{"id":"https://openalex.org/W3033744148","doi":null,"title":"Multi-parametric optimization of dopamine transporter SPECT software quantification for diagnosis of parkinsonian syndromes.","display_name":"Multi-parametric optimization of dopamine transporter SPECT software quantification for diagnosis of parkinsonian syndromes.","publication_year":2020,"publication_date":"2020-05-01","ids":{"openalex":"https://openalex.org/W3033744148","mag":"3033744148"},"language":"en","primary_location":{"id":"mag:3033744148","doi":null,"is_oa":false,"landing_page_url":"https://jnm.snmjournals.org/content/61/supplement_1/1557","pdf_url":null,"source":{"id":"https://openalex.org/S4210180780","display_name":"Journal of Nuclear Medicine","issn_l":"0161-5505","issn":["0161-5505","1535-5667","2159-662X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315767","host_organization_name":"Society of Nuclear Medicine and Molecular Imaging","host_organization_lineage":["https://openalex.org/P4310315767"],"host_organization_lineage_names":["Society of Nuclear Medicine and Molecular Imaging"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Nuclear Medicine","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109626955","display_name":"Matthew Neill","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Neill","raw_affiliation_strings":["University of Arizona Tucson AZ United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arizona Tucson AZ United States","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Julia M. Fisher","orcid":"https://orcid.org/0000-0003-4427-4882","observed_orcids":["https://orcid.org/0000-0003-4427-4882"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julia M. Fisher","raw_affiliation_strings":["University of Arizona Tucson AZ United States"],"raw_orcid":"https://orcid.org/0000-0003-4427-4882","affiliations":[{"raw_affiliation_string":"University of Arizona Tucson AZ United States","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102953549","display_name":"Matthew D. Kay","orcid":"https://orcid.org/0000-0003-2870-6948","observed_orcids":["https://orcid.org/0000-0003-2870-6948"]},"institutions":[{"id":"https://openalex.org/I4210124665","display_name":"Banner - University Medical Center Tucson","ror":"https://ror.org/02xbk5j62","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210124665"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew D. Kay","raw_affiliation_strings":["Banner University of Arizona Medical Center Tucson AZ United States"],"raw_orcid":"https://orcid.org/0000-0003-2870-6948","affiliations":[{"raw_affiliation_string":"Banner University of Arizona Medical Center Tucson AZ United States","institution_ids":["https://openalex.org/I4210124665"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100437465","display_name":"Tianyi Zhang","orcid":"https://orcid.org/0009-0001-8703-0100","observed_orcids":["https://orcid.org/0009-0001-8703-0100","https://orcid.org/0009-0005-4021-2651"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tianyi Zhang","raw_affiliation_strings":["University of Arizona Tucson AZ United States"],"raw_orcid":"https://orcid.org/0009-0001-8703-0100","affiliations":[{"raw_affiliation_string":"University of Arizona Tucson AZ United States","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111973362","display_name":"Scott J. Sherman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott J. Sherman","raw_affiliation_strings":["University of Arizona Tucson AZ United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arizona Tucson AZ United States","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083383180","display_name":"Hong Lei","orcid":"https://orcid.org/0000-0002-5619-3097","observed_orcids":["https://orcid.org/0000-0002-5619-3097"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hong Lei","raw_affiliation_strings":["University of Arizona Tucson AZ United States"],"raw_orcid":"https://orcid.org/0000-0002-5619-3097","affiliations":[{"raw_affiliation_string":"University of Arizona Tucson AZ United States","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014472658","display_name":"Ying\u2010hui Chou","orcid":"https://orcid.org/0000-0003-0707-286X","observed_orcids":["https://orcid.org/0000-0003-0707-286X","https://orcid.org/0000-0003-0005-1580"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying\u2010hui Chou","raw_affiliation_strings":["University of Arizona Tucson AZ United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arizona Tucson AZ United States","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011727526","display_name":"Phillip H. Kuo","orcid":"https://orcid.org/0000-0002-4957-8298","observed_orcids":["https://orcid.org/0000-0002-4957-8298"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Phillip