{"id":"https://openalex.org/W3034328149","doi":"https://doi.org/10.20883/medical.391","title":"A thousand words about the challenges of photodynamic therapy","display_name":"A thousand words about the challenges of photodynamic therapy","publication_year":2019,"publication_date":"2019-11-28","ids":{"openalex":"https://openalex.org/W3034328149","doi":"https://doi.org/10.20883/medical.391","mag":"3034328149"},"language":"en","primary_location":{"id":"doi:10.20883/medical.391","doi":"https://doi.org/10.20883/medical.391","is_oa":true,"landing_page_url":"https://doi.org/10.20883/medical.391","pdf_url":null,"source":{"id":"https://openalex.org/S4210199745","display_name":"Journal of Medical Science","issn_l":"2353-9798","issn":["2353-9798","2353-9801"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["ddh","doaj","jufo-1","poland-20"],"host_organization":"https://openalex.org/P4310319130","host_organization_name":"Iran University of Medical Sciences","host_organization_lineage":["https://openalex.org/P4310319130"],"host_organization_lineage_names":["Iran University of Medical Sciences"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.20883/medical.391","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079636370","display_name":"Jerzy Jankun","orcid":"https://orcid.org/0000-0003-2354-4046","observed_orcids":["https://orcid.org/0000-0003-2354-4046"]},"institutions":[{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jerzy Jankun","raw_affiliation_strings":["Department of Urology, Health Science Campus, The University of Toledo, USA"],"raw_orcid":"https://orcid.org/0000-0003-2354-4046","affiliations":[{"raw_affiliation_string":"Department of Urology, Health Science Campus, The University of Toledo, USA","institution_ids":["https://openalex.org/I90871651"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5079636370"],"corresponding_institution_ids":["https://openalex.org/I90871651"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.31023965,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"88","issue":"3","first_page":"195","last_page":"199"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11306","display_name":"Nonmelanoma Skin Cancer Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/photodynamic-therapy","display_name":"photodynamic therapy","score":1.0},{"id":"https://openalex.org/keywords/photosensitizers","display_name":"photosensitizers","score":0.875},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.7760000228881836},{"id":"https://openalex.org/keywords/light-distribution","display_name":"light distribution","score":0.5070000290870667},{"id":"https://openalex.org/keywords/oxygen-distribution","display_name":"oxygen distribution","score":0.9660000205039978},{"id":"https://openalex.org/keywords/treatment-planning","display_name":"treatment planning","score":0.8859999775886536},{"id":"https://openalex.org/keywords/laser-activation","display_name":"laser activation","score":0.4699999988079071},{"id":"https://openalex.org/keywords/clinical-implementation-barriers","display_name":"clinical implementation barriers","score":0.39100000262260437}],"concepts":[{"id":"https://openalex.org/C2781323092","wikidata":"https://www.wikidata.org/wiki/Q1428072","display_name":"Photodynamic therapy","level":2,"score":0.947009801864624},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.5974443554878235},{"id":"https://openalex.org/C3019816032","wikidata":"https://www.wikidata.org/wiki/Q2575340","display_name":"Cancer treatment","level":3,"score":0.5566763877868652},{"id":"https://openalex.org/C2983331546","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer therapy","level":3,"score":0.520183801651001},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49678948521614075},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.48294609785079956},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4020633101463318},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.38786035776138306},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.14159837365150452},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11516270041465759},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.20883/medical.391","doi":"https://doi.org/10.20883/medical.391","is_oa":true,"landing_page_url":"https://doi.org/10.20883/medical.391","pdf_url":null,"source":{"id":"https://openalex.org/S4210199745","display_name":"Journal of Medical Science","issn_l":"2353-9798","issn":["2353-9798","2353-9801"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["ddh","doaj","jufo-1","poland-20"],"host_organization":"https://openalex.org/P4310319130","host_organization_name":"Iran University of Medical Sciences","host_organization_lineage":["https://openalex.org/P4310319130"],"host_organization_lineage_names":["Iran