{"id":"https://openalex.org/W3032417876","doi":"https://doi.org/10.3760/cma.j.issn.0253-3006.2007.11.005","title":"Portal area inflammatory infiltration and cytokines expressions in biliary atresia","display_name":"Portal area inflammatory infiltration and cytokines expressions in biliary atresia","publication_year":2007,"publication_date":"2007-11-15","ids":{"openalex":"https://openalex.org/W3032417876","doi":"https://doi.org/10.3760/cma.j.issn.0253-3006.2007.11.005","mag":"3032417876"},"language":"en","primary_location":{"id":"mag:3032417876","doi":"https://doi.org/10.3760/cma.j.issn.0253-3006.2007.11.005","is_oa":false,"landing_page_url":"http://rs.yiigle.com/CN421158200711/153533.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2765034180","display_name":"Zhonghua xiaoerwaike zazhi","issn_l":"0253-3006","issn":["0253-3006"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4320800525","host_organization_name":"Chinese Medical Association","host_organization_lineage":["https://openalex.org/P4320800525"],"host_organization_lineage_names":["Chinese Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhonghua xiaoerwaike zazhi","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105838999","display_name":"Huang Lei","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Huang Lei","raw_affiliation_strings":["430030,\u6b66\u6c49,\u534e\u4e2d\u79d1\u6280\u5927\u5b66\u540c\u6d4e\u533b\u5b66\u9662\u9644\u5c5e\u540c\u6d4e\u533b\u9662\u5c0f\u513f\u5916\u79d1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"430030,\u6b66\u6c49,\u534e\u4e2d\u79d1\u6280\u5927\u5b66\u540c\u6d4e\u533b\u5b66\u9662\u9644\u5c5e\u540c\u6d4e\u533b\u9662\u5c0f\u513f\u5916\u79d1","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014334036","display_name":"\u9b4f\u660e\u53d1","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u9b4f\u660e\u53d1","raw_affiliation_strings":["430030,\u6b66\u6c49,\u534e\u4e2d\u79d1\u6280\u5927\u5b66\u540c\u6d4e\u533b\u5b66\u9662\u9644\u5c5e\u540c\u6d4e\u533b\u9662\u5c0f\u513f\u5916\u79d1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"430030,\u6b66\u6c49,\u534e\u4e2d\u79d1\u6280\u5927\u5b66\u540c\u6d4e\u533b\u5b66\u9662\u9644\u5c5e\u540c\u6d4e\u533b\u9662\u5c0f\u513f\u5916\u79d1","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018348017","display_name":"Feng Xiong","orcid":"https://orcid.org/0000-0002-6434-4588","observed_orcids":["https://orcid.org/0000-0002-6434-4588"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Feng Xiong","raw_affiliation_strings":["430030,\u6b66\u6c49,\u534e\u4e2d\u79d1\u6280\u5927\u5b66\u540c\u6d4e\u533b\u5b66\u9662\u9644\u5c5e\u540c\u6d4e\u533b\u9662\u5c0f\u513f\u5916\u79d1"],"raw_orcid":"https://orcid.org/0000-0002-6434-4588","affiliations":[{"raw_affiliation_string":"430030,\u6b66\u6c49,\u534e\u4e2d\u79d1\u6280\u5927\u5b66\u540c\u6d4e\u533b\u5b66\u9662\u9644\u5c5e\u540c\u6d4e\u533b\u9662\u5c0f\u513f\u5916\u79d1","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020891271","display_name":"\u8881\u7ee7\u708e","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u8881\u7ee7\u708e","raw_affiliation_strings":["430030,\u6b66\u6c49,\u534e\u4e2d\u79d1\u6280\u5927\u5b66\u540c\u6d4e\u533b\u5b66\u9662\u9644\u5c5e\u540c\u6d4e\u533b\u9662\u5c0f\u513f\u5916\u79d1