{"id":"https://openalex.org/W3032214830","doi":"https://doi.org/10.1038/s41375-020-0880-3","title":"Neoplastic fibrocytes play an essential role in bone marrow fibrosis in Jak2V617F-induced primary myelofibrosis mice","display_name":"Neoplastic fibrocytes play an essential role in bone marrow fibrosis in Jak2V617F-induced primary myelofibrosis mice","publication_year":2020,"publication_date":"2020-05-29","ids":{"openalex":"https://openalex.org/W3032214830","doi":"https://doi.org/10.1038/s41375-020-0880-3","mag":"3032214830","pmid":"https://pubmed.ncbi.nlm.nih.gov/32472085","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7862060"},"language":"en","primary_location":{"id":"doi:10.1038/s41375-020-0880-3","doi":"https://doi.org/10.1038/s41375-020-0880-3","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41375-020-0880-3","pdf_url":"https://www.nature.com/articles/s41375-020-0880-3.pdf","source":{"id":"https://openalex.org/S149476849","display_name":"Leukemia","issn_l":"0887-6924","issn":["0887-6924","1476-5551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/s41375-020-0880-3.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040080787","display_name":"Yoshinori Ozono","orcid":"https://orcid.org/0000-0003-4616-5831","observed_orcids":["https://orcid.org/0000-0003-4616-5831"]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshinori Ozono","raw_affiliation_strings":["Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040331469","display_name":"Kotaro Shide","orcid":"https://orcid.org/0000-0002-0046-3254","observed_orcids":["https://orcid.org/0000-0002-0046-3254"]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kotaro Shide","raw_affiliation_strings":["Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030683315","display_name":"Takuro Kameda","orcid":"https://orcid.org/0000-0003-0100-1710","observed_orcids":["https://orcid.org/0000-0003-0100-1710"]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takuro Kameda","raw_affiliation_strings":["Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020241997","display_name":"Ayako Kamiunten","orcid":"https://orcid.org/0000-0002-6347-4305","observed_orcids":["https://orcid.org/0000-0002-6347-4305"]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ayako Kamiunten","raw_affiliation_strings":["Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070628001","display_name":"Yuki Tahira","orcid":"https://orcid.org/0000-0001-6640-4559","observed_orcids":["https://orcid.org/0000-0001-6640-4559"]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuki Tahira","raw_affiliation_strings":["Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072491642","display_name":"Masaaki Sekine","orcid":"https://orcid.org/0000-0001-5481-3451","observed_orcids":["https://orcid.org/0000-0001-5481-3451"]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaaki Sekine","raw_affiliation_strings":["Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014327036","display_name":"Keiichi Akizuki","orcid":"https://orcid.org/0000-0003-0031-3456","observed_orcids":["https://orcid.org/0000-0003-0031-3456"]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keiichi Akizuki","raw_affiliation_strings":["Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005598571","display_name":"Kenichi Nakamura","orcid":"https://orcid.org/0000-0002-9665-3940","observed_orcids":["https://orcid.org/0000-0002-9665-3940"]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenichi Nakamura","raw_affiliation_strings":["Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084132492","display_name":"Hisayoshi Iwakiri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hisayoshi Iwakiri","raw_affiliation_strings":["Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056835914","display_name":"Mitsue Sueta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mitsue Sueta","raw_affiliation_strings":["Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036728147","display_name":"Tomonori Hidaka","orcid":"https://orcid.org/0000-0002-7018-3653","observed_orcids":["https://orcid.org/0000-0002-7018-3653"]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomonori Hidaka","raw_affiliation_strings":["Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031290393","display_name":"Yoko Kubuki","orcid":"https://orcid.org/0000-0002-0763-9136","observed_orcids":["https://orcid.org/0000-0002-0763-9136"]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoko Kubuki","raw_affiliation_strings":["Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061528812","display_name":"Shojiro Yamamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shojiro Yamamoto","raw_affiliation_strings":["Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024916484","display_name":"Satoru Hasuike","orcid":"https://orcid.org/0000-0002-5312-5152","observed_orcids":["https://orcid.org/0000-0002-5312-5152"]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoru Hasuike","raw_affiliation_strings":["Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078444333","display_name":"Akira Sawaguchi","orcid":"https://orcid.org/0000-0003-2234-769X","observed_orcids":["https://orcid.org/0000-0003-2234-769X"]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akira Sawaguchi","raw_affiliation_strings":["Department of Anatomy, Ultrastructural Cell Biology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Ultrastructural Cell Biology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046779019","display_name":"Kenji Nagata","orcid":"https://orcid.org/0000-0002-9955-9431","observed_orcids":["https://orcid.org/0000-0002-9955-9431","https://orcid.org/0000-0001-7861-6372","https://orcid.org/0000-0001-9894-4461"]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenji