{"id":"https://openalex.org/W3031660105","doi":"https://doi.org/10.1200/jco.2020.38.15_suppl.4002","title":"First-line FOLFOX plus panitumumab versus 5FU plus panitumumab in RAS-BRAF wild-type metastatic colorectal cancer elderly patients: The PANDA study.","display_name":"First-line FOLFOX plus panitumumab versus 5FU plus panitumumab in RAS-BRAF wild-type metastatic colorectal cancer elderly patients: The PANDA study.","publication_year":2020,"publication_date":"2020-05-20","ids":{"openalex":"https://openalex.org/W3031660105","doi":"https://doi.org/10.1200/jco.2020.38.15_suppl.4002","mag":"3031660105"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2020.38.15_suppl.4002","doi":"https://doi.org/10.1200/jco.2020.38.15_suppl.4002","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2020.38.15_suppl.4002","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051613962","display_name":"Sara Lonardi","orcid":"https://orcid.org/0000-0002-7593-8138","observed_orcids":["https://orcid.org/0000-0002-7593-8138"]},"institutions":[{"id":"https://openalex.org/I4210109345","display_name":"Istituto Oncologico Veneto","ror":"https://ror.org/01xcjmy57","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109345","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sara Lonardi","raw_affiliation_strings":["Veneto Institute of Oncology (IOV)-IRCCS, Padua, Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veneto Institute of Oncology (IOV)-IRCCS, Padua, Italy;","institution_ids":["https://openalex.org/I4210109345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048141257","display_name":"Marta Schirripa","orcid":"https://orcid.org/0000-0001-8316-4411","observed_orcids":["https://orcid.org/0000-0001-8316-4411"]},"institutions":[{"id":"https://openalex.org/I4210109345","display_name":"Istituto Oncologico Veneto","ror":"https://ror.org/01xcjmy57","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109345","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marta Schirripa","raw_affiliation_strings":["Department of Oncology, Oncology 1, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Oncology 1, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy;","institution_ids":["https://openalex.org/I4210109345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069801309","display_name":"Federica Buggin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109345","display_name":"Istituto Oncologico Veneto","ror":"https://ror.org/01xcjmy57","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109345","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Federica Buggin","raw_affiliation_strings":["Department of Oncology, Oncology 1, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Oncology 1, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy;","institution_ids":["https://openalex.org/I4210109345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002745641","display_name":"Lorenzo Antonuzzo","orcid":"https://orcid.org/0000-0003-3349-5604","observed_orcids":["https://orcid.org/0000-0003-3349-5604"]},"institutions":[{"id":"https://openalex.org/I4210115393","display_name":"Azienda Ospedaliero-Universitaria Careggi","ror":"https://ror.org/02crev113","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210115393"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Lorenzo Antonuzzo","raw_affiliation_strings":["Medical Oncology, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy;","institution_ids":["https://openalex.org/I4210115393"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030046392","display_name":"Barbara Merelli","orcid":"https://orcid.org/0009-0000-8535-119X","observed_orcids":["https://orcid.org/0009-0000-8535-119X"]},"institutions":[{"id":"https://openalex.org/I4210106645","display_name":"Ospedale Papa Giovanni XXIII","ror":"https://ror.org/01savtv33","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210106645"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Barbara Merelli","raw_affiliation_strings":["Oncology Unit, ASST Papa Giovanni XXIII, Bergamo, Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Unit, ASST Papa Giovanni XXIII, Bergamo, Italy;","institution_ids":["https://openalex.org/I4210106645"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052513941","display_name":"Giorgia Boscolo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giorgia Boscolo","raw_affiliation_strings":["Medical Specialties Department, Oncology and Oncologic Hematology, ULSS 3 Serenissima, Milan, Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Specialties Department, Oncology and