{"id":"https://openalex.org/W3033490672","doi":"https://doi.org/10.1111/rda.13737","title":"Absence of Sirtuin 1 impairs the testicular development in cattleyak by inactivating SF\u20101","display_name":"Absence of Sirtuin 1 impairs the testicular development in cattleyak by inactivating SF\u20101","publication_year":2020,"publication_date":"2020-06-04","ids":{"openalex":"https://openalex.org/W3033490672","doi":"https://doi.org/10.1111/rda.13737","mag":"3033490672","pmid":"https://pubmed.ncbi.nlm.nih.gov/32497285"},"language":"en","primary_location":{"id":"doi:10.1111/rda.13737","doi":"https://doi.org/10.1111/rda.13737","is_oa":false,"landing_page_url":"https://doi.org/10.1111/rda.13737","pdf_url":null,"source":{"id":"https://openalex.org/S147868187","display_name":"Reproduction in Domestic Animals","issn_l":"0044-5371","issn":["0044-5371","0936-6768","1439-0531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproduction in Domestic Animals","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024802403","display_name":"Shi Yin","orcid":"https://orcid.org/0000-0001-7730-633X","observed_orcids":["https://orcid.org/0000-0001-7730-633X"]},"institutions":[{"id":"https://openalex.org/I2799449666","display_name":"State Ethnic Affairs Commission","ror":"https://ror.org/01p9g6b97","country_code":"CN","type":"government","lineage":["https://openalex.org/I2799449666"]},{"id":"https://openalex.org/I6645349","display_name":"Southwest Minzu University","ror":"https://ror.org/04gaexw88","country_code":"CN","type":"education","lineage":["https://openalex.org/I6645349"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shi Yin","raw_affiliation_strings":["College of Life Science and Technology, Southwest Minzu University, Chengdu, China","Key Laboratory of Modem Technology (Southwest Minzu University), State Ethnic Affairs Commission, Chengdu, China","Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization, Ministry of Education, Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization Key Laboratory of Sichuan Province, Chengdu, China"],"raw_orcid":"https://orcid.org/0000-0001-7730-633X","affiliations":[{"raw_affiliation_string":"College of Life Science and Technology, Southwest Minzu University, Chengdu, China","institution_ids":["https://openalex.org/I6645349"]},{"raw_affiliation_string":"Key Laboratory of Modem Technology (Southwest Minzu University), State Ethnic Affairs Commission, Chengdu, China","institution_ids":["https://openalex.org/I2799449666","https://openalex.org/I6645349"]},{"raw_affiliation_string":"Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization, Ministry of Education, Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization Key Laboratory of Sichuan Province, Chengdu, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012688271","display_name":"Wenchang Qin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I6645349","display_name":"Southwest Minzu University","ror":"https://ror.org/04gaexw88","country_code":"CN","type":"education","lineage":["https://openalex.org/I6645349"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenchang Qin","raw_affiliation_strings":["College of Life Science and Technology, Southwest Minzu University, Chengdu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Science and Technology, Southwest Minzu University, Chengdu, China","institution_ids":["https://openalex.org/I6645349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100372377","display_name":"Bin Wang","orcid":"https://orcid.org/0000-0002-6159-5242","observed_orcids":["https://orcid.org/0000-0002-6159-5242"]},"institutions":[{"id":"https://openalex.org/I6645349","display_name":"Southwest Minzu University","ror":"https://ror.org/04gaexw88","country_code":"CN","type":"education","lineage":["https://openalex.org/I6645349"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin Wang","raw_affiliation_strings":["College of Life Science and Technology, Southwest Minzu University, Chengdu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Science and Technology, Southwest Minzu University, Chengdu, China","institution_ids":["https://openalex.org/I6645349"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jingwen Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I6645349","display_name":"Southwest Minzu University","ror":"https://ror.org/04gaexw88","country_code":"CN","type":"education","lineage":["https://openalex.org/I6645349"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingwen Zhou","raw_affiliation_strings":["College of Life Science and Technology, Southwest Minzu University, Chengdu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Science and Technology, Southwest Minzu University, Chengdu, China","institution_ids":["https://openalex.org/I6645349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052747073","display_name":"Liuqing Yang","orcid":"https://orcid.org/0000-0002-6518-474X","observed_orcids":["https://orcid.org/0000-0002-6518-474X"]},"institutions":[{"id":"https://openalex.org/I6645349","display_name":"Southwest Minzu University","ror":"https://ror.org/04gaexw88","country_code":"CN","type":"education","lineage":["https://openalex.org/I6645349"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liuqing Yang","raw_affiliation_strings":["College of Life Science and Technology, Southwest Minzu University, Chengdu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Science