{"id":"https://openalex.org/W3033734675","doi":"https://doi.org/10.1038/s41467-020-16747-y","title":"A multi-omics analysis reveals the unfolded protein response regulon and stress-induced resistance to folate-based antimetabolites","display_name":"A multi-omics analysis reveals the unfolded protein response regulon and stress-induced resistance to folate-based antimetabolites","publication_year":2020,"publication_date":"2020-06-10","ids":{"openalex":"https://openalex.org/W3033734675","doi":"https://doi.org/10.1038/s41467-020-16747-y","mag":"3033734675","pmid":"https://pubmed.ncbi.nlm.nih.gov/32522993","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7287054"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-020-16747-y","doi":"https://doi.org/10.1038/s41467-020-16747-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-020-16747-y","pdf_url":"https://www.nature.com/articles/s41467-020-16747-y.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-020-16747-y.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013793110","display_name":"Stefan Reich","orcid":"https://orcid.org/0000-0001-8822-2908","observed_orcids":["https://orcid.org/0000-0001-8822-2908"]},"institutions":[{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefan Reich","raw_affiliation_strings":["Biochemistry I, University of Regensburg, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry I, University of Regensburg, Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104075218","display_name":"Chi Nguyen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121365","display_name":"Leibniz Institute for Analytical Sciences - ISAS","ror":"https://ror.org/02jhqqg57","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210121365"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Chi D. L. Nguyen","raw_affiliation_strings":["Leibniz-Institut f\u00fcr Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leibniz-Institut f\u00fcr Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany","institution_ids":["https://openalex.org/I4210121365"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077917099","display_name":"Canan Has","orcid":"https://orcid.org/0000-0003-2355-3727","observed_orcids":["https://orcid.org/0000-0003-2355-3727"]},"institutions":[{"id":"https://openalex.org/I4210121365","display_name":"Leibniz Institute for Analytical Sciences - ISAS","ror":"https://ror.org/02jhqqg57","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210121365"]},{"id":"https://openalex.org/I78650965","display_name":"Technische Universit\u00e4t Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Canan Has","raw_affiliation_strings":["Institute for Clinical Chemistry and Laboratory Medicine, Technical University Dresden, Dresden, Germany","Leibniz-Institut f\u00fcr Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Clinical Chemistry and Laboratory Medicine, Technical University Dresden, Dresden, Germany","institution_ids":["https://openalex.org/I78650965"]},{"raw_affiliation_string":"Leibniz-Institut f\u00fcr Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany","institution_ids":["https://openalex.org/I4210121365"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052712105","display_name":"Sascha Steltgens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sascha Steltgens","raw_affiliation_strings":["Department of Neuropathology, Heinrich Heine University D\u00fcsseldorf, D\u00fcsseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuropathology, Heinrich Heine University D\u00fcsseldorf, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034804036","display_name":"Himanshu Soni","orcid":"https://orcid.org/0000-0002-4765-2968","observed_orcids":["https://orcid.org/0000-0002-4765-2968"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Himanshu Soni","raw_affiliation_strings":["Molecular Mechanisms of Tumor Invasion, German Cancer Research Center (DKFZ), Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Mechanisms of Tumor Invasion, German Cancer Research Center (DKFZ), Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029473600","display_name":"Cristina Coman","orcid":"https://orcid.org/0000-0002-3771-2410","observed_orcids":["https://orcid.org/0000-0002-3771-2410"]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Cristina Coman","raw_affiliation_strings":["Department of Analytical Chemistry, University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Analytical Chemistry, University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044046145","display_name":"Moritz Freyberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Moritz Freyberg","raw_affiliation_strings":["Biochemistry I, University of Regensburg, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry I, University of Regensburg, Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090553262","display_name":"Anna Bichler","orcid":"https://orcid.org/0009-0009-9983-1480","observed_orcids":["https://orcid.org/0009-0009-9983-1480"]},"institutions":[{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anna