{"id":"https://openalex.org/W3033035941","doi":null,"title":"Understanding and promoting the functional integration of neural transplants in Parkinson\u2019s disease","display_name":"Understanding and promoting the functional integration of neural transplants in Parkinson\u2019s disease","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W3033035941","mag":"3033035941"},"language":"en","primary_location":{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/240400","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11343/240400","pdf_url":null,"source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PhD thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082091074","display_name":"Vanessa Penna","orcid":"https://orcid.org/0000-0003-0963-3106","observed_orcids":["https://orcid.org/0000-0003-0963-3106"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Vanessa Penna","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0963-3106","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5082091074"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.38109999895095825,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.38109999895095825,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.15629999339580536,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.13680000603199005,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.925000011920929},{"id":"https://openalex.org/keywords/neural-transplantation","display_name":"neural transplantation","score":0.9340000152587891},{"id":"https://openalex.org/keywords/functional-integration","display_name":"functional integration","score":0.8560000061988831},{"id":"https://openalex.org/keywords/cell-therapy","display_name":"cell therapy","score":0.3799999952316284},{"id":"https://openalex.org/keywords/dopaminergic-neurons","display_name":"dopaminergic neurons","score":0.7820000052452087},{"id":"https://openalex.org/keywords/neuroprosthetics","display_name":"neuroprosthetics","score":0.4259999990463257}],"concepts":[{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.8779821395874023},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5603602528572083},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47650519013404846},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.46666163206100464},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2863031029701233},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19359201192855835}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/240400","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11343/240400","pdf_url":null,"source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PhD thesis"},{"id":"mag:3033035941","doi":null,"is_oa":false,"landing_page_url":"https://minerva-access.unimelb.edu.au/handle/11343/240400","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":108,"referenced_works":["https://openalex.org/W1492739061","https://openalex.org/W1493812048","https://openalex.org/W1494460428","https://openalex.org/W1534130849","https://openalex.org/W1569253487","https://openalex.org/W1575301577","https://openalex.org/W1600024584","https://openalex.org/W1607137690","https://openalex.org/W1623154787","https://openalex.org/W1709926499","https://openalex.org/W1749091761","https://openalex.org/W1773217809","https://openalex.org/W1811114279","https://openalex.org/W1840177221","https://openalex.org/W1966476278","https://openalex.org/W1981154110","https://openalex.org/W1984767115","https://openalex.org/W1985378500","https://openalex.org/W1987492515","https://openalex.org/W1992094448","https://openalex.org/W2001877790","https://openalex.org/W2006598319","https://openalex.org/W2019597880","https://openalex.org/W2023172568","https://openalex.org/W2024714506","https://openalex.org/W2027724821","https://openalex.org/W2029735177","https://openalex.org/W2030895474","https://openalex.org/W2033712349","https://openalex.org/W2037562977","https://openalex.org/W2037875572","https://openalex.org/W2043637039","https://openalex.org/W2043834555","https://openalex.org/W2045298299","https://openalex.org/W2046867426","https://openalex.org/W2052578535","https://openalex.org/W2054810445","https://openalex.org/W2057181320","https://openalex.org/W2057335179","https://openalex.org/W2057459600","https://openalex.org/W2