and Technology, Southwest Minzu University, Chengdu, China","institution_ids":["https://openalex.org/I6645349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013680127","display_name":"Xianrong Xiong","orcid":"https://orcid.org/0000-0002-5470-122X","observed_orcids":["https://orcid.org/0000-0002-5470-122X"]},"institutions":[{"id":"https://openalex.org/I6645349","display_name":"Southwest Minzu University","ror":"https://ror.org/04gaexw88","country_code":"CN","type":"education","lineage":["https://openalex.org/I6645349"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xianrong Xiong","raw_affiliation_strings":["College of Life Science and Technology, Southwest Minzu University, Chengdu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Science and Technology, Southwest Minzu University, Chengdu, China","institution_ids":["https://openalex.org/I6645349"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100402619","display_name":"Jian Li","orcid":"https://orcid.org/0000-0003-4517-5819","observed_orcids":["https://orcid.org/0000-0003-4517-5819"]},"institutions":[{"id":"https://openalex.org/I6645349","display_name":"Southwest Minzu University","ror":"https://ror.org/04gaexw88","country_code":"CN","type":"education","lineage":["https://openalex.org/I6645349"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jian Li","raw_affiliation_strings":["College of Life Science and Technology, Southwest Minzu University, Chengdu, China","Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization, Ministry of Education, Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization Key Laboratory of Sichuan Province, Chengdu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Science and Technology, Southwest Minzu University, Chengdu, China","institution_ids":["https://openalex.org/I6645349"]},{"raw_affiliation_string":"Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization, Ministry of Education, Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization Key Laboratory of Sichuan Province, Chengdu, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100402619"],"corresponding_institution_ids":["https://openalex.org/I6645349"],"apc_list":{"value":3600,"currency":"USD","value_usd":3600},"apc_paid":null,"fwci":1.5415,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.8084378,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"55","issue":"9","first_page":"1054","last_page":"1060"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11077","display_name":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","score":0.008899999782443047,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sirt1","display_name":"SIRT1","score":0.8700000047683716},{"id":"https://openalex.org/keywords/steroidogenic-factor-1","display_name":"steroidogenic factor 1","score":0.8709999918937683},{"id":"https://openalex.org/keywords/yak","display_name":"yak","score":0.9070000052452087},{"id":"https://openalex.org/keywords/testicular-development","display_name":"testicular development","score":0.8330000042915344},{"id":"https://openalex.org/keywords/male-infertility","display_name":"male infertility","score":0.7839999794960022},{"id":"https://openalex.org/keywords/histone-acetylation","display_name":"histone acetylation","score":0.7960000038146973},{"id":"https://openalex.org/keywords/sertoli-cells","display_name":"Sertoli cells","score":0.9350000023841858},{"id":"https://openalex.org/keywords/steroidogenesis","display_name":"steroidogenesis","score":0.9800000190734863},{"id":"https://openalex.org/keywords/p53-acetylation","display_name":"p53 acetylation","score":0.8700000047683716},{"id":"https://openalex.org/keywords/interspecific-hybrid","display_name":"interspecific hybrids","score":0.5740000009536743}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6935074329376221},{"id":"https://openalex.org/C2781068068","wikidata":"https://www.wikidata.org/wiki/Q195614","display_name":"Sertoli cell","level":3,"score":0.6477912664413452},{"id":"https://openalex.org/C123765429","wikidata":"https://www.wikidata.org/wiki/Q36961","display_name":"Spermatogenesis","level":2,"score":0.6043052077293396},{"id":"https://openalex.org/C119157956","wikidata":"https://www.wikidata.org/wiki/Q796604","display_name":"Acetylation","level":3,"score":0.5780458450317383},{"id":"https://openalex.org/C2780561631","wikidata":"https://www.wikidata.org/wiki/Q421331","display_name":"Sirtuin","level":4,"score":0.563576877117157},{"id":"https://openalex.org/C2776687438","wikidata":"https://www.wikidata.org/wiki/Q3749492","display_name":"Sterility","level":2,"score":0.5440619587898254},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5408945083618164},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5346958041191101},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.5329505205154419},{"id":"https://openalex.org/C2776536020","wikidata":"https://www.wikidata.org/wiki/Q21113719","display_name":"Sirtuin 