{"id":"https://openalex.org/W3033969740","doi":"https://doi.org/10.1038/s41598-020-66458-z","title":"The PPAR \u03b1/\u03b3 Agonist Saroglitazar Improves Insulin Resistance and Steatohepatitis in a Diet Induced Animal Model of Nonalcoholic Fatty Liver Disease","display_name":"The PPAR \u03b1/\u03b3 Agonist Saroglitazar Improves Insulin Resistance and Steatohepatitis in a Diet Induced Animal Model of Nonalcoholic Fatty Liver Disease","publication_year":2020,"publication_date":"2020-06-09","ids":{"openalex":"https://openalex.org/W3033969740","doi":"https://doi.org/10.1038/s41598-020-66458-z","mag":"3033969740","pmid":"https://pubmed.ncbi.nlm.nih.gov/32518275","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7283326"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-020-66458-z","doi":"https://doi.org/10.1038/s41598-020-66458-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-020-66458-z","pdf_url":"https://www.nature.com/articles/s41598-020-66458-z.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-020-66458-z.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040452026","display_name":"Divya P. Kumar","orcid":"https://orcid.org/0000-0001-5935-379X","observed_orcids":["https://orcid.org/0000-0001-5935-379X"]},"institutions":[{"id":"https://openalex.org/I126824641","display_name":"JSS Academy of Higher Education and Research","ror":"https://ror.org/013x70191","country_code":"IN","type":"education","lineage":["https://openalex.org/I126824641"]},{"id":"https://openalex.org/I86826812","display_name":"JSS Medical College and Hospital","ror":"https://ror.org/02xf0fd83","country_code":"IN","type":"education","lineage":["https://openalex.org/I86826812"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Divya P. Kumar","raw_affiliation_strings":["Department of Biochemistry, CEMR, JSS Medical College, JSS Academy of Higher Education and Research, Mysore, Karnataka, India. divyapkumar@jssuni.edu.in","Department of Biochemistry, CEMR, JSS Medical College, JSS Academy of Higher Education and Research, Mysore, Karnataka, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, CEMR, JSS Medical College, JSS Academy of Higher Education and Research, Mysore, Karnataka, India. divyapkumar@jssuni.edu.in","institution_ids":["https://openalex.org/I126824641","https://openalex.org/I86826812"]},{"raw_affiliation_string":"Department of Biochemistry, CEMR, JSS Medical College, JSS Academy of Higher Education and Research, Mysore, Karnataka, India","institution_ids":["https://openalex.org/I126824641","https://openalex.org/I86826812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030569322","display_name":"Rebecca Caffrey","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rebecca Caffrey","raw_affiliation_strings":["Sanyal Biotechnology LLC, Norfolk, Virginia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sanyal Biotechnology LLC, Norfolk, Virginia, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076146318","display_name":"Jonathon Marioneaux","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonathon Marioneaux","raw_affiliation_strings":["Sanyal Biotechnology LLC, Norfolk, Virginia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sanyal Biotechnology LLC, Norfolk, Virginia, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021773531","display_name":"Prasanna K. Santhekadur","orcid":"https://orcid.org/0000-0003-3338-375X","observed_orcids":["https://orcid.org/0000-0003-3338-375X"]},"institutions":[{"id":"https://openalex.org/I126824641","display_name":"JSS Academy of Higher Education and Research","ror":"https://ror.org/013x70191","country_code":"IN","type":"education","lineage":["https://openalex.org/I126824641"]},{"id":"https://openalex.org/I86826812","display_name":"JSS Medical College and Hospital","ror":"https://ror.org/02xf0fd83","country_code":"IN","type":"education","lineage":["https://openalex.org/I86826812"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Prasanna K. Santhekadur","raw_affiliation_strings":["Department of Biochemistry, CEMR, JSS Medical College, JSS Academy of Higher Education and Research, Mysore, Karnataka, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, CEMR, JSS Medical College, JSS Academy of Higher Education and Research, Mysore, Karnataka, India","institution_ids":["https://openalex.org/I126824641","https://openalex.org/I86826812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034082652","display_name":"Madhavi Bhat","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Madhavi Bhat","raw_affiliation_strings":["Sanyal Biotechnology LLC, Norfolk, Virginia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sanyal Biotechnology LLC, Norfolk, Virginia, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079688872","display_name":"Cristina Alonso","orcid":"https://orcid.org/0000-0002-2019-678X","observed_orcids":["https://orcid.org/0000-0002-2019-678X"]},"institutions":[{"id":"https://openalex.org/I4210108933","display_name":"OWL (Spain)","ror":"https://ror.org/01wc0pn13","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210108933"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Cristina Alonso","raw_affiliation_strings":["OWL Metabolomics, Derio, Bizkaia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"OWL Metabolomics, Derio, Bizkaia, Spain","institution_ids":["https://openalex.org/I4210108933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072425635","display_name":"Srinivas V. Koduru","orcid":"https://orcid.org/0000-0001-6827-2908","observed_orcids":["https://orcid.org/0000-0001-6827-2908"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Srinivas V. Koduru","raw_affiliation_strings":["Gene Arrays, Entity of Vedic Research, Inc, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Arrays, Entity of Vedic Research, Inc, New York, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Binu Philip","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132663","display_name":"Zydus Lifesciences Limited (India)","ror":"https://ror.org/03ktyvw44","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210132663"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Binu Philip","raw_affiliation_strings":["Zydus Research Centre, Cadila Healthcare Limited, Ahmedabad, Gujarat, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zydus Research Centre, Cadila Healthcare Limited, Ahmedabad, Gujarat, India","institution_ids":["https://openalex.org/I4210132663"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102971102","display_name":"Mukul Rameshchandra Jain","orcid":"https://orcid.org/0000-0001-5730-1435","observed_orcids":["https://orcid.org/0000-0001-5730-1435"]},"institutions":[{"id":"https://openalex.org/I4210132663","display_name":"Zydus Lifesciences Limited (India)","ror":"https://ror.org/03ktyvw44","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210132663"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Mukul R. Jain","raw_affiliation_strings":["Zydus Research Centre, Cadila Healthcare Limited, Ahmedabad, Gujarat, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zydus Research Centre, Cadila Healthcare Limited, Ahmedabad, Gujarat, India","institution_ids":["https://openalex.org/I4210132663"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062135784","display_name":"Suresh R. Giri","orcid":"https://orcid.org/0000-0003-0063-5738","observed_orcids":["https://orcid.org/0000-0003-0063-5738"]},"institutions":[{"id":"https://openalex.org/I4210132663","display_name":"Zydus Lifesciences Limited (India)","ror":"https://ror.org/03ktyvw44","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210132663"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Suresh R. Giri","raw_affiliation_strings":["Zydus Research Centre, Cadila Healthcare Limited, Ahmedabad, Gujarat, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zydus Research Centre, Cadila Healthcare Limited, Ahmedabad, Gujarat, India","institution_ids":["https://openalex.org/I4210132663"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038609111","display_name":"Pierre B\u00e9dossa","orcid":"https://orcid.org/0000-0002-8487-7322","observed_orcids":["https://orcid.org/0000-0002-8487-7322"]},"institutions":[{"id":"https://openalex.org/I2799502834","display_name":"H\u00f4pital Beaujon","ror":"https://ror.org/03jyzk483","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I2799502834","https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4387154366","display_name":"Universit\u00e9 Paris Diderot","ror":"https://ror.org/02n7qrg46","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387154366"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pierre Bedossa","raw_affiliation_strings":["Department of Pathology, Hospital Beaujon, University Paris-Diderot, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Hospital Beaujon, University Paris-Diderot, Paris, France","institution_ids":["https://openalex.org/I2799502834","https://openalex.org/I4387154366"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070639714","display_name":"Arun Jayant Sanyal","orcid":"https://orcid.org/0000-0001-8682-5748","observed_orcids":["https://orcid.org/0000-0001-8682-5748"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Arun J. Sanyal","raw_affiliation_strings":["Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University, Richmond, Virginia, USA. arun.sanyal@vcuhealth.org","Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University, Richmond, Virginia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University, Richmond, Virginia, USA. arun.sanyal@vcuhealth.org","institution_ids":["https://openalex.org/I184840846"]},{"raw_affiliation_string":"Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University, Richmond, Virginia, USA","institution_ids":["https://openalex.org/I184840846"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5040452026","https://openalex.org/A5070639714"],"corresponding_institution_ids":["https://openalex.org/I126824641","https://openalex.org/I184840846","https://openalex.org/I86826812"],"apc_list":{"value":1870,"currency":"USD","value_usd":1870},"apc_paid":{"value":1870,"currency":"USD","value_usd":1870},"fwci":13.7957,"has_fulltext":true,"cited_by_count":116,"citation_normalized_percentile":{"value":0.99424731,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"10","issue":"1","first_page":"9330","last_page":"9330"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/saroglitazar","display_name":"saroglitazar","score":1.0},{"id":"https://openalex.org/keywords/ppar-alpha-gamma-agonist","display_name":"PPAR