{"id":"https://openalex.org/W3033233138","doi":"https://doi.org/10.1097/aln.0000000000003365","title":"Mineralocorticoid Dysfunction during Critical Illness","display_name":"Mineralocorticoid Dysfunction during Critical Illness","publication_year":2020,"publication_date":"2020-06-05","ids":{"openalex":"https://openalex.org/W3033233138","doi":"https://doi.org/10.1097/aln.0000000000003365","mag":"3033233138","pmid":"https://pubmed.ncbi.nlm.nih.gov/32501957"},"language":"en","primary_location":{"id":"doi:10.1097/aln.0000000000003365","doi":"https://doi.org/10.1097/aln.0000000000003365","is_oa":false,"landing_page_url":"https://doi.org/10.1097/aln.0000000000003365","pdf_url":null,"source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017405827","display_name":"Gladness Dakalo Nethathe","orcid":"https://orcid.org/0000-0001-6875-8422","observed_orcids":["https://orcid.org/0000-0001-6875-8422"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I192619145","display_name":"University of the Witwatersrand","ror":"https://ror.org/03rp50x72","country_code":"ZA","type":"education","lineage":["https://openalex.org/I192619145"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I2799393793","display_name":"Royal Brisbane and Women's Hospital","ror":"https://ror.org/05p52kj31","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1302211766","https://openalex.org/I2799393793","https://openalex.org/I2801244131"]},{"id":"https://openalex.org/I2800284578","display_name":"Wesley Hospital","ror":"https://ror.org/018kd1e03","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800284578"]},{"id":"https://openalex.org/I4210110309","display_name":"The George Institute for Global Health","ror":"https://ror.org/023331s46","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210110309"]},{"id":"https://openalex.org/I69552723","display_name":"University of Pretoria","ror":"https://ror.org/00g0p6g84","country_code":"ZA","type":"education","lineage":["https://openalex.org/I69552723"]}],"countries":["AU","FR","ZA"],"is_corresponding":false,"raw_author_name":"Gladness Dakalo Nethathe","raw_affiliation_strings":["From the School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa (G.D.N., C.F.) the Department of Anaesthesia and Perioperative Medicine, Royal Brisbane and Women's Hospital, Queensland, Australia (G.D.N.) the Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia (G.D.N., J.C., J.L.) The George Institute, Sydney, New South Wales, Australia (J.C.) The Wesley Hospital, Brisbane, Queensland, Australia (J.C.) Intensive Care Services, Royal Brisbane and Women's Hospital, Herston, Brisbane, Queensland, Australia (J.C., J.L.) Nimes University Hospital, University of Montpellier, Nimes, France (J.L.) the Institute for Cellular and Molecular Medicine, Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa (R.A.)","From the School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa (G.D.N., C.F.)","Intensive Care Services, Royal Brisbane and Women's Hospital, Herston, Brisbane, Queensland, Australia (J.C., J.L.)","Nimes University Hospital, University of Montpellier, Nimes, France (J.L.)","Submitted for publication August 16, 2019. Accepted for publication April 17, 2020. Published online first on June 3, 2020","The George Institute, Sydney, New South Wales, Australia (J.C.)","The Wesley Hospital, Brisbane, Queensland, Australia (J.C.)","This article is featured in \"This Month in Anesthesiology,\" page 1A","the Department of Anaesthesia and Perioperative Medicine, Royal Brisbane and Women's Hospital, Queensland, Australia (G.D.N.)","the Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia (G.D.N., J.C., J.L.)","the Institute for Cellular and Molecular Medicine, Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa (R.A.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa (G.D.N., C.F.) the Department of Anaesthesia and Perioperative Medicine, Royal Brisbane and Women's Hospital, Queensland, Australia (G.D.N.) the Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia (G.D.N., J.C., J.L.) The George Institute, Sydney, New South Wales, Australia (J.C.) The Wesley Hospital, Brisbane, Queensland, Australia (J.C.) Intensive Care Services, Royal Brisbane and Women's Hospital, Herston, Brisbane, Queensland, Australia (J.C., J.L.) Nimes University Hospital, University of Montpellier, Nimes, France (J.L.) the Institute for Cellular and Molecular Medicine, Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa (R.A.)","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I192619145","https://openalex.org/I19894307","https://openalex.org/I2799393793","https://openalex.org/I2800284578","https://openalex.org/I69552723"]},{"raw_affiliation_string":"From the School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa (G.D.N., C.F.)","institution_ids":["https://openalex.org/I192619145"]},{"raw_affiliation_string":"Intensive Care Services, Royal Brisbane and Women's Hospital, Herston, Brisbane, Queensland, Australia (J.C., J.L.)","institution_ids":["https://openalex.org/I2799393793"]},{"raw_affiliation_string":"Nimes University Hospital, University of Montpellier, Nimes, France (J.L.)","institution_ids":["https://openalex.org/I19894307"]},{"raw_affiliation_string":"Submitted for publication August 16, 2019. Accepted for publication April 17, 2020. Published online first on June 3, 2020","institution_ids":[]},{"raw_affiliation_string":"The George Institute, Sydney, New South Wales, Australia (J.C.)","institution_ids":["https://openalex.org/I4210110309"]},{"raw_affiliation_string":"The Wesley Hospital, Brisbane, Queensland, Australia (J.C.)","institution_ids":["https://openalex.org/I2800284578"]},{"raw_affiliation_string":"This article