H. Kuo","raw_affiliation_strings":["University of Arizona Tucson AZ United States"],"raw_orcid":"https://orcid.org/0000-0002-4957-8298","affiliations":[{"raw_affiliation_string":"University of Arizona Tucson AZ United States","institution_ids":["https://openalex.org/I138006243"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.07224547,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"61","issue":null,"first_page":"1557","last_page":"1557"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.763700008392334,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.763700008392334,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.1876000016927719,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":0.015399999916553497,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dopamine-transporter-spect","display_name":"dopamine transporter SPECT","score":0.9629999995231628},{"id":"https://openalex.org/keywords/parkinsonism","display_name":"parkinsonism","score":0.8610000014305115},{"id":"https://openalex.org/keywords/putamen","display_name":"putamen","score":0.6520000100135803},{"id":"https://openalex.org/keywords/caudate-nucleus","display_name":"caudate nucleus","score":0.8980000019073486},{"id":"https://openalex.org/keywords/specific-binding-ratio","display_name":"specific binding ratio","score":0.6970000267028809},{"id":"https://openalex.org/keywords/z-score","display_name":"Z-score","score":0.8389999866485596},{"id":"https://openalex.org/keywords/diagnostic-accuracy","display_name":"diagnostic accuracy","score":0.8519999980926514},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.6029999852180481},{"id":"https://openalex.org/keywords/multiple-system-atrophy","display_name":"multiple system atrophy","score":0.6430000066757202},{"id":"https://openalex.org/keywords/multiple-system-atrophy-with-parkinsonism","display_name":"multiple system atrophy with parkinsonism","score":0.6000000238418579},{"id":"https://openalex.org/keywords/differential-diagnosis","display_name":"differential diagnosis","score":0.38199999928474426},{"id":"https://openalex.org/keywords/logistic-regression-prediction-model","display_name":"logistic regression prediction model","score":0.5899999737739563},{"id":"https://openalex.org/keywords/leave-one-out-cross-validation","display_name":"leave-one-out cross-validation","score":0.6629999876022339}],"concepts":[{"id":"https://openalex.org/C2779714222","wikidata":"https://www.wikidata.org/wiki/Q550934","display_name":"Putamen","level":2,"score":0.865730345249176},{"id":"https://openalex.org/C2776755682","wikidata":"https://www.wikidata.org/wiki/Q2271947","display_name":"Dopamine transporter","level":4,"score":0.656600832939148},{"id":"https://openalex.org/C122048520","wikidata":"https://www.wikidata.org/wiki/Q2913954","display_name":"Percentile","level":2,"score":0.6536096334457397},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.6170850396156311},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5695080757141113},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.5604692697525024},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.5534124374389648},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34543102979660034},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.2723011374473572},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.26405948400497437},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.1476450264453888},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.0809980034828186}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:3033744148","doi":null,"is_oa":false,"landing_page_url":"https://jnm.snmjournals.org/content/61/supplement_1/1557","pdf_url":null,"source":{"id":"https://openalex.org/S4210180780","display_name":"Journal of Nuclear Medicine","issn_l":"0161-5505","issn":["0161-5505","1535-5667","2159-662X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315767","host_organization_name":"Society of Nuclear Medicine and Molecular Imaging","host_organization_lineage":["https://openalex.org/P4310315767"],"host_organization_lineage_names":["Society of Nuclear Medicine and Molecular Imaging"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Nuclear Medicine","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4200060160","https://openalex.org/W2768017870","https://openalex.org/W2922167346","https://openalex.org/W2999068153","https://openalex.org/W1977214431","https://openalex.org/W3095463191","https://openalex.org/W4403301354","https://openalex.org/W4250828706","https://openalex.org/W1865939547","https://openalex.org/W3132959966"],"abstract_inverted_index":{"1557":[0],"Objectives:":[2],"Evaluate":[5],"diagnostic":[6],"accuracy":[7,164,341,364,429,444,469],"of":[8,26,41,47,66,104,144,183,226,232,246,283,296,307,329,405,430,449,453],"the":[9,69,87,113,118,134,138,198,211,214,221,254,259,265,275,281,291,339,345,350,362,372,384,389,395,421,435,443,458,467,483,488,502],"parameters":[10],"generated":[11],"by":[12,33,117],"a":[13,27,34,102,142,230,238,243,300,305,312,317,417],"commercial":[14],"quantification":[15,94,119],"software":[16],"for":[17,78,163,253,258,264,280,416],"dopamine":[18],"transporter":[19],"(DaT)":[20],"SPECT.