{"id":"https://openalex.org/W3033479596","doi":"https://doi.org/10.1016/j.bonr.2020.100288","title":"Romosozumab was not effective in preventing multiple spontaneous clinical vertebral fractures after denosumab discontinuation: A case report","display_name":"Romosozumab was not effective in preventing multiple spontaneous clinical vertebral fractures after denosumab discontinuation: A case report","publication_year":2020,"publication_date":"2020-06-05","ids":{"openalex":"https://openalex.org/W3033479596","doi":"https://doi.org/10.1016/j.bonr.2020.100288","mag":"3033479596","pmid":"https://pubmed.ncbi.nlm.nih.gov/32548215","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7284126"},"language":"en","primary_location":{"id":"doi:10.1016/j.bonr.2020.100288","doi":"https://doi.org/10.1016/j.bonr.2020.100288","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bonr.2020.100288","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2352187220300486/pdf","source":{"id":"https://openalex.org/S2764541639","display_name":"Bone Reports","issn_l":"2352-1872","issn":["2352-1872"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S2352187220300486/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003895917","display_name":"Masafumi Kashii","orcid":"https://orcid.org/0000-0002-7552-0356","observed_orcids":["https://orcid.org/0000-0002-7552-0356"]},"institutions":[{"id":"https://openalex.org/I4210088412","display_name":"Toyonaka Municipal Hospital","ror":"https://ror.org/0056qeq43","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210088412"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Masafumi Kashii","raw_affiliation_strings":["Department of Orthopedic Surgery, Toyonaka Municipal Hospital, Toyonaka, Osaka, Japan"],"raw_orcid":"https://orcid.org/0000-0002-7552-0356","affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Toyonaka Municipal Hospital, Toyonaka, Osaka, Japan","institution_ids":["https://openalex.org/I4210088412"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033870789","display_name":"Kosuke Ebina","orcid":"https://orcid.org/0000-0002-2426-1024","observed_orcids":["https://orcid.org/0000-0002-2426-1024"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kosuke Ebina","raw_affiliation_strings":["Department of Musculoskeletal Regenerative Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Musculoskeletal Regenerative Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032618920","display_name":"Kazuma Kitaguchi","orcid":"https://orcid.org/0000-0003-2483-087X","observed_orcids":["https://orcid.org/0000-0003-2483-087X"]},"institutions":[{"id":"https://openalex.org/I4210088412","display_name":"Toyonaka Municipal Hospital","ror":"https://ror.org/0056qeq43","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210088412"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuma Kitaguchi","raw_affiliation_strings":["Department of Orthopedic Surgery, Toyonaka Municipal Hospital, Toyonaka, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Toyonaka Municipal Hospital, Toyonaka, Osaka, Japan","institution_ids":["https://openalex.org/I4210088412"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100601421","display_name":"Hideki Yoshikawa","orcid":"https://orcid.org/0000-0002-7697-8035","observed_orcids":["https://orcid.org/0000-0002-7697-8035"]},"institutions":[{"id":"https://openalex.org/I4210088412","display_name":"Toyonaka Municipal Hospital","ror":"https://ror.org/0056qeq43","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210088412"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideki Yoshikawa","raw_affiliation_strings":["Department of Orthopedic Surgery, Toyonaka Municipal Hospital, Toyonaka, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Toyonaka Municipal Hospital, Toyonaka, Osaka, Japan","institution_ids":["https://openalex.org/I4210088412"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5003895917"],"corresponding_institution_ids":["https://openalex.org/I4210088412"],"apc_list":{"value":1450,"currency":"USD","value_usd":1450},"apc_paid":{"value":1450,"currency":"USD","value_usd":1450},"fwci":4.0684,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.94087885,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"13","issue":null,"first_page":"100288","last_page":"100288"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/romosozumab","display_name":"romosozumab","score":0.9990000128746033},{"id":"https://openalex.org/keywords/denosumab-discontinuation","display_name":"denosumab discontinuation","score":0.972000002861023},{"id":"https://openalex.org/keywords/sclerostin-inhibition","display_name":"sclerostin inhibition","score":0.8040000200271606},{"id":"https://openalex.org/keywords/low-back-pain","display_name":"low back pain","score":0.6759999990463257},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.6959999799728394},{"id":"https://openalex.org/keywords/bone-resorption-markers","display_name":"bone resorption markers","score":0.6380000114440918},{"id":"https://openalex.org/keywords/anti-osteoporotic-therapy","display_name":"anti-osteoporotic therapy","score":0.7080000042915344}],"concepts":[{"id":"https://openalex.org/C2776286101","wikidata":"https://www.wikidata.org/wiki/Q408283","display_name":"Denosumab","level":3,"score":0.9378988742828369},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8769658207893372},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.8603639602661133},{"id":"https://openalex.org/C2779277721","wikidata":"https://www.wikidata.org/wiki/Q14887295","display_name":"Sclerostin","level":4,"score":0.8115353584289551},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.5827510356903076},{"id":"https://openalex.org/C673006","wikidata":"https://www.wikidata.org/wiki/Q4941581","display_name":"Bone