Bichler","raw_affiliation_strings":["Biochemistry I, University of Regensburg, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry I, University of Regensburg, Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018370934","display_name":"Nicole Seifert","orcid":"https://orcid.org/0000-0002-2191-523X","observed_orcids":["https://orcid.org/0000-0002-2191-523X"]},"institutions":[{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nicole Seifert","raw_affiliation_strings":["Biochemistry I, University of Regensburg, Regensburg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-2191-523X","affiliations":[{"raw_affiliation_string":"Biochemistry I, University of Regensburg, Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031056636","display_name":"Dominik Conrad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dominik Conrad","raw_affiliation_strings":["Biochemistry I, University of Regensburg, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry I, University of Regensburg, Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016218771","display_name":"Christiane Brigitte Knobbe-Thomsen","orcid":"https://orcid.org/0000-0003-1231-0076","observed_orcids":["https://orcid.org/0000-0003-1231-0076"]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christiane B. Knobbe-Thomsen","raw_affiliation_strings":["Department of Neuropathology, Heinrich Heine University D\u00fcsseldorf, D\u00fcsseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuropathology, Heinrich Heine University D\u00fcsseldorf, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025594062","display_name":"Bj\u00f6rn Tews","orcid":"https://orcid.org/0000-0002-5917-8909","observed_orcids":["https://orcid.org/0000-0002-5917-8909"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I4210128201","display_name":"AbbVie (Germany)","ror":"https://ror.org/03538jp08","country_code":"DE","type":"company","lineage":["https://openalex.org/I2948539688","https://openalex.org/I4210128201"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bj\u00f6rn Tews","raw_affiliation_strings":["AbbVie Deutschland GmbH & Co.KG, Wiesbaden, Germany","Molecular Mechanisms of Tumor Invasion, German Cancer Research Center (DKFZ), Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AbbVie Deutschland GmbH & Co.KG, Wiesbaden, Germany","institution_ids":["https://openalex.org/I4210128201"]},{"raw_affiliation_string":"Molecular Mechanisms of Tumor Invasion, German Cancer Research Center (DKFZ), Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040137291","display_name":"Grischa Toedt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210138560","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/03mstc592","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I4210153543","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/050589e39","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560","https://openalex.org/I4210153543"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Grischa Toedt","raw_affiliation_strings":["Computational Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany","institution_ids":["https://openalex.org/I4210138560","https://openalex.org/I4210153543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041939518","display_name":"Robert Ahrends","orcid":"https://orcid.org/0000-0003-0232-3375","observed_orcids":["https://orcid.org/0000-0003-0232-3375"]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]},{"id":"https://openalex.org/I4210121365","display_name":"Leibniz Institute for Analytical Sciences - ISAS","ror":"https://ror.org/02jhqqg57","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210121365"]}],"countries":["AT","DE"],"is_corresponding":true,"raw_author_name":"Robert Ahrends","raw_affiliation_strings":["Department of Analytical Chemistry, University of Vienna, Vienna, Austria. Robert.Ahrends@univie.ac.at","Leibniz-Institut f\u00fcr Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany. Robert.Ahrends@univie.ac.at","Department of Analytical Chemistry, University of Vienna, Vienna, Austria"],"raw_orcid":"https://orcid.org/0000-0003-0232-3375","affiliations":[{"raw_affiliation_string":"Department of Analytical Chemistry, University of Vienna, Vienna, Austria. Robert.Ahrends@univie.ac.at","institution_ids":["https://openalex.org/I129774422"]},{"raw_affiliation_string":"Leibniz-Institut f\u00fcr Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany. Robert.Ahrends@univie.ac.at","institution_ids":["https://openalex.org/I4210121365"]},{"raw_affiliation_string":"Department of Analytical Chemistry, University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072419423","display_name":"Jan Medenbach","orcid":"https://orcid.org/0000-0003-0749-7788","observed_orcids":["https://orcid.org/0000-0003-0749-7788"]},"institutions":[{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Jan Medenbach","raw_affiliation_strings":["Biochemistry I, University of Regensburg, Regensburg, Germany. Jan.Medenbach@ur.de","Biochemistry I, University of Regensburg, Regensburg, Germany"],"raw_orcid":"https://orcid.org/0000-0003-0749-7788","affiliations":[{"raw_affiliation_string":"Biochemistry