{"id":"https://openalex.org/W3031908884","doi":"https://doi.org/10.3877/cma.j.issn.2096-0263.2019.02.004","title":"Research on bone marrow derived-mesenchymal stem cells and human umbilical cord blood derived-mesenchymal stem cells modified with the gene of human bone morphogenetic protein-2","display_name":"Research on bone marrow derived-mesenchymal stem cells and human umbilical cord blood derived-mesenchymal stem cells modified with the gene of human bone morphogenetic protein-2","publication_year":2019,"publication_date":"2019-04-05","ids":{"openalex":"https://openalex.org/W3031908884","doi":"https://doi.org/10.3877/cma.j.issn.2096-0263.2019.02.004","mag":"3031908884"},"language":"en","primary_location":{"id":"mag:3031908884","doi":"https://doi.org/10.3877/cma.j.issn.2096-0263.2019.02.004","is_oa":false,"landing_page_url":"http://rs.yiigle.com/CN119364201902/1127456.htm","pdf_url":null,"source":{"id":"https://openalex.org/S4306506103","display_name":"Chin J Geriatr Orthop Rehabil(Electronic Edition)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Chin J Geriatr Orthop Rehabil(Electronic Edition)","raw_type":null},"parent_works":[],"lineage":["https://openalex.org/W3031908884"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100436895","display_name":"Jie Zhang","orcid":"https://orcid.org/0000-0003-4342-6776","observed_orcids":["https://orcid.org/0000-0003-4342-6776"]},"institutions":[{"id":"https://openalex.org/I4210159744","display_name":"Weifang Chinese Medicine Hospital","ror":"https://ror.org/05mfqj750","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159744"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Zhang","raw_affiliation_strings":["Department of Endocrinology, Weifang Traditional Chinese Hosptial, Weifang 261000, China"],"raw_orcid":"https://orcid.org/0000-0003-4342-6776","affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Weifang Traditional Chinese Hosptial, Weifang 261000, China","institution_ids":["https://openalex.org/I4210159744"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100609555","display_name":"Hui Huang","orcid":"https://orcid.org/0000-0002-4741-4361","observed_orcids":["https://orcid.org/0000-0002-4741-4361"]},"institutions":[{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Huang","raw_affiliation_strings":["Department of Anesthesiology, the Affiliated Hospital of Qingdao University, Qingdao 266000, China"],"raw_orcid":"https://orcid.org/0000-0002-4741-4361","affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, the Affiliated Hospital of Qingdao University, Qingdao 266000, China","institution_ids":["https://openalex.org/I4210116869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101542402","display_name":"Junguo Wang","orcid":"https://orcid.org/0000-0001-5972-5848","observed_orcids":["https://orcid.org/0000-0001-5972-5848","https://orcid.org/0000-0003-3745-720X"]},"institutions":[{"id":"https://openalex.org/I4405267615","display_name":"Qingdao Haici Medical Group","ror":"https://ror.org/03k2ra854","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4405267615"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junguo Wang","raw_affiliation_strings":["Department of Joint Surgery, Qingdao Haici Hosptial, Qingdao 266000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Joint Surgery, Qingdao Haici Hosptial, Qingdao 266000, China","institution_ids":["https://openalex.org/I4405267615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020711979","display_name":"Yi Sun","orcid":"https://orcid.org/0000-0002-5279-8099","observed_orcids":["https://orcid.org/0000-0002-5279-8099"]},"institutions":[{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Sun","raw_affiliation_strings":["Department of Joint Surgery, The Affiliated Hospital of Qingdao University, Qingdao 266000, China"],"raw_orcid":"https://orcid.org/0000-0002-5279-8099","affiliations":[{"raw_affiliation_string":"Department of Joint Surgery, The Affiliated Hospital of Qingdao University, Qingdao 266000, China","institution_ids":["https://openalex.org/I4210116869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100664366","display_name":"Haining Zhang","orcid":"https://orcid.org/0000-0002-4367-4369","observed_orcids":["https://orcid.org/0000-0002-4367-4369"]},"institutions":[{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haining Zhang","raw_affiliation_strings":["Department of Joint Surgery, The Affiliated Hospital of Qingdao University, Qingdao 266000, China"],"raw_orcid":"https://orcid.org/0000-0002-4367-4369","affiliations":[{"raw_affiliation_string":"Department of Joint Surgery, The Affiliated Hospital of Qingdao University, Qingdao 266000, China","institution_ids":["https://openalex.org/I4210116869"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101684277","display_name":"Yingzhen Wang","orcid":"https://orcid.org/0009-0002-1088-0817","observed_orcids":["https://orcid.org/0009-0002-1088-0817"]},"institutions":[{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yingzhen Wang","raw_affiliation_strings":["Department of Joint Surgery, The Affiliated Hospital of Qingdao University, Qingdao 266000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Joint Surgery, The Affiliated Hospital of Qingdao University, Qingdao 266000, China","institution_ids":["https://openalex.org/I4210116869"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"2","first_page":"82","last_page":"86"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9020000100135803},{"id":"https://openalex.org/keywords/bone-marrow-derived-stem-cells","display_name":"bone marrow-derived stem cells","score":0.8709999918937683},{"id":"https://openalex.org/keywords/umbilical-cord-blood-stem-cells","display_name":"umbilical