{"id":"https://openalex.org/W3033847663","doi":null,"title":"Monocyte SIRT7 and Cytokine Expression in Alcoholic Hepatitis","display_name":"Monocyte SIRT7 and Cytokine Expression in Alcoholic Hepatitis","publication_year":2019,"publication_date":"2019-05-31","ids":{"openalex":"https://openalex.org/W3033847663","mag":"3033847663"},"language":"en","primary_location":{"id":"pmh:oai:kuscholarworks.ku.edu:1808/30124","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1808/30124","pdf_url":"http://hdl.handle.net/1808/30124","source":{"id":"https://openalex.org/S4306400421","display_name":"KU ScholarWorks (The University of Kansas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I146416000","host_organization_name":"University of Kansas","host_organization_lineage":["https://openalex.org/I146416000"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/1808/30124","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003339828","display_name":"Jordan K. Voss","orcid":"https://orcid.org/0000-0001-5229-4811","observed_orcids":["https://orcid.org/0000-0001-5229-4811"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jordan K. Voss","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5229-4811","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5003339828"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-alcoholic-hepatitis","display_name":"acute alcoholic hepatitis","score":0.9800000190734863},{"id":"https://openalex.org/keywords/sirt7","display_name":"SIRT7","score":0.996999979019165},{"id":"https://openalex.org/keywords/peripheral-blood-monocytes","display_name":"peripheral blood monocytes","score":0.8830000162124634},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9729999899864197},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.9240000247955322},{"id":"https://openalex.org/keywords/lipopolysaccharide-stimulation","display_name":"lipopolysaccharide stimulation","score":0.9110000133514404},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.7049999833106995},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9120000004768372},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.8709999918937683},{"id":"https://openalex.org/keywords/icam-1","display_name":"ICAM-1","score":0.878000020980835},{"id":"https://openalex.org/keywords/meld-score","display_name":"MELD score","score":0.8500000238418579},{"id":"https://openalex.org/keywords/maddrey-discriminant-function","display_name":"Maddrey discriminant function","score":0.8640000224113464},{"id":"https://openalex.org/keywords/alcohol-induced-liver-injury","display_name":"alcohol-induced liver injury","score":0.5839999914169312},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.7590000033378601}],"concepts":[{"id":"https://openalex.org/C2780732942","wikidata":"https://www.wikidata.org/wiki/Q3144986","display_name":"Alcoholic hepatitis","level":4,"score":0.517535388469696},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.48849165439605713},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4340866506099701},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.4129330515861511},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39257127046585083},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3759429454803467},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32745361328125},{"id":"https://openalex.org/C2777575235","wikidata":"https://www.wikidata.org/wiki/Q558404","display_name":"Alcoholic liver disease","level":3,"score":0.21389225125312805},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.17135539650917053},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1461775302886963},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:kuscholarworks.ku.edu:1808/30124","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1808/30124","pdf_url":"http://hdl.handle.net/1808/30124","source":{"id":"https://openalex.org/S4306400421","display_name":"KU ScholarWorks (The University of Kansas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I146416000","host_organization_name":"University of Kansas","host_organization_lineage":["https://openalex.org/I146416000"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:3033847663","doi":null,"is_oa":false,"landing_page_url":"https://kuscholarworks.ku.edu/handle/1808/30124","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:kuscholarworks.ku.edu:1808/30124","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1808/30124","pdf_url":"http://hdl.handle.net/1808/30124","source":{"id":"https://openalex.org/S4306400421","display_name":"KU ScholarWorks (The University of Kansas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I146416000","host_organization_name":"University of Kansas","host_organization_lineage":["https://openalex.org/I146416000"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G9000911979","display_name":"NRSA Training Core","funder_award_id":"TL1TR002368","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334384","display_name":"Frontiers Clinical and Translational Science Institute, University of Kansas","ror":null},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3033847663.pdf","grobid_xml":"https://content.openalex.org/works/W3033847663.