I, University of Regensburg, Regensburg, Germany. Jan.Medenbach@ur.de","institution_ids":["https://openalex.org/I60668342"]},{"raw_affiliation_string":"Biochemistry I, University of Regensburg, Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5041939518","https://openalex.org/A5072419423"],"corresponding_institution_ids":["https://openalex.org/I129774422","https://openalex.org/I4210121365","https://openalex.org/I60668342"],"apc_list":{"value":5380,"currency":"USD","value_usd":5380},"apc_paid":{"value":5212,"currency":"EUR","value_usd":5621},"fwci":4.0909,"has_fulltext":true,"cited_by_count":93,"citation_normalized_percentile":{"value":0.95858064,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"11","issue":"1","first_page":"2936","last_page":"2936"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/unfolded-protein-response","display_name":"unfolded protein response","score":1.0},{"id":"https://openalex.org/keywords/stress-response-pathways","display_name":"stress response pathways","score":0.6919999718666077},{"id":"https://openalex.org/keywords/methotrexate","display_name":"methotrexate","score":0.8700000047683716},{"id":"https://openalex.org/keywords/pemetrexed","display_name":"pemetrexed","score":1.0},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.8629999756813049},{"id":"https://openalex.org/keywords/translational-control","display_name":"translational regulation","score":0.9309999942779541},{"id":"https://openalex.org/keywords/one-carbon-metabolism","display_name":"one-carbon metabolism","score":0.9200000166893005},{"id":"https://openalex.org/keywords/mitochondrial-metabolism","display_name":"mitochondrial metabolism","score":0.847000002861023},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.718999981880188},{"id":"https://openalex.org/keywords/transcriptome","display_name":"transcriptome","score":0.7519999742507935},{"id":"https://openalex.org/keywords/proteome","display_name":"proteome","score":0.9879999756813049},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.5329999923706055},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.5799999833106995}],"concepts":[{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.7137038707733154},{"id":"https://openalex.org/C2779638656","wikidata":"https://www.wikidata.org/wiki/Q6043166","display_name":"Integrated stress response","level":5,"score":0.6782441139221191},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6703937649726868},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6187325119972229},{"id":"https://openalex.org/C2780900454","wikidata":"https://www.wikidata.org/wiki/Q21102119","display_name":"ATF4","level":4,"score":0.5527023673057556},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5423673987388611},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5005757808685303},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.4965057969093323},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.4953960180282593},{"id":"https://openalex.org/C2780096491","wikidata":"https://www.wikidata.org/wiki/Q60574533","display_name":"Cellular stress response","level":4,"score":0.4865814447402954},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.4814681112766266},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4318951368331909},{"id":"https://openalex.org/C62361671","wikidata":"https://www.wikidata.org/wiki/Q1754612","display_name":"Regulon","level":4,"score":0.428202360868454},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41066625714302063},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4090423583984375},{"id":"https://openalex.org/C78604142","wikidata":"https://www.wikidata.org/wiki/Q1640582","display_name":"Fight-or-flight response","level":3,"score":0.2673183083534241},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2571371793746948},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.13556748628616333}],"mesh":[{"descriptor_ui":"D000068437","descriptor_name":"Pemetrexed","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000963","descriptor_name":"Antimetabolites","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005492","descriptor_name":"Folic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018085","descriptor_name":"Regulon","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018085","descriptor_name":"Regulon","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056811","descriptor_name":"Unfolded Protein Response","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D056811","descriptor_name":"Unfolded Protein Response","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1038/s41467-020-16747-y","doi":"https://doi.org/10.1038/s41467-020-16747-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-020-16747-y","pdf_url":"https://www.nature.com/articles/s41467-020-16747-y.