059157898","https://openalex.org/W2060245619","https://openalex.org/W2065152018","https://openalex.org/W2066011849","https://openalex.org/W2067147530","https://openalex.org/W2068889776","https://openalex.org/W2072949502","https://openalex.org/W2073795835","https://openalex.org/W2074432223","https://openalex.org/W2082067280","https://openalex.org/W2083776533","https://openalex.org/W2084565997","https://openalex.org/W2085676048","https://openalex.org/W2085835811","https://openalex.org/W2086943348","https://openalex.org/W2087786585","https://openalex.org/W2089683266","https://openalex.org/W2093600932","https://openalex.org/W2096882342","https://openalex.org/W2097226043","https://openalex.org/W2100479578","https://openalex.org/W2102678193","https://openalex.org/W2104334777","https://openalex.org/W2108244474","https://openalex.org/W2111525324","https://openalex.org/W2116831995","https://openalex.org/W2118353064","https://openalex.org/W2124248841","https://openalex.org/W2127508962","https://openalex.org/W2134526812","https://openalex.org/W2134964344","https://openalex.org/W2138977668","https://openalex.org/W2142519779","https://openalex.org/W2154761807","https://openalex.org/W2158217645","https://openalex.org/W2158683840","https://openalex.org/W2162098634","https://openalex.org/W2166496419","https://openalex.org/W2179438025","https://openalex.org/W2181139080","https://openalex.org/W2395631443","https://openalex.org/W2403316467","https://openalex.org/W2410312204","https://openalex.org/W2520469409","https://openalex.org/W2530453271","https://openalex.org/W2530855489","https://openalex.org/W2543278732","https://openalex.org/W2559588208","https://openalex.org/W2611663512","https://openalex.org/W2745895255","https://openalex.org/W2746335001","https://openalex.org/W2749359109","https://openalex.org/W2750559769","https://openalex.org/W2762598804","https://openalex.org/W2768282623","https://openalex.org/W2794013167","https://openalex.org/W2800310166","https://openalex.org/W2808772662","https://openalex.org/W2883722976","https://openalex.org/W2883857116","https://openalex.org/W2886986075","https://openalex.org/W2891290422","https://openalex.org/W2891678790","https://openalex.org/W2901616237","https://openalex.org/W2901835229","https://openalex.org/W2917207851","https://openalex.org/W2958717364","https://openalex.org/W3140584349"],"related_works":["https://openalex.org/W2738953030","https://openalex.org/W3009378013","https://openalex.org/W4240964587","https://openalex.org/W1543363646","https://openalex.org/W2405420408","https://openalex.org/W2728142715","https://openalex.org/W2682835736","https://openalex.org/W2460067404","https://openalex.org/W2148561346","https://openalex.org/W7019796384"],"abstract_inverted_index":{"Clinical":[0],"trials":[1],"have":[2,58],"provided":[3],"evidence":[4],"that":[5,154],"the":[6,14,36,41,64,94,117,161,174,191,206,218,249,255,267,271,275,319,345,358,361,386,396,400,404,430,442,456,474],"transplantation":[7],"of":[8,16,47,66,99,114,136,143,160,179,215,225,235,257,270,277,308,321,327,341,347,357,385,432,449,460,477,499],"new":[9,369,470],"dopamine":[10,74],"neurons":[11,324,329],"(DAn)":[12],"into":[13,73,194,472,508],"striatum":[15],"Parkinson\u2019s":[17],"disease":[18],"(PD)":[19],"patients":[20],"can":[21],"survive,":[22],"integrate":[23,167],"and":[24,53,80,97,111,139,169,176,245,297,334,373,388,392,424,428,451,454,492],"restore":[25],"motor":[26,332,342],"function.":[27],"Demonstrated":[28],"first":[29,457],"using":[30,200],"fetal":[31,103,149,168,294],"donor":[32,82],"tissue":[33,49,104,295,382],"isolated":[34],"from":[35,406],"developing":[37,162],"ventral":[38],"midbrain":[39],"(VM),":[40],"procedure":[42],"was":[43,213,251],"hindered":[44],"by":[45,199,220,426],"challenges":[46],"poor":[48],"standardisation,":[50],"limited":[51],"availability":[52],"ethical":[54],"considerations.":[55],"Recently,":[56],"studies":[57],"seen":[59],"a":[60,77,133,155,201,222,226,368,484],"rapid":[61],"advancement":[62],"in":[63,261,305,339,395,441],"use":[65],"human":[67,298,461],"pluripotent":[68,299],"stem":[69,300],"cells":[70,115,138,196,219,504],"(hPSC),":[71],"differentiated":[72],"progenitors,":[75],"as":[76,481,483,502],"viable":[78],"alternative":[79],"standardized":[81],"source.":[83],"Despite":[84],"recently":[85],"advancing":[86],"to":[87,147,164,204,217,253,288,351,371,402,436,464,486,506],"clinical":[88,509],"trials,":[89],"several":[90],"questions":[91],"remain":[92],"regarding":[93],"safety,":[95],"predictability":[96],"efficacy":[98],"these":[100,312,503],"cells.":[101],"While":[102],"has":[105],"an":[106],"estimated":[107],"20%":[108],"cell":[109,239,301],"survival":[110],"just":[112],"10%":[113],"within":[116,363],"graft":[118,316,387],"are":[119,125,197],"DA":[120,328],"neurons,":[121],"hPSC-derived":[122,348,437],"neural":[123,180],"transplants":[124,181],"notably":[126],"poorer":[127],"\u2013":[128,337],"remaining":[129],"highly":[130],"heterogeneous":[131],"with":[132,354],"high":[134,223],"proportion":[135],"non-dopaminergic":[137],"display":[140],"inferior":[141],"reinnervation":[142],"target":[144],"tissues":[145],"compared":[146],"their":[148],"counterpart.":[150],"Such":[151,495],"observations":[152],"suggest":[153],"more":[156],"conducive":[157],"environment,":[158],"reminiscent":[159],"brain,":[163],"support":[165],"newly":[166],"hPSC-DA":[170],"progenitors":[171],"could":[172],"improve":[173],"differentiation":[175,244],"functional":[177,475],"capacity":[178,269],"for":[182,292,489],"PD.":[183,309],"The":[184,210,378,420,445],"present":[185],"thesis":[186,265,365,468],"had":[187],"focused":[188],"on":[189],"improving":[190,473],"host":[192,390,407],"environment":[193],"which":[195],"delivered":[198],"tissue-specific":[202,272],"hydrogel/biomaterial":[203],"mimic":[205],"extracellular":[207],"matrix":[208],"(ECM).":[209],"employed":[211],"biomaterial":[212,250],"capable":[214,234],"signalling":[216],"presenting":[221],"density":[224],"laminin":[227],"epitope":[228],"(the":[229,325],"main":[230],"brain":[231],"ECM":[232],"component)":[233],"influencing":[236,331],"not":[237],"only":[238],"adhesion":[240],"but":[241],"also":[242,366],"survival,":[243,317],"plasticity.":[246],"In":[247],"addition,":[248],"utilised":[252],"sustain":[254],"delivery":[256,276],"trophic":[258],"proteins,":[259],"absent":[260],"adult":[262],"brain.":[263,444],"This":[264],"demonstrated":[266,311,425],"synergistic":[268],"hydrogel,":[273],"sustaining":[274],"stromal":[278],"derived":[279,302],"factor1":[280],"(SDF1)":[281],"or":[282,415],"glial":[283],"cell-derived":[284],"neurotrophic":[285],"factor":[286],"(GDNF)":[287],"enhance":[289,335],"grafting":[290],"outcome":[291],"rodent":[293,306,443],"grafts":[296,350,440,463,488],"grafts,":[303,480],"respectively,":[304],"models":[307],"Finding":[310],"functionalised":[313],"scaffolds":[314],"promoted":[315],"improved":[318],"specification":[320],"A9":[322],"dopaminergic":[323],"subpopulation":[326],"responsible":[330],"function)":[333],"plasticity":[336],"resulting":[338],"restoration":[340],"deficits.":[343],"\\nRecognising":[344],"heterogeneity":[346],"VM":[349,438,462,478],"date,":[352],"yet":[353],"little":[355],"knowledge":[356,496],"cellular":[359],"composition,":[360],"work":[362],"this":[364,467],"developed":[367],"method":[370,379],"rapidly":[372],"efficiently":[374],"transcriptionally":[375],"profile":[376],"xenografts.":[377],"employs":[380],"bulk":[381],"dissection,":[383],"inclusive":[384],"surrounding":[389],"tissue,":[391],"utilises":[393],"differences":[394],"RNA":[397,417],"sequences":[398],"between":[399],"species":[401],"discriminate":[403],"xenograft":[405],"gene":[408],"expression":[409],"-using":[410],"either":[411],"real-time":[412],"qPCR":[413],"(qPCR)":[414],"whole":[416],"sequencing":[418],"(RNAseq).":[419],"technique":[421],"is":[422],"validated":[423],"assessing":[427],"comparing":[429],"composition":[431],"undifferentiated":[433],"hPSC":[434],"grafts/teratomas":[435],"progenitor":[439],"approaches":[446],"enable":[447],"identification":[448],"known":[450],"novel":[452],"genes":[453],"provides":[455,469],"complete":[458],"characterisation":[459],"date.":[465],"\\nCollectively,":[466],"insight":[471],"outcomes":[476],"progenitors\u2019":[479],"well":[482],"means":[485],"screen":[487],"both":[490],"safety":[491],"predictable":[493],"efficacy.":[494],"will":[497],"be":[498],"critical":[500],"important":[501],"continue":[505],"move":[507],"trials.":[510]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-06-12T00:00:00"}