Oncologic Hematology, ULSS 3 Serenissima, Milan, Italy;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008166009","display_name":"Saverio Cinieri","orcid":"https://orcid.org/0000-0002-5555-0814","observed_orcids":["https://orcid.org/0000-0002-5555-0814"]},"institutions":[{"id":"https://openalex.org/I4210103648","display_name":"Ospedale A. Perrino","ror":"https://ror.org/01ae87070","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210099368","https://openalex.org/I4210103648","https://openalex.org/I4210117053"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Saverio Cinieri","raw_affiliation_strings":["Department of Oncology, Medical Oncology, \"Antonio Perrino\" Hospital, Brindisi, Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Medical Oncology, \"Antonio Perrino\" Hospital, Brindisi, Italy;","institution_ids":["https://openalex.org/I4210103648"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076960990","display_name":"Samantha Di Donato","orcid":"https://orcid.org/0000-0001-8436-7042","observed_orcids":["https://orcid.org/0000-0001-8436-7042"]},"institutions":[{"id":"https://openalex.org/I4210156494","display_name":"Ospedale di Prato Santo Stefano","ror":"https://ror.org/05v48bz32","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210156494","https://openalex.org/I4210156604"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Samantha Di Donato","raw_affiliation_strings":["Medical Oncology Department, Nuovo Ospedale-Santo Stefano, Prato, Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology Department, Nuovo Ospedale-Santo Stefano, Prato, Italy;","institution_ids":["https://openalex.org/I4210156494"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009450386","display_name":"Riccardo Lobefaro","orcid":"https://orcid.org/0000-0003-3484-9718","observed_orcids":["https://orcid.org/0000-0003-3484-9718"]},"institutions":[{"id":"https://openalex.org/I4210156707","display_name":"Fondazione IRCCS Istituto Nazionale dei Tumori","ror":"https://ror.org/05dwj7825","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210156707"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Riccardo Lobefaro","raw_affiliation_strings":["Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy;","institution_ids":["https://openalex.org/I4210156707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029529736","display_name":"Roberto Moretto","orcid":"https://orcid.org/0000-0001-8456-9269","observed_orcids":["https://orcid.org/0000-0001-8456-9269"]},"institutions":[{"id":"https://openalex.org/I4210165410","display_name":"Azienda Ospedaliera Universitaria Pisana","ror":"https://ror.org/05xrcj819","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210165410"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Roberto Moretto","raw_affiliation_strings":["Department of Translational Research and New Technologies in Medicine and Surgery, Unit of Medical Oncology 2, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Translational Research and New Technologies in Medicine and Surgery, Unit of Medical Oncology 2, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy;","institution_ids":["https://openalex.org/I4210165410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041185139","display_name":"Vincenzo Formica","orcid":"https://orcid.org/0000-0002-5380-3144","observed_orcids":["https://orcid.org/0000-0002-5380-3144"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Vincenzo Formica","raw_affiliation_strings":["Medical Oncology Unit, Tor Vergata University, Rome, Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology Unit, Tor Vergata University, Rome, Italy;","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087670194","display_name":"Alessandro Passardi","orcid":"https://orcid.org/0000-0002-7099-240X","observed_orcids":["https://orcid.org/0000-0002-7099-240X"]},"institutions":[{"id":"https://openalex.org/I4210097834","display_name":"Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori","ror":"https://ror.org/013wkc921","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210097834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandro Passardi","raw_affiliation_strings":["Department of Medical Oncology, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy;","institution_ids":["https://openalex.org/I4210097834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101992152","display_name":"Vincenzo Ricci","orcid":"https://orcid.org/0000-0002-8779-4792","observed_orcids":["https://orcid.org/0000-0002-8779-4792"]},"institutions":[{"id":"https://openalex.org/I4210137935","display_name":"Azienda