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7287054","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7287054","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmid:32522993","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32522993","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:epub.uni-regensburg.de:44035","doi":null,"is_oa":false,"landing_page_url":"https://epub.uni-regensburg.de/44035/1/s41467-020-16747-y.pdf","pdf_url":"https://epub.uni-regensburg.de/44035/1/s41467-020-16747-y.pdf","source":{"id":"https://openalex.org/S4306401229","display_name":"University of Regensburg Publication Server (University of Regensburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I60668342","host_organization_name":"University of Regensburg","host_organization_lineage":["https://openalex.org/I60668342"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-16747-y","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-020-16747-y","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:79d8f5e4871145f68820d3fe6d215985","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/79d8f5e4871145f68820d3fe6d215985","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)","raw_type":"article"},{"id":"doi:10.5283/epub.44035","doi":"https://doi.org/10.5283/epub.44035","is_oa":true,"landing_page_url":"https://doi.org/10.5283/epub.44035","pdf_url":null,"source":{"id":"https://openalex.org/S4306401229","display_name":"University of Regensburg Publication Server (University of Regensburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I60668342","host_organization_name":"University of Regensburg","host_organization_lineage":["https://openalex.org/I60668342"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1038/s41467-020-16747-y","doi":"https://doi.org/10.1038/s41467-020-16747-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-020-16747-y","pdf_url":"https://www.nature.com/articles/s41467-020-16747-y.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1017261758","display_name":null,"funder_award_id":"DFG SFB960/2","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G215637042","display_name":"de.NBI - Partner - LIFS","funder_award_id":"031L0108A","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G246369285","display_name":"'Juniorverb\u00fcnde in der Systemmedizin': Systembiologie der ungefalteten Proteinantwort in Gliomen (SUPR-G), EMBL Heidelberg: Konstruktion, Vergleich und Anwendung von ungefalteter Proteinantwort (UPR), ER-Stress bezogenen Netzwerken und Vorhersagen von UPR-System Verhalten","funder_award_id":"01ZX1401E","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G2495073160","display_name":null,"funder_award_id":"DFG SFB960/2, B11","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G3254877218","display_name":null,"funder_award_id":"SFB 960","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G3257801184","display_name":"'Juniorverb\u00fcnde in der Systemmedizin': Systembiologie der ungefalteten Proteinantwort in Gliomen (SUPR-G), Universit\u00e4t D\u00fcsseldorf: Die Bedeutung der ungefalteten Proteinantwort in infiltrierenden Gliomzellen","funder_award_id":"01ZX1401B","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G3279183305","display_name":"'Juniorverb\u00fcnde in der Systemmedizin': Systembiologie der ungefalteten Proteinantwort in Gliomen (SUPR-G), Universit\u00e4t Regensburg: Quantitative Analyse der globalen Translation w\u00e4hrend der 'Unfolded Protein Response' in Gliomen","funder_award_id":"01ZX1401D","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G4523048879","display_name":"'Juniorverb\u00fcnde in der Systemmedizin': Systembiologie der ungefalteten Proteinantwort in Gliomen (SUPR-G), Leibniz-Institut Dortmund: Ein systembiologischer Ansatz zur Bestimmung des Equilibriums der ungefalteten Proteinantwort","funder_award_id":"01ZX1401C","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G453056226","display_name":null,"funder_award_id":"SFB960/2, B11","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G5448141689","display_name":null,"funder_award_id":"SFB 960/2","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G648564533","display_name":null,"funder_award_id":"#110663","funder_id":"https://openalex.org/F4320323556","funder_display_name":"Deutsche Krebshilfe"},{"id":"https://openalex.org/G7283570862","display_name":"'Juniorverb\u00fcnde in der Systemmedizin': Systembiologie der ungefalteten Proteinantwort in Gliomen (SUPR-G), DKFZ Heidelberg: Funktionale Charakterisierung pro-invasiver sekretierter Proteine in Gliomen","funder_award_id":"01ZX1401A","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"}],"funders":[{"id":"https://openalex.org/F4320310697","display_name":"Joachim Herz Stiftung","ror":"https://ror.org/01j8qgg43"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"},{"id":"https://openalex.org/F4320323556","display_name":"Deutsche Krebshilfe","ror":"https://ror.org/01wxdd722"},{"id":"https://openalex.org/F4320330124","display_name":"German Network for Bioinformatics