alpha/gamma agonist","score":0.8330000042915344},{"id":"https://openalex.org/keywords/non-alcoholic-steatohepatitis","display_name":"nonalcoholic steatohepatitis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.9359999895095825},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9940000176429749},{"id":"https://openalex.org/keywords/high-fat-western-diet","display_name":"high-fat Western diet","score":0.7009999752044678},{"id":"https://openalex.org/keywords/pioglitazone","display_name":"pioglitazone","score":0.9629999995231628},{"id":"https://openalex.org/keywords/hepatic-steatosis","display_name":"hepatic steatosis","score":0.9340000152587891},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.8130000233650208},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8240000009536743},{"id":"https://openalex.org/keywords/unfolded-protein-response","display_name":"unfolded protein response","score":0.9929999709129333},{"id":"https://openalex.org/keywords/lipidomics","display_name":"lipidomics","score":0.7059999704360962},{"id":"https://openalex.org/keywords/sphingomyelin","display_name":"sphingomyelin","score":0.7680000066757202},{"id":"https://openalex.org/keywords/ceramide","display_name":"ceramide","score":0.9300000071525574},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.5109999775886536}],"concepts":[{"id":"https://openalex.org/C2778384471","wikidata":"https://www.wikidata.org/wiki/Q417765","display_name":"Pioglitazone","level":4,"score":0.7462679147720337},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.6123719215393066},{"id":"https://openalex.org/C2776954865","wikidata":"https://www.wikidata.org/wiki/Q1546498","display_name":"Nonalcoholic fatty liver disease","level":4,"score":0.5817911624908447},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5631996393203735},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5549229979515076},{"id":"https://openalex.org/C2776175330","wikidata":"https://www.wikidata.org/wiki/Q1365091","display_name":"Steatosis","level":2,"score":0.5314452052116394},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4109753668308258},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4080088436603546},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36084771156311035},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.3230982720851898},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.3088718056678772},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.2611314058303833},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.24027985334396362},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.08039268851280212}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D010666","descriptor_name":"Phenylpropionates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010666","descriptor_name":"Phenylpropionates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011758","descriptor_name":"Pyrroles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011758","descriptor_name":"Pyrroles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047493","descriptor_name":"PPAR alpha","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D050171","descriptor_name":"Dyslipidemias","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D059865","descriptor_name":"Endoplasmic Reticulum Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D065626","descriptor_name":"Non-alcoholic Fatty Liver Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D065626","descriptor_name":"Non-alcoholic Fatty Liver Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D065626","descriptor_name":"Non-alcoholic Fatty Liver Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D065626","descriptor_name":"Non-alcoholic Fatty Liver Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41598-020-66458-z","doi":"https://doi.org/10.1038/s41598-020-66458-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-020-66458-z","pdf_url":"https://www.nature.com/articles/s41598-020-66458-z.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7283326","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7283326","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:32518275","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32518275","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:d45c25c827cc43f29d734da65c99d76f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d45c25c827cc43f29d734da65c99d76f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-020-66458-z","doi":"https://doi.org/10.1038/s41598-020-66458-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-020-66458-z","pdf_url":"https://www.nature.com/articles/s41598-020-66458-z.