Sanitaria Ospedaliera S.Croce e Carle Cuneo","ror":"https://ror.org/03pz7fw94","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210137935"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Vincenzo Ricci","raw_affiliation_strings":["Medical Oncology, A.O. S. Croce and Carle Teaching Hospital, Cuneo, Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology, A.O. S. Croce and Carle Teaching Hospital, Cuneo, Italy;","institution_ids":["https://openalex.org/I4210137935"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079256460","display_name":"Nicoletta Pella","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129043915","display_name":"University of Udine","ror":"https://ror.org/05ht0mh31","country_code":"IT","type":"education","lineage":["https://openalex.org/I129043915"]},{"id":"https://openalex.org/I4405267403","display_name":"Azienda sanitaria universitaria Friuli Centrale","ror":"https://ror.org/02kmqc238","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4405267403"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Nicoletta Pella","raw_affiliation_strings":["Department of Oncology - ASUI Udine University Hospital, Udine, Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology - ASUI Udine University Hospital, Udine, Italy;","institution_ids":["https://openalex.org/I129043915","https://openalex.org/I4405267403"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034035272","display_name":"Mario Scartozzi","orcid":"https://orcid.org/0000-0001-5977-5546","observed_orcids":["https://orcid.org/0000-0001-5977-5546"]},"institutions":[{"id":"https://openalex.org/I172446870","display_name":"University of Cagliari","ror":"https://ror.org/003109y17","country_code":"IT","type":"education","lineage":["https://openalex.org/I172446870"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mario Scartozzi","raw_affiliation_strings":["Medical Oncology Department, University Hospital, University of Cagliari, Cagliari, Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology Department, University Hospital, University of Cagliari, Cagliari, Italy;","institution_ids":["https://openalex.org/I172446870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030122361","display_name":"Fable Zustovich","orcid":"https://orcid.org/0009-0001-4983-6218","observed_orcids":["https://orcid.org/0009-0001-4983-6218","https://orcid.org/0000-0002-9348-2904"]},"institutions":[{"id":"https://openalex.org/I4405266438","display_name":"Azienda ULSS n. 1 Dolomiti","ror":"https://ror.org/02xpztw61","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4405266438"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Fable Zustovich","raw_affiliation_strings":["Medical Oncology Unit, Azienda ULSS 1, Belluno, Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology Unit, Azienda ULSS 1, Belluno, Italy;","institution_ids":["https://openalex.org/I4405266438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034356923","display_name":"Vittorina Zagonel","orcid":"https://orcid.org/0000-0002-0829-2525","observed_orcids":["https://orcid.org/0000-0002-0829-2525","https://orcid.org/0009-0004-2762-1998"]},"institutions":[{"id":"https://openalex.org/I4210109345","display_name":"Istituto Oncologico Veneto","ror":"https://ror.org/01xcjmy57","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109345","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Vittorina Zagonel","raw_affiliation_strings":["Oncologia Medica 1, Istituto Oncologico Veneto IRCCS Padova, Padua, Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncologia Medica 1, Istituto Oncologico Veneto IRCCS Padova, Padua, Italy;","institution_ids":["https://openalex.org/I4210109345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046301295","display_name":"Matteo Fassan","orcid":"https://orcid.org/0000-0001-6515-5482","observed_orcids":["https://orcid.org/0000-0001-6515-5482"]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Matteo Fassan","raw_affiliation_strings":["Department of Medicine (DIMED), Pathology Unit, University of Padua, Padua, Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine (DIMED), Pathology Unit, University of Padua, Padua, Italy;","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080826945","display_name":"Luca Boni","orcid":"https://orcid.org/0000-0003-2217-4047","observed_orcids":["https://orcid.org/0000-0003-2217-4047"]},"institutions":[{"id":"https://openalex.org/I4210115393","display_name":"Azienda Ospedaliero-Universitaria