Infrastructure","ror":"https://ror.org/01vmpm840"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3033734675.pdf","grobid_xml":"https://content.openalex.org/works/W3033734675.grobid-xml"},"referenced_works_count":76,"referenced_works":["https://openalex.org/W625755886","https://openalex.org/W1511417959","https://openalex.org/W1527321800","https://openalex.org/W1966923590","https://openalex.org/W1977603207","https://openalex.org/W1978245389","https://openalex.org/W1979592430","https://openalex.org/W1980438612","https://openalex.org/W1983971444","https://openalex.org/W1988548899","https://openalex.org/W1996992222","https://openalex.org/W1998646075","https://openalex.org/W2002583208","https://openalex.org/W2003755766","https://openalex.org/W2010375635","https://openalex.org/W2013996883","https://openalex.org/W2014847284","https://openalex.org/W2019158910","https://openalex.org/W2022031287","https://openalex.org/W2022899908","https://openalex.org/W2023374667","https://openalex.org/W2029849110","https://openalex.org/W2035692565","https://openalex.org/W2053543069","https://openalex.org/W2056129497","https://openalex.org/W2074471441","https://openalex.org/W2085592353","https://openalex.org/W2089198803","https://openalex.org/W2089783252","https://openalex.org/W2096614722","https://openalex.org/W2102050179","https://openalex.org/W2102959508","https://openalex.org/W2103334789","https://openalex.org/W2106749088","https://openalex.org/W2108244474","https://openalex.org/W2110524342","https://openalex.org/W2119147112","https://openalex.org/W2120736516","https://openalex.org/W2122103893","https://openalex.org/W2126524529","https://openalex.org/W2130326770","https://openalex.org/W2130706354","https://openalex.org/W2131271579","https://openalex.org/W2132940659","https://openalex.org/W2134526812","https://openalex.org/W2138009056","https://openalex.org/W2143224622","https://openalex.org/W2144018378","https://openalex.org/W2152740213","https://openalex.org/W2155163967","https://openalex.org/W2160285962","https://openalex.org/W2164440257","https://openalex.org/W2167715756","https://openalex.org/W2168735777","https://openalex.org/W2169456326","https://openalex.org/W2173466127","https://openalex.org/W2179438025","https://openalex.org/W2179581654","https://openalex.org/W2258318060","https://openalex.org/W2301480990","https://openalex.org/W2332328360","https://openalex.org/W2405069786","https://openalex.org/W2495220859","https://openalex.org/W2518959324","https://openalex.org/W2520894026","https://openalex.org/W2726524491","https://openalex.org/W2740930667","https://openalex.org/W2768032770","https://openalex.org/W2778954596","https://openalex.org/W2897704361","https://openalex.org/W2898079638","https://openalex.org/W2898598946","https://openalex.org/W2899760200","https://openalex.org/W2950101275","https://openalex.org/W2950345178","https://openalex.org/W4211141680"],"related_works":["https://openalex.org/W3105153535","https://openalex.org/W7065146046","https://openalex.org/W7046685971","https://openalex.org/W2038600646","https://openalex.org/W7116076685","https://openalex.org/W7166591983","https://openalex.org/W828612247","https://openalex.org/W3150593050","https://openalex.org/W4388894444","https://openalex.org/W2897704361"],"abstract_inverted_index":{"Stress":[0],"response":[1,58,63,94],"pathways":[2],"are":[3,26,37],"critical":[4],"for":[5],"cellular":[6],"homeostasis,":[7],"promoting":[8],"survival":[9],"through":[10],"adaptive":[11],"changes":[12,49,73,141],"in":[13,22,28,66,92,109],"gene":[14,51,143],"expression":[15,52,105,144],"and":[16,25,31,72,133,145],"metabolism.":[17,122],"They":[18],"play":[19],"key":[20],"roles":[21],"numerous":[23],"diseases":[24],"implicated":[27,91],"cancer":[29],"progression":[30],"chemoresistance.":[32],"However,":[33],"the":[34,60,68,70,79,104,124,129],"underlying":[35],"mechanisms":[36],"only":[38],"poorly":[39],"understood.":[40],"We":[41,96],"have":[42,87],"employed":[43],"a":[44,56,110,136],"multi-omics":[45],"approach":[46],"to":[47,50,74,118,128,142,147],"monitor":[48],"after":[53],"induction":[54,80],"of":[55,81,85,106],"stress":[57,93],"pathway,":[59],"unfolded":[61],"protein":[62],"(UPR),":[64],"probing":[65],"parallel":[67],"transcriptome,":[69],"proteome,":[71],"translation.":[75],"Stringent":[76],"filtering":[77],"reveals":[78],"267":[82],"genes,":[83],"many":[84],"which":[86],"not":[88],"previously":[89],"been":[90],"pathways.":[95],"experimentally":[97],"demonstrate":[98],"that":[99,112],"UPR-mediated":[100],"translational":[101],"control":[102],"induces":[103],"enzymes":[107],"involved":[108],"pathway":[111],"diverts":[113],"intermediate":[114],"metabolites":[115],"from":[116],"glycolysis":[117],"fuel":[119],"mitochondrial":[120],"one-carbon":[121],"Concomitantly,":[123],"cells":[125],"become":[126],"resistant":[127],"folate-based":[130],"antimetabolites":[131],"Methotrexate":[132],"Pemetrexed,":[134],"establishing":[135],"direct":[137],"link":[138],"between":[139],"UPR-driven":[140],"resistance":[146],"pharmacological":[148],"treatment.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":16},{"year":2025,"cited_by_count":18},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":17},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2020-06-12T00:00:00"}