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"430030,\u6b66\u6c49,\u534e\u4e2d\u79d1\u6280\u5927\u5b66\u540c\u6d4e\u533b\u5b66\u9662\u9644\u5c5e\u540c\u6d4e\u533b\u9662\u5c0f\u513f\u5916\u79d1","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083053059","display_name":"\u738b\u5c0f\u6797","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u738b\u5c0f\u6797","raw_affiliation_strings":["430030,\u6b66\u6c49,\u534e\u4e2d\u79d1\u6280\u5927\u5b66\u540c\u6d4e\u533b\u5b66\u9662\u9644\u5c5e\u540c\u6d4e\u533b\u9662\u5c0f\u513f\u5916\u79d1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"430030,\u6b66\u6c49,\u534e\u4e2d\u79d1\u6280\u5927\u5b66\u540c\u6d4e\u533b\u5b66\u9662\u9644\u5c5e\u540c\u6d4e\u533b\u9662\u5c0f\u513f\u5916\u79d1","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"28","issue":"11","first_page":"575","last_page":"578"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12460","display_name":"Pediatric Hepatobiliary Diseases and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12460","display_name":"Pediatric Hepatobiliary Diseases and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biliary-atresia","display_name":"biliary atresia","score":1.0},{"id":"https://openalex.org/keywords/congenital-biliary-dilatation","display_name":"congenital biliary dilatation","score":0.9269999861717224},{"id":"https://openalex.org/keywords/th1-response","display_name":"Th1 response","score":0.5600000023841858},{"id":"https://openalex.org/keywords/th2-response","display_name":"Th2 immune response","score":0.8299999833106995},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8579999804496765},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9350000023841858},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.9580000042915344},{"id":"https://openalex.org/keywords/il-5","display_name":"IL-5","score":0.9940000176429749},{"id":"https://openalex.org/keywords/granzymes","display_name":"granzymes","score":0.7799999713897705},{"id":"https://openalex.org/keywords/perforin","display_name":"perforin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.7170000076293945},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.7950000166893005},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.968999981880188},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.8769999742507935},{"id":"https://openalex.org/keywords/fas","display_name":"Fas","score":0.925000011920929}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9553821682929993},{"id":"https://openalex.org/C2779243279","wikidata":"https://www.wikidata.org/wiki/Q659033","display_name":"Biliary atresia","level":4,"score":0.7863255739212036},{"id":"https://openalex.org/C153400128","wikidata":"https://www.wikidata.org/wiki/Q3150731","display_name":"Infiltration (HVAC)","level":2,"score":0.7701448202133179},{"id":"https://openalex.org/C2781149206","wikidata":"https://www.wikidata.org/wiki/Q757722","display_name":"Atresia","level":2,"score":0.5955844521522522},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39064428210258484},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.38262298703193665},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3808262050151825},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C2779609443","wikidata":"https://www.wikidata.org/wiki/Q1368191","display_name":"Liver transplantation","level":3,"score":0.0},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:3032417876","doi":"https://doi.org/10.3760/cma.j.issn.0253-3006.2007.11.005","is_oa":false,"landing_page_url":"http://rs.yiigle.com/CN421158200711/153533.