\n":[21],"Methods:":[23],"Diagnosis":[25],"Parkinsonian":[28,418],"syndrome":[29,419],"(PS)":[30],"was":[31,97,131,278],"determined":[32],"neurologist":[35],"after":[36],"at":[37],"least":[38],"two":[39,145],"years":[40],"clinical":[42],"follow-up":[43],"and":[44,63,76,80,91,123,151,207,216,262,272,326,331,354,377,394,403,408,424,439,451,463,493],"knowing":[45],"result":[46],"DaT":[48,52],"scan.":[49],"Iodine-123":[50],"ioflupane":[51],"SPECT":[53],"scans":[54],"were":[55,126,153,165,186,251],"quantified":[56],"using":[57,112,141,155],"DaTQUANT":[58],"(GE":[59],"Healthcare),":[60],"which":[61],"quantifies":[62],"compares":[64],"regions":[65],"interest":[67],"in":[68],"striatum,":[70],"reporting":[71],"Specific":[72],"Binding":[73],"Ratio":[74],"(SBR)":[75],"Z-score":[77],"right":[79],"left":[81],"sides.":[82],"The":[83,234,248,321,334,357,380,479],"ROI":[84],"corresponding":[85],"to":[86,108,397,445,495],"most":[88,335,358,411],"abnormal":[89],"side":[90],"therefore":[92],"lowest":[93],"value":[95],"(Z-score)":[96],"selected.":[98],"We":[99],"then":[100],"fit":[101],"series":[103],"logistic":[105],"regression":[106],"models":[107,125,285,289,298,310],"predict":[109],"PS":[110],"status":[111],"multiple":[114],"variables":[115,196],"provided":[116],"software.":[120],"Both":[121],"single-":[122],"multi-predictor":[124],"explored":[127],"where":[128],"one":[129],"predictor":[130,136],"fixed":[132],"as":[133,167,342,344,365,367],"best":[135,340,363],"from":[137],"single-predictor":[139],"models,":[140],"maximum":[143],"additional":[146],"predictors.":[147],"Prediction":[148],"accuracy,":[149,200,293,401],"sensitivity,":[150,240,302,402],"specificity":[152,225,245,306,327,404,452,473,503],"evaluated":[154],"leave-one-out":[156],"cross":[157],"validation.":[158],"One-sided":[159],"95%":[160],"confidence":[161,347,369],"intervals":[162,172],"constructed":[166],"bootstrap":[168],"case":[169],"cross-validation":[170],"percentile":[171],"with":[173,188,192,304,338,361,383,400,427,447,471,482],"bias":[174],"reduction":[175],"(1).\n":[176],"Results:":[178],"A":[181,432,455],"total":[182],"129":[184],"DaTscans":[185],"included":[187,487],"79":[189],"patients":[190],"diagnosed":[191],"PS.":[193],"Three":[194,295],"single":[195,223,413],"demonstrated":[197,220,237,299,311],"highest":[199,222,292,385,484],"0.90,":[201,332],"including":[202],"whole":[203,266,425],"putamen,":[204,206,256,261,353,374,391,437,460,490],"anterior":[205,215,260],"posterior":[208,217,255,276,352,373,390,436,459,489],"putamen.":[209,267],"Using":[210],"same":[212,468],"threshold,":[213],"putamen":[218,236,277,355,375,396,426,440,461,494],"also":[219],"parameter":[224],"0.88":[227],"while":[228],"maintaining":[229],"sensitivity":[231,319,325,387,448,477,485],"0.91.":[233,294],"entire":[235],"higher":[239,301,313,472],"0.94,":[241,315],"but":[242,316,475,498],"lower":[244,318,476],"0.84.":[247],"threshold":[249],"Z-scores":[250],"-1.9":[252],"-1.4":[257],"-1.3":[263],"Based":[268],"on":[269],"our":[270],"results":[271],"prior":[273],"publications,":[274],"selected":[279],"construction":[282],"multi-parametric":[284,288,381],"(2-4).":[286],"Six":[287],"produced":[290],"these":[297],"0.92,":[303],"0.88.":[308,454],"Two":[309],"specificity,":[314],"0.89.":[320],"last":[322],"model":[323,337,360,382,433,456,481],"had":[324],"values":[328],"0.91":[330,446],"respectively.":[333],"sensitive":[336],"well":[343,366],"narrowest":[346,368],"interval":[348,370],"utilized":[349,371,388],"caudate,":[351,438],"asymmetry.":[356,379],"specific":[359],"asymmetry,":[376,393,462,492],"caudate":[378,392,398,464,491,496],"overall":[386],"ratio":[399],"0.89,":[406],"0.96,":[407],"0.78,":[409],"respectively.\nCONCLUSION:The":[410],"accurate":[412],"variable":[414],"predictors":[415],"are":[420],"anterior,":[422],"posterior,":[423],"an":[428],"0.90.":[431],"incorporating":[434,457],"asymmetry":[441,465],"increases":[442],"0.92":[450],"attained":[466],"(0.91)":[470],"(0.94)":[474],"(0.89).":[478],"multiparametric":[480],"(0.96)":[486],"ratio,":[497],"this":[499],"significantly":[500],"lowered":[501],"(0.78).":[504]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-06-12T00:00:00"}