resorption","level":2,"score":0.5370259881019592},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.5260567665100098},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4071013629436493},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.32539474964141846},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.bonr.2020.100288","doi":"https://doi.org/10.1016/j.bonr.2020.100288","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bonr.2020.100288","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2352187220300486/pdf","source":{"id":"https://openalex.org/S2764541639","display_name":"Bone Reports","issn_l":"2352-1872","issn":["2352-1872"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone Reports","raw_type":"journal-article"},{"id":"pmid:32548215","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32548215","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone reports","raw_type":"Case Reports"},{"id":"pmh:oai:pubmedcentral.nih.gov:7284126","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7284126/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone Rep","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:b0ee5ce45e4a412aa78a85b013112d02","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b0ee5ce45e4a412aa78a85b013112d02","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bone Reports, Vol 13, Iss , Pp 100288- (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.bonr.2020.100288","doi":"https://doi.org/10.1016/j.bonr.2020.100288","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bonr.2020.100288","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2352187220300486/pdf","source":{"id":"https://openalex.org/S2764541639","display_name":"Bone Reports","issn_l":"2352-1872","issn":["2352-1872"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3033479596.pdf","grobid_xml":"https://content.openalex.org/works/W3033479596.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W1533291475","https://openalex.org/W1911703092","https://openalex.org/W2005828584","https://openalex.org/W2025343005","https://openalex.org/W2032956576","https://openalex.org/W2040400629","https://openalex.org/W2096627331","https://openalex.org/W2134910437","https://openalex.org/W2520995084","https://openalex.org/W2531652035","https://openalex.org/W2565573303","https://openalex.org/W2594420699","https://openalex.org/W2620350575","https://openalex.org/W2738136796","https://openalex.org/W2787273932","https://openalex.org/W2787743849","https://openalex.org/W2799569094","https://openalex.org/W2935865486","https://openalex.org/W2980928034","https://openalex.org/W2999036028","https://openalex.org/W3019606932","https://openalex.org/W3028568035","https://openalex.org/W4235887951"],"related_works":["https://openalex.org/W4400037995","https://openalex.org/W7111086093","https://openalex.org/W2999036028","https://openalex.org/W2912223367","https://openalex.org/W2531903877","https://openalex.org/W2807909818","https://openalex.org/W3092642176","https://openalex.org/W2771455692","https://openalex.org/W3132139696","https://openalex.org/W4414121828"],"abstract_inverted_index":{"Discontinuation":[0],"of":[1,8,40,50,86,94,105,118,129,211,249],"denosumab":[2,106,132,147,176,265],"is":[3,43,56,71,75,256],"associated":[4],"with":[5,101,203,206],"the":[6,48,57,137,142,145,153,159,174,179,242],"increase":[7],"bone":[9,18,22,67,156,195,239,245],"turnover":[10,246],"markers":[11],"to":[12,80],"above-baseline":[13],"levels":[14,200],"(so-called":[15],"rebound":[16,243],"in":[17,158,244,259],"turnover)":[19],"and":[20,64,107,123,125,197,219,230],"rapid":[21],"loss.":[23],"Several":[24],"studies":[25],"have":[26],"reported":[27,90],"vertebral":[28],"fractures":[29],"(VFs),":[30],"particularly":[31],"multiple":[32],"spontaneous":[33,213],"clinical":[34,186],"VFs":[35,51,82,121,225,261],"(MSCVFs),":[36],"occurring":[37,83],"after":[38,84,103,170,247,264],"discontinuation":[39,85,104,248],"denosumab.":[41,87,207,250],"There":[42],"currently":[44],"no":[45,185,235],"recommendation":[46],"for":[47],"management":[49],"including":[52],"MSCVFs.":[53],"Presently,":[54],"romosozumab":[55,74,102,112,166,181,255],"strongest":[58],"anti-osteoporotic":[59],"agent":[60],"that":[61,73,254],"inhibits":[62],"sclerostin":[63],"rapidly":[65],"increases":[66],"mass,":[68],"but":[69,193],"it":[70],"uncertain":[72],"an":[76],"effective":[77,258],"treatment":[78],"choice":[79],"treat":[81],"Herein":[88],"we":[89],"a":[91,95,116],"novel":[92],"case":[93,252],"60-year-old":[96],"woman":[97],"who":[98],"was":[99,149,167],"treated":[100,205],"subsequently":[108],"suffered":[109],"MSCVFs":[110,263],"under":[111],"treatment.":[113],"She":[114],"had":[115,184,234],"history":[117],"two":[119],"osteoporotic":[120],"(T6":[122],"T8)":[124],"received":[126],"five":[127,223],"doses":[128,210],"60":[130],"mg":[131,165],"every":[133],"6":[134],"months":[135,172],"following":[136,173],"osteoporosis":[138],"diagnosis.":[139],"As":[140],"per":[141],"patient's":[143],"convenience,":[144],"sixth":[146],"injection":[148],"postponed.":[150],"To":[151],"improve":[152],"persistent":[154],"low":[155,190,215],"mass":[157],"lumbar":[160],"spine":[161],"(T-score":[162],"-3.8),":[163],"210":[164],"administered":[168],"monthly":[169],"9":[171],"last":[175],"injection.":[177],"At":[178],"first":[180],"injection,":[182],"she":[183],"symptoms":[187],"such":[188],"as":[189],"back":[191,216],"pain,":[192],"her":[194],"formation":[196],"resorption":[198,240],"marker":[199],"elevated":[201],"compared":[202],"those":[204],"After":[208],"three":[209],"romosozumab,":[212],"severe":[214],"pain":[217],"occurred,":[218],"time-course":[220],"radiographs":[221],"revealed":[222],"new":[224],"(T12,":[226],"L2,":[227],"L3,":[228],"L4,":[229],"L5).":[231],"Romosozumab":[232],"administration":[233],"suppressive":[236],"effect":[237],"on":[238],"during":[241],"This":[251],"suggests":[253],"not":[257],"preventing":[260],"or":[262],"discontinuation.":[266]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-06-12T00:00:00"}
