{"id":"https://openalex.org/W3032044322","doi":null,"title":"Prognostic Impact of Alpha Fetoprotein at Diagnosis on Overall Survival of Single Small Hepatocellular Carcinomas.","display_name":"Prognostic Impact of Alpha Fetoprotein at Diagnosis on Overall Survival of Single Small Hepatocellular Carcinomas.","publication_year":2020,"publication_date":"2020-05-01","ids":{"openalex":"https://openalex.org/W3032044322","mag":"3032044322","pmid":"https://pubmed.ncbi.nlm.nih.gov/32476652"},"language":"en","primary_location":{"id":"pmid:32476652","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32476652","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Gulf journal of oncology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007989869","display_name":"Nada Lahmidani","orcid":"https://orcid.org/0000-0001-8759-4638","observed_orcids":["https://orcid.org/0000-0001-8759-4638"]},"institutions":[{"id":"https://openalex.org/I4210134492","display_name":"Centre Hospitalier Universitaire Hassan II","ror":"https://ror.org/03m2nqg26","country_code":"MA","type":"healthcare","lineage":["https://openalex.org/I4210134492"]},{"id":"https://openalex.org/I81605866","display_name":"Sidi Mohamed Ben Abdellah University","ror":"https://ror.org/04efg9a07","country_code":"MA","type":"education","lineage":["https://openalex.org/I81605866"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"N Lahmidani","raw_affiliation_strings":["University Hospital Hassan II, School of Medicine and Pharmacy of Fez, Fez, Morocco","University Sidi Mohammed Ben Abdallah, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Hassan II, School of Medicine and Pharmacy of Fez, Fez, Morocco","institution_ids":["https://openalex.org/I4210134492"]},{"raw_affiliation_string":"University Sidi Mohammed Ben Abdallah, Morocco","institution_ids":["https://openalex.org/I81605866"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019477353","display_name":"FZ Hamdoun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134492","display_name":"Centre Hospitalier Universitaire Hassan II","ror":"https://ror.org/03m2nqg26","country_code":"MA","type":"healthcare","lineage":["https://openalex.org/I4210134492"]},{"id":"https://openalex.org/I81605866","display_name":"Sidi Mohamed Ben Abdellah University","ror":"https://ror.org/04efg9a07","country_code":"MA","type":"education","lineage":["https://openalex.org/I81605866"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"F Z Hamdoun","raw_affiliation_strings":["University Hospital Hassan II, School of Medicine and Pharmacy of Fez, Fez, Morocco","University Sidi Mohammed Ben Abdallah, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Hassan II, School of Medicine and Pharmacy of Fez, Fez, Morocco","institution_ids":["https://openalex.org/I4210134492"]},{"raw_affiliation_string":"University Sidi Mohammed Ben Abdallah, Morocco","institution_ids":["https://openalex.org/I81605866"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018844975","display_name":"Mar\u00eda Lahlali","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134492","display_name":"Centre Hospitalier Universitaire Hassan II","ror":"https://ror.org/03m2nqg26","country_code":"MA","type":"healthcare","lineage":["https://openalex.org/I4210134492"]},{"id":"https://openalex.org/I81605866","display_name":"Sidi Mohamed Ben Abdellah University","ror":"https://ror.org/04efg9a07","country_code":"MA","type":"education","lineage":["https://openalex.org/I81605866"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"M Lahlali","raw_affiliation_strings":["University Hospital Hassan II, School of Medicine and Pharmacy of Fez, Fez, Morocco","University Sidi Mohammed Ben Abdallah, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Hassan II, School of Medicine and Pharmacy of Fez, Fez, Morocco","institution_ids":["https://openalex.org/I4210134492"]},{"raw_affiliation_string":"University Sidi Mohammed Ben Abdallah, Morocco","institution_ids":["https://openalex.org/I81605866"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083438603","display_name":"Hakima Abid","orcid":"https://orcid.org/0000-0003-1611-9893","observed_orcids":["https://orcid.org/0000-0003-1611-9893"]},"institutions":[{"id":"https://openalex.org/I4210134492","display_name":"Centre Hospitalier Universitaire Hassan II","ror":"https://ror.org/03m2nqg26","country_code":"MA","type":"healthcare","lineage":["https://openalex.org/I4210134492"]},{"id":"https://openalex.org/I81605866","display_name":"Sidi Mohamed Ben Abdellah University","ror":"https://ror.org/04efg9a07","country_code":"MA","type":"education","lineage":["https://openalex.org/I81605866"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"H