Careggi","ror":"https://ror.org/02crev113","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210115393"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luca Boni","raw_affiliation_strings":["Clinical Trial Coordinating Center, AOU Careggi, Florence, Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Trial Coordinating Center, AOU Careggi, Florence, Italy;","institution_ids":["https://openalex.org/I4210115393"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054413273","display_name":"Fotios Loupakis","orcid":"https://orcid.org/0000-0001-9651-0395","observed_orcids":["https://orcid.org/0000-0001-9651-0395"]},"institutions":[{"id":"https://openalex.org/I4210109345","display_name":"Istituto Oncologico Veneto","ror":"https://ror.org/01xcjmy57","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109345","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Fotios Loupakis","raw_affiliation_strings":["Department of Oncology, Oncology 1, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Oncology 1, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy;","institution_ids":["https://openalex.org/I4210109345"]}]},{"author_position":"last","author":{"id":null,"display_name":"Gono Group","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gono Group","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":15,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"38","issue":"15_suppl","first_page":"4002","last_page":"4002"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/foxes","display_name":"foxes","score":0.8220000267028809},{"id":"https://openalex.org/keywords/panitumumab","display_name":"panitumumab","score":0.9580000042915344},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.9160000085830688},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.5339999794960022},{"id":"https://openalex.org/keywords/metastatic-colorectal-cancer","display_name":"metastatic colorectal cancer","score":0.9819999933242798},{"id":"https://openalex.org/keywords/ras-wild-type","display_name":"RAS wild-type","score":0.7670000195503235},{"id":"https://openalex.org/keywords/braf-wild-type","display_name":"BRAF wild-type","score":0.9779999852180481},{"id":"https://openalex.org/keywords/anti-egfr-therapy","display_name":"anti-EGFR therapy","score":0.9300000071525574},{"id":"https://openalex.org/keywords/first-line-treatment","display_name":"first-line therapy","score":0.7419999837875366},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9599999785423279},{"id":"https://openalex.org/keywords/geriatric-assessment","display_name":"geriatric assessment","score":0.765999972820282},{"id":"https://openalex.org/keywords/g8-score","display_name":"G8 score","score":0.6420000195503235},{"id":"https://openalex.org/keywords/maintenance-therapy","display_name":"maintenance therapy","score":0.6179999709129333},{"id":"https://openalex.org/keywords/ecog-performance-status","display_name":"ECOG performance status","score":0.5329999923706055}],"concepts":[{"id":"https://openalex.org/C2778260052","wikidata":"https://www.wikidata.org/wiki/Q117636","display_name":"FOLFOX","level":5,"score":0.9259703755378723},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8913836479187012},{"id":"https://openalex.org/C2778332735","wikidata":"https://www.wikidata.org/wiki/Q417775","display_name":"Panitumumab","level":5,"score":0.8872365951538086},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6888348460197449},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5992733240127563},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5915377140045166},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.5512731671333313},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.5329728126525879},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.49078020453453064},{"id":"https://openalex.org/C2779384505","wikidata":"https://www.wikidata.org/wiki/Q17007513","display_name":"Concomitant","level":2,"score":0.4276086688041687},{"id":"https://openalex.org/C2780962732","wikidata":"https://www.wikidata.org/wiki/Q422327","display_name":"Oxaliplatin","level":4,"score":0.3965199589729309},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3181321322917938}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2020.38.15_suppl.4002","doi":"https://doi.org/10.1200/jco.2020.38.15_suppl.4002","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2020.38.15_suppl.4002","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2478045368","https://openalex.org/W2789151258","https://openalex.org/W4385519950","https://openalex.org/W2892380827","https://openalex.org/W4403130006","https://openalex.org/W4405310814","https://openalex.org/W2890279416","https://openalex.org/W3005523192","https://openalex.org/W2145104284","https://openalex.org/W4254167620"],"abstract_inverted_index":{"4002":[0],"Background:":[1],"Data":[2],"on":[3],"first-line":[4],"treatment":[5,144,350],"efficacy":[6],"in":[7,115,175,286,296,333,348,371,382],"elderly":[8,49,336,372],"patients":[9,85,174,223,374],"are":[10,338],"limited.":[11],"Many":[12],"analyses":[13],"adopt":[14],"a":[15,69,169,182,187,219,264,368],"questionable":[16],"cut-off":[17],"of":[18,60,172,184,221,268],"65":[19],"years":[20],"and":[21,78,132,232,239,291],"specific":[22],"evidence":[23],"with":[24,63,135,165,186,289,299,340,375],"anti-EGFRs":[25],"is":[26,30,68],"low.":[27],"FOLFOX-panitumumab":[28],"(pan)":[29],"an":[31,46,64,158],"option":[32,47,370],"for":[33,48,99,149,198,230,355],"RAS":[34],"wild-type":[35],"(wt)":[36],"untreated":[37,80],"mCRC":[38,84,337,373],"patients.":[39],"Guidelines":[40],"recommend":[41],"considering":[42],"fluoropyrimidine":[43],"monotherapy":[44],"as":[45],"patients,":[50],"but":[51],"no":[52],"randomized":[53,75,89,235,331],"studies":[54,332],"have":[55],"ever":[56],"explored":[57],"the":[58,61,146,180,200,207],"role":[59],"combination":[62],"anti-EGFR.":[65],"Methods:":[66],"This":[67],"prospective,":[70],"open-label,":[71],"multicenter":[72,341],"phase":[73,383],"II":[74],"trial.":[76],"Unresectable":[77],"previously":[79],"RAS-":[81],"BRAF":[82],"wt":[83,377],"aged":[86],"\u226570":[87],"were":[88,120,224,227,234,246,277,303,310],"to":[90,101,179,193,216,357],"receive":[91],"FOLFOX-pan":[92,290],"(arm":[93,97,247,272,304,311],"A),":[94],"or":[95],"5FU/LV-pan":[96],"B)":[98],"up":[100,267,356],"12":[102,358],"cycles":[103,359],"followed":[104,360],"by":[105,361],"pan":[106],"maintenance":[107,363],"until":[108,364],"PD.":[109],"The":[110],"primary":[111],"EP":[112,345],"was":[113,152,210,281,346],"PFS":[114,151,161,280],"both":[116,166,349],"arms.":[117,351],"Stratification":[118],"criteria":[119],"age":[121,252],"(\u226475":[122],"vs":[123,130,139],">":[124,140,260],"75":[125],"years),":[126],"ECOG":[127],"PS":[128],"(0\u20131":[129],"2)":[131],"geriatric":[133],"assessment":[134],"G8":[136,259],"Score":[137],"(\u226414":[138],"14).":[141],"In":[142],"each":[143,176],"arm,":[145],"null":[147,201],"hypothesis":[148],"median":[150,160,251,265],"set":[153],"at":[154],"\u22646":[155],"months.":[156],"Assuming":[157],"expected":[159],"time":[162],"\u22659.5":[163],"months":[164],"experimental":[167],"regimens,":[168],"sample":[170],"size":[171],"90":[173],"arm":[177,237,241,287,297],"granted":[178],"study":[181],"power":[183],"90%,":[185],"type":[188],"I":[189],"error":[190],"rate":[191],"equal":[192],"5%":[194],"(1-sided":[195],"Brookmeyer-Crowley":[196],"test)":[197],"rejecting":[199],"hypothesis.":[202],"No":[203],"formal":[204],"comparison":[205],"between":[206],"two":[208],"arms":[209],"planned.":[211],"Results:":[212],"From":[213],"Jul":[214],"2016":[215],"Apr":[217],"2019":[218],"total":[220],"394":[222],"screened,":[225],"211":[226],"deemed":[228],"eligible":[229],"inclusion":[231],"185":[233],"(92":[236],"A":[238,288],"93":[240],"B).":[242],"Main":[243],"pts\u2019":[244],"characteristics":[245],"A/B):":[248,305,312],"males":[249],"66%/61%;":[250],"77/77y;":[253],"PS\u22651":[254],"49%/55%;":[255],"right":[256],"colon":[257],"23%/21%;":[258],"14":[261],"31%/30%.":[262],"At":[263],"follow":[266],"20.5":[269],"mos,":[270],"135":[271],"A/B:":[273],"64/71)":[274],"PD":[275,365],"events":[276],"collected.":[278],"Median":[279],"9.6":[282],"(95%":[283,293],"CI":[284,294],"8.8-10.9)":[285],"9.1":[292],"7.7-9.9)":[295],"B":[298],"5FU/LV-pan.":[300],"Response":[301],"rates":[302],"65%/57%.":[306],"Grade":[307],"3-4":[308],"toxicities":[309],"neutropenia":[313],"9.8%/1.1%;":[314],"diarrhea":[315],"16.3%/1.1%;":[316],"stomatitis":[317],"9.8%/4.4%;":[318],"neurotoxicity":[319],"3.3%/0%;":[320],"fatigue":[321],"6.5%/4.4%;":[322],"skin":[323],"rash":[324],"25%/24.2%,":[325],"hypomagnesemia":[326],"3.3%/7.7%.":[327],"Conclusions:":[328],"Large":[329],"prospective":[330],"molecularly":[334],"selected":[335],"feasible":[339],"collaborative":[342],"efforts.":[343],"Primary":[344],"met":[347],"5FU/LV":[352],"plus":[353],"panitumumab":[354,362],"might":[366],"be":[367],"reasonable":[369],"RAS/BRAF":[376],"tumors":[378],"deserving":[379],"further":[380],"investigations":[381],"III":[384],"trials.":[385],"Clinical":[386],"trial":[387],"information:":[388],"NCT02904031":[389],".":[390]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2020-06-05T00:00:00"}