is featured in \"This Month in Anesthesiology,\" page 1A","institution_ids":[]},{"raw_affiliation_string":"the Department of Anaesthesia and Perioperative Medicine, Royal Brisbane and Women's Hospital, Queensland, Australia (G.D.N.)","institution_ids":["https://openalex.org/I2799393793"]},{"raw_affiliation_string":"the Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia (G.D.N., J.C., J.L.)","institution_ids":["https://openalex.org/I165143802"]},{"raw_affiliation_string":"the Institute for Cellular and Molecular Medicine, Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa (R.A.)","institution_ids":["https://openalex.org/I69552723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025600481","display_name":"Jeremy Cohen","orcid":"https://orcid.org/0000-0002-1356-8506","observed_orcids":["https://orcid.org/0000-0002-1356-8506"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I192619145","display_name":"University of the Witwatersrand","ror":"https://ror.org/03rp50x72","country_code":"ZA","type":"education","lineage":["https://openalex.org/I192619145"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I2799393793","display_name":"Royal Brisbane and Women's Hospital","ror":"https://ror.org/05p52kj31","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1302211766","https://openalex.org/I2799393793","https://openalex.org/I2801244131"]},{"id":"https://openalex.org/I2800284578","display_name":"Wesley Hospital","ror":"https://ror.org/018kd1e03","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800284578"]},{"id":"https://openalex.org/I4210110309","display_name":"The George Institute for Global Health","ror":"https://ror.org/023331s46","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210110309"]},{"id":"https://openalex.org/I69552723","display_name":"University of Pretoria","ror":"https://ror.org/00g0p6g84","country_code":"ZA","type":"education","lineage":["https://openalex.org/I69552723"]}],"countries":["AU","FR","ZA"],"is_corresponding":false,"raw_author_name":"Jeremy Cohen","raw_affiliation_strings":["Address correspondence to Dr. Nethathe: Level 4, Ned Hanlon Building, Royal Brisbane and Women\u2019s Hospital, Butterfield Street, Herston, Brisbane, 4029 Queensland, Australia. . Anesthesiology\u2019s articles are made freely accessible to all readers on www.anesthesiology.org, for personal use only, 6 months from the cover date of the issue","From the School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa (G.D.N., C.F.); the Department of Anaesthesia and Perioperative Medicine, Royal Brisbane and Women\u2019s Hospital, Queensland, Australia (G.D.N.); the Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia (G.D.N., J.C., J.L.); The George Institute, Sydney, New South Wales, Australia (J.C.); The Wesley Hospital, Brisbane, Queensland, Australia (J.C.); Intensive Care Services, Royal Brisbane and Women\u2019s Hospital, Herston, Brisbane, Queensland, Australia (J.C., J.L.); Nimes University Hospital, University of Montpellier, Nimes, France (J.L.); and the Institute for Cellular and Molecular Medicine, Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa (R.A.)","Submitted for publication August 16, 2019. Accepted for publication April 17, 2020. Published online first on June 3, 2020","This article is featured in \u201cThis Month in Anesthesiology,\u201d page 1A","From the School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa (G.D.N., C.F.)","Intensive Care Services, Royal Brisbane and Women's Hospital, Herston, Brisbane, Queensland, Australia (J.C., J.L.)","Nimes University Hospital, University of Montpellier, Nimes, France (J.L.)","The George Institute, Sydney, New South Wales, Australia (J.C.)","The Wesley Hospital, Brisbane, Queensland, Australia (J.C.)","the Department of Anaesthesia and Perioperative Medicine, Royal Brisbane and Women's Hospital, Queensland, Australia (G.D.N.)","the Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia (G.D.N., J.C., J.L.)","the Institute for Cellular and Molecular Medicine, Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa (R.A.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Address correspondence to Dr. Nethathe: Level 4, Ned Hanlon Building, Royal Brisbane and Women\u2019s Hospital, Butterfield Street, Herston, Brisbane, 4029 Queensland, Australia. . Anesthesiology\u2019s articles are made freely accessible to all readers on www.anesthesiology.org, for personal use only, 6 months from the cover date of the issue","institution_ids":["https://openalex.org/I2799393793"]},{"raw_affiliation_string":"From the School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa (G.D.N., C.F.); the Department of Anaesthesia and Perioperative Medicine, Royal Brisbane and Women\u2019s Hospital, Queensland, Australia (G.D.N.); the Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia (G.D.N., J.C., J.L.); The George Institute, Sydney, New South Wales, Australia (J.C.); The Wesley Hospital, Brisbane, Queensland, Australia (J.C.); Intensive Care Services, Royal Brisbane and Women\u2019s Hospital, Herston, Brisbane, Queensland, Australia (J.C., J.L.); Nimes University Hospital, University of Montpellier, Nimes, France (J.L.); and the Institute for Cellular and Molecular Medicine, Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa (R.A.)","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I192619145","https://openalex.org/I19894307","https://openalex.org/I2799393793","https://openalex.org/I2800284578","https://openalex.org/I69552723"]},{"raw_affiliation_string":"Submitted for publication August 16, 2019. Accepted for publication April 17, 2020. Published online first on June 3, 2020","institution_ids":[]},{"raw_affiliation_string":"This article