{"id":"https://openalex.org/W3032035226","doi":"https://doi.org/10.1097/j.pain.0000000000001926","title":"A disintegrin and metalloproteinase domain 17-epidermal growth factor receptor signaling contributes to oral cancer pain","display_name":"A disintegrin and metalloproteinase domain 17-epidermal growth factor receptor signaling contributes to oral cancer pain","publication_year":2020,"publication_date":"2020-05-19","ids":{"openalex":"https://openalex.org/W3032035226","doi":"https://doi.org/10.1097/j.pain.0000000000001926","mag":"3032035226","pmid":"https://pubmed.ncbi.nlm.nih.gov/32453136","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9244849"},"language":"en","primary_location":{"id":"doi:10.1097/j.pain.0000000000001926","doi":"https://doi.org/10.1097/j.pain.0000000000001926","is_oa":false,"landing_page_url":"https://doi.org/10.1097/j.pain.0000000000001926","pdf_url":null,"source":{"id":"https://openalex.org/S140848990","display_name":"Pain","issn_l":"0304-3959","issn":["0304-3959","1872-6623"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pain","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9244849","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020474875","display_name":"Nicole N. Scheff","orcid":"https://orcid.org/0000-0002-5587-4990","observed_orcids":["https://orcid.org/0000-0002-5587-4990"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicole N. Scheff","raw_affiliation_strings":["Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY, United States","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101652031","display_name":"Yi Ye","orcid":"https://orcid.org/0000-0002-1075-5584","observed_orcids":["https://orcid.org/0000-0002-1075-5584"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi Ye","raw_affiliation_strings":["Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY, United States","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028747022","display_name":"Zachary Ryan Conley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zachary R. Conley","raw_affiliation_strings":["Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY, United States","Doctor of Dental Surgery Program, New York University College of Dentistry, New York, NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY, United States","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Doctor of Dental Surgery Program, New York University College of Dentistry, New York, NY, United States","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072509107","display_name":"Jen Wui Quan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jen Wui Quan","raw_affiliation_strings":["Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY, United States","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084983725","display_name":"Yat Vong Ronald Lam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yat Vong Ronald Lam","raw_affiliation_strings":["Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY, United States","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042427280","display_name":"Richard Klares","orcid":"https://orcid.org/0000-0002-7527-4175","observed_orcids":["https://orcid.org/0000-0002-7527-4175"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Klares","raw_affiliation_strings":["Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY, United States","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086013200","display_name":"Kamalpreet Singh","orcid":"https://orcid.org/0000-0001-8569-1119","observed_orcids":["https://orcid.org/0000-0001-8569-1119"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kamalpreet Singh","raw_affiliation_strings":["Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY, United States","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015929707","display_name":"Brian L. Schmidt","orcid":"https://orcid.org/0000-0002-2409-8984","observed_orcids":["https://orcid.org/0000-0002-2409-8984"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian L. Schmidt","raw_affiliation_strings":["Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY, United States","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008145165","display_name":"Bradley E. Aouizerat","orcid":"https://orcid.org/0000-0002-6047-9397","observed_orcids":["https://orcid.org/0000-0002-6047-9397"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bradley E. Aouizerat","raw_affiliation_strings":["Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY, United States","institution_ids":["https://openalex.org/I57206974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5008145165"],"corresponding_institution_ids":["https://openalex.org/I57206974"],"apc_list":null,"apc_paid":null,"fwci":1.1654,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.76626357,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"161","issue":"10","first_page":"2330","last_page":"2343"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oral-cancer-pain","display_name":"oral