{"id":"https://openalex.org/W3034576966","doi":"https://doi.org/10.21304/2018.0501.00229","title":"Usefulness of multiplex molecular diagnostics in diagnosis and management of critical infections in Picu- A single center retrospective analysis","display_name":"Usefulness of multiplex molecular diagnostics in diagnosis and management of critical infections in Picu- A single center retrospective analysis","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W3034576966","doi":"https://doi.org/10.21304/2018.0501.00229","mag":"3034576966"},"language":"en","primary_location":{"id":"doi:10.21304/2018.0501.00229","doi":"https://doi.org/10.21304/2018.0501.00229","is_oa":true,"landing_page_url":"https://doi.org/10.21304/2018.0501.00229","pdf_url":null,"source":{"id":"https://openalex.org/S4210223000","display_name":"JOURNAL OF PEDIATRIC CRITICAL CARE","issn_l":"2349-6592","issn":["2349-6592","2455-7099"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pediatric Critical Care","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W3034576966"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.21304/2018.0501.00229","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109461243","display_name":"RN Ashwath Ram","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165321","display_name":"Manipal Hospital","ror":"https://ror.org/05mryn396","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210165321"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"RN Ashwath","raw_affiliation_strings":["Consultant Pediatric Intensivist, PICU Manipal Hospital, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Consultant Pediatric Intensivist, PICU Manipal Hospital, Bangalore, India","institution_ids":["https://openalex.org/I4210165321"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018406047","display_name":"Shivakumar Shamarao","orcid":"https://orcid.org/0000-0003-2202-4663","observed_orcids":["https://orcid.org/0000-0003-2202-4663"]},"institutions":[{"id":"https://openalex.org/I4210165321","display_name":"Manipal Hospital","ror":"https://ror.org/05mryn396","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210165321"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shivakumar Shamarao","raw_affiliation_strings":["Consultant Pediatric Intensivist, PICU Manipal Hospital, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Consultant Pediatric Intensivist, PICU Manipal Hospital, Bangalore, India","institution_ids":["https://openalex.org/I4210165321"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210165321"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"7","first_page":"51","last_page":"51"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12167","display_name":"Bacterial Identification and Susceptibility Testing","score":0.6416000127792358,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12167","display_name":"Bacterial Identification and Susceptibility Testing","score":0.6416000127792358,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11961","display_name":"Neonatal and Maternal Infections","score":0.23499999940395355,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.11550000309944153,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.7850000262260437},{"id":"https://openalex.org/keywords/multiplex-pcr","display_name":"multiplex PCR","score":0.6439999938011169},{"id":"https://openalex.org/keywords/molecular-diagnosis","display_name":"molecular diagnosis","score":0.7400000095367432},{"id":"https://openalex.org/keywords/pediatric-intensive-care","display_name":"pediatric intensive care","score":0.7749999761581421},{"id":"https://openalex.org/keywords/meningitis","display_name":"meningitis","score":0.6119999885559082},{"id":"https://openalex.org/keywords/febrile-neutropenia","display_name":"febrile neutropenia","score":0.949999988079071},{"id":"https://openalex.org/keywords/blood-culture","display_name":"blood culture","score":0.4690000116825104},{"id":"https://openalex.org/keywords/cerebrospinal-fluid","display_name":"cerebrospinal fluid","score":0.8989999890327454},{"id":"https://openalex.org/keywords/virulence-gene-detection","display_name":"virulence gene detection","score":0.6389999985694885},{"id":"https://openalex.org/keywords/procalcitonin","display_name":"procalcitonin","score":0.765999972820282},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.8299999833106995},{"id":"https://openalex.org/keywords/antimicrobial-therapy","display_name":"antimicrobial