{"id":"https://openalex.org/W3033765486","doi":"https://doi.org/10.1111/mec.15503","title":"Evolutionary trade\u2010offs of insecticide resistance \u2014 The fitness costs associated with target\u2010site mutations in the nAChR of Drosophila melanogaster","display_name":"Evolutionary trade\u2010offs of insecticide resistance \u2014 The fitness costs associated with target\u2010site mutations in the nAChR of Drosophila melanogaster","publication_year":2020,"publication_date":"2020-06-08","ids":{"openalex":"https://openalex.org/W3033765486","doi":"https://doi.org/10.1111/mec.15503","mag":"3033765486","pmid":"https://pubmed.ncbi.nlm.nih.gov/32510730","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7496652"},"language":"en","primary_location":{"id":"doi:10.1111/mec.15503","doi":"https://doi.org/10.1111/mec.15503","is_oa":true,"landing_page_url":"https://doi.org/10.1111/mec.15503","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/mec.15503","source":{"id":"https://openalex.org/S22454499","display_name":"Molecular Ecology","issn_l":"0962-1083","issn":["0962-1083","1365-294X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Ecology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W3033765486"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/mec.15503","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012084185","display_name":"Rafael A. Homem","orcid":"https://orcid.org/0000-0001-9649-1825","observed_orcids":["https://orcid.org/0000-0001-9649-1825"]},"institutions":[{"id":"https://openalex.org/I2799553609","display_name":"Rothamsted Research","ror":"https://ror.org/0347fy350","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2799553609","https://openalex.org/I2799693246","https://openalex.org/I4210087105"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Rafael A. Homem","raw_affiliation_strings":["Rothamsted Research, Biointeractions and Crop Protection Department, Harpenden, Hertfordshire, UK"],"raw_orcid":"https://orcid.org/0000-0001-9649-1825","affiliations":[{"raw_affiliation_string":"Rothamsted Research, Biointeractions and Crop Protection Department, Harpenden, Hertfordshire, UK","institution_ids":["https://openalex.org/I2799553609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015736340","display_name":"Bliss Buttery","orcid":"https://orcid.org/0000-0003-0911-9852","observed_orcids":["https://orcid.org/0000-0003-0911-9852"]},"institutions":[{"id":"https://openalex.org/I2799553609","display_name":"Rothamsted Research","ror":"https://ror.org/0347fy350","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2799553609","https://openalex.org/I2799693246","https://openalex.org/I4210087105"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Bliss Buttery","raw_affiliation_strings":["Rothamsted Research, Biointeractions and Crop Protection Department, Harpenden, Hertfordshire, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rothamsted Research, Biointeractions and Crop Protection Department, Harpenden, Hertfordshire, UK","institution_ids":["https://openalex.org/I2799553609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062911842","display_name":"Ewan Richardson","orcid":"https://orcid.org/0000-0002-9937-4197","observed_orcids":["https://orcid.org/0000-0002-9937-4197"]},"institutions":[{"id":"https://openalex.org/I2799553609","display_name":"Rothamsted Research","ror":"https://ror.org/0347fy350","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2799553609","https://openalex.org/I2799693246","https://openalex.org/I4210087105"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ewan Richardson","raw_affiliation_strings":["Rothamsted Research, Biointeractions and Crop Protection Department, Harpenden, Hertfordshire, UK"],"raw_orcid":"https://orcid.org/0000-0002-9937-4197","affiliations":[{"raw_affiliation_string":"Rothamsted Research, Biointeractions and Crop Protection Department, Harpenden, Hertfordshire, UK","institution_ids":["https://openalex.org/I2799553609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101667259","display_name":"Yao Tan","orcid":"https://orcid.org/0000-0002-8450-9888","observed_orcids":["https://orcid.org/0000-0002-8450-9888"]},"institutions":[{"id":"https://openalex.org/I120379545","display_name":"Inner Mongolia Agricultural University","ror":"https://ror.org/015d0jq83","country_code":"CN","type":"education","lineage":["https://openalex.org/I120379545"]},{"id":"https://openalex.org/I2799553609","display_name":"Rothamsted Research","ror":"https://ror.org/0347fy350","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2799553609","https://openalex.org/I2799693246","https://openalex.org/I4210087105"]}],"countries":["CN","GB"],"is_corresponding":false,"raw_author_name":"Yao Tan","raw_affiliation_strings":["Research Centre for Grassland Entomology, Inner Mongolian Agricultural