is featured in \u201cThis Month in Anesthesiology,\u201d page 1A","institution_ids":[]},{"raw_affiliation_string":"From the School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa (G.D.N., C.F.)","institution_ids":["https://openalex.org/I192619145"]},{"raw_affiliation_string":"Intensive Care Services, Royal Brisbane and Women's Hospital, Herston, Brisbane, Queensland, Australia (J.C., J.L.)","institution_ids":["https://openalex.org/I2799393793"]},{"raw_affiliation_string":"Nimes University Hospital, University of Montpellier, Nimes, France (J.L.)","institution_ids":["https://openalex.org/I19894307"]},{"raw_affiliation_string":"The George Institute, Sydney, New South Wales, Australia (J.C.)","institution_ids":["https://openalex.org/I4210110309"]},{"raw_affiliation_string":"The Wesley Hospital, Brisbane, Queensland, Australia (J.C.)","institution_ids":["https://openalex.org/I2800284578"]},{"raw_affiliation_string":"the Department of Anaesthesia and Perioperative Medicine, Royal Brisbane and Women's Hospital, Queensland, Australia (G.D.N.)","institution_ids":["https://openalex.org/I2799393793"]},{"raw_affiliation_string":"the Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia (G.D.N., J.C., J.L.)","institution_ids":["https://openalex.org/I165143802"]},{"raw_affiliation_string":"the Institute for Cellular and Molecular Medicine, Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa (R.A.)","institution_ids":["https://openalex.org/I69552723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066789024","display_name":"Jeffrey Lipman","orcid":"https://orcid.org/0000-0002-5965-9876","observed_orcids":["https://orcid.org/0000-0002-5965-9876"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I192619145","display_name":"University of the Witwatersrand","ror":"https://ror.org/03rp50x72","country_code":"ZA","type":"education","lineage":["https://openalex.org/I192619145"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I2799393793","display_name":"Royal Brisbane and Women's Hospital","ror":"https://ror.org/05p52kj31","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1302211766","https://openalex.org/I2799393793","https://openalex.org/I2801244131"]},{"id":"https://openalex.org/I2800284578","display_name":"Wesley Hospital","ror":"https://ror.org/018kd1e03","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800284578"]},{"id":"https://openalex.org/I4210110309","display_name":"The George Institute for Global Health","ror":"https://ror.org/023331s46","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210110309"]},{"id":"https://openalex.org/I69552723","display_name":"University of Pretoria","ror":"https://ror.org/00g0p6g84","country_code":"ZA","type":"education","lineage":["https://openalex.org/I69552723"]}],"countries":["AU","FR","ZA"],"is_corresponding":false,"raw_author_name":"Jeffrey Lipman","raw_affiliation_strings":["Address correspondence to Dr. Nethathe: Level 4, Ned Hanlon Building, Royal Brisbane and Women\u2019s Hospital, Butterfield Street, Herston, Brisbane, 4029 Queensland, Australia. . Anesthesiology\u2019s articles are made freely accessible to all readers on www.anesthesiology.org, for personal use only, 6 months from the cover date of the issue","From the School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa (G.D.N., C.F.); the Department of Anaesthesia and Perioperative Medicine, Royal Brisbane and Women\u2019s Hospital, Queensland, Australia (G.D.N.); the Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia (G.D.N., J.C., J.L.); The George Institute, Sydney, New South Wales, Australia (J.C.); The Wesley Hospital, Brisbane, Queensland, Australia (J.C.); Intensive Care Services, Royal Brisbane and Women\u2019s Hospital, Herston, Brisbane, Queensland, Australia (J.C., J.L.); Nimes University Hospital, University of Montpellier, Nimes, France (J.L.); and the Institute for Cellular and Molecular Medicine, Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa (R.A.)","Submitted for publication August 16, 2019. Accepted for publication April 17, 2020. Published online first on June 3, 2020","This article is featured in \u201cThis Month in Anesthesiology,\u201d page 1A","From the School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa (G.D.N., C.F.)","Intensive Care Services, Royal Brisbane and Women's Hospital, Herston, Brisbane, Queensland, Australia (J.C., J.L.)","Nimes University Hospital, University of Montpellier, Nimes, France (J.L.)","The George Institute, Sydney, New South Wales, Australia (J.C.)","The Wesley Hospital, Brisbane, Queensland, Australia (J.C.)","the Department of Anaesthesia and Perioperative Medicine, Royal Brisbane and Women's Hospital, Queensland, Australia (G.D.N.)","the Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia (G.D.N., J.C., J.L.)","the Institute for Cellular and Molecular Medicine, Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa (R.A.