University of Medical Sciences"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Science","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:3654d8c1c71944c49fc8fba6e9ee663e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3654d8c1c71944c49fc8fba6e9ee663e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Medical Science, Vol 88, Iss 3 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.20883/medical.391","doi":"https://doi.org/10.20883/medical.391","is_oa":true,"landing_page_url":"https://doi.org/10.20883/medical.391","pdf_url":null,"source":{"id":"https://openalex.org/S4210199745","display_name":"Journal of Medical Science","issn_l":"2353-9798","issn":["2353-9798","2353-9801"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["ddh","doaj","jufo-1","poland-20"],"host_organization":"https://openalex.org/P4310319130","host_organization_name":"Iran University of Medical Sciences","host_organization_lineage":["https://openalex.org/P4310319130"],"host_organization_lineage_names":["Iran University of Medical Sciences"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Science","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1543202536","https://openalex.org/W1596848781","https://openalex.org/W1620448903","https://openalex.org/W1784512359","https://openalex.org/W1982913841","https://openalex.org/W1988071018","https://openalex.org/W1998512967","https://openalex.org/W2010875128","https://openalex.org/W2022339623","https://openalex.org/W2029130214","https://openalex.org/W2064862705","https://openalex.org/W2133549869","https://openalex.org/W2188671013","https://openalex.org/W2314113908","https://openalex.org/W2410775491","https://openalex.org/W2417748816","https://openalex.org/W2590269927","https://openalex.org/W2597117278","https://openalex.org/W2745647351","https://openalex.org/W2755032655","https://openalex.org/W2760253305","https://openalex.org/W2778625276","https://openalex.org/W2791625177","https://openalex.org/W2801209298","https://openalex.org/W2807855656","https://openalex.org/W2892517938","https://openalex.org/W2898655969","https://openalex.org/W2922048936"],"related_works":["https://openalex.org/W3178967475","https://openalex.org/W7115062229","https://openalex.org/W7220564600","https://openalex.org/W1987046265","https://openalex.org/W2166393507","https://openalex.org/W2110738019","https://openalex.org/W7223145121","https://openalex.org/W7055434916","https://openalex.org/W3134898736","https://openalex.org/W1608061535"],"abstract_inverted_index":{"The":[0,69],"outbreak":[1],"of":[2,11,25,33,38,43,62,118,147,153,166,189],"interest":[3],"in":[4,110,121,163,182],"photodynamic":[5,190],"therapy":[6,29,57,181,191],"(PDT)":[7],"at":[8],"the":[9,23,34,39,60,66,82,86,104,111,145,167,187],"end":[10],"last":[12],"century":[13],"to":[14,52,155,177,196,198],"treat":[15],"cancer":[16,56],"and":[17,30,81,107,169,194],"other":[18],"diseases":[19],"was":[20],"based":[21],"on":[22,59,160],"promise":[24],"localised":[26],"treatment,":[27],"cheaper":[28],"fast":[31],"ablation":[32],"treated":[35,112],"organ.":[36],"One":[37],"most":[40],"attractive":[41],"features":[42],"PDT":[44,54,124,154],"is":[45,72,95,125],"that":[46,93,130,140],"it":[47,136],"can":[48,131,141],"evade":[49],"cancer\u2019s":[50],"resistance":[51],"photosensitisers.":[53],"for":[55],"depends":[58,158],"absorption":[61],"a":[63,79,96,127],"photosensitiser":[64],"within":[65],"malignant":[67],"tissue.":[68,88],"photosensitising":[70],"drug":[71,84],"then":[73],"activated":[74],"by":[75,134],"light":[76,106],"(usually":[77],"from":[78],"laser)":[80],"active":[83],"destroys":[85],"targeted":[87],"However,":[89],"one":[90],"must":[91],"consider":[92],"this":[94,119,185],"complex":[97,148],"mechanism":[98],"involving":[99],"many":[100],"factors":[101],"such":[102],"as":[103],"diverse":[105],"oxygen":[108],"distribution":[109],"organs,":[113],"which":[114],"has":[115],"mitigated":[116],"application":[117],"technique":[120],"clinical":[122],"practice.":[123],"not":[126],"simple":[128],"treatment":[129,157],"be":[132,142],"done":[133,143],"eyeballing;":[135],"requires":[137],"precise":[138],"planning":[139],"with":[144],"help":[146],"computer":[149],"programs.":[150],"Computer":[151],"simulation":[152],"optimise":[156],"heavily":[159],"intense":[161],"calculations":[162],"all":[164],"steps":[165],"procedure,":[168],"desktop":[170],"computers":[171],"are":[172,192,201],"only":[173],"now":[174],"sufficiently":[175],"powerful":[176],"assist":[178],"physicians":[179],"during":[180],"real-time.":[183],"In":[184],"mini-review,":[186],"challenges":[188],"described,":[193],"possible":[195],"solutions":[197],"overcome":[199],"these":[200],"presented.":[202]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2020-06-19T00:00:00"}