University, Hohhot, China","Rothamsted Research, Biointeractions and Crop Protection Department, Harpenden, Hertfordshire, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Centre for Grassland Entomology, Inner Mongolian Agricultural University, Hohhot, China","institution_ids":["https://openalex.org/I120379545"]},{"raw_affiliation_string":"Rothamsted Research, Biointeractions and Crop Protection Department, Harpenden, Hertfordshire, UK","institution_ids":["https://openalex.org/I2799553609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063915590","display_name":"L. M. Field","orcid":"https://orcid.org/0000-0002-3328-2513","observed_orcids":["https://orcid.org/0000-0002-3328-2513"]},"institutions":[{"id":"https://openalex.org/I2799553609","display_name":"Rothamsted Research","ror":"https://ror.org/0347fy350","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2799553609","https://openalex.org/I2799693246","https://openalex.org/I4210087105"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Linda M. Field","raw_affiliation_strings":["Rothamsted Research, Biointeractions and Crop Protection Department, Harpenden, Hertfordshire, UK"],"raw_orcid":"https://orcid.org/0000-0002-3328-2513","affiliations":[{"raw_affiliation_string":"Rothamsted Research, Biointeractions and Crop Protection Department, Harpenden, Hertfordshire, UK","institution_ids":["https://openalex.org/I2799553609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081784352","display_name":"Martin S. Williamson","orcid":"https://orcid.org/0000-0002-4089-3670","observed_orcids":["https://orcid.org/0000-0002-4089-3670"]},"institutions":[{"id":"https://openalex.org/I2799553609","display_name":"Rothamsted Research","ror":"https://ror.org/0347fy350","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2799553609","https://openalex.org/I2799693246","https://openalex.org/I4210087105"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Martin S. Williamson","raw_affiliation_strings":["Rothamsted Research, Biointeractions and Crop Protection Department, Harpenden, Hertfordshire, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rothamsted Research, Biointeractions and Crop Protection Department, Harpenden, Hertfordshire, UK","institution_ids":["https://openalex.org/I2799553609"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067558533","display_name":"T. G. E. Davies","orcid":"https://orcid.org/0000-0002-9452-2947","observed_orcids":["https://orcid.org/0000-0002-9452-2947"]},"institutions":[{"id":"https://openalex.org/I2799553609","display_name":"Rothamsted Research","ror":"https://ror.org/0347fy350","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2799553609","https://openalex.org/I2799693246","https://openalex.org/I4210087105"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"T. G. Emyr Davies","raw_affiliation_strings":["Rothamsted Research, Biointeractions and Crop Protection Department, Harpenden, Hertfordshire, UK"],"raw_orcid":"https://orcid.org/0000-0002-9452-2947","affiliations":[{"raw_affiliation_string":"Rothamsted Research, Biointeractions and Crop Protection Department, Harpenden, Hertfordshire, UK","institution_ids":["https://openalex.org/I2799553609"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5012084185","https://openalex.org/A5067558533"],"corresponding_institution_ids":["https://openalex.org/I2799553609"],"apc_list":{"value":4250,"currency":"USD","value_usd":4250},"apc_paid":{"value":4250,"currency":"USD","value_usd":4250},"fwci":3.2159,"has_fulltext":true,"cited_by_count":86,"citation_normalized_percentile":{"value":0.94026735,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"29","issue":"14","first_page":"2661","last_page":"2675"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11075","display_name":"Insect Resistance and Genetics","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11075","display_name":"Insect Resistance and Genetics","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11641","display_name":"Insect and Pesticide Research","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insecticide-resistance","display_name":"insecticide resistance","score":0.9480000138282776},{"id":"https://openalex.org/keywords/neonicotinoids","display_name":"neonicotinoids","score":0.9259999990463257},{"id":"https://openalex.org/keywords/nicotinic-acetylcholine-receptors","display_name":"nicotinic acetylcholine receptors","score":0.9789999723434448},{"id":"https://openalex.org/keywords/target-site-mutations","display_name":"target-site mutations","score":0.8610000014305115},{"id":"https://openalex.org/keywords/fitness-cost","display_name":"fitness cost","score":0.7400000095367432},{"id":"https://openalex.org/keywords/drosophila-melanogaster","display_name":"Drosophila melanogaster","score":0.9169999957084656},{"id":"https://openalex.org/keywords/crispr-cas9-mutagenesis","display_name":"CRISPR/Cas9 