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Address correspondence to Dr. Nethathe: Level 4, Ned Hanlon Building, Royal Brisbane and Women\u2019s Hospital, Butterfield Street, Herston, Brisbane, 4029 Queensland, Australia. . Anesthesiology\u2019s articles are made freely accessible to all readers on www.anesthesiology.org, for personal use only, 6 months from the cover date of the issue","institution_ids":["https://openalex.org/I2799393793"]},{"raw_affiliation_string":"From the School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa (G.D.N., C.F.); the Department of Anaesthesia and Perioperative Medicine, Royal Brisbane and Women\u2019s Hospital, Queensland, Australia (G.D.N.); the Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia (G.D.N., J.C., J.L.); The George Institute, Sydney, New South Wales, Australia (J.C.); The Wesley Hospital, Brisbane, Queensland, Australia (J.C.); Intensive Care Services, Royal Brisbane and Women\u2019s Hospital, Herston, Brisbane, Queensland, Australia (J.C., J.L.); Nimes University Hospital, University of Montpellier, Nimes, France (J.L.); and the Institute for Cellular and Molecular Medicine, Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa (R.A.)","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I192619145","https://openalex.org/I19894307","https://openalex.org/I2799393793","https://openalex.org/I2800284578","https://openalex.org/I69552723"]},{"raw_affiliation_string":"Submitted for publication August 16, 2019. Accepted for publication April 17, 2020. Published online first on June 3, 2020","institution_ids":[]},{"raw_affiliation_string":"This article is featured in \u201cThis Month in Anesthesiology,\u201d page 1A","institution_ids":[]},{"raw_affiliation_string":"From the School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa (G.D.N., C.F.)","institution_ids":["https://openalex.org/I192619145"]},{"raw_affiliation_string":"Intensive Care Services, Royal Brisbane and Women's Hospital, Herston, Brisbane, Queensland, Australia (J.C., J.L.)","institution_ids":["https://openalex.org/I2799393793"]},{"raw_affiliation_string":"Nimes University Hospital, University of Montpellier, Nimes, France (J.L.)","institution_ids":["https://openalex.org/I19894307"]},{"raw_affiliation_string":"The George Institute, Sydney, New South Wales, Australia (J.C.)","institution_ids":["https://openalex.org/I4210110309"]},{"raw_affiliation_string":"The Wesley Hospital, Brisbane, Queensland, Australia (J.C.)","institution_ids":["https://openalex.org/I2800284578"]},{"raw_affiliation_string":"the Department of Anaesthesia and Perioperative Medicine, Royal Brisbane and Women's Hospital, Queensland, Australia (G.D.N.)","institution_ids":["https://openalex.org/I2799393793"]},{"raw_affiliation_string":"the Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia (G.D.N., J.C., J.L.)","institution_ids":["https://openalex.org/I165143802"]},{"raw_affiliation_string":"the Institute for Cellular and Molecular Medicine, Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa (R.A.)","institution_ids":["https://openalex.org/I69552723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030988903","display_name":"Ronald Anderson","orcid":"https://orcid.org/0000-0002-5925-6452","observed_orcids":["https://orcid.org/0000-0002-5925-6452"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I192619145","display_name":"University of the Witwatersrand","ror":"https://ror.org/03rp50x72","country_code":"ZA","type":"education","lineage":["https://openalex.org/I192619145"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I2799393793","display_name":"Royal Brisbane and Women's Hospital","ror":"https://ror.org/05p52kj31","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1302211766","https://openalex.org/I2799393793","https://openalex.org/I2801244131"]},{"id":"https://openalex.org/I2800284578","display_name":"Wesley Hospital","ror":"https://ror.org/018kd1e03","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800284578"]},{"id":"https://openalex.org/I4210110309","display_name":"The George Institute for Global Health","ror":"https://ror.org/023331s46","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210110309"]},{"id":"https://openalex.org/I69552723","display_name":"University of Pretoria","ror":"https://ror.org/00g0p6g84","country_code":"ZA","type":"education","lineage":["https://openalex.org/I69552723"]}],"countries":["AU","FR","ZA"],"is_corresponding":false,"raw_author_name":"Ronald Anderson","raw_affiliation_strings":["Address correspondence to Dr. Nethathe: Level 4, Ned Hanlon Building, Royal Brisbane and Women\u2019s Hospital, Butterfield Street, Herston, Brisbane, 4029 Queensland, Australia. . Anesthesiology\u2019s articles are made freely accessible to all readers on www.anesthesiology.org, for personal use only, 6 months from the cover date of the issue","From the School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa (G.D.N., C.F.); the Department of Anaesthesia and Perioperative Medicine, Royal Brisbane and Women\u2019s Hospital, Queensland, Australia (G.D.N.); the Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia (G.D.N., J.C., J.L.); The George Institute, Sydney, New South Wales, Australia (J.C.); The Wesley Hospital, Brisbane, Queensland, Australia (J.C.); Intensive Care Services, Royal Brisbane and Women\u2019s Hospital, Herston, Brisbane, Queensland, Australia (J.C., J.L.); Nimes University Hospital, University of Montpellier, Nimes, France (J.L.); and the Institute for Cellular and Molecular Medicine, Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa (R.A.)","Submitted for publication August 16, 2019. Accepted for publication April 17, 2020. Published online first on June 3, 2020","This article is featured in \u201cThis Month in Anesthesiology,\u201d page 1A","From the School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa (G.D.N., C.F.)","Intensive Care Services, Royal Brisbane and Women's Hospital, Herston, Brisbane, Queensland, Australia (J.C., J.L.)","Nimes University Hospital, University of Montpellier, Nimes, France (J.L.)","The George Institute, Sydney, New South Wales, Australia (J.C.)","The Wesley Hospital, Brisbane, Queensland, Australia (J.C.)","the Department of Anaesthesia and Perioperative Medicine, Royal Brisbane and Women's Hospital, Queensland, Australia (G.D.N.)","the Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia (G.D.N., J.C., J.L.)","the Institute for Cellular and Molecular Medicine, Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa (R.A.