{"id":"https://openalex.org/W3032701030","doi":"https://doi.org/10.3892/etm.2020.8826","title":"Mechanism of TGF\u2011\u03b21 inhibiting Kupffer cell immune responses in cholestatic cirrhosis","display_name":"Mechanism of TGF\u2011\u03b21 inhibiting Kupffer cell immune responses in cholestatic cirrhosis","publication_year":2020,"publication_date":"2020-05-30","ids":{"openalex":"https://openalex.org/W3032701030","doi":"https://doi.org/10.3892/etm.2020.8826","mag":"3032701030","pmid":"https://pubmed.ncbi.nlm.nih.gov/32742385","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7388376"},"language":"en","primary_location":{"id":"doi:10.3892/etm.2020.8826","doi":"https://doi.org/10.3892/etm.2020.8826","is_oa":true,"landing_page_url":"https://doi.org/10.3892/etm.2020.8826","pdf_url":"https://www.spandidos-publications.com/10.3892/etm.2020.8826/download","source":{"id":"https://openalex.org/S151424340","display_name":"Experimental and Therapeutic Medicine","issn_l":"1792-0981","issn":["1792-0981","1792-1015"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Therapeutic Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.spandidos-publications.com/10.3892/etm.2020.8826/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100655642","display_name":"Jun Qian","orcid":"https://orcid.org/0000-0002-3700-4190","observed_orcids":["https://orcid.org/0000-0002-3700-4190"]},"institutions":[{"id":"https://openalex.org/I4210151861","display_name":"Changzhou No.2 People's Hospital","ror":"https://ror.org/04bkhy554","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210151861"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Qian","raw_affiliation_strings":["Department of General Surgery, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, Jiangsu 213000, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, Jiangsu 213000, P.R. China","institution_ids":["https://openalex.org/I4210151861","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015892925","display_name":"Yuwen Jiao","orcid":"https://orcid.org/0000-0001-9417-4279","observed_orcids":["https://orcid.org/0000-0001-9417-4279"]},"institutions":[{"id":"https://openalex.org/I4210151861","display_name":"Changzhou No.2 People's Hospital","ror":"https://ror.org/04bkhy554","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210151861"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuwen Jiao","raw_affiliation_strings":["Department of General Surgery, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, Jiangsu 213000, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, Jiangsu 213000, P.R. China","institution_ids":["https://openalex.org/I4210151861","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111044299","display_name":"Guangyao Wang","orcid":"https://orcid.org/0009-0006-4029-6143","observed_orcids":["https://orcid.org/0009-0006-4029-6143"]},"institutions":[{"id":"https://openalex.org/I4210151861","display_name":"Changzhou No.2 People's Hospital","ror":"https://ror.org/04bkhy554","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210151861"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guangyao Wang","raw_affiliation_strings":["Department of General Surgery, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, Jiangsu 213000, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, Jiangsu 213000, P.R. China","institution_ids":["https://openalex.org/I4210151861","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045611682","display_name":"Hanyang Liu","orcid":"https://orcid.org/0000-0002-1035-4895","observed_orcids":["https://orcid.org/0000-0002-1035-4895","https://orcid.org/0009-0004-7830-0393","https://orcid.org/0009-0008-4176-5225"]},"institutions":[{"id":"https://openalex.org/I4210151861","display_name":"Changzhou No.2 People's Hospital","ror":"https://ror.org/04bkhy554","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210151861"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hanyang Liu","raw_affiliation_strings":["Department of General Surgery, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, Jiangsu 213000, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, Jiangsu 213000, P.R. China","institution_ids":["https://openalex.org/I4210151861","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101523113","display_name":"Xiang Cao","orcid":"https://orcid.org/0009-0008-8488-9535","observed_orcids":["https://orcid.org/0009-0008-8488-9535"]},"institutions":[{"id":"https://openalex.org/I4210151861","display_name":"Changzhou No.2 People's Hospital","ror":"https://ror.org/04bkhy554","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210151861"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiang Cao","raw_affiliation_strings":["Department of General Surgery, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, Jiangsu 213000, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, Jiangsu 213000, P.R. China","institution_ids":["https://openalex.org/I4210151861","https://openalex.org/I83519826"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101531388","display_name":"Haojun