalex.org/keywords/endotoxemia","display_name":"endotoxemia","score":0.8510000109672546},{"id":"https://openalex.org/keywords/lipopolysaccharide-binding-protein","display_name":"lipopolysaccharide-binding protein","score":0.9750000238418579},{"id":"https://openalex.org/keywords/skeletal-muscle-insulin-sensitivity","display_name":"skeletal muscle insulin sensitivity","score":0.8870000243186951},{"id":"https://openalex.org/keywords/milk-fat","display_name":"milk fat","score":0.5070000290870667},{"id":"https://openalex.org/keywords/ceacam1","display_name":"CEACAM1","score":0.7400000095367432},{"id":"https://openalex.org/keywords/intestinal-permeability","display_name":"intestinal permeability","score":0.6069999933242798},{"id":"https://openalex.org/keywords/healthy-men","display_name":"healthy men","score":0.5270000100135803},{"id":"https://openalex.org/keywords/weight-gain","display_name":"weight gain","score":0.6349999904632568},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.4090000092983246},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9750000238418579},{"id":"https://openalex.org/keywords/hyperinsulinemic-euglycemic-clamp","display_name":"hyperinsulinemic-euglycemic clamp","score":0.8690000176429749}],"concepts":[{"id":"https://openalex.org/C2780988686","wikidata":"https://www.wikidata.org/wiki/Q14375936","display_name":"Hyperinsulinemia","level":4,"score":0.9385592341423035},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8510619401931763},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8367831707000732},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6858148574829102},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.6479043960571289},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.43715977668762207},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.4115992784500122},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39677029848098755},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.3509499430656433},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.30616816878318787},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29392337799072266}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2337/db20-1864-p","doi":"https://doi.org/10.2337/db20-1864-p","is_oa":false,"landing_page_url":"https://doi.org/10.2337/db20-1864-p","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2401139202","https://openalex.org/W1988879418","https://openalex.org/W2410952378","https://openalex.org/W92332735","https://openalex.org/W2983614893","https://openalex.org/W2033704972","https://openalex.org/W2420185505","https://openalex.org/W2026880258","https://openalex.org/W1980928521","https://openalex.org/W2475280487"],"abstract_inverted_index":{"Hyperinsulinemia":[0],"is":[1,115],"observed":[2],"in":[3,7,22,47,71,127,234,270],"obese":[4],"subject.":[5],"Even":[6],"healthy":[8,72,142],"non-obese":[9,143],"subjects,":[10,73],"intentional":[11],"small":[12],"weight":[13],"gain":[14],"by":[15,28,33,166,197,216],"a":[16,109,159,172,209],"high-calorie,":[17],"high-fat":[18],"diet":[19,161],"(HCHFD)":[20],"resulted":[21],"hyperinsulinemia":[23,59],"which":[24],"was":[25,44,213,230],"caused":[26],"not":[27],"increased":[29,215,257],"insulin":[30,39,67,132,183,191],"secretion":[31],"but":[32],"decreased":[34,196,247],"metabolic":[35,147],"clearance":[36],"rate":[37],"of":[38,53,56,75,111,158,211,224,259,268,537,544],"(MCRI).":[40],"In":[41,202,243],"addition,":[42,203],"it":[43,92,114],"reported":[45],"that":[46,82,96],"the":[48,79,89,186,219],"mice":[49,63],"with":[50,168,256],"genetic":[51],"deletion":[52],"CEACAM-1,":[54],"impairment":[55],"MCRI":[57,76,128,179,188,235,248],"induces":[58,83,98],"and":[60,66,86,102,104,121,145,149,153,180,189,199,238,249,251,263,542],"subsequently":[61],"these":[62,105],"develop":[64],"obesity":[65,85],"resistance":[68],"(IR).":[69],"Therefore,":[70],"reduction":[74],"could":[77,107],"be":[78,108],"primary":[80],"change":[81],"hyperinsulinemia,":[84],"IR.":[87,112],"On":[88],"other":[90],"hand,":[91],"has":[93],"been":[94],"shown":[95],"HCHFD":[97,156,246,262],"enhanced":[99],"gut":[100,119,150,228,271],"permeability":[101],"endotoxemia":[103,122,260],"changes":[106,126,148,233,253],"cause":[110],"However,":[113],"totally":[116],"unknown":[117],"whether":[118],"microbiota":[120,151],"are":[123],"related":[124],"to":[125,232],"as":[129,131],"well":[130],"sensitivity":[133,192],"after":[134,154,218,261],"HCHFD.":[135,220],"To":[136],"address":[137],"this,":[138],"we":[139,177],"recruited":[140],"21":[141],"men":[144],"evaluated":[146,178],"before":[152],"6-day":[155],"consisting":[157],"regular":[160],"plus":[162],"45%":[163],"energy":[164],"excess":[165],"supplementation":[167],"dairy":[169],"fat.":[170],"Using":[171],"2-step":[173],"hyperinsulinemic":[174],"euglycemic":[175],"clamp,":[176],"tissue":[181],"specific":[182],"sensitivity.":[184],"After":[185],"HCHFD,":[187],"muscle":[190],"(M-IS)":[193],"were":[194,254],"significantly":[195,214],"6%":[198],"4%,":[200],"respectively.":[201,242],"circulating":[204],"lipopolysaccharide":[205],"(LPS)":[206],"binding":[207],"protein,":[208],"marker":[210,258],"endotoxemia,":[212],"14%":[217],"Baseline":[221],"relative":[222,266],"abundance":[223,267],"Bacteroidetes,":[225],"LPS-producing":[226],"Gram-negative":[227],"microbiota,":[229],"correlated":[231],"(r=-0.57,":[236],"p=0.009)":[237],"M-IS":[239,250],"(r=-0.46,":[240],"p=0.040),":[241],"conclusion,":[244],"short-term":[245],"those":[252],"associated":[255],"higher":[264],"baseline":[265],"Bacteroidetes":[269],"microbiota.":[272],"Disclosure":[273],"S.":[274,313],"Kadowaki:":[275],"None.":[276,303,306,309,312,315,318,321,337],"Y.":[277,304],"Tamura:":[278],"Advisory":[279,340],"Panel;":[280,341],"Self;":[281,287,293,326,342,386,473],"Astellas":[282,345,387,474],"Pharma":[283,328,346,367,388,422,425,451,456,468,475,510,528],"Inc.":[284],"Research":[285,384],"Support;":[286,385],"Kowa":[288,357,407,495],"Company,":[289,358,408,496],"Ltd.":[290,300],"Speaker\u2019s":[291,324,471],"Bureau;":[292,325,472],"Novo":[294,369,427,515],"Nordisk":[295,370,428,516],"Inc.,":[296,347,351,356,371,389,396,429,440,476,484,517],"Ono":[297,372,430,518],"Pharmaceutical":[298,332,373,378,404,431,435,460,464,492,519,532],"Co.,":[299,363,374,405,413,432,436,447,452,457,461,493,501,520,529],"D.":[301],"Sugimoto:":[302],"Someya:":[305],"H.":[307,338],"Kaga:":[308],"R.":[310,335],"Suzuki:":[311],"Kakehi:":[314],"N.":[316],"Yamasaki:":[317],"M.":[319],"Sato:":[320],"A.":[322],"Kanazawa:":[323],"Novartis":[327,424,512],"K.K.,":[329,402,426,490],"Sanofi,":[330],"Takeda":[331,377,463,531],"Company":[333,379,465,533],"Limited.":[334,534],"Kawamori:":[336],"Watada:":[339],"Abbott,":[343],"Ajinomoto,":[344],"Boehringer":[348,393,481],"Ingelheim":[349,394,482],"Pharmaceuticals,":[350,355,395,483],"Fuji":[352],"Film,":[353],"Janssen":[354],"Ltd.,":[359,364,375,392,406,409,414,433,437,448,453,458,462,480,494,497,502,521,530],"Kyowa":[360,410,498],"Hakko":[361,411,499],"Kirin":[362,412,500],"Mitsubishi":[365,420,508],"Tanabe":[366,421,509],"Corporation,":[368,423,511,514],"Sanofi-Aventis,":[376,441,522],"Limited,":[380,466,469],"Terumo":[381],"Medical":[382],"Corporation.":[383],"Bayer":[390,478],"Yakuhin,":[391,479],"Daiichi":[397,485],"Sankyo,":[398,486],"Eli":[399,487],"Lilly":[400,488],"Japan":[401,439,489,545],"Kissei":[403,491],"Merck":[415,503],"Sharp":[416,504],"&":[417,446,505],"Dohme":[418,506],"Corp.,":[419,507],"Otsuka":[434],"Pfizer":[438],"Sanwa":[442,523],"Kagaku":[443,524],"Kenkyusho,":[444,525],"Shionogi":[445],"Sumitomo":[449,454,526],"Dainippon":[450,455,527],"Taisho":[459],"Teijin":[467],"Yakult.":[470],"AstraZeneca,":[477],"Pharmaceuticals":[513],"Funding":[535],"Ministry":[536],"Education,":[538],"Culture,":[539],"Sports,":[540],"Science":[541],"Technology":[543],"(18H03196)":[546]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2025-10-10T00:00:00"}