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Address correspondence to Dr. Nethathe: Level 4, Ned Hanlon Building, Royal Brisbane and Women\u2019s Hospital, Butterfield Street, Herston, Brisbane, 4029 Queensland, Australia. . Anesthesiology\u2019s articles are made freely accessible to all readers on www.anesthesiology.org, for personal use only, 6 months from the cover date of the issue","institution_ids":["https://openalex.org/I2799393793"]},{"raw_affiliation_string":"From the School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa (G.D.N., C.F.); the Department of Anaesthesia and Perioperative Medicine, Royal Brisbane and Women\u2019s Hospital, Queensland, Australia (G.D.N.); the Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia (G.D.N., J.C., J.L.); The George Institute, Sydney, New South Wales, Australia (J.C.); The Wesley Hospital, Brisbane, Queensland, Australia (J.C.); Intensive Care Services, Royal Brisbane and Women\u2019s Hospital, Herston, Brisbane, Queensland, Australia (J.C., J.L.); Nimes University Hospital, University of Montpellier, Nimes, France (J.L.); and the Institute for Cellular and Molecular Medicine, Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa (R.A.)","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I192619145","https://openalex.org/I19894307","https://openalex.org/I2799393793","https://openalex.org/I2800284578","https://openalex.org/I69552723"]},{"raw_affiliation_string":"Submitted for publication August 16, 2019. Accepted for publication April 17, 2020. Published online first on June 3, 2020","institution_ids":[]},{"raw_affiliation_string":"This article is featured in \u201cThis Month in Anesthesiology,\u201d page 1A","institution_ids":[]},{"raw_affiliation_string":"From the School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa (G.D.N., C.F.)","institution_ids":["https://openalex.org/I192619145"]},{"raw_affiliation_string":"Intensive Care Services, Royal Brisbane and Women's Hospital, Herston, Brisbane, Queensland, Australia (J.C., J.L.)","institution_ids":["https://openalex.org/I2799393793"]},{"raw_affiliation_string":"Nimes University Hospital, University of Montpellier, Nimes, France (J.L.)","institution_ids":["https://openalex.org/I19894307"]},{"raw_affiliation_string":"The George Institute, Sydney, New South Wales, Australia (J.C.)","institution_ids":["https://openalex.org/I4210110309"]},{"raw_affiliation_string":"The Wesley Hospital, Brisbane, Queensland, Australia (J.C.)","institution_ids":["https://openalex.org/I2800284578"]},{"raw_affiliation_string":"the Department of Anaesthesia and Perioperative Medicine, Royal Brisbane and Women's Hospital, Queensland, Australia (G.D.N.)","institution_ids":["https://openalex.org/I2799393793"]},{"raw_affiliation_string":"the Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia (G.D.N., J.C., J.L.)","institution_ids":["https://openalex.org/I165143802"]},{"raw_affiliation_string":"the Institute for Cellular and Molecular Medicine, Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa (R.A.)","institution_ids":["https://openalex.org/I69552723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056953136","display_name":"Charles H. Feldman","orcid":"https://orcid.org/0000-0002-6881-8314","observed_orcids":["https://orcid.org/0000-0002-6881-8314","https://orcid.org/0000-0002-9334-4456"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I192619145","display_name":"University of the Witwatersrand","ror":"https://ror.org/03rp50x72","country_code":"ZA","type":"education","lineage":["https://openalex.org/I192619145"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I2799393793","display_name":"Royal Brisbane and Women's Hospital","ror":"https://ror.org/05p52kj31","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1302211766","https://openalex.org/I2799393793","https://openalex.org/I2801244131"]},{"id":"https://openalex.org/I2800284578","display_name":"Wesley Hospital","ror":"https://ror.org/018kd1e03","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800284578"]},{"id":"https://openalex.org/I4210110309","display_name":"The George Institute for Global Health","ror":"https://ror.org/023331s46","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210110309"]},{"id":"https://openalex.org/I69552723","display_name":"University of Pretoria","ror":"https://ror.org/00g0p6g84","country_code":"ZA","type":"education","lineage":["https://openalex.org/I69552723"]}],"countries":["AU","FR","ZA"],"is_corresponding":false,"raw_author_name":"Charles Feldman","raw_affiliation_strings":["Address correspondence to Dr. Nethathe: Level 4, Ned Hanlon Building, Royal Brisbane and Women\u2019s Hospital, Butterfield Street, Herston, Brisbane, 4029 Queensland, Australia. . Anesthesiology\u2019s articles are made freely accessible to all readers on www.anesthesiology.org, for personal use only, 6 months from the cover date of the issue","From the School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa (G.D.N., C.F.); the Department of Anaesthesia and Perioperative Medicine, Royal Brisbane and Women\u2019s Hospital, Queensland, Australia (G.D.N.); the Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia (G.D.N., J.C., J.L.); The George Institute, Sydney, New South Wales, Australia (J.C.); The Wesley Hospital, Brisbane, Queensland, Australia (J.C.); Intensive Care Services, Royal Brisbane and Women\u2019s Hospital, Herston, Brisbane, Queensland, Australia (J.C., J.L.); Nimes University Hospital, University of Montpellier, Nimes, France (J.L.); and the Institute for Cellular and Molecular Medicine, Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa (R.A.)","Submitted for publication