cancer pain","score":0.9449999928474426},{"id":"https://openalex.org/keywords/adam17","display_name":"ADAM17","score":0.9470000267028809},{"id":"https://openalex.org/keywords/egfr-signaling","display_name":"EGFR signaling","score":0.7730000019073486},{"id":"https://openalex.org/keywords/cancer-pain","display_name":"cancer pain","score":0.5509999990463257},{"id":"https://openalex.org/keywords/nociception","display_name":"nociception","score":0.7760000228881836},{"id":"https://openalex.org/keywords/cetuximab","display_name":"cetuximab","score":0.8320000171661377},{"id":"https://openalex.org/keywords/cancer-cell-lines","display_name":"cancer cell lines","score":0.5830000042915344},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.5379999876022339}],"concepts":[{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5656523704528809},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.5597864389419556},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5100656151771545},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4943838119506836},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49297642707824707},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.4426061511039734},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.32390928268432617},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11113318800926208}],"mesh":[{"descriptor_ui":"D000072198","descriptor_name":"ADAM17 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000072198","descriptor_name":"ADAM17 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000072716","descriptor_name":"Cancer Pain","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019483","descriptor_name":"Disintegrins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1097/j.pain.0000000000001926","doi":"https://doi.org/10.1097/j.pain.0000000000001926","is_oa":false,"landing_page_url":"https://doi.org/10.1097/j.pain.0000000000001926","pdf_url":null,"source":{"id":"https://openalex.org/S140848990","display_name":"Pain","issn_l":"0304-3959","issn":["0304-3959","1872-6623"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pain","raw_type":"journal-article"},{"id":"pmid:32453136","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32453136","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pain","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9244849","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9244849","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Pain","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9244849","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9244849","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Pain","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1253232778","display_name":"Schwann cell activation in oral cancer perineurial invasion and neuropathic pain","funder_award_id":"R01DE029493","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G2035152305","display_name":"Does Neutrophil Infiltrate Impact Oral Cancer Pain","funder_award_id":"F32DE027269","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G2154278428","display_name":"Schwann Cell Activation and Oral Cancer Pain","funder_award_id":"R03DE027777","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G2615620076","display_name":"Protease/PAR2/TRPV4 Axis and Oral Cancer Pain","funder_award_id":"R01DE026806","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":90,"referenced_works":["https://openalex.org/W17444167","https://openalex.org/W1514134885","https://openalex.org/W1578104218","https://openalex.org/W1885155229","https://openalex.org/W1946793929","https://openalex.org/W1964575719","https://openalex.org/W1973268693","https://openalex.org/W1980211974","https://openalex.org/W1992660677","https://openalex.org/W1995242599","https://openalex.org/W2000492372","https://openalex.org/W2004408045","https://openalex.org/W2015276888","https://openalex.org/W2025892095","https://openalex.org/W2026795077","https://openalex.org/W2027889563","https://openalex.org/W2028552358","https://openalex.org/W2035402013","https://openalex.org/W2037791777","https://openalex.org/W2039559587","https://openalex.org/W2045311928","https://openalex.org/W2049271604","https://openalex.org/W2052144512","https://openalex.org/W2056781391","https://openalex.org/W2062091642","https://openalex.org/W2072069139","https://openalex.org/W2081263700","https://openalex.org/W2102278945","https://openalex.org/W2103017472","https://openalex.org/W2104005232","https://openalex.org/W2106448082","https://openalex.org/W2107363136","https://openalex.org/W2108234281","https://openalex.org/W2112744827","https://openalex.org/W2115790682","https://openalex.org/W2118258530","https://openalex.org/W2120718661","https://openalex.org/W2122982115","https://openalex.org/W2129255