{"id":"https://openalex.org/W3034466664","doi":"https://doi.org/10.3390/proceedings2020050073","title":"Characterization of JC Polyomavirus Entry by Serotonin Receptors","display_name":"Characterization of JC Polyomavirus Entry by Serotonin Receptors","publication_year":2020,"publication_date":"2020-06-17","ids":{"openalex":"https://openalex.org/W3034466664","doi":"https://doi.org/10.3390/proceedings2020050073","mag":"3034466664"},"language":"en","primary_location":{"id":"doi:10.3390/proceedings2020050073","doi":"https://doi.org/10.3390/proceedings2020050073","is_oa":true,"landing_page_url":"https://doi.org/10.3390/proceedings2020050073","pdf_url":"https://www.mdpi.com/2504-3900/50/1/73/pdf?version=1592356902","source":{"id":"https://openalex.org/S7407096475","display_name":"Viruses Conference: Novel Concepts in Virology","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"conference"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Viruses 2020&amp;mdash;Novel Concepts in Virology","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.mdpi.com/2504-3900/50/1/73/pdf?version=1592356902","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076826339","display_name":"Melissa S. Maginnis","orcid":"https://orcid.org/0000-0002-7479-8663","observed_orcids":["https://orcid.org/0000-0002-7479-8663"]},"institutions":[{"id":"https://openalex.org/I7947594","display_name":"University of Maine","ror":"https://ror.org/01adr0w49","country_code":"US","type":"education","lineage":["https://openalex.org/I2802397601","https://openalex.org/I7947594"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Melissa Maginnis","raw_affiliation_strings":["Molecular & Biomedical Sciences, The University of Maine, Orono, ME 04469, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular & Biomedical Sciences, The University of Maine, Orono, ME 04469, USA","institution_ids":["https://openalex.org/I7947594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043355585","display_name":"Colleen L. Mayberry","orcid":"https://orcid.org/0000-0002-4631-545X","observed_orcids":["https://orcid.org/0000-0002-4631-545X"]},"institutions":[{"id":"https://openalex.org/I7947594","display_name":"University of Maine","ror":"https://ror.org/01adr0w49","country_code":"US","type":"education","lineage":["https://openalex.org/I2802397601","https://openalex.org/I7947594"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Colleen L. Mayberry","raw_affiliation_strings":["Molecular & Biomedical Sciences, The University of Maine, Orono, ME 04469, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular & Biomedical Sciences, The University of Maine, Orono, ME 04469, USA","institution_ids":["https://openalex.org/I7947594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061835796","display_name":"Kashif Mehmood","orcid":"https://orcid.org/0000-0001-7199-3861","observed_orcids":["https://orcid.org/0000-0001-7199-3861"]},"institutions":[{"id":"https://openalex.org/I7947594","display_name":"University of Maine","ror":"https://ror.org/01adr0w49","country_code":"US","type":"education","lineage":["https://openalex.org/I2802397601","https://openalex.org/I7947594"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kashif Mehmood","raw_affiliation_strings":["Molecular & Biomedical Sciences, The University of Maine, Orono, ME 04469, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular & Biomedical Sciences, The University of Maine, Orono, ME 04469, USA","institution_ids":["https://openalex.org/I7947594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019713711","display_name":"Matthew T. Parent","orcid":"https://orcid.org/0000-0002-3346-1271","observed_orcids":["https://orcid.org/0000-0002-3346-1271"]},"institutions":[{"id":"https://openalex.org/I7947594","display_name":"University of Maine","ror":"https://ror.org/01adr0w49","country_code":"US","type":"education","lineage":["https://openalex.org/I2802397601","https://openalex.org/I7947594"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Parent","raw_affiliation_strings":["Department of Physics and Astronomy, The University of Maine, Orono,\u2009ME 04469, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics and Astronomy, The University of Maine, Orono,\u2009ME 04469, USA","institution_ids":["https://openalex.org/I7947594"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102843280","display_name":"Samuel T. Hess","orcid":"https://orcid.org/0000-0003-2359-6540","observed_orcids":["https://orcid.org/0000-0003-2359-6540"]},"institutions":[{"id":"https://openalex.org/I7947594","display_name":"University