August 16, 2019. Accepted for publication April 17, 2020. Published online first on June 3, 2020","This article is featured in \u201cThis Month in Anesthesiology,\u201d page 1A","From the School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa (G.D.N., C.F.)","Intensive Care Services, Royal Brisbane and Women's Hospital, Herston, Brisbane, Queensland, Australia (J.C., J.L.)","Nimes University Hospital, University of Montpellier, Nimes, France (J.L.)","The George Institute, Sydney, New South Wales, Australia (J.C.)","The Wesley Hospital, Brisbane, Queensland, Australia (J.C.)","the Department of Anaesthesia and Perioperative Medicine, Royal Brisbane and Women's Hospital, Queensland, Australia (G.D.N.)","the Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia (G.D.N., J.C., J.L.)","the Institute for Cellular and Molecular Medicine, Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa (R.A.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Address correspondence to Dr. Nethathe: Level 4, Ned Hanlon Building, Royal Brisbane and Women\u2019s Hospital, Butterfield Street, Herston, Brisbane, 4029 Queensland, Australia. . Anesthesiology\u2019s articles are made freely accessible to all readers on www.anesthesiology.org, for personal use only, 6 months from the cover date of the issue","institution_ids":["https://openalex.org/I2799393793"]},{"raw_affiliation_string":"From the School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa (G.D.N., C.F.); the Department of Anaesthesia and Perioperative Medicine, Royal Brisbane and Women\u2019s Hospital, Queensland, Australia (G.D.N.); the Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia (G.D.N., J.C., J.L.); The George Institute, Sydney, New South Wales, Australia (J.C.); The Wesley Hospital, Brisbane, Queensland, Australia (J.C.); Intensive Care Services, Royal Brisbane and Women\u2019s Hospital, Herston, Brisbane, Queensland, Australia (J.C., J.L.); Nimes University Hospital, University of Montpellier, Nimes, France (J.L.); and the Institute for Cellular and Molecular Medicine, Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa (R.A.)","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I192619145","https://openalex.org/I19894307","https://openalex.org/I2799393793","https://openalex.org/I2800284578","https://openalex.org/I69552723"]},{"raw_affiliation_string":"Submitted for publication August 16, 2019. Accepted for publication April 17, 2020. Published online first on June 3, 2020","institution_ids":[]},{"raw_affiliation_string":"This article is featured in \u201cThis Month in Anesthesiology,\u201d page 1A","institution_ids":[]},{"raw_affiliation_string":"From the School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa (G.D.N., C.F.)","institution_ids":["https://openalex.org/I192619145"]},{"raw_affiliation_string":"Intensive Care Services, Royal Brisbane and Women's Hospital, Herston, Brisbane, Queensland, Australia (J.C., J.L.)","institution_ids":["https://openalex.org/I2799393793"]},{"raw_affiliation_string":"Nimes University Hospital, University of Montpellier, Nimes, France (J.L.)","institution_ids":["https://openalex.org/I19894307"]},{"raw_affiliation_string":"The George Institute, Sydney, New South Wales, Australia (J.C.)","institution_ids":["https://openalex.org/I4210110309"]},{"raw_affiliation_string":"The Wesley Hospital, Brisbane, Queensland, Australia (J.C.)","institution_ids":["https://openalex.org/I2800284578"]},{"raw_affiliation_string":"the Department of Anaesthesia and Perioperative Medicine, Royal Brisbane and Women's Hospital, Queensland, Australia (G.D.N.)","institution_ids":["https://openalex.org/I2799393793"]},{"raw_affiliation_string":"the Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia (G.D.N., J.C., J.L.)","institution_ids":["https://openalex.org/I165143802"]},{"raw_affiliation_string":"the Institute for Cellular and Molecular Medicine, Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa (R.A.)","institution_ids":["https://openalex.org/I69552723"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3816,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.39396226,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"133","issue":"2","first_page":"439","last_page":"457"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.5400000214576721,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.5400000214576721,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.427700012922287,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.015200000256299973,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/critical-illness","display_name":"critical illness","score":0.9049999713897705},{"id":"https://openalex.org/keywords/septic-shock","display_name":"septic shock","score":0.8180000185966492},{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.7850000262260437},{"id":"https://openalex.org/keywords/fludrocortisone","display_name":"fludrocortisone","score":0.996999979019165},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.9660000205039978},{"id":"https://openalex.org/keywords/vasodilatory-shock","display_name":"vasodilatory shock","score":0.8820000290870667},{"id":"https://openalex.org/keywords/mineralocorticoid-receptor","display_name":"mineralocorticoid receptor","score":0.9520000219345093},{"id":"https://openalex.org/keywords/aldosterone","display_name":"aldosterone","score":0.8650000095367432},{"id":"https://openalex.org/keywords/adrenal-zona-glomerulosa","display_name":"adrenal zona glomerulosa","score":0.9620000123977661},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.48399999737739563}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8208955526351929},{"id":"https://openalex.org/C189135053","wikidata":"https://www.wikidata.org/wiki/Q3454531","display_name":"Mineralocorticoid