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3033969740.pdf","grobid_xml":"https://content.openalex.org/works/W3033969740.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1598608016","https://openalex.org/W1856151485","https://openalex.org/W1868475579","https://openalex.org/W1972175299","https://openalex.org/W1979820286","https://openalex.org/W1984180526","https://openalex.org/W1988457908","https://openalex.org/W1996715170","https://openalex.org/W1998675312","https://openalex.org/W2002349285","https://openalex.org/W2003979065","https://openalex.org/W2060049330","https://openalex.org/W2061363337","https://openalex.org/W2062812115","https://openalex.org/W2073695538","https://openalex.org/W2076204761","https://openalex.org/W2082702559","https://openalex.org/W2082761367","https://openalex.org/W2086066803","https://openalex.org/W2102061487","https://openalex.org/W2127161077","https://openalex.org/W2128057304","https://openalex.org/W2144259092","https://openalex.org/W2151713218","https://openalex.org/W2162051951","https://openalex.org/W2163484250","https://openalex.org/W2164118055","https://openalex.org/W2253552256","https://openalex.org/W2289624028","https://openalex.org/W2415876542","https://openalex.org/W2481177375","https://openalex.org/W2558996269","https://openalex.org/W2581693313","https://openalex.org/W2588037944","https://openalex.org/W2607399164","https://openalex.org/W2735464323","https://openalex.org/W2744982526","https://openalex.org/W2768977224","https://openalex.org/W2771222944","https://openalex.org/W2779339038","https://openalex.org/W2799667792","https://openalex.org/W2800636005","https://openalex.org/W2805990623","https://openalex.org/W2810166530","https://openalex.org/W2810423511","https://openalex.org/W2896985838","https://openalex.org/W2899985735","https://openalex.org/W2901944682","https://openalex.org/W2903951077","https://openalex.org/W2910830636","https://openalex.org/W2911972126","https://openalex.org/W2934946727","https://openalex.org/W2951346714","https://openalex.org/W2953485865","https://openalex.org/W2991033511"],"related_works":["https://openalex.org/W2768977224","https://openalex.org/W3204151388","https://openalex.org/W3112075036","https://openalex.org/W3149930516","https://openalex.org/W3096860088","https://openalex.org/W4387734719","https://openalex.org/W7128959562","https://openalex.org/W4403332333","https://openalex.org/W4389507444","https://openalex.org/W4394680716"],"abstract_inverted_index":{"Insulin":[0],"resistance":[1],"and":[2,38,47,89,105,114,139,146,156,172],"hepatic":[3],"lipid":[4],"accumulation":[5],"constitute":[6],"the":[7,16,28,185],"metabolic":[8],"underpinning":[9],"of":[10,32,187],"nonalcoholic":[11],"steatohepatitis":[12],"(NASH).":[13],"We":[14],"tested":[15],"hypothesis":[17],"that":[18,165],"saroglitazar,":[19],"a":[20,178],"PPAR":[21],"\u03b1/\u03b3":[22],"agonist":[23],"would":[24],"improve":[25],"NASH":[26,117,188],"in":[27,119,189],"diet-induced":[29],"animal":[30],"model":[31],"NAFLD.":[33],"Mice":[34],"received":[35],"chow":[36],"diet":[37,46],"normal":[39],"water":[40,51],"(CDNW)":[41],"or":[42,74,130],"high":[43],"fat":[44],"western":[45],"ad":[48],"lib":[49],"sugar":[50],"(WDSW).":[52],"After":[53],"12":[54,82],"weeks,":[55],"WDSW":[56,64,67,71,76,88,94],"fed":[57],"mice":[58,86,92,121],"were":[59,126],"randomized":[60],"to":[61,85,132],"receive":[62],"(1)":[63],"alone,":[65],"(2)":[66],"+":[68,72,77,95],"vehicle,":[69],"(3)":[70],"pioglitazone":[73],"(4)":[75],"saroglitazar":[78,96,166,183],"for":[79,181,184],"an":[80,157],"additional":[81],"weeks.":[83],"Compared":[84],"on":[87],"vehicle":[90],"controls,":[91],"receiving":[93,122],"had":[97],"lower":[98,100],"weight,":[99],"HOMA-IR,":[101],"triglycerides,":[102,169],"total":[103],"cholesterol,":[104],"ALT.":[106],"Saroglitazar":[107],"improved":[108],"steatosis,":[109],"lobular":[110],"inflammation,":[111],"hepatocellular":[112],"ballooning":[113],"fibrosis":[115],"stage.":[116],"resolved":[118],"all":[120],"saroglitazar.":[123,161],"These":[124,174],"effects":[125],"at":[127],"par":[128],"with":[129,160],"superior":[131],"pioglitazone.":[133],"Molecular":[134],"analyses":[135,163],"confirmed":[136,152],"target":[137],"engagement":[138],"reduced":[140,168],"oxidative":[141],"stress,":[142],"unfolded":[143],"protein":[144],"response":[145],"fibrogenic":[147],"signaling.":[148],"Transcriptomic":[149],"analysis":[150],"further":[151],"increased":[153],"PPAR-target":[154],"expression":[155],"anti-inflammatory":[158],"effect":[159],"Lipidomic":[162],"demonstrated":[164],"also":[167],"diglycerides,":[170],"sphingomyelins":[171],"ceramides.":[173],"preclinical":[175],"data":[176],"provide":[177],"strong":[179],"rationale":[180],"developing":[182],"treatment":[186],"humans.":[190]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":24},{"year":2023,"cited_by_count":29},{"year":2022,"cited_by_count":21},{"year":2021,"cited_by_count":23},{"year":2020,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-06-12T00:00:00"}