Abid","raw_affiliation_strings":["University Hospital Hassan II, School of Medicine and Pharmacy of Fez, Fez, Morocco","University Sidi Mohammed Ben Abdallah, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Hassan II, School of Medicine and Pharmacy of Fez, Fez, Morocco","institution_ids":["https://openalex.org/I4210134492"]},{"raw_affiliation_string":"University Sidi Mohammed Ben Abdallah, Morocco","institution_ids":["https://openalex.org/I81605866"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110458183","display_name":"M. El Yousfi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134492","display_name":"Centre Hospitalier Universitaire Hassan II","ror":"https://ror.org/03m2nqg26","country_code":"MA","type":"healthcare","lineage":["https://openalex.org/I4210134492"]},{"id":"https://openalex.org/I81605866","display_name":"Sidi Mohamed Ben Abdellah University","ror":"https://ror.org/04efg9a07","country_code":"MA","type":"education","lineage":["https://openalex.org/I81605866"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"M El Yousfi","raw_affiliation_strings":["University Hospital Hassan II, School of Medicine and Pharmacy of Fez, Fez, Morocco","University Sidi Mohammed Ben Abdallah, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Hassan II, School of Medicine and Pharmacy of Fez, Fez, Morocco","institution_ids":["https://openalex.org/I4210134492"]},{"raw_affiliation_string":"University Sidi Mohammed Ben Abdallah, Morocco","institution_ids":["https://openalex.org/I81605866"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035283477","display_name":"D. A. Benajah","orcid":"https://orcid.org/0000-0002-1815-1080","observed_orcids":["https://orcid.org/0000-0002-1815-1080"]},"institutions":[{"id":"https://openalex.org/I4210134492","display_name":"Centre Hospitalier Universitaire Hassan II","ror":"https://ror.org/03m2nqg26","country_code":"MA","type":"healthcare","lineage":["https://openalex.org/I4210134492"]},{"id":"https://openalex.org/I81605866","display_name":"Sidi Mohamed Ben Abdellah University","ror":"https://ror.org/04efg9a07","country_code":"MA","type":"education","lineage":["https://openalex.org/I81605866"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"D A Benajah","raw_affiliation_strings":["University Hospital Hassan II, School of Medicine and Pharmacy of Fez, Fez, Morocco","University Sidi Mohammed Ben Abdallah, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Hassan II, School of Medicine and Pharmacy of Fez, Fez, Morocco","institution_ids":["https://openalex.org/I4210134492"]},{"raw_affiliation_string":"University Sidi Mohammed Ben Abdallah, Morocco","institution_ids":["https://openalex.org/I81605866"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019555960","display_name":"Mohammed El Abkari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134492","display_name":"Centre Hospitalier Universitaire Hassan II","ror":"https://ror.org/03m2nqg26","country_code":"MA","type":"healthcare","lineage":["https://openalex.org/I4210134492"]},{"id":"https://openalex.org/I81605866","display_name":"Sidi Mohamed Ben Abdellah University","ror":"https://ror.org/04efg9a07","country_code":"MA","type":"education","lineage":["https://openalex.org/I81605866"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"M El Abkari","raw_affiliation_strings":["University Hospital Hassan II, School of Medicine and Pharmacy of Fez, Fez, Morocco","University Sidi Mohammed Ben Abdallah, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Hassan II, School of Medicine and Pharmacy of Fez, Fez, Morocco","institution_ids":["https://openalex.org/I4210134492"]},{"raw_affiliation_string":"University Sidi Mohammed Ben Abdallah, Morocco","institution_ids":["https://openalex.org/I81605866"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027069738","display_name":"Sidi Adil Ibrahimi","orcid":"https://orcid.org/0000-0002-2873-0588","observed_orcids":["https://orcid.org/0000-0002-2873-0588"]},"institutions":[{"id":"https://openalex.org/I4210134492","display_name":"Centre Hospitalier Universitaire Hassan II","ror":"https://ror.org/03m2nqg26","country_code":"MA","type":"healthcare","lineage":["https://openalex.org/I4210134492"]},{"id":"https://openalex.org/I81605866","display_name":"Sidi Mohamed Ben Abdellah University","ror":"https://ror.org/04efg9a07","country_code":"MA","type":"education","lineage":["https://openalex.org/I81605866"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"S A Ibrahimi","raw_affiliation_strings":["University Hospital Hassan II, School of Medicine and Pharmacy of Fez, Fez, Morocco","University