{"id":"https://openalex.org/W3033668237","doi":null,"title":"Histone Variant H2A.Z's Effects on Nicotine Locomotor Sensitization and Reward","display_name":"Histone Variant H2A.Z's Effects on Nicotine Locomotor Sensitization and Reward","publication_year":2019,"publication_date":"2019-11-01","ids":{"openalex":"https://openalex.org/W3033668237","mag":"3033668237"},"language":"en","primary_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/98394","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/98394","pdf_url":"https://utoronto.scholaris.ca/bitstreams/ec0f523c-1676-4b81-bced-2e92aef89cf2/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://utoronto.scholaris.ca/bitstreams/ec0f523c-1676-4b81-bced-2e92aef89cf2/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010994326","display_name":"Carl Frank David Steininger","orcid":"https://orcid.org/0000-0002-9656-3072","observed_orcids":["https://orcid.org/0000-0002-9656-3072"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Carl Frank David Steininger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5010994326"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.6104000210762024,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.6104000210762024,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.13179999589920044,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.07970000058412552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histone-h2a-z","display_name":"histone H2A.Z","score":0.972000002861023},{"id":"https://openalex.org/keywords/nicotine","display_name":"nicotine","score":0.7279999852180481},{"id":"https://openalex.org/keywords/locomotor-sensitization","display_name":"locomotor sensitization","score":0.8679999709129333},{"id":"https://openalex.org/keywords/conditioned-place-preference","display_name":"conditioned place preference","score":0.9710000157356262},{"id":"https://openalex.org/keywords/reward","display_name":"reward","score":0.5860000252723694},{"id":"https://openalex.org/keywords/nicotine-dependence","display_name":"nicotine dependence","score":0.8600000143051147},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.8600000143051147},{"id":"https://openalex.org/keywords/neuroplasticity","display_name":"neuroplasticity","score":0.9229999780654907},{"id":"https://openalex.org/keywords/psychostimulants","display_name":"psychostimulants","score":0.9039999842643738}],"concepts":[{"id":"https://openalex.org/C2776217527","wikidata":"https://www.wikidata.org/wiki/Q944828","display_name":"Sensitization","level":2,"score":0.6610724925994873},{"id":"https://openalex.org/C2779547902","wikidata":"https://www.wikidata.org/wiki/Q28086552","display_name":"Nicotine","level":2,"score":0.5931736826896667},{"id":"https://openalex.org/C3019662062","wikidata":"https://www.wikidata.org/wiki/Q12029","display_name":"Behavioral sensitization","level":4,"score":0.571413516998291},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4797997772693634},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.45047223567962646},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4437508285045624},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.43361136317253113},{"id":"https://openalex.org/C2993436365","wikidata":"https://www.wikidata.org/wiki/Q925958","display_name":"Locomotor activity","level":2,"score":0.43087172508239746},{"id":"https://openalex.org/C48856860","wikidata":"https://www.wikidata.org/wiki/Q12029","display_name":"Addiction","level":2,"score":0.4130805730819702},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36574578285217285},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3127472400665283},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23487436771392822},{"id":"https://openalex.org/C2776552330","wikidata":"https://www.wikidata.org/wiki/Q1476178","display_name":"Nucleus accumbens","level":3,"score":0.2258577048778534},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.10386720299720764},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:utoronto.scholaris.ca:1807/98394","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/98394","pdf_url":"https://utoronto.scholaris.ca/bitstreams/ec0f523c-1676-4b81-bced-2e92aef89cf2/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:3033668237","doi":null,"is_oa":false,"landing_page_url":"https://tspace.library.utoronto.ca/bitstream/1807/98394/1/Steininger_Carl_F_201911_MA_thesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/98394","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/98394","pdf_url":"https://utoronto.scholaris.ca/bitstreams/ec0f523c-1676-4b81-bced-2e92aef89cf2/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"score":0.504800021648407,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3033668237.pdf","grobid_xml":"https://content.openalex.org/works/W3033668237.