mutagenesis","score":0.8809999823570251},{"id":"https://openalex.org/keywords/spinosyns","display_name":"spinosyns","score":0.8339999914169312},{"id":"https://openalex.org/keywords/evolutionary-trade-offs","display_name":"evolutionary trade-offs","score":0.6359999775886536}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8886138200759888},{"id":"https://openalex.org/C2777500947","wikidata":"https://www.wikidata.org/wiki/Q902225","display_name":"Neonicotinoid","level":4,"score":0.8440847396850586},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.7335699796676636},{"id":"https://openalex.org/C2779570518","wikidata":"https://www.wikidata.org/wiki/Q412256","display_name":"Nicotinic acetylcholine receptor","level":4,"score":0.6791703701019287},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.645508885383606},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.47031843662261963},{"id":"https://openalex.org/C2776784398","wikidata":"https://www.wikidata.org/wiki/Q420098","display_name":"Imidacloprid","level":3,"score":0.4327215552330017},{"id":"https://openalex.org/C188987157","wikidata":"https://www.wikidata.org/wiki/Q7030581","display_name":"Nicotinic agonist","level":3,"score":0.3931167721748352},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.3233761489391327},{"id":"https://openalex.org/C161176658","wikidata":"https://www.wikidata.org/wiki/Q131656","display_name":"Pesticide","level":2,"score":0.22655460238456726},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.194204181432724},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.15873008966445923},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09264558553695679}],"mesh":[{"descriptor_ui":"D000073943","descriptor_name":"Neonicotinoids","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007305","descriptor_name":"Insecticide Resistance","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007306","descriptor_name":"Insecticides","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011978","descriptor_name":"Receptors, Nicotinic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D056084","descriptor_name":"Genetic Fitness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1111/mec.15503","doi":"https://doi.org/10.1111/mec.15503","is_oa":true,"landing_page_url":"https://doi.org/10.1111/mec.15503","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/mec.15503","source":{"id":"https://openalex.org/S22454499","display_name":"Molecular Ecology","issn_l":"0962-1083","issn":["0962-1083","1365-294X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Ecology","raw_type":"journal-article"},{"id":"pmid:32510730","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32510730","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular ecology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7496652","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7496652/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Ecol","raw_type":"Text"},{"id":"pmh:oai:repository.rothamsted.ac.uk:29633","doi":null,"is_oa":true,"landing_page_url":"https://repository.rothamsted.ac.uk/id/eprint/29633/","pdf_url":"https://repository.rothamsted.ac.uk/id/eprint/29633/1/mec.15503.pdf","source":{"id":"https://openalex.org/S4306402645","display_name":"Rothamsted Repository (Rothamsted Repository)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2799553609","host_organization_name":"Rothamsted Research","host_organization_lineage":["https://openalex.org/I2799553609"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:repository.rothamsted.ac.uk:97v1z","doi":null,"is_oa":false,"landing_page_url":"https://doi.org/10.1111/mec.15503","pdf_url":null,"source":{"id":"https://openalex.org/S4306402645","display_name":"Rothamsted Repository (Rothamsted Repository)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2799553609","host_organization_name":"Rothamsted Research","host_organization_lineage":["https://openalex.org/I2799553609"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1111/mec.15503","doi":"https://doi.org/10.1111/mec.15503","is_oa":true,"landing_page_url":"https://doi.org/10.1111/mec.15503","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/mec.15503","source":{"id":"https://openalex.org/S22454499","display_name":"Molecular Ecology","issn_l":"0962-1083","issn":["0962-1083","1365-294X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Ecology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Zero hunger","score":0.5365999937057495,"id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1319691494","display_name":"Investigation and characterisation of diamide insecticide resistance conferred by target-site mutations in the ryanodine receptor of lepidopteran pest","funder_award_id":"1653661","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G8294655365","display_name":"BBSRC Strategic Programme in Smart Crop Protection","funder_award_id":"BBS/OS/CP/000001","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320332735","display_name":"Bayer CropScience","ror":"https://ror.org/04hmn8g73"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3033765486.pdf","grobid_xml":"https://content.openalex.org/works/W3033765486.