cord blood stem cells","score":0.9700000286102295},{"id":"https://openalex.org/keywords/bmp-2","display_name":"BMP-2","score":0.9700000286102295},{"id":"https://openalex.org/keywords/transfection","display_name":"transfection","score":0.7710000276565552},{"id":"https://openalex.org/keywords/transfection-efficiency","display_name":"transfection efficiency","score":0.8700000047683716},{"id":"https://openalex.org/keywords/type-ii-collagen","display_name":"type II collagen","score":0.9700000286102295},{"id":"https://openalex.org/keywords/chondrogenic-differentiation","display_name":"chondrogenic differentiation","score":0.8769999742507935},{"id":"https://openalex.org/keywords/plasmid-transfection","display_name":"plasmid transfection","score":0.5429999828338623}],"concepts":[{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.7961177825927734},{"id":"https://openalex.org/C2776955114","wikidata":"https://www.wikidata.org/wiki/Q172563","display_name":"Umbilical cord","level":2,"score":0.6174466013908386},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5985434055328369},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.590194582939148},{"id":"https://openalex.org/C13685319","wikidata":"https://www.wikidata.org/wiki/Q7607302","display_name":"Stem cell transplantation for articular cartilage repair","level":5,"score":0.5341680645942688},{"id":"https://openalex.org/C100787162","wikidata":"https://www.wikidata.org/wiki/Q17009135","display_name":"Cord lining","level":5,"score":0.5277144312858582},{"id":"https://openalex.org/C2780914630","wikidata":"https://www.wikidata.org/wiki/Q914952","display_name":"Cord blood","level":2,"score":0.49090486764907837},{"id":"https://openalex.org/C109661977","wikidata":"https://www.wikidata.org/wiki/Q3664294","display_name":"Amniotic stem cells","level":5,"score":0.4630209803581238},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.46079760789871216},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.45547202229499817},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3883602023124695},{"id":"https://openalex.org/C20875687","wikidata":"https://www.wikidata.org/wiki/Q2642600","display_name":"Adult stem cell","level":4,"score":0.35543662309646606},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.321402370929718},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2853350043296814},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.1930726170539856},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.1767609417438507},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05013084411621094},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.04654055833816528},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:3031908884","doi":"https://doi.org/10.3877/cma.j.issn.2096-0263.2019.02.004","is_oa":false,"landing_page_url":"http://rs.yiigle.com/CN119364201902/1127456.htm","pdf_url":null,"source":{"id":"https://openalex.org/S4306506103","display_name":"Chin J Geriatr Orthop Rehabil(Electronic Edition)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Chin J Geriatr Orthop Rehabil(Electronic Edition)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2403988427","https://openalex.org/W3031402072","https://openalex.org/W3029384522","https://openalex.org/W2364352951","https://openalex.org/W2262574271","https://openalex.org/W2352311679","https://openalex.org/W2749932773","https://openalex.org/W2583356399","https://openalex.org/W2349515745","https://openalex.org/W2751302063"],"abstract_inverted_index":{"Objective\r\nTo":[0],"study":[1],"the":[2,20,76,170],"modification":[3,21],"of":[4,95,147,149,160,179],"bone":[5,50,135,150,197],"marrow":[6,23,51,101,136,151,198],"and":[7,18,24,34,40,52,75,90,102,113,137,169,183,199,207],"human":[8,25,53,103,138,161,200],"umbilical":[9,26,54,104,139,162,201],"cord":[10,27,55,105,140,163,202],"blood":[11,28,56,106,141,164,203],"mesenchymal":[12,29,57,107,142,152,165,204],"stem":[13,30,58,108,143,153,166,205,215],"cells":[14,31,59,96,109,117,154,167,206],"with":[15],"hBMP-2":[16,45,124],"gene":[17,193],"compare":[19],"results.\r\n\r\n\r\nMethods\r\nBone":[22],"were":[32,110,187],"separated":[33],"cultured":[35],"by":[36,60,71,85,99,127],"density":[37],"gradient":[38],"centrifugation":[39],"adherent":[41],"culture.":[42],"The":[43,66,81,87,115,122,145,177],"recombinant":[44,123],"plasmid":[46,125],"was":[47,69,79,83,97,131,156,172],"transfected":[48,133,191],"into":[49,134],"high-performance":[61,128],"non-liposome":[62,129],"reagent":[63,130],"X-treme":[64],"GENE.":[65],"fluorescence":[67,73],"intensity":[68],"measured":[70],"inverted":[72],"microscopy":[74],"transfection":[77,148],"efficiency":[78,146],"calculated.":[80],"hBMP":[82],"detected":[84,98,188],"qPCR.":[86],"expression":[88,178],"of-2":[89],"chondronectin":[91],"in":[92,189],"two":[93,116],"kinds":[94],"immunohistochemistry.\r\n\r\n\r\nResults\r\nBone":[100],"successfully":[111,132],"isolated":[112],"cultured.":[114],"had":[118],"different":[119],"growth":[120],"characteristics.":[121],"mediated":[126],"cells.":[144],"(18.44\u00b15.94)%":[155],"lower":[157],"than":[158],"that":[159],"(27.74\u00b17.59)%,":[168],"difference":[171],"statistically":[173],"significant":[174],"(t=3.027,":[175],"P<0.05).":[176],"hBMP-2,":[180],"cartilage":[181],"connectin":[182],"collagen":[184],"type":[185],"II":[186],"both":[190],"cells.\r\n\r\n\r\nConclusion\r\nhBMP-2":[192],"can":[194],"effectively":[195],"modify":[196],"promote":[208],"chondrocyte":[209],"differentiation.\r\n\r\n\r\nKey":[210],"words:":[211],"\r\nBMP2":[212],"protein,":[213],"human;\u00a0Mesenchymal":[214],"cells;\u00a0Liposomes":[216]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-06-05T00:00:00"}