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2765034180","display_name":"Zhonghua xiaoerwaike zazhi","issn_l":"0253-3006","issn":["0253-3006"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4320800525","host_organization_name":"Chinese Medical Association","host_organization_lineage":["https://openalex.org/P4320800525"],"host_organization_lineage_names":["Chinese Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhonghua xiaoerwaike zazhi","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1987387406","https://openalex.org/W2024243449","https://openalex.org/W2036456812","https://openalex.org/W2770415009","https://openalex.org/W4408885236","https://openalex.org/W2223988148","https://openalex.org/W3028732284","https://openalex.org/W2079179121","https://openalex.org/W2059127158","https://openalex.org/W3031726116"],"abstract_inverted_index":{"\u76ee\u7684":[0],"\u4e86\u89e3\u80c6\u9053\u95ed\u9501(biliary":[1],"atresia,BA)\u809d\u5185\u6c47\u7ba1\u533a\u708e\u75c7\u53cd\u5e94\u7c7b\u578b\u53ca\u7ec6\u80de\u56e0\u5b50\u8868\u8fbe\u548c\u5177\u4f53\u4f5c\u7528\u673a\u5236.\u65b9\u6cd5":[2],"\u5e94\u7528\u514d\u75ab\u7ec4\u7ec7\u5316\u5b66\u3001\u514d\u75ab\u8367\u5149\u548c\u514d\u75ab\u5370\u8ff9\u7684\u65b9\u6cd5\u5bf918\u4f8b\u80c6\u9053\u95ed\u9501\u60a3\u513f\u4e0e15\u4f8b\u5148\u5929\u6027\u80c6\u7ba1\u6269\u5f20\u75c7(congenital":[3],"biliary":[4],"dilatation":[5],",CBD)\u60a3\u513f\u809d\u810f\u6807\u672c\u8fdb\u884c\u5bf9\u6bd4\u7814\u7a76.\u7ed3\u679c":[6],"BA\u60a3\u513f\u809d\u5185\u6c47\u7ba1\u533a\u5927\u91cfCD4+\u3001CD8+\u3001CD68+\u7ec6\u80de\u6d78\u6da6(\u4e0eCBD\u7ec4\u76f8\u6bd4\u5747P\uff1c0.01).\u809d\u5185Th1\u901a\u8def\u76f8\u5173\u7ec6\u80de\u56e0\u5b50IFN-\u03b3(\u5e72\u6270\u7d20-\u03b3)\u3001TNF-\u03b1(\u80bf\u7624\u574f\u6b7b\u56e0\u5b50-\u03b1)\u8868\u8fbe,\u800cCBD\u7ec4\u4e3a\u9634\u6027.Th2\u76f8\u5173\u7ec6\u80de\u56e0\u5b50IL-4(\u767d\u4ecb\u7d20-4)\u3001IL-5(\u767d\u4ecb\u7d20-5)\u53caCD8+\u76f8\u5173\u7ec6\u80de\u56e0\u5b50\u7c92\u9176\u3001\u7a7f\u5b54\u7d20\u8868\u8fbe\u5728BA\u7ec4\u4e0eCBD\u7ec4\u5747\u4e3a\u9634\u6027.BA\u7ec4\u809d\u5185iNOS(\u8bf1\u5bfc\u578b\u4e00\u6c27\u5316\u6c2e\u5408\u9176)\u68c0\u6d4b\u9633\u6027,\u80c6\u7ba1\u4e0a\u76aeFas(\u81ea\u6740\u76f8\u5173\u56e0\u5b50)\u8868\u8fbe(0.60\u00b10.13)\u4e0eCBD\u7ec4(0.29\u00b10.16)\u76f8\u6bd4\u660e\u663e\u4e0a\u8c03(P\uff1c0.01),\u4e0a\u76ae\u7ec6\u80de\u51cb\u4ea1\u6307\u6570(49\u00b113)%\u8fdc\u5927\u4e8eCBD\u7ec4(22\u00b116)%(P\uff1c0.01).\u7ed3\u8bba":[7],"BA\u809d\u5185\u6c47\u7ba1\u533a\u708e\u75c7\u53cd\u5e94\u5f3a\u70c8,\u662f\u7531CD4+\u7ec6\u80deTh1\u4e9a\u578b\u53ca\u5176\u76f8\u5173\u7ec6\u80de\u56e0\u5b50\u6240\u4ecb\u5bfc\u7684\u539f\u53d1\u7279\u5f02\u6027\u708e\u75c7.\u5de8\u566c\u7ec6\u80de\u53c2\u4e0e\u7684Th1\u708e\u75c7\u901a\u8def\u53ef\u80fd\u5728BA\u80c6\u7ba1\u4e0a\u76ae\u8fdb\u884c\u6027\u635f\u4f24\u4e2d\u8d77\u7740\u5173\u952e\u4f5c\u7528\u3002":[8]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2020-06-05T00:00:00"}