therapy","score":0.7310000061988831},{"id":"https://openalex.org/keywords/diagnostic-yield","display_name":"diagnostic yield","score":0.7039999961853027},{"id":"https://openalex.org/keywords/critically-ill-children","display_name":"critically ill children","score":0.5360000133514404},{"id":"https://openalex.org/keywords/bronchoalveolar-lavage","display_name":"bronchoalveolar lavage","score":0.7879999876022339}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7556807994842529},{"id":"https://openalex.org/C2779473907","wikidata":"https://www.wikidata.org/wiki/Q886695","display_name":"Blood culture","level":3,"score":0.6613282561302185},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.6399889588356018},{"id":"https://openalex.org/C149453125","wikidata":"https://www.wikidata.org/wiki/Q5437094","display_name":"Fastidious organism","level":3,"score":0.5639310479164124},{"id":"https://openalex.org/C90583042","wikidata":"https://www.wikidata.org/wiki/Q1952456","display_name":"Multiplex polymerase chain reaction","level":4,"score":0.5083519816398621},{"id":"https://openalex.org/C2777961210","wikidata":"https://www.wikidata.org/wiki/Q927148","display_name":"Bronchoalveolar lavage","level":3,"score":0.47798556089401245},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4737437665462494},{"id":"https://openalex.org/C2781026528","wikidata":"https://www.wikidata.org/wiki/Q48143","display_name":"Meningitis","level":2,"score":0.4729178547859192},{"id":"https://openalex.org/C40993552","wikidata":"https://www.wikidata.org/wiki/Q514654","display_name":"Gold standard (test)","level":2,"score":0.469115287065506},{"id":"https://openalex.org/C2780073493","wikidata":"https://www.wikidata.org/wiki/Q7523837","display_name":"Single Center","level":2,"score":0.46115589141845703},{"id":"https://openalex.org/C179786068","wikidata":"https://www.wikidata.org/wiki/Q16257937","display_name":"Molecular diagnostics","level":2,"score":0.45143088698387146},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.44533589482307434},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.38072049617767334},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3366144597530365},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.32943302392959595},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16003668308258057},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.15130716562271118},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.14789482951164246},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.1371852159500122},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21304/2018.0501.00229","doi":"https://doi.org/10.21304/2018.0501.00229","is_oa":true,"landing_page_url":"https://doi.org/10.21304/2018.0501.00229","pdf_url":null,"source":{"id":"https://openalex.org/S4210223000","display_name":"JOURNAL OF PEDIATRIC CRITICAL CARE","issn_l":"2349-6592","issn":["2349-6592","2455-7099"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pediatric Critical Care","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.21304/2018.0501.00229","doi":"https://doi.org/10.21304/2018.0501.00229","is_oa":true,"landing_page_url":"https://doi.org/10.21304/2018.0501.00229","pdf_url":null,"source":{"id":"https://openalex.org/S4210223000","display_name":"JOURNAL OF PEDIATRIC CRITICAL CARE","issn_l":"2349-6592","issn":["2349-6592","2455-7099"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pediatric Critical Care","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2806663978","https://openalex.org/W2155228321","https://openalex.org/W2223036665","https://openalex.org/W1964892813","https://openalex.org/W2464355077","https://openalex.org/W2419270246","https://openalex.org/W2160444868","https://openalex.org/W3174798028","https://openalex.org/W3217371482","https://openalex.org/W3035078236"],"abstract_inverted_index":{"Background":[0],":":[1,98,193,388],"Sepsis":[2],"forms":[3],"a":[4,132,224,396],"major":[5],"cause":[6],"of":[7,64,143,216,227,281,295,339,430,479],"morbidity":[8],"and":[9,33,39,127,155,182,207,237,246,259,279,283,293,297,307,313,317,349,366,417,439,476],"mortality":[10],"in":[11,29,46,77,94,256,277,291,315,347,351,360,364,370,380,400,425,428,463,467],"children.Currently,":[12],"the":[13,69,266,431],"gold":[14],"standard":[15],"for":[16,18,213,269,335],"diagnosis":[17],"sepsis":[19],"is":[20,86,131],"culture.":[21,337,409],"However,":[22],"they":[23],"suffer":[24],"from":[25],"low":[26],"yield,":[27],"delay":