Nagata","raw_affiliation_strings":["Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079272025","display_name":"Kazuya Shimoda","orcid":"https://orcid.org/0000-0002-2555-8188","observed_orcids":["https://orcid.org/0000-0002-2555-8188"]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kazuya Shimoda","raw_affiliation_strings":["Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan. kshimoda@med.miyazaki-u.ac.jp","Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan. kshimoda@med.miyazaki-u.ac.jp","institution_ids":["https://openalex.org/I118574687"]},{"raw_affiliation_string":"Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan","institution_ids":["https://openalex.org/I118574687"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5079272025"],"corresponding_institution_ids":["https://openalex.org/I118574687"],"apc_list":{"value":4480,"currency":"USD","value_usd":4480},"apc_paid":{"value":4480,"currency":"USD","value_usd":4480},"fwci":8.1843,"has_fulltext":true,"cited_by_count":75,"citation_normalized_percentile":{"value":0.98296829,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"35","issue":"2","first_page":"454","last_page":"467"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/primary-myelofibrosis","display_name":"primary myelofibrosis","score":0.9610000252723694},{"id":"https://openalex.org/keywords/bone-marrow-fibrosis","display_name":"bone marrow fibrosis","score":0.968999981880188},{"id":"https://openalex.org/keywords/jak2-v617f-mutation","display_name":"JAK2 V617F mutation","score":0.9520000219345093},{"id":"https://openalex.org/keywords/myeloproliferative-neoplasms","display_name":"myeloproliferative neoplasms","score":0.9480000138282776},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.9440000057220459},{"id":"https://openalex.org/keywords/monocyte-differentiation","display_name":"monocyte differentiation","score":0.75},{"id":"https://openalex.org/keywords/monocyte-depletion","display_name":"monocyte depletion","score":0.7160000205039978},{"id":"https://openalex.org/keywords/collagen","display_name":"collagen","score":0.4560000002384186},{"id":"https://openalex.org/keywords/fibronectin","display_name":"fibronectin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/splenomegaly","display_name":"splenomegaly","score":0.9440000057220459},{"id":"https://openalex.org/keywords/anemia","display_name":"anemia","score":0.9539999961853027},{"id":"https://openalex.org/keywords/transgenic-mouse-model","display_name":"transgenic mouse model","score":0.652999997138977}],"concepts":[{"id":"https://openalex.org/C2780076729","wikidata":"https://www.wikidata.org/wiki/Q1752571","display_name":"Myelofibrosis","level":3,"score":0.9219412207603455},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.7354939579963684},{"id":"https://openalex.org/C75786153","wikidata":"https://www.wikidata.org/wiki/Q152093","display_name":"Fibrocyte","level":2,"score":0.660336434841156},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6509265899658203},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6286492347717285},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5557032227516174},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.38051724433898926}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008533","descriptor_name":"Megakaryocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008533","descriptor_name":"Megakaryocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013163","descriptor_name":"Splenomegaly","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053614","descriptor_name":"Janus Kinase 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053614","descriptor_name":"Janus Kinase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055728","descriptor_name":"Primary Myelofibrosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055728","descriptor_name":"Primary Myelofibrosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055728","descriptor_name":"Primary Myelofibrosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41375-020-0880-3","doi":"https://doi.org/10.1038/s41375-020-0880-3","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41375-020-0880-3","pdf_url":"https://www.nature.com/articles/s41375-020-0880-3.pdf","source":{"id":"https://openalex.org/S149476849","display_name":"Leukemia","issn_l":"0887-6924","issn":["0887-6924","1476-5551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"journal-article"},{"id":"pmid:32472085","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32472085","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7862060","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7862060/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"Text"},{"id":"pmh:oai:irdb.nii.ac.jp:00851:0005949192","doi":null,"is_oa":true,"landing_page_url":"https://miyazaki-u.repo.nii.ac.jp/records/2000172","pdf_url":"https://miyazaki-u.repo.nii.ac.jp/record/2000172/files/s41375-020-0880-3.