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W37946941","https://openalex.org/W1126279254","https://openalex.org/W1481524796","https://openalex.org/W1537399027","https://openalex.org/W1846476752","https://openalex.org/W1977661660","https://openalex.org/W1981775300","https://openalex.org/W2006187783","https://openalex.org/W2018630692","https://openalex.org/W2053542703","https://openalex.org/W2059724105","https://openalex.org/W2079185589","https://openalex.org/W2083367491","https://openalex.org/W2101198806","https://openalex.org/W2104608657","https://openalex.org/W2127300984","https://openalex.org/W2128372435","https://openalex.org/W2128652580","https://openalex.org/W2135155547","https://openalex.org/W2135757563","https://openalex.org/W2153848855","https://openalex.org/W2235911259","https://openalex.org/W2254967598","https://openalex.org/W2286042547","https://openalex.org/W2319056744","https://openalex.org/W2416525049","https://openalex.org/W2419661615","https://openalex.org/W2461417384","https://openalex.org/W2464189667","https://openalex.org/W2514764389","https://openalex.org/W2526726708","https://openalex.org/W2547429997","https://openalex.org/W2767706304","https://openalex.org/W2805498115","https://openalex.org/W2809675996","https://openalex.org/W2910227631","https://openalex.org/W2911082440"],"related_works":["https://openalex.org/W4405930890","https://openalex.org/W2983135024","https://openalex.org/W2340575324","https://openalex.org/W2887917093","https://openalex.org/W2611657958","https://openalex.org/W2005670014","https://openalex.org/W2327148116","https://openalex.org/W2000715885","https://openalex.org/W2142263586","https://openalex.org/W1963530722"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Acute":[2],"alcoholic":[3,11,61,79],"hepatitis":[4],"(AH)":[5],"is":[6,26,51,242,251],"a":[7,32],"distinct":[8],"form":[9],"of":[10,34,40,68,84,126,164,266,296,298],"liver":[12,192],"disease":[13,193],"characterized":[14],"by":[15,28],"acute":[16,41,60,106,149,208,300],"jaundice":[17],"and":[18,20,46,70,96,119,121,129,151,155,170,180,196,231,317],"hepatic":[19],"systemic":[21],"inflammation.":[22],"Heavy":[23],"alcohol":[24],"consumption":[25],"well-tolerated":[27],"most":[29],"individuals.":[30],"Only":[31],"minority":[33],"heavy":[35],"drinkers":[36,228],"experience":[37],"an":[38],"episode":[39],"AH.":[42,139,301],"Variation":[43],"in":[44,59,74,78,100,103,133,217],"resident":[45],"infiltrating":[47],"macrophage":[48],"immune":[49],"response":[50,99],"believed":[52],"to":[53,123,275],"underly":[54],"the":[55,66,91,110],"variable":[56],"penetrance":[57],"observed":[58],"hepatitis.":[62,80],"Here":[63],"we":[64],"examine":[65],"relationship":[67,92],"SIRT7":[69,179,219,240,249,267,303,316],"inflammatory":[71,97,115,130],"cytokine":[72,98,116,131,181],"expression":[73,117,132,163,182,220,241,246,250,305],"peripheral":[75],"blood":[76,142],"monocytes":[77,102,143],"Objectives:":[81],"The":[82],"objectives":[83],"this":[85],"study":[86],"were":[87,144,156,172,184,210,268],"to:":[88],"1)":[89],"determine":[90],"between":[93,112],"p-FOXO3,":[94,127],"SIRT7,":[95,128,165],"circulating":[101],"patients":[104,134,147,222,233,237,273],"with":[105,148,158,188,207,223,238,244,254],"AH;":[107],"2)":[108],"assess":[109],"association":[111],"clinical":[113,311],"outcomes,":[114],"levels,":[118],"SIRT7;":[120],"3)":[122],"compare":[124],"levels":[125,265,320],"at":[135,277],"varying":[136],"risk":[137,279,286,293],"for":[138,186,190],"Methods:":[140],"Peripheral":[141],"isolated":[145],"from":[146],"AH":[150,209],"various":[152],"control":[153],"groups":[154],"treated":[157],"100ng/mL":[159],"lipopolysaccharide":[160],"(LPS).":[161],"Relative":[162],"TNF\u03b1,":[166,255],"IL-6,":[167],"IL-10,":[168],"ICAM1,":[169,257],"CCL2":[171,245],"measured":[173],"using":[174],"reverse":[175],"transcriptase":[176],"real-time":[177],"PCR.":[178],"data":[183],"assessed":[185],"correlation":[187],"model":[189],"end-stage":[191],"(MELD)":[194],"score":[195],"Maddrey":[197],"Discriminant":[198],"Function":[199],"(MDF)":[200],"score.":[201,263],"Results:":[202],"Ninety-nine":[203],"subjects,":[204],"including":[205],"22":[206],"enrolled.":[211],"There":[212],"was":[213],"no":[214],"significant":[215],"difference":[216],"LPS-stimulated":[218,264],"among":[221,272],"AH,":[224,239],"healthy":[225,227,283],"controls,":[226],"(alcohol":[229],"control),":[230],"sepsis":[232],"(inflammatory":[234],"control).":[235],"In":[236],"correlated":[243,253],"(R=0.689,":[247],"P=0.0004).":[248],"not":[252,269,307],"IL6,":[256],"IL10,":[258],"MELD":[259],"score,":[260],"or":[261,291,310],"MDF":[262],"significantly":[270],"different":[271],"hypothesized":[274],"be":[276],"low":[278],"(healthy":[280],"controls":[281],"&":[282,288],"drinkers),":[284],"medium":[285],"(alcoholic":[287],"non-alcoholic":[289],"cirrhosis),":[290],"high":[292],"(previous":[294],"history":[295],"AH)":[297],"developing":[299],"Conclusions:":[302],"mRNA":[304],"does":[306],"reflect":[308],"monocyte":[309],"phenotype.":[312],"Further":[313],"studies":[314],"assessing":[315],"FOXO3":[318],"protein":[319],"are":[321],"needed.":[322]},"counts_by_year":[],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2020-06-12T00:00:00"}