receptor","level":3,"score":0.7729982137680054},{"id":"https://openalex.org/C2776069600","wikidata":"https://www.wikidata.org/wiki/Q422519","display_name":"Mineralocorticoid","level":3,"score":0.6757789850234985},{"id":"https://openalex.org/C2778525890","wikidata":"https://www.wikidata.org/wiki/Q184564","display_name":"Aldosterone","level":2,"score":0.6265290379524231},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5909922122955322},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5776461362838745},{"id":"https://openalex.org/C59493245","wikidata":"https://www.wikidata.org/wiki/Q14877410","display_name":"Glucocorticoid receptor","level":3,"score":0.5206172466278076},{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.5048373341560364},{"id":"https://openalex.org/C2776138174","wikidata":"https://www.wikidata.org/wiki/Q2378552","display_name":"Hypoaldosteronism","level":4,"score":0.4966610074043274},{"id":"https://openalex.org/C2780178468","wikidata":"https://www.wikidata.org/wiki/Q3551060","display_name":"Zona glomerulosa","level":4,"score":0.48851120471954346},{"id":"https://openalex.org/C2776899810","wikidata":"https://www.wikidata.org/wiki/Q2697578","display_name":"Fludrocortisone","level":3,"score":0.4615478813648224},{"id":"https://openalex.org/C2777628635","wikidata":"https://www.wikidata.org/wiki/Q1765564","display_name":"Septic shock","level":3,"score":0.4589558243751526},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.4437369704246521},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.4177532196044922},{"id":"https://openalex.org/C2778709874","wikidata":"https://www.wikidata.org/wiki/Q190875","display_name":"Hydrocortisone","level":2,"score":0.38705188035964966},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.34200751781463623},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.15503773093223572},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.10132288932800293}],"mesh":[{"descriptor_ui":"D000450","descriptor_name":"Aldosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000450","descriptor_name":"Aldosterone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006994","descriptor_name":"Hypoaldosteronism","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006994","descriptor_name":"Hypoaldosteronism","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D008901","descriptor_name":"Mineralocorticoids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008901","descriptor_name":"Mineralocorticoids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016638","descriptor_name":"Critical Illness","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1097/aln.0000000000003365","doi":"https://doi.org/10.1097/aln.0000000000003365","is_oa":false,"landing_page_url":"https://doi.org/10.1097/aln.0000000000003365","pdf_url":null,"source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},{"id":"pmid:32501957","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32501957","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"Journal Article"},{"id":"pmh:oai:repository.up.ac.za:2263/78753","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2263/78753","pdf_url":null,"source":{"id":"https://openalex.org/S4306401870","display_name":"UpSpace Institutional Repository (University of Pretoria)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I69552723","host_organization_name":"University of Pretoria","host_organization_lineage":["https://openalex.org/I69552723"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Postprint Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":158,"referenced_works":["https://openalex.org/W67620887","https://openalex.org/W69372009","https://openalex.org/W117613380","https://openalex.org/W150410016","https://openalex.org/W156539719","https://openalex.org/W189809036","https://openalex.org/W1475381583","https://openalex.org/W1518760783","https://openalex.org/W1536138982","https://openalex.org/W1827617621","https://openalex.org/W1837110840","https://openalex.org/W1912795550","https://openalex.org/W1952126732","https://openalex.org/W1964422730","https://openalex.org/W1975264966","https://openalex.org/W1975780236","https://openalex.org/W1978414789","https://openalex.org/W1980553256","https://openalex.org/W1982935335","https://openalex.org/W1983528779","https://openalex.org/W1985153491","https://openalex.org/W1986860007","https://openalex.org/W1988585246","https://openalex.org/W1988909210","https://openalex.org/W1989030284","https://openalex.org/W1989782967","https://openalex.org/W1996488152","https://openalex.org/W1996913485","https://openalex.org/W1997062534","https://openalex.org/W2002663120","https://openalex.org/W2003814400","https://openalex.org/W2003917740","https://openalex.org/W2009171847","https://openalex.org/W2009596435","https://openalex.org/W2009701324","https://openalex.org/W2011822352","https://openalex.org/W2012816393","https://openalex.org/W2014086287","https://openalex.org/W2014319693","https://openalex.org/W2016121150","https://openalex.org/W2018530877","https://openalex.org/W2022879611","https://openalex.org/W2023844410","https://openalex.org/W2027163029","https://openalex.org/W2030884103","https://openalex.org/W2034814721","https://openalex.org/W2037574757","https://openalex.org/W2040235874","https://openalex.org/W2040879729","https://openalex.org/W2044500161","https://openalex.org/W2046571833","https://openalex.org/W2051393784","https://openalex.org/W2051431609","https://openalex.org/W2059104720","https://openalex.org/W2059337594","https://openalex.org/W2062144523","https://openalex.org/W2064377767","https://openalex.org/W2068111