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W124133982","https://openalex.org/W613851713","https://openalex.org/W1524000563","https://openalex.org/W1598032040","https://openalex.org/W1927744746","https://openalex.org/W1964662732","https://openalex.org/W1988320485","https://openalex.org/W1992909979","https://openalex.org/W1995716106","https://openalex.org/W1998356880","https://openalex.org/W1999588263","https://openalex.org/W2020042478","https://openalex.org/W2022364385","https://openalex.org/W2027235988","https://openalex.org/W2030346470","https://openalex.org/W2031549807","https://openalex.org/W2040264716","https://openalex.org/W2047795241","https://openalex.org/W2063558597","https://openalex.org/W2065915778","https://openalex.org/W2067298118","https://openalex.org/W2075868368","https://openalex.org/W2077894786","https://openalex.org/W2086834159","https://openalex.org/W2091677407","https://openalex.org/W2111679716","https://openalex.org/W2112444085","https://openalex.org/W2126624677","https://openalex.org/W2135370889","https://openalex.org/W2135563396","https://openalex.org/W2136437080","https://openalex.org/W2142553004","https://openalex.org/W2149936423","https://openalex.org/W2162785377","https://openalex.org/W2163961572","https://openalex.org/W2178265743","https://openalex.org/W2180613448","https://openalex.org/W2186045438","https://openalex.org/W2229990037","https://openalex.org/W2258866379","https://openalex.org/W2271935749","https://openalex.org/W2285807817","https://openalex.org/W2343195612","https://openalex.org/W2402498701","https://openalex.org/W2493642512","https://openalex.org/W2537685223","https://openalex.org/W2554509660","https://openalex.org/W2560653535","https://openalex.org/W2568328160","https://openalex.org/W2609118107","https://openalex.org/W2617440950","https://openalex.org/W2741981309","https://openalex.org/W2759657994","https://openalex.org/W2783926023","https://openalex.org/W2797981751","https://openalex.org/W2801539719","https://openalex.org/W2803371852","https://openalex.org/W2891748480","https://openalex.org/W2900335747","https://openalex.org/W2937747363","https://openalex.org/W7067607097"],"related_works":["https://openalex.org/W4280652065","https://openalex.org/W2019403855","https://openalex.org/W2033754951","https://openalex.org/W4391960189","https://openalex.org/W2343195612","https://openalex.org/W2051535311","https://openalex.org/W7119498978","https://openalex.org/W3022781942","https://openalex.org/W2767075862"],"abstract_inverted_index":{"The":[0],"evolution":[1],"of":[2,37,65,76,105,132,140,149],"resistance":[3,42,80],"to":[4,12,24,46,55,82,92,97,116,146],"drugs":[5],"and":[6,15,35,81],"pesticides":[7],"poses":[8],"a":[9,121,130],"major":[10],"threat":[11],"human":[13],"health":[14],"food":[16],"security.":[17],"Neonicotinoids":[18],"are":[19],"highly":[20],"effective":[21],"insecticides":[22,150],"used":[23,96],"control":[25],"agricultural":[26],"pests.":[27],"They":[28],"target":[29,138],"the":[30,38,66,74,103,133,137],"insect":[31],"nicotinic":[32],"acetylcholine":[33],"receptor":[34,39],"mutations":[36],"that":[40],"confer":[41,87],"have":[43],"been":[44],"slow":[45],"develop,":[47],"with":[48],"only":[49],"one":[50],"field-evolved":[51],"mutation":[52,101],"being":[53],"reported":[54],"date.":[56],"This":[57],"is":[58],"an":[59,99,112,143],"arginine-to-threonine":[60],"substitution":[61],"at":[62],"position":[63],"81":[64],"nAChR_\u03b21":[67],"subunit":[68],"in":[69,78,102,124],"neonicotinoid-resistant":[70],"aphids.":[71],"To":[72],"validate":[73],"role":[75],"R81T":[77,110],"neonicotinoid":[79,117],"test":[83],"whether":[84],"it":[85],"may":[86],"any":[88],"significant":[89,122],"fitness":[90,155],"costs":[91],"insects,":[93],"CRISPR/Cas9":[94],"was":[95],"introduce":[98],"analogous":[100],"genome":[104],"Drosophila":[106],"melanogaster.":[107],"Flies":[108],"carrying":[109,129],"showed":[111,142],"increased":[113,144],"tolerance":[114,145],"(resistance)":[115],"insecticides,":[118],"accompanied":[119],"by":[120],"reduction":[123],"fitness.":[125],"In":[126],"comparison,":[127],"flies":[128],"deletion":[131],"whole":[134],"nAChR_\u03b16":[135],"subunit,":[136],"site":[139],"spinosyns,":[141],"this":[147],"class":[148],"but":[151],"presented":[152],"almost":[153],"no":[154],"deficits.":[156]},"counts_by_year":[{"year":2026,"cited_by_count":16},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2020-06-12T00:00:00"}