527","https://openalex.org/W2131396892","https://openalex.org/W2132235170","https://openalex.org/W2139120823","https://openalex.org/W2141101945","https://openalex.org/W2141224543","https://openalex.org/W2143464311","https://openalex.org/W2144694460","https://openalex.org/W2145070131","https://openalex.org/W2146512944","https://openalex.org/W2147580772","https://openalex.org/W2148708580","https://openalex.org/W2157305173","https://openalex.org/W2159096710","https://openalex.org/W2159195088","https://openalex.org/W2159978590","https://openalex.org/W2160133587","https://openalex.org/W2163857222","https://openalex.org/W2169353806","https://openalex.org/W2173048904","https://openalex.org/W2179438025","https://openalex.org/W2281080727","https://openalex.org/W2298101895","https://openalex.org/W2313578479","https://openalex.org/W2324003800","https://openalex.org/W2340761255","https://openalex.org/W2396579854","https://openalex.org/W2409420104","https://openalex.org/W2409479160","https://openalex.org/W2432815617","https://openalex.org/W2474643665","https://openalex.org/W2474747771","https://openalex.org/W2515367508","https://openalex.org/W2523208571","https://openalex.org/W2535658743","https://openalex.org/W2549954586","https://openalex.org/W2593843419","https://openalex.org/W2628396830","https://openalex.org/W2736267104","https://openalex.org/W2737800162","https://openalex.org/W2742580821","https://openalex.org/W2745520892","https://openalex.org/W2752592405","https://openalex.org/W2758837853","https://openalex.org/W2766941260","https://openalex.org/W2781615726","https://openalex.org/W2793481677","https://openalex.org/W2883299124","https://openalex.org/W2896166955","https://openalex.org/W2900877533","https://openalex.org/W2905734600","https://openalex.org/W4210702584"],"related_works":["https://openalex.org/W2923615815","https://openalex.org/W2599446778","https://openalex.org/W2597553766","https://openalex.org/W4224241029","https://openalex.org/W2752592405","https://openalex.org/W3083326408","https://openalex.org/W7125803645","https://openalex.org/W7163995736","https://openalex.org/W2080051564","https://openalex.org/W4228999493"],"abstract_inverted_index":{"Cancer":[0,76],"cells":[1],"secrete":[2],"pronociceptive":[3],"mediators":[4,18],"that":[5,38,46,151,209],"sensitize":[6],"adjacent":[7],"sensory":[8],"neurons":[9,182],"and":[10,14,72,103,113,133,222,237],"cause":[11],"pain.":[12],"Identification":[13],"characterization":[15],"of":[16,64,116],"these":[17,207],"could":[19],"pinpoint":[20],"novel":[21],"targets":[22,143,232],"for":[23,40,233],"cancer":[24,35,58,92,125,200,215,235],"pain":[25,59,93,126,201,236],"treatment.":[26],"In":[27],"this":[28,52],"study,":[29],"we":[30,54],"identified":[31,118,140],"candidate":[32,230],"genes":[33,112,119,221],"in":[34,89,161,175,183,196,214],"cell":[36,43,69,77,105,154,163,169,191],"lines":[37,155],"encode":[39],"secreted":[41,224],"or":[42],"surface":[44],"proteins":[45],"may":[47,227],"drive":[48],"nociception.":[49,217],"To":[50],"undertake":[51],"work,":[53],"used":[55],"an":[56,90,197],"acute":[57,91,198],"mouse":[60,94,202],"model,":[61],"transcriptomic":[62],"analysis":[63],"publicly":[65],"available":[66],"human":[67],"tumor-derived":[68],"line":[70,78,192],"data,":[71],"a":[73,82],"literature":[74],"review.":[75],"supernatants":[79],"were":[80,120,139],"assigned":[81],"phenotype":[83],"based":[84],"on":[85],"evoked":[86],"nociceptive":[87,102,153,194],"behavior":[88,195],"model.":[95,203],"We":[96,149,204],"compared":[97,166],"gene":[98],"expression":[99],"data":[100,208],"from":[101,206],"nonnociceptive":[104,168],"lines.":[106,170],"Our":[107],"analyses":[108],"revealed":[109],"differentially":[110,146,219],"expressed":[111,147,220],"pathways;":[114],"many":[115],"the":[117,145,152,162],"not":[121],"previously":[122],"associated":[123],"with":[124],"signaling.":[127],"Epidermal":[128],"growth":[129],"factor":[130],"receptor":[131],"(EGFR)":[132],"disintegrin":[134],"metalloprotease":[135],"domain":[136],"17":[137],"(ADAM17)":[138],"as":[141,229],"potential":[142],"among":[144],"genes.":[148],"found":[150],"contained":[156],"significantly":[157],"more":[158],"ADAM17":[159],"protein":[160,225],"culture":[164],"supernatant":[165],"to":[167],"Cytoplasmic":[171],"EGFR":[172],"was":[173],"present":[174],"almost":[176],"all":[177],"(>90%)":[178],"tongue":[179],"primary":[180],"afferent":[181],"mice.":[184],"Monoclonal":[185],"antibody":[186],"against":[187],"EGFR,":[188],"cetuximab,":[189],"inhibited":[190],"supernatant-induced":[193],"oral":[199,234],"infer":[205],"ADAM17-EGFR":[210],"signaling":[211],"is":[212],"involved":[213],"mediator-induced":[216],"The":[218],"their":[223],"products":[226],"serve":[228],"therapeutic":[231],"warrant":[238],"further":[239],"evaluation.":[240]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-06-05T00:00:00"}