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Leukemia","raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.1038/s41375-020-0880-3","doi":"https://doi.org/10.1038/s41375-020-0880-3","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41375-020-0880-3","pdf_url":"https://www.nature.com/articles/s41375-020-0880-3.pdf","source":{"id":"https://openalex.org/S149476849","display_name":"Leukemia","issn_l":"0887-6924","issn":["0887-6924","1476-5551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1567973791","display_name":"Control of myelofibrosis targeting the amplification mechanism of CALR mutant stem cells and the functional motif of CALR mutant proteins","funder_award_id":"19K08819","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G2360093632","display_name":null,"funder_award_id":"19K17404","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G2805900773","display_name":"MPN research focusing on ER stress response and  tumor-derived fibrocytes","funder_award_id":"20H03713","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3861989185","display_name":"Regulation of the pathogenesis of myeloproliferative neoplasms with a focus on IFNalpha signaling and the mechanism of renal dysfunction.","funder_award_id":"20K17404","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4019441096","display_name":null,"funder_award_id":"19K08819","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G4155595802","display_name":"Elucidation of the role of hematopoietic cells in the development and progression of liver cirrhosis due to NASH and establishment of new therapeutic targets.","funder_award_id":"19K17404","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7308282470","display_name":"Myeloproliferative neoplasms research for drug discovery focusing on CALR mutation and fibrocyte","funder_award_id":"17H04210","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7667063334","display_name":"Role of Epigenomic alterations in Myeloproliferative neoplasms","funder_award_id":"19K17834","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8419453372","display_name":null,"funder_award_id":"17H04210","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G8674427564","display_name":null,"funder_award_id":"19K17834","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"}],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3032214830.pdf","grobid_xml":"https://content.openalex.org/works/W3032214830.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1487373628","https://openalex.org/W1578893636","https://openalex.org/W1599309632","https://openalex.org/W1605230984","https://openalex.org/W1953357409","https://openalex.org/W1975353758","https://openalex.org/W1983343123","https://openalex.org/W1988201931","https://openalex.org/W1990250202","https://openalex.org/W2002373999","https://openalex.org/W2021436633","https://openalex.org/W2025915995","https://openalex.org/W2036705767","https://openalex.org/W2037919426","https://openalex.org/W2040662877","https://openalex.org/W2051540735","https://openalex.org/W2052033797","https://openalex.org/W2063756127","https://openalex.org/W2070075266","https://openalex.org/W2070959673","https://openalex.org/W2078710631","https://openalex.org/W2085581142","https://openalex.org/W2088188253","https://openalex.org/W2101048388","https://openalex.org/W2115351357","https://openalex.org/W2121743767","https://openalex.org/W2122519498","https://openalex.org/W2337651628","https://openalex.org/W2404783736","https://openalex.org/W2416281109","https://openalex.org/W2471203955","https://openalex.org/W2493190817","https://openalex.org/W2531856938","https://openalex.org/W2605217861","https://openalex.org/W2897600982","https://openalex.org/W2911435756","https://openalex.org/W2954952837","https://openalex.org/W2978289394","https://openalex.org/W4248565951","https://openalex.org/W4250007760"],"related_works":["https://openalex.org/W2990157279","https://openalex.org/W2493190817","https://openalex.org/W4389243375","https://openalex.org/W2978289394","https://openalex.org/W7167074518","https://openalex.org/W2979455236","https://openalex.org/W2591468345","https://openalex.org/W2005661051","https://openalex.org/W2337651628","https://openalex.org/W4283373293"],"abstract_inverted_index":{"Primary":[0],"myelofibrosis":[1,82],"(PMF)":[2],"is":[3,185],"a":[4,27],"myeloproliferative":[5],"neoplasm":[6],"(MPN)":[7],"characterized":[8],"by":[9,31,38,144,164],"clonal":[10],"myeloproliferation,":[11],"progressive":[12],"bone":[13],"marrow":[14],"(BM)":[15],"fibrosis,":[16,116],"splenomegaly,":[17,119],"and":[18,72,78,97,102,104,118,130,135,157,183],"anemia.":[19],"BM":[20,56,77,101,115,179],"fibrosis":[21,57,180],"was":[22,58,142],"previously":[23],"thought":[24],"to":[25,155,178],"be":[26],"reactive":[28],"phenomenon":[29],"induced":[30],"mesenchymal":[32],"stromal":[33],"cells":[34,74,132,146],"that":[35,66,171],"are":[36,174],"stimulated":[37],"the":[39,50,67,76,125,150,175],"overproduction":[40],"of":[41,52,70,80,128,152],"cytokines":[42],"such":[43],"as":[44],"transforming":[45],"growth":[46],"factor":[47],"(TGF)-\u03b21.":[48],"However,":[49],"involvement":[51],"neoplastic":[53,89,153,172],"fibrocytes":[54,86,99,173],"in":[55,75,100,110,133,137,181],"recently":[59],"reported.":[60],"In":[61],"this":[62],"study,":[63],"we":[64],"showed":[65],"vast":[68],"majority":[69],"collagen-":[71,96],"fibronectin-producing":[73,98],"spleens":[79],"Jak2V617F-induced":[81],"(MF)":[83],"mice":[84],"were":[85,162],"derived":[87],"from":[88],"hematopoietic":[90,145],"cells.":[91],"Neoplastic":[92],"monocyte":[93,165],"depletion":[94],"eliminated":[95],"spleen,":[103],"ameliorated":[105],"most":[106],"characteristic":[107],"MF":[108],"features":[109],"Jak2V617F":[111],"transgenic":[112],"mice,":[113],"including":[114,147],"anemia,":[117],"while":[120],"had":[121],"little":[122],"effect":[123],"on":[124],"elevated":[126,158],"numbers":[127],"megakaryocytes":[129],"stem":[131],"BM,":[134],"leukothrombocytosis":[136],"peripheral":[138],"blood.":[139],"TGF-\u03b21,":[140],"which":[141],"produced":[143],"fibrocytes,":[148,156],"promoted":[149],"differentiation":[151],"monocytes":[154],"plasma":[159],"TGF-\u03b21":[160,184],"levels":[161],"normalized":[163],"depletion.":[166],"Collectively,":[167],"our":[168],"data":[169],"suggest":[170],"major":[176],"contributor":[177],"PMF,":[182],"required":[186],"for":[187],"their":[188],"differentiation.":[189]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":33},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-06-05T00:00:00"}