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W104238112","https://openalex.org/W203197496","https://openalex.org/W1555243468","https://openalex.org/W1579352208","https://openalex.org/W1642159886","https://openalex.org/W1955082011","https://openalex.org/W1966037459","https://openalex.org/W1967662259","https://openalex.org/W1984436755","https://openalex.org/W1988182239","https://openalex.org/W1988680001","https://openalex.org/W1992902970","https://openalex.org/W1999998616","https://openalex.org/W2000251389","https://openalex.org/W2003661073","https://openalex.org/W2008463684","https://openalex.org/W2022703549","https://openalex.org/W2022851859","https://openalex.org/W2024316065","https://openalex.org/W2033856541","https://openalex.org/W2043346837","https://openalex.org/W2046308099","https://openalex.org/W2046691617","https://openalex.org/W2047492603","https://openalex.org/W2048767879","https://openalex.org/W2050445493","https://openalex.org/W2051483319","https://openalex.org/W2051692581","https://openalex.org/W2054017008","https://openalex.org/W2054668681","https://openalex.org/W2063295516","https://openalex.org/W2065871313","https://openalex.org/W2067821921","https://openalex.org/W2070846125","https://openalex.org/W2071761663","https://openalex.org/W2072002750","https://openalex.org/W2074624810","https://openalex.org/W2075213209","https://openalex.org/W2075907707","https://openalex.org/W2075943770","https://openalex.org/W2076312647","https://openalex.org/W2076503199","https://openalex.org/W2076749095","https://openalex.org/W2078241277","https://openalex.org/W2081391428","https://openalex.org/W2085795680","https://openalex.org/W2095111919","https://openalex.org/W2102419243","https://openalex.org/W2106862702","https://openalex.org/W2115818350","https://openalex.org/W2117918664","https://openalex.org/W2121417064","https://openalex.org/W2122592499","https://openalex.org/W2123032740","https://openalex.org/W2131366415","https://openalex.org/W2141452262","https://openalex.org/W2151079096","https://openalex.org/W2511170176","https://openalex.org/W2621586846","https://openalex.org/W2774067901","https://openalex.org/W2780334091","https://openalex.org/W2786912169","https://openalex.org/W2889834626","https://openalex.org/W2901621178","https://openalex.org/W2908144185","https://openalex.org/W4231752535"],"related_works":["https://openalex.org/W2094395884","https://openalex.org/W2062878579","https://openalex.org/W2069384390","https://openalex.org/W4391358019","https://openalex.org/W1991932838","https://openalex.org/W2951645239","https://openalex.org/W2041495185","https://openalex.org/W2171252218","https://openalex.org/W7095866124","https://openalex.org/W2152418590"],"abstract_inverted_index":{"Epigenetic":[0],"modifications":[1],"are":[2,9,25],"key":[3],"regulators":[4,29],"of":[5,14,30,52,56,67,70,81,127],"neural":[6,31],"plasticity":[7,32],"and":[8,21,33,72,86,105,131],"implicated":[10],"in":[11,17,49,135],"various":[12],"forms":[13],"experience-induced":[15],"changes":[16],"behavior,":[18],"including":[19],"memory":[20,43],"addiction.":[22,149],"Histone":[23],"variants":[24],"newly":[26],"identified":[27],"epigenetic":[28],"the":[34,65,78,119],"histone":[35],"variant":[36],"H2A.Z":[37,63,128,134,142],"has":[38],"been":[39],"shown":[40],"to":[41,60,74,108,122,132,138,145],"regulate":[42],"formation,":[44],"suggesting":[45,140],"a":[46,124],"potential":[47],"role":[48],"other":[50],"types":[51],"plasticity.":[53],"The":[54],"goal":[55],"this":[57],"thesis":[58],"was":[59],"determine":[61],"whether":[62],"regulates":[64],"development":[66],"preference":[68,103],"(index":[69],"reward)":[71],"sensitization":[73,107],"nicotine":[75,148],"by":[76],"isolating":[77],"unique":[79],"contributions":[80],"two":[82],"H2A.Z-encoding":[83],"genes,":[84],"H2afv":[85],"H2Afz.":[87],"Using":[88],"conditional-inducible":[89],"knockout":[90],"mice":[91],"for":[92,147],"each":[93],"gene,":[94],"we":[95],"showed":[96],"that":[97,141],"H2Afv":[98],"deletion":[99,112],"eliminated":[100],"conditioned":[101],"place":[102],"(CPP)":[104],"locomotor":[106,115],"nicotine,":[109],"whereas":[110],"H2Afz":[111],"selectively":[113],"impaired":[114],"sensitization.":[116],"This":[117],"is":[118],"first":[120],"study":[121],"demonstrate":[123],"gene-specific":[125],"effect":[126],"on":[129],"behavior":[130],"implicate":[133],"regulating":[136],"responses":[137],"psychostimulants,":[139],"may":[143],"contribute":[144],"risk":[146]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2020-06-12T00:00:00"}