Sidi Mohammed Ben Abdallah, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Hassan II, School of Medicine and Pharmacy of Fez, Fez, Morocco","institution_ids":["https://openalex.org/I4210134492"]},{"raw_affiliation_string":"University Sidi Mohammed Ben Abdallah, Morocco","institution_ids":["https://openalex.org/I81605866"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2449,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.51267922,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"1","issue":"33","first_page":"64","last_page":"67"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-fetoprotein","display_name":"alpha-fetoprotein","score":0.9959999918937683},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9860000014305115},{"id":"https://openalex.org/keywords/small-hepatocellular-carcinoma","display_name":"small hepatocellular carcinoma","score":0.8980000019073486},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.7110000252723694},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7039999961853027},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9710000157356262},{"id":"https://openalex.org/keywords/serum-tumor-markers","display_name":"serum tumor markers","score":0.9160000085830688}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9518812894821167},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.8608927726745605},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7716600298881531},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.756662905216217},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6977254152297974},{"id":"https://openalex.org/C2780624289","wikidata":"https://www.wikidata.org/wiki/Q306076","display_name":"Alpha-fetoprotein","level":3,"score":0.6629614233970642},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.5272654294967651},{"id":"https://openalex.org/C2776283816","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Survival rate","level":2,"score":0.44404134154319763},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.35792404413223267}],"mesh":[{"descriptor_ui":"D000509","descriptor_name":"alpha-Fetoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:32476652","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32476652","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Gulf journal of oncology","raw_type":"Journal Article"},{"id":"mag:3032044322","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32476652","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3159206865","https://openalex.org/W2169878655","https://openalex.org/W2101151609","https://openalex.org/W1989727210","https://openalex.org/W3005225909","https://openalex.org/W4407785288","https://openalex.org/W1982770614","https://openalex.org/W7204255001","https://openalex.org/W2977476251","https://openalex.org/W2784590900"],"abstract_inverted_index":{"BACKGROUND:":[0],"Alpha-fetoprotein":[1,161],"(AFP)":[2],"is":[3,27],"a":[4,57,82,93],"serum":[5,162],"tumor":[6],"marker":[7],"used":[8],"in":[9,20,30,61,140,145,169],"the":[10,31,41,45,51,69,76,130],"past":[11],"for":[12,117],"surveillance":[13],"and":[14,98,119],"screening":[15],"of":[16,35,44,54,113,158],"hepatocellular":[17],"carcinoma":[18],"(HCC)":[19],"patients":[21,55,62,71,80,91,114,170],"with":[22,56,63,73,92,102,171],"cirrhosis.":[23,64],"Its":[24],"prognostic":[25,42,156,167],"value":[26,168],"still":[28],"debated":[29],"literature.":[32],"The":[33,133,148],"aim":[34],"this":[36],"study":[37,77],"was":[38,127,138,151],"to":[39,165],"evaluate":[40],"impact":[43],"AFP":[46,95,104,149],"rate":[47],"at":[48,85,135],"diagnosis":[49],"on":[50],"overall":[52],"survival":[53,126,134],"small":[58,83,173],"HCC":[59,74,84],"(<3cm)":[60],"PATIENTS":[65],"AND":[66],"METHODS:":[67],"Among":[68],"122":[70],"diagnosed":[72],"during":[75],"period,":[78],"49":[79],"had":[81],"diagnosis,":[86],"including":[87],"40,8%":[88],"(N":[89,100],"20)":[90],"negative":[94],"(group":[96,109],"I)":[97],"59,18%":[99],"29)":[101],"an":[103,154],">10":[105],"ng":[106],"/":[107],"ml":[108],"II).":[110],"Both":[111],"groups":[112],"were":[115],"comparable":[116],"age":[118],"WHO":[120],"status":[121],"(World":[122],"Health":[123],"Organization).":[124],"Patient":[125],"assessed":[128],"by":[129],"Kaplan-Meier":[131],"method.":[132],"5":[136],"years":[137],"35.7%":[139],"group":[141,146],"1":[142],"vs":[143],"12.3%":[144],"2.":[147],"level":[150],"identified":[152],"as":[153],"independent":[155],"factor":[157],"survival.":[159],"CONCLUSION:":[160],"positivity":[163],"seems":[164],"have":[166],"single":[172],"HCC.":[174]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-06-05T00:00:00"}