1","level":4,"score":0.5269302129745483},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.44544094800949097},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.41788846254348755},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37095504999160767},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3529059886932373},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2608722448348999},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08704757690429688},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.08362177014350891}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003433","descriptor_name":"Crosses, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007248","descriptor_name":"Infertility, Male","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007248","descriptor_name":"Infertility, Male","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012708","descriptor_name":"Sertoli Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013256","descriptor_name":"Steroids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054339","descriptor_name":"Steroidogenic Factor 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054339","descriptor_name":"Steroidogenic Factor 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D056564","descriptor_name":"Sirtuin 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056564","descriptor_name":"Sirtuin 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/rda.13737","doi":"https://doi.org/10.1111/rda.13737","is_oa":false,"landing_page_url":"https://doi.org/10.1111/rda.13737","pdf_url":null,"source":{"id":"https://openalex.org/S147868187","display_name":"Reproduction in Domestic Animals","issn_l":"0044-5371","issn":["0044-5371","0936-6768","1439-0531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproduction in Domestic Animals","raw_type":"journal-article"},{"id":"pmid:32497285","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32497285","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproduction in domestic animals = Zuchthygiene","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1969480537","https://openalex.org/W1986598783","https://openalex.org/W2007043260","https://openalex.org/W2010548987","https://openalex.org/W2022018162","https://openalex.org/W2024173190","https://openalex.org/W2029333246","https://openalex.org/W2054225988","https://openalex.org/W2097948853","https://openalex.org/W2119391432","https://openalex.org/W2124595934","https://openalex.org/W2125026216","https://openalex.org/W2137702233","https://openalex.org/W2138919043","https://openalex.org/W2291543263","https://openalex.org/W2342500436","https://openalex.org/W2497851730","https://openalex.org/W2550993539","https://openalex.org/W2561386110","https://openalex.org/W2604197619","https://openalex.org/W2742040401","https://openalex.org/W2783579130","https://openalex.org/W2802249544","https://openalex.org/W2893350455","https://openalex.org/W2903416411","https://openalex.org/W2914563906","https://openalex.org/W2944584202","https://openalex.org/W2944862113","https://openalex.org/W2961184804","https://openalex.org/W2987523076","https://openalex.org/W2995904401"],"related_works":["https://openalex.org/W1969480537","https://openalex.org/W2125026216","https://openalex.org/W4309516128","https://openalex.org/W2529642018","https://openalex.org/W3008060627","https://openalex.org/W7162756353","https://openalex.org/W2352525634","https://openalex.org/W6958541095","https://openalex.org/W4328101678","https://openalex.org/W4292466658"],"abstract_inverted_index":{"Cattleyak,":[0],"which":[1],"are":[2,20,51],"interspecific":[3],"hybrids":[4],"between":[5],"cattle":[6],"and":[7,49,92,120,127,165,183],"yak,":[8],"display":[9],"much":[10],"higher":[11],"growth":[12],"performances":[13],"than":[14],"yak.":[15],"However,":[16],"F1":[17],"male":[18],"cattleyak":[19,50,77,83,104,132,147,181],"infertile":[21],"due":[22],"to":[23],"defective":[24],"testicular":[25,45,67,169,196],"development.":[26,170,197],"Sirtuin":[27],"1":[28],"(SIRT1)":[29],"is":[30,35],"a":[31],"histone":[32,87],"deacetylase":[33],"that":[34,58,82],"essential":[36],"for":[37,116,142,176],"various":[38,63],"biological":[39],"processes,":[40],"while":[41,72],"the":[42,143,154,166,178,189],"roles":[43,190],"of":[44,65,95,110,156,163,168,180,191],"SIRT1":[46,59,96,157,192],"in":[47,62,76,103,131,146,158,187,193],"yak":[48,66,159,195],"still":[52],"poorly":[53],"understood.":[54],"Here,":[55],"we":[56],"found":[57],"was":[60,74,101,139],"localized":[61],"kinds":[64],"cells":[68],"except":[69],"elongated":[70],"spermatids":[71],"it":[73],"deficient":[75],"testis.":[78,133,148],"Further":[79],"studies":[80],"indicated":[81],"testis":[84,105,160],"exhibited":[85],"decreased":[86,129],"acetylation":[88,138],"levels":[89],"on":[90],"H3":[91],"H4.":[93],"One":[94],"co-factors,":[97],"steroidogenic":[98],"factor-1":[99],"(SF-1),":[100],"lost":[102],"at":[106],"protein":[107],"level.":[108],"Expressions":[109],"several":[111],"SF-1":[112,164],"target":[113],"genes":[114],"responsible":[115,141],"Sertoli":[117],"cell":[118,144],"development":[119],"steroidogenesis,":[121],"including":[122],"STAR,":[123],"CYP11A1,":[124],"CYP26B1,":[125],"FDX1":[126],"HSD3B,":[128],"significantly":[130],"In":[134],"addition,":[135],"SIRT1-mediated":[136],"P53":[137],"not":[140],"apoptosis":[145],"Taken":[149],"together,":[150],"our":[151],"results":[152],"suggested":[153],"deficiency":[155],"caused":[161],"inactivation":[162],"impairment":[167],"This":[171],"research":[172],"provides":[173],"theoretical":[174],"bases":[175],"understanding":[177],"mechanism":[179],"sterility":[182],"gives":[184],"new":[185],"insights":[186],"revealing":[188],"regulating":[194]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-06-12T00:00:00"}