[28],"providing":[30],"actionable":[31],"results":[32,322,411,422],"inability":[34],"to":[35,43,67,75,110,116,174,325,332,407,413],"grow":[36],"fastidious":[37],"organisms":[38],"fungus":[40],"quickly":[41],"enough":[42],"guide":[44],"therapy":[45,177,382,427],"time.":[47],"Newer":[48],"molecular":[49,136,449,461],"methods":[50],"like":[51,160,451],"multiplex":[52,133,141],"polymerase":[53],"chain":[54],"reaction(PCR)":[55],"systems":[56],"have":[57,394,453],"been":[58],"recommended":[59],"by":[60,148,166,232,272],"Infectious":[61],"Disease":[62],"Society":[63],"America":[65],"(IDSA)":[66],"improve":[68],"yield":[70,267],"as":[71,73,168,170,185,187,330,405],"well":[72,169,186],"time":[74],"intervention":[76],"these":[78,249],"life":[79],"threatening":[80],"emergencies.":[81],"Syndrome":[82],"Evaluation":[83],"System":[84],"(SES)":[85],"one":[87],"such":[88],"test":[89],"which":[90,217],"has":[91],"shown":[92],"benefits":[93],"neonatal":[95],"sepsis.":[96],"Methods":[97],"In":[99,353,373,389],"this":[100,390],"retrospective":[101,391],"case":[102],"series,":[103],"we":[104,344,357,393,436],"analysed":[105],"57":[106,194],"paediatric":[107],"cases":[108,195,286,300,319],"admitted":[109],"our":[111],"PICU":[112,464],"during":[113],"October":[114],"2015":[115],"February":[117],"2017.":[118],"The":[119,433],"clinical":[120,444],"presentations":[121],"were":[122,164,190,204,211,251,323],"sepsis,":[123],"systemic":[124],"infections,":[125],"meningitis":[126],"febrile":[128],"neutropenia.":[129],"SES":[130,167,206,233,253,274,288,310,321,341,355,385,410,421,452],"PCR":[134],"based":[135,179,383],"diagnostics":[137,450,462],"involving":[138],"DNA":[139],"extraction,":[140],"amplification":[142],"virulence":[144],"specific":[145,150,158],"genes":[146],"followed":[147],"sequence":[149],"hybridization.":[151],"Blood,Cerebrospinal":[152],"fluid(":[153],"CSF)":[154],"other":[156,239,262],"focal":[157],"samples":[159,242],"Bronchoalveolar":[161],"Lavage(BAL),":[162],"etc":[163],"tested":[165],"routine":[171],"cultures.":[172],"Decision":[173],"change":[175,369,379,424],"antimicrobial":[176,381,426,474],"was":[178,254,275,289,311],"on":[180,384],"culture":[181],"sensitivity":[183],"results,":[184],"SES.":[188,247,273],"Outcomes":[189],"recorded.":[191],"Results":[192],"(28":[196],"males,":[197],"29":[198],"females,":[199],"mean":[200],"age":[201],"5.72\u00b14.34":[202],"years)":[203],"analysed.":[205],"corresponding":[208],"Blood":[209],"cultures":[210,245,250,270],"done":[212],"26":[214],"patients,":[215],"4":[218],"had":[219],"positive":[220,255,276,285,306,312,342],"blood":[221],"cultures,":[222],"yielding":[223],"detection":[225,401],"rate":[226],"15.4%":[228],"vs":[229],"26.9%":[230],"7":[231,238,260],"(7/26)":[234],".24":[235],"CSF":[236,303],"body":[240,263],"fluid":[241],"underwent":[243,378],"both":[244],"All":[248],"negative.":[252],"5":[257],"(20.8%)CSF":[258],"(100%)":[261],"fluids.":[264],"Overall,":[265],"was7.0%":[268],"vs33.3%":[271],"89.5%":[278],"94.7%":[280],"CRP":[282,296,416],"Procalcitonin":[284],"respectively.":[287,301,320],"negative":[290,299,308,314,455],"87.7%":[292],"93.3%":[294],"procalcitonin":[298],"Among":[302],"cell":[304],"count":[305],"cases,":[309,343],"30%":[316],"81.2%":[318],"available":[324],"us":[326],"within":[327],"24":[328],"hours,":[329],"compared":[331,406],"48":[333],"hours":[334],"traditional":[336,408,470],"Out":[338],"19":[340],"escalated":[345,363],"antimicrobials":[346,359],"10":[348],"de-escalated":[350,358,437],"9.":[352],"38":[354],"negatives,":[356],"16":[361],",":[362],"1":[365],"made":[367],"no":[368,442],"remaining":[371],"21.":[372],"effect":[374],"36":[375],"/57cases":[376],"(63.15%),":[377],"results.":[386],"Conclusion":[387],"analysis,":[392],"seen":[395],"4.75":[397],"fold":[398],"increase":[399],"rates":[402],"using":[403],"SES,":[404],"seem":[412],"correlate":[414],"with":[415,441,469],"Procalcitonin.":[418],"Most":[419],"importantly,":[420],"elicited":[423],"63.15%":[429],"cases.":[432],"fact":[434],"that":[435,447,460],"antibiotics":[438],"antivirals,":[440],"adverse":[443],"course,":[445],"shows":[446],"emerging":[448],"good":[454],"predictive":[456],"value.":[457],"We":[458],"feel":[459],"setting,":[465],"used":[466],"conjunction":[468],"culture,":[471],"may":[472],"reduce":[473],"usage":[475],"overall":[477],"cost":[478],"therapy.":[480]},"counts_by_year":[],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2020-06-19T00:00:00"}