956","https://openalex.org/W2070335171","https://openalex.org/W2070441271","https://openalex.org/W2073719647","https://openalex.org/W2076234746","https://openalex.org/W2080498417","https://openalex.org/W2083089138","https://openalex.org/W2087596864","https://openalex.org/W2087938367","https://openalex.org/W2089151545","https://openalex.org/W2098703177","https://openalex.org/W2102184369","https://openalex.org/W2107272046","https://openalex.org/W2108380199","https://openalex.org/W2110936858","https://openalex.org/W2113760558","https://openalex.org/W2115706074","https://openalex.org/W2116631824","https://openalex.org/W2116903950","https://openalex.org/W2124087925","https://openalex.org/W2125701765","https://openalex.org/W2126846194","https://openalex.org/W2126964454","https://openalex.org/W2131398176","https://openalex.org/W2132238446","https://openalex.org/W2133069858","https://openalex.org/W2140635961","https://openalex.org/W2142604187","https://openalex.org/W2142927411","https://openalex.org/W2145461177","https://openalex.org/W2145864819","https://openalex.org/W2147452643","https://openalex.org/W2148180667","https://openalex.org/W2148636250","https://openalex.org/W2149067424","https://openalex.org/W2151348753","https://openalex.org/W2152231347","https://openalex.org/W2153879939","https://openalex.org/W2156052955","https://openalex.org/W2157006832","https://openalex.org/W2159281942","https://openalex.org/W2159509588","https://openalex.org/W2161309175","https://openalex.org/W2161771249","https://openalex.org/W2163762391","https://openalex.org/W2164706268","https://openalex.org/W2165101701","https://openalex.org/W2165835843","https://openalex.org/W2167827578","https://openalex.org/W2172937506","https://openalex.org/W2182908708","https://openalex.org/W2188136802","https://openalex.org/W2198925224","https://openalex.org/W2212446234","https://openalex.org/W2234917292","https://openalex.org/W2270579544","https://openalex.org/W2302201028","https://openalex.org/W2315161183","https://openalex.org/W2323458614","https://openalex.org/W2328926651","https://openalex.org/W2335083369","https://openalex.org/W2473587640","https://openalex.org/W2477360231","https://openalex.org/W2492910238","https://openalex.org/W2503593475","https://openalex.org/W2524689298","https://openalex.org/W2536735747","https://openalex.org/W2550507245","https://openalex.org/W2556628326","https://openalex.org/W2577233327","https://openalex.org/W2590720329","https://openalex.org/W2593910489","https://openalex.org/W2613190330","https://openalex.org/W2614578436","https://openalex.org/W2622282058","https://openalex.org/W2741152505","https://openalex.org/W2742010142","https://openalex.org/W2754921158","https://openalex.org/W2757291679","https://openalex.org/W2758480091","https://openalex.org/W2768674433","https://openalex.org/W2782943268","https://openalex.org/W2784412824","https://openalex.org/W2794125559","https://openalex.org/W2811326444","https://openalex.org/W2886758581","https://openalex.org/W2891460166","https://openalex.org/W2899214195","https://openalex.org/W2911303213","https://openalex.org/W2912107210","https://openalex.org/W2914944811","https://openalex.org/W2915506231","https://openalex.org/W2921041421","https://openalex.org/W2941469411","https://openalex.org/W2942879963","https://openalex.org/W2963481938","https://openalex.org/W3009348385","https://openalex.org/W4236401983","https://openalex.org/W4246606395","https://openalex.org/W4285719527","https://openalex.org/W6734130489"],"related_works":["https://openalex.org/W4285022259","https://openalex.org/W2044182115","https://openalex.org/W4409116615","https://openalex.org/W2159281942","https://openalex.org/W7165936075","https://openalex.org/W4389101664","https://openalex.org/W2061302496","https://openalex.org/W2185244237","https://openalex.org/W1999414906","https://openalex.org/W2608710410"],"abstract_inverted_index":{"The":[0,95],"recent":[1],"demonstration":[2],"of":[3,24,37,89,106],"the":[4,22,35,38,49,104,107],"significant":[5],"reduction":[6],"in":[7,9,27,34,41,86],"mortality":[8,115],"patients":[10],"with":[11,15,19,67,112],"septic":[12],"shock":[13,30],"treated":[14],"adjunctive":[16],"glucocorticoids":[17],"combined":[18],"fludrocortisone":[20],"and":[21,61,134],"effectiveness":[23],"angiotensin":[25,132],"II":[26,133],"treating":[28],"vasodilatory":[29],"have":[31,45],"renewed":[32],"interest":[33],"role":[36],"mineralocorticoid":[39,50,53,58],"axis":[40],"critical":[42],"illness.":[43],"Glucocorticoids":[44],"variable":[46],"interactions":[47,55,60,64],"at":[48,103,124],"receptor.":[51],"Similarly,":[52],"receptor-aldosterone":[54],"differ":[56,66],"from":[57],"receptor-glucocorticoid":[59],"predicate":[62],"receptor-ligand":[63],"that":[65,98,117],"respect":[68],"to":[69,81,138],"cellular":[70],"effects.":[71],"Hyperreninemic":[72],"hypoaldosteronism":[73],"or":[74],"selective":[75],"hypoaldosteronism,":[76],"an":[77,120],"impaired":[78],"adrenal":[79,108],"response":[80,122],"increasing":[82,125],"renin":[83],"levels,":[84],"occurs":[85],"a":[87,101,113],"subgroup":[88],"hemodynamically":[90],"unstable":[91],"critically":[92],"ill":[93],"patients.":[94],"suggestion":[96],"is":[97,100],"there":[99],"defect":[102],"level":[105],"zona":[109],"glomerulosa":[110],"associated":[111],"high":[114],"rate":[116],"may":[118],"represent":[119],"adaptive":[121],"aimed":[123],"cortisol":[126],"levels.":[127],"Furthermore,":[128],"cross-talk":[129],"exists":[130],"between":[131],"aldosterone,":[135],"which":[136],"needs":[137],"be":[139],"considered":[140],"when":[141],"employing":[142],"therapeutic":[143],"strategies.":[144]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-06-12T00:00:00"}