Yang","orcid":"https://orcid.org/0000-0003-1421-554X","observed_orcids":["https://orcid.org/0000-0003-1421-554X"]},"institutions":[{"id":"https://openalex.org/I4210151861","display_name":"Changzhou No.2 People's Hospital","ror":"https://ror.org/04bkhy554","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210151861"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Haojun Yang","raw_affiliation_strings":["Department of General Surgery, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, Jiangsu 213000, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, Jiangsu 213000, P.R. China","institution_ids":["https://openalex.org/I4210151861","https://openalex.org/I83519826"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101531388"],"corresponding_institution_ids":["https://openalex.org/I4210151861","https://openalex.org/I83519826"],"apc_list":null,"apc_paid":null,"fwci":0.3673,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.56558956,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"20","issue":"2","first_page":"1541","last_page":"1549"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.9549999833106995},{"id":"https://openalex.org/keywords/kupffer-cells","display_name":"Kupffer cells","score":0.9890000224113464},{"id":"https://openalex.org/keywords/cholestatic-cirrhosis","display_name":"cholestatic cirrhosis","score":0.9670000076293945},{"id":"https://openalex.org/keywords/bile-duct-ligation","display_name":"bile duct ligation","score":0.9369999766349792},{"id":"https://openalex.org/keywords/m2-macrophage-polarization","display_name":"M2 macrophage polarization","score":0.8370000123977661},{"id":"https://openalex.org/keywords/liver-inflammation","display_name":"liver inflammation","score":0.796999990940094},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.902999997138977},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.75},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.7049999833106995},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9399999976158142},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.8960000276565552},{"id":"https://openalex.org/keywords/arginase-1","display_name":"arginase-1","score":0.9929999709129333},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.8489999771118164},{"id":"https://openalex.org/keywords/galunisertib","display_name":"galunisertib","score":0.8349999785423279}],"concepts":[{"id":"https://openalex.org/C2778904781","wikidata":"https://www.wikidata.org/wiki/Q513486","display_name":"Kupffer cell","level":2,"score":0.7768908739089966},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5235647559165955},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5105339288711548},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.48815661668777466},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.47722867131233215},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45568016171455383},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.44185835123062134},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.41376906633377075},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.3414176106452942},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.27303004264831543},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26271605491638184},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2569658160209656}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3892/etm.2020.8826","doi":"https://doi.org/10.3892/etm.2020.8826","is_oa":true,"landing_page_url":"https://doi.org/10.3892/etm.2020.8826","pdf_url":"https://www.spandidos-publications.com/10.3892/etm.2020.8826/download","source":{"id":"https://openalex.org/S151424340","display_name":"Experimental and Therapeutic Medicine","issn_l":"1792-0981","issn":["1792-0981","1792-1015"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Therapeutic Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7388376","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7388376","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Exp Ther Med","raw_type":"Text"},{"id":"pmid:32742385","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32742385","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and therapeutic medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3892/etm.2020.8826","doi":"https://doi.org/10.3892/etm.2020.8826","is_oa":true,"landing_page_url":"https://doi.org/10.3892/etm.2020.8826","pdf_url":"https://www.spandidos-publications.com/10.3892/etm.2020.8826/download","source":{"id":"https://openalex.org/S151424340","display_name":"Experimental and Therapeutic Medicine","issn_l":"1792-0981","issn":["1792-0981","1792-1015"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Therapeutic Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3032701030.pdf","grobid_xml":"https://content.openalex.org/works/W3032701030.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1534551308","https://openalex.org/W1863475412","https://openalex.org/W1916893403","https://openalex.org/W1966916675","https://openalex.org/W1974123756","https://openalex.org/W1977348907","https://openalex.org/W1996127229","https://openalex.org/W2004644526","https://openalex.org/W2009571147","https://openalex.org/W2038009598","https://openalex.org/W2040309484","https://openalex.org/W2046796966","https://openalex.org/W2111013311","https://openalex.org/W2113313714","https://openalex.org/W2135786628","https://openalex.org/W2138440979","https://openalex.org/W2141966839","https://openalex.org/W2271556415","https://openalex.org/W2382675198","https://openalex.org/W2397986877","https://openalex.org/W2597542119","https://openalex.org/W2625823623","https://openalex.org/W2730973121","https://openalex.org/W2755334850","https://openalex.org/W2760116603","https://openalex.org/W2763028698","https://openalex.org/W2789001259","https://openalex.org/W2793835122","https://openalex.org/W2793931447","https://openalex.org/W2803750312","https://openalex.org/W2896839691","https://openalex.org/W2900020201","https://openalex.org/W2903211975","https://openalex.org/W2904084583","https://openalex.org/W2905361893","https://openalex.org/W2906626342","https://openalex.org/W2907158961","https://openalex.org/W2907569180","https://openalex.org/W2908396527","https://openalex.org/W2914107133","https://openalex.org/W2917714624","https://openalex.org/W2919483263","https://openalex.org/W2921091918","https://openalex.org/W2921393312","https://openalex.org/W2923133373","https://openalex.org/W2924574985","https://openalex.org/W2941772899","https://openalex.org/W2973014817","https://openalex.org/W3010528392","https://openalex.org/W3022452414","https://openalex.org/W3023170535","https://openalex.org/W4237270856","https://openalex.org/W4293201222","https://openalex.org/W7052910947"],"related_works":["https://openalex.org/W2362933390","https://openalex.org/W2142196461","https://openalex.org/W2022313019","https://openalex.org/W2791921254","https://openalex.org/W2017698887","https://openalex.org/W2974455690","https://openalex.org/W4414602932","https://openalex.org/W3029052858","https://openalex.org/W4403057724","https://openalex.org/W2096538739"],"abstract_inverted_index":{"Effect":[0],"of":[1,59,73,88,101,131,141,159,165,184,203,216,230,239,254,263],"exogenous":[2],"transforming":[3],"growth":[4],"factor-\u03b21":[5],"(TGF-\u03b21)":[6],"on":[7],"cholestatic":[8],"mice":[9,24,167,217,257],"by":[10,154,258],"inhibiting":[11,259],"Kupffer":[12,98,214],"cell":[13,149,223],"immune":[14],"responses":[15],"in":[16,69,97,168,177,189,196,212,218,245,256],"liver":[17,103,160,163,191,213],"was":[18,85,104,125,205],"investigated.":[19],"To":[20],"induce":[21],"cholestasis,":[22],"BALB/c":[23],"received":[25],"a":[26,33],"sham":[27],"operation":[28],"(Mock":[29],"group),":[30],"or":[31],"underwent":[32],"bile":[34],"duct":[35],"ligation":[36],"(BDL":[37],"group)":[38],"and":[39,66,80,94,118,121,137,145,162,187,234,241,265],"then":[40],"were":[41,53,109,152,172,192],"subcutaneously":[42],"injected":[43],"with":[44],"TGF-\u03b21":[45],"at":[46],"multiple":[47],"sites":[48],"(TGF":[49],"group).":[50],"Liver":[51],"functions":[52],"evaluated":[54],"according":[55],"to":[56,127],"the":[57,102,129,166,169,178,190,197,201,219,228,237,252,260],"levels":[58,183],"alanine":[60],"aminotransferase":[61,64],"(ALT),":[62],"aspartate":[63],"AST":[65],"\u03b3-glutamyltranspeptidase":[67],"(\u03b3-GT)":[68],"serum":[70],"samples.":[71],"Expression":[72,87],"nuclear":[74],"factor-\u03baB":[75],"(NF-\u03baB),":[76],"interleukin-6":[77],"(IL-6),":[78],"IL-1\u03b2":[79],"tumor":[81],"necrosis":[82],"factor-\u03b1":[83],"(TNF-\u03b1)":[84],"detected.":[86,105],"inducible":[89],"nitric":[90],"oxide":[91],"synthase":[92],"(iNOS)":[93],"arginase-1":[95],"(Arg-1)":[96],"cells":[99,215],"(KCs)":[100],"The":[106,139,157,182],"isolated":[107],"KCs":[108,264],"divided":[110],"into":[111],"control":[112],"group,":[113,115,199],"LPS":[114],"TGF":[116,170,220,225],"group":[117,120,171,180],"Galunisertib":[119],"western":[122],"blot":[123],"analysis":[124],"used":[126],"detect":[128],"expression":[130,229,238],"NF-\u03baB,":[132,235],"IL-6,":[133,232],"IL-1\u03b2,":[134,185,231],"TNF-\u03b1,":[135],"iNOS":[136],"Arg-1.":[138],"percentage":[140],"CD40,":[142],"CD86,":[143],"CD204":[144],"CD206":[146],"as":[147],"macrophage":[148],"surface":[150],"antigens":[151],"measured":[153],"flow":[155],"cytometry.":[156],"indexes":[158],"function":[161],"fibrosis":[164],"significantly":[173,206],"lower":[174,193],"than":[175,194],"those":[176,195],"BDL":[179,198],"(P<0.05).":[181,208,247],"IL-6":[186],"TNF-\u03b1":[188,233],"while":[200],"level":[202],"IL-10":[204],"increased":[207,236],"M2-type":[209,243],"transformation":[210,244],"occurred":[211],"group.":[221],"In":[222,248],"experiments,":[224],"treatment":[226],"downregulated":[227],"IL-10,":[240],"induced":[242],"macrophages":[246],"conclusion,":[249],"TGF-\u00df1":[250],"diminished":[251],"progression":[253],"cholestasis":[255],"inflammatory":[261],"response":[262],"regulating":[266],"KC":[267],"polarization.":[268]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-06-05T00:00:00"}