{"id":"https://openalex.org/W3033333373","doi":"https://doi.org/10.5958/0974-360x.2020.00428.x","title":"In silico Molecular docking of Luteolin from Momordica charantia for dementia in Alzheimer's disease","display_name":"In silico Molecular docking of Luteolin from Momordica charantia for dementia in Alzheimer's disease","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W3033333373","doi":"https://doi.org/10.5958/0974-360x.2020.00428.x","mag":"3033333373"},"language":"en","primary_location":{"id":"doi:10.5958/0974-360x.2020.00428.x","doi":"https://doi.org/10.5958/0974-360x.2020.00428.x","is_oa":true,"landing_page_url":"https://doi.org/10.5958/0974-360x.2020.00428.x","pdf_url":null,"source":{"id":"https://openalex.org/S4210228335","display_name":"Research Journal of Pharmacy and Technology","issn_l":"0974-360X","issn":["0974-360X","0974-3618"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research Journal of Pharmacy and Technology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.5958/0974-360x.2020.00428.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017297146","display_name":"T. Tamilanban","orcid":"https://orcid.org/0000-0002-3240-0645","observed_orcids":["https://orcid.org/0000-0002-3240-0645"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. Tamilanban","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103909897","display_name":"V Naveen Kumar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V Naveen Kumar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033141272","display_name":"Jayasankar Narayanan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Narayanan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009398904","display_name":"S Prathusa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Prathusa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076958140","display_name":"N Dhivya","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Dhivya","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112037803","display_name":"K. Manasa","orcid":"https://orcid.org/0000-0001-8695-446X","observed_orcids":["https://orcid.org/0000-0001-8695-446X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Manasa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1866,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.41642432,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"13","issue":"5","first_page":"2381","last_page":"2381"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.8184000253677368,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.8184000253677368,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.07519999891519547,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.06369999796152115,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/luteolin","display_name":"luteolin","score":1.0},{"id":"https://openalex.org/keywords/momordica-charantia","display_name":"Momordica charantia","score":1.0},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8610000014305115},{"id":"https://openalex.org/keywords/dementia","display_name":"dementia","score":0.9369999766349792},{"id":"https://openalex.org/keywords/anti-alzheimer-activity","display_name":"anti-Alzheimer activity","score":0.718999981880188},{"id":"https://openalex.org/keywords/protein-ligand-docking","display_name":"protein-ligand docking","score":0.8299999833106995},{"id":"https://openalex.org/keywords/multitarget-drug-candidates","display_name":"multi-target drug candidates","score":0.5860000252723694},{"id":"https://openalex.org/keywords/binding-affinity","display_name":"binding affinity","score":0.5669999718666077},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.5709999799728394}],"concepts":[{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.7307729125022888},{"id":"https://openalex.org/C2778686829","wikidata":"https://www.wikidata.org/wiki/Q179937","display_name":"Momordica","level":2,"score":0.7189642786979675},{"id":"https://openalex.org/C2776080593","wikidata":"https://www.wikidata.org/wiki/Q415011","display_name":"Luteolin","level":4,"score":0.5834606289863586},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.5586007237434387},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5341277122497559},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.5171222686767578},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46323129534721375},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.42366456985473633},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.3853263258934021},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34061819314956665},{"id":"https://openalex.org/C42972112","wikidata":"https://www.wikidata.org/wiki/Q170201","display_name":"Veterinary medicine","level":1,"score":0.19940054416656494},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19089877605438232},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18573248386383057},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.0},{"id":"https://openalex.org/C2781263971","wikidata":"https://www.wikidata.org/wiki/Q409478","display_name":"Quercetin","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.5958/0974-360x.2020.00428.x","doi":"https://doi.org/10.5958/0974-360x.2020.00428.x","is_oa":true,"landing_page_url":"https://doi.org/10.5958/0974-360x.2020.00428.x","pdf_url":null,"source":{"id":"https://openalex.org/S4210228335","display_name":"Research Journal of Pharmacy and Technology","issn_l":"0974-360X","issn":["0974-360X","0974-3618"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research Journal of Pharmacy and Technology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.5958/0974-360x.2020.00428.x","doi":"https://doi.org/10.5958/0974-360x.2020.00428.x","is_oa":true,"landing_page_url":"https://doi.org/10.5958/0974-360x.2020.00428.x","pdf_url":null,"source":{"id":"https://openalex.org/S4210228335","display_name":"Research Journal of Pharmacy and Technology","issn_l":"0974-360X","issn":["0974-360X","0974-3618"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research Journal of Pharmacy and Technology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W6968235696","https://openalex.org/W3160210115","https://openalex.org/W4403224765","https://openalex.org/W6892617984","https://openalex.org/W4390764241","https://openalex.org/W4389849097","https://openalex.org/W3046150156","https://openalex.org/W3170907477","https://openalex.org/W7154143795","https://openalex.org/W3154269685"],"abstract_inverted_index":{"Objective:":[0],"In":[1,27,59],"the":[2,38,45,86,94,120,129,134,137,142,145,151],"present":[3],"study,":[4],"luteolin":[5,130],"was":[6,97,107,116,131,139,154,163],"isolated":[7],"from":[8,85,102],"Momordica":[9],"charantia":[10],"and":[11,15,44,105,114,136,172],"characterized":[12],"by":[13,156],"IR":[14],"NMR":[16],"spectroscopy,":[17],"undergone":[18],"in":[19],"silico":[20,28],"docking":[21,30,115,126],"to":[22,36,119,165],"study":[23],"its":[24],"anti-Alzheimer's":[25],"role.":[26],"molecular":[29,125],"is":[31,174,179],"a":[32,52,70],"computational":[33],"system":[34],"employed":[35],"predict":[37],"interaction":[39],"vitality":[40],"between":[41],"two":[42],"particles":[43],"best":[46],"introduction":[47],"of":[48,144,148],"ligand":[49,95,149],"that":[50,178],"shapes":[51],"complex":[53],"with":[54,133,150],"general":[55],"least":[56],"vitality.":[57],"Methods:":[58],"this":[60],"Protein":[61,88],"Ligand":[62],"Docking,":[63],"we":[64],"have":[65,166],"used":[66],"HEX":[67],"8.0.0":[68],"as":[69,99],"Docking":[71],"Software.":[72],"The":[73,124],"receptors":[74,135],"(PDB":[75],"ID:":[76],"4PQE,":[77],"1P0I,":[78],"5O3L,":[79],"1J1C,":[80],"3NYJ,":[81],"2FJZ)":[82],"were":[83],"retrieved":[84,98],"RCSB":[87],"Data":[89],"Bank":[90],"(PDB)":[91],"Database":[92],"while":[93],"structure":[96],"mol":[100],"format":[101,110],"ChEBI":[103],"database":[104],"it":[106,173],"converted":[108],"as.pdb":[109],"using":[111,157],"Chimera":[112,158],"1.12":[113,159],"done":[117],"according":[118],"specified":[121],"parameters.":[122],"Results:":[123],"process":[127],"for":[128,169,181],"performed":[132],"E-value":[138],"determined.":[140],"Further,":[141],"result":[143],"binding":[146],"site":[147],"target":[152,170],"proteins":[153],"interpreted":[155],"software.":[160],"Conclusion:":[161],"Luteolin":[162],"proved":[164],"good":[167],"affinity":[168],"protein":[171],"having":[175],"multitarget":[176],"activity":[177],"responsible":[180],"AD.":[182]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-06-12T00:00:00"}