of Maine","ror":"https://ror.org/01adr0w49","country_code":"US","type":"education","lineage":["https://openalex.org/I2802397601","https://openalex.org/I7947594"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel Hess","raw_affiliation_strings":["Department of Physics and Astronomy, The University of Maine, Orono,\u2009ME 04469, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics and Astronomy, The University of Maine, Orono,\u2009ME 04469, USA","institution_ids":["https://openalex.org/I7947594"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5076826339"],"corresponding_institution_ids":["https://openalex.org/I7947594"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.21665696,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"73","last_page":"73"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11827","display_name":"Polyomavirus and related diseases","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11827","display_name":"Polyomavirus and related diseases","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/jc-virus","display_name":"JC virus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/virus-entry","display_name":"viral entry","score":0.7039999961853027},{"id":"https://openalex.org/keywords/5-ht2-receptor","display_name":"5-HT2 receptor","score":0.890999972820282},{"id":"https://openalex.org/keywords/5-ht2a-receptor","display_name":"5-HT2A receptor","score":0.9470000267028809},{"id":"https://openalex.org/keywords/beta-arrestin","display_name":"beta-arrestin","score":0.8159999847412109},{"id":"https://openalex.org/keywords/clathrin-mediated-endocytosis","display_name":"clathrin-mediated endocytosis","score":0.925000011920929},{"id":"https://openalex.org/keywords/ap2","display_name":"AP-2","score":0.5619999766349792},{"id":"https://openalex.org/keywords/dynamin","display_name":"dynamin","score":0.996999979019165},{"id":"https://openalex.org/keywords/sialic-acid-receptors","display_name":"sialic acid receptors","score":0.7419999837875366},{"id":"https://openalex.org/keywords/progressive-multifocal-leukoencephalopathy","display_name":"progressive multifocal leukoencephalopathy","score":0.9620000123977661},{"id":"https://openalex.org/keywords/demyelination","display_name":"demyelination","score":0.7099999785423279},{"id":"https://openalex.org/keywords/viral-receptor-interaction","display_name":"viral receptor interaction","score":0.421999990940094},{"id":"https://openalex.org/keywords/antiviral-drug-targets","display_name":"antiviral drug targets","score":0.6029999852180481}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6797297596931458},{"id":"https://openalex.org/C2780644213","wikidata":"https://www.wikidata.org/wiki/Q704930","display_name":"Progressive multifocal leukoencephalopathy","level":3,"score":0.6413908004760742},{"id":"https://openalex.org/C58475186","wikidata":"https://www.wikidata.org/wiki/Q4118894","display_name":"Viral entry","level":4,"score":0.6257360577583313},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5934634208679199},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5274420380592346},{"id":"https://openalex.org/C156407911","wikidata":"https://www.wikidata.org/wiki/Q420160","display_name":"Dynamin","level":4,"score":0.46619266271591187},{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.4405038058757782},{"id":"https://openalex.org/C2779150272","wikidata":"https://www.wikidata.org/wiki/Q1676563","display_name":"JC virus","level":4,"score":0.41321492195129395},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3646671175956726},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.34330153465270996},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.2761082053184509},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.23160403966903687},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0865778923034668}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3390/proceedings2020050073","doi":"https://doi.org/10.3390/proceedings2020050073","is_oa":true,"landing_page_url":"https://doi.org/10.3390/proceedings2020050073","pdf_url":"https://www.mdpi.com/2504-3900/50/1/73/pdf?version=1592356902","source":{"id":"https://openalex.org/S7407096475","display_name":"Viruses Conference: Novel Concepts in Virology","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"conference"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Viruses 2020&amp;mdash;Novel Concepts in Virology","raw_type":"proceedings-article"},{"id":"pmh:oai:doaj.org/article:6158244759f443f0898bffe2011daa93","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6158244759f443f0898bffe2011daa93","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proceedings, Vol 50, Iss 1, p 73 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/proceedings2020050073","doi":"https://doi.org/10.3390/proceedings2020050073","is_oa":true,"landing_page_url":"https://doi.org/10.3390/proceedings2020050073","pdf_url":"https://www.mdpi.com/2504-3900/50/1/73/pdf?version=1592356902","source":{"id":"https://openalex.org/S7407096475","display_name":"Viruses Conference: Novel Concepts in Virology","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"conference"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Viruses 2020&amp;mdash;Novel Concepts in Virology","raw_type":"proceedings-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1080582735","display_name":"Characterization of Viral Receptors and Signaling Networks in JC Polyomavirus Infection","funder_award_id":"R15AI144686","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000891837","display_name":"The Maine Biomedical Research Network (INBRE)","funder_award_id":"P20GM103423","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3034466664.pdf","grobid_xml":"https://content.openalex.org/works/W3034466664.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2116156311","https://openalex.org/W2887466332","https://openalex.org/W2945237626","https://openalex.org/W3216796572","https://openalex.org/W3118802123","https://openalex.org/W2041192078","https://openalex.org/W4309723373","https://openalex.org/W6999149882","https://openalex.org/W4206840526","https://openalex.org/W2784223323"],"abstract_inverted_index":{"JC":[0],"polyomavirus":[1],"(JCPyV)":[2],"causes":[3],"a":[4,187,195],"lifelong":[5],"persistent":[6],"infection":[7,46,93,225],"in":[8,11,26,198,222],"the":[9,12,15,27,55,58,87,95,117,126,168,199,203,217],"kidney":[10],"majority":[13],"of":[14,50,57,102,202,219],"population.":[16],"In":[17,75],"severely":[18],"immunocompromised":[19],"individuals,":[20],"JCPyV":[21,115,130,152,210],"can":[22],"become":[23],"reactivated,":[24],"spread":[25],"central":[28],"nervous":[29],"system,":[30],"and":[31,36,47,94,105,179,212,226],"infect":[32],"glial":[33,51],"cells,":[34],"astrocytes,":[35],"oligodendrocytes":[37],"which":[38,67,129],"are":[39,69,99,181],"necessary":[40],"for":[41,66,183,209,230],"myelin":[42],"production.":[43],"The":[44],"viral":[45,106,161,184,220,224],"cytolytic":[48],"destruction":[49],"cells":[52,137],"leads":[53],"to":[54,77,85,111,122,134],"development":[56],"fatal":[59],"demyelinating":[60],"disease":[61,107],"progressive":[62],"multifocal":[63],"leukoencephalopathy":[64],"(PML),":[65],"there":[68],"currently":[70],"no":[71],"approved":[72],"treatment":[73],"options.":[74],"order":[76],"develop":[78],"effective":[79],"antiviral":[80,231],"therapies,":[81],"it":[82],"is":[83,138,207],"essential":[84],"define":[86],"virus\u2013host":[88],"cell":[89],"interactions":[90,97],"that":[91,98,151,167,206],"drive":[92],"virus\u2013receptor":[96],"major":[100],"regulators":[101],"tissue":[103],"tropism":[104],"outcomes.":[108],"Following":[109],"attachment":[110],"sialic":[112],"acid":[113],"receptors,":[114],"requires":[116],"serotonin":[118],"5-hydroxytryptamine":[119],"(5-HT2)":[120],"receptors":[121,133,156,221],"mediate":[123],"internalization.":[124],"However,":[125],"mechanism":[127],"by":[128],"utilizes":[131],"5-HT2":[132,155,169],"invade":[135],"host":[136],"poorly":[139],"understood.":[140],"Using":[141],"super-resolution":[142],"fluorescence":[143],"photoactivation":[144],"localization":[145],"microscopy":[146],"(FPALM),":[147],"we":[148,164,192],"have":[149,165,193],"determined":[150,166],"localizes":[153],"with":[154,160],"at":[157],"timepoints":[158],"consistent":[159],"entry.":[162],"Furthermore,":[163],"receptor-associated":[170],"scaffolding":[171],"proteins":[172],"beta-arrestin,":[173],"adaptor":[174],"protein":[175],"complex":[176],"2":[177],"(AP2)":[178],"dynamin":[180],"required":[182],"internalization":[185],"through":[186],"clathrin-mediated":[188],"endocytosis":[189],"pathway.":[190],"Additionally,":[191],"identified":[194],"beta-arrestin-binding":[196],"motif":[197],"intracellular":[200],"loop":[201],"5-HT2A":[204],"receptor":[205],"critical":[208],"entry":[211],"infection.":[213],"These":[214],"findings":[215],"highlight":[216],"importance":[218],"regulating":[223],"illuminate":[227],"potential":[228],"targets":[229],"treatment.":[232]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2020-06-19T00:00:00"}
