{"id":"https://openalex.org/W3031618436","doi":"https://doi.org/10.3760/cma.j.issn.1673-4114.2012.05.011","title":"The effects of antisense peptide nucleic acid on the expression of thyroid stimulating hormone receptor mRNA","display_name":"The effects of antisense peptide nucleic acid on the expression of thyroid stimulating hormone receptor mRNA","publication_year":2012,"publication_date":"2012-09-25","ids":{"openalex":"https://openalex.org/W3031618436","doi":"https://doi.org/10.3760/cma.j.issn.1673-4114.2012.05.011","mag":"3031618436"},"language":"sv","primary_location":{"id":"mag:3031618436","doi":"https://doi.org/10.3760/cma.j.issn.1673-4114.2012.05.011","is_oa":false,"landing_page_url":"http://rs.yiigle.com/CN121381201205/310463.htm","pdf_url":null,"source":{"id":"https://openalex.org/S4306514257","display_name":"Int J Radiat Med Nuel Med","issn_l":"1673-4114","issn":["1673-4114"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Int J Radiat Med Nuel Med","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010280439","display_name":"Lijuan Huang","orcid":"https://orcid.org/0009-0009-6921-5695","observed_orcids":["https://orcid.org/0009-0009-6921-5695"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lijuan Huang","raw_affiliation_strings":["TianJian Biotechnologies(Tianjin)Limited Company, Tianjin 300457,China"],"raw_orcid":"https://orcid.org/0009-0009-6921-5695","affiliations":[{"raw_affiliation_string":"TianJian Biotechnologies(Tianjin)Limited Company, Tianjin 300457,China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tao Meng","orcid":"https://orcid.org/0000-0002-2740-9901","observed_orcids":["https://orcid.org/0000-0002-2740-9901"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tao Meng","raw_affiliation_strings":["TianJian Biotechnologies(Tianjin)Limited Company, Tianjin 300457,China"],"raw_orcid":"https://orcid.org/0000-0002-2740-9901","affiliations":[{"raw_affiliation_string":"TianJian Biotechnologies(Tianjin)Limited Company, Tianjin 300457,China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100633381","display_name":"Zhiyang Zhang","orcid":"https://orcid.org/0000-0002-2930-5575","observed_orcids":["https://orcid.org/0000-0002-2930-5575"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhiyang Zhang","raw_affiliation_strings":["TianJian Biotechnologies(Tianjin)Limited Company, Tianjin 300457,China"],"raw_orcid":"https://orcid.org/0000-0002-2930-5575","affiliations":[{"raw_affiliation_string":"TianJian Biotechnologies(Tianjin)Limited Company, Tianjin 300457,China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"36","issue":"05","first_page":"310","last_page":"312"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9336000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9336000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.02850000001490116,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.01549999974668026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thyroid-stimulating-hormone-receptor","display_name":"thyroid-stimulating hormone receptor","score":0.9100000262260437},{"id":"https://openalex.org/keywords/nuclear-localization-signal","display_name":"nuclear localization signal","score":0.7210000157356262},{"id":"https://openalex.org/keywords/gene-silencing","display_name":"gene silencing","score":0.6150000095367432},{"id":"https://openalex.org/keywords/thyroid-cells","display_name":"thyroid cells","score":0.6179999709129333},{"id":"https://openalex.org/keywords/cellular-uptake","display_name":"cellular uptake","score":0.6039999723434448},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7020000219345093},{"id":"https://openalex.org/keywords/rna-interference","display_name":"RNA interference","score":0.3230000138282776}],"concepts":[{"id":"https://openalex.org/C186435350","wikidata":"https://www.wikidata.org/wiki/Q1050365","display_name":"NLS","level":4,"score":0.7496578693389893},{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.6972687840461731},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.6767650842666626},{"id":"https://openalex.org/C2777608072","wikidata":"https://www.wikidata.org/wiki/Q4862366","display_name":"Thyrotropin receptor","level":4,"score":0.5942748785018921},{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.5857823491096497},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5553125143051147},{"id":"https://openalex.org/C2777343594","wikidata":"https://www.wikidata.org/wiki/Q412152","display_name":"Peptide nucleic acid","level":3,"score":0.5056309700012207},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.48355934023857117},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.4803772568702698},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.47400128841400146},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46486860513687134},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.46163463592529297},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4463627338409424},{"id":"https://openalex.org/C49805395","wikidata":"https://www.wikidata.org/wiki/Q910966","display_name":"Nuclear localization sequence","level":3,"score":0.4161979854106903},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34222692251205444},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24523165822029114},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23967748880386353},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2058241367340088},{"id":"https://openalex.org/C2776652619","wikidata":"https://www.wikidata.org/wiki/Q16483","display_name":"Graves' disease","level":3,"score":0.1322365403175354}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:3031618436","doi":"https://doi.org/10.3760/cma.j.issn.1673-4114.2012.05.011","is_oa":false,"landing_page_url":"http://rs.yiigle.com/CN121381201205/310463.htm","pdf_url":null,"source":{"id":"https://openalex.org/S4306514257","display_name":"Int J Radiat Med Nuel Med","issn_l":"1673-4114","issn":["1673-4114"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Int J Radiat Med Nuel Med","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2032466173","https://openalex.org/W3085703229","https://openalex.org/W2378028245","https://openalex.org/W2037725238","https://openalex.org/W2936560356","https://openalex.org/W2139458752","https://openalex.org/W3152449020","https://openalex.org/W2363513643","https://openalex.org/W1991860484","https://openalex.org/W2358078917"],"abstract_inverted_index":{"Objective":[0],"To":[1],"study":[2],"the":[3,29,65,84,104,113,120,134,147,158,169,173],"effects":[4],"of":[5,15,23,56,68,81,86,107,123,136,140,149,160,175],"antisense":[6],"peptide":[7,57],"nucleic":[8,58,180],"acid(asPNA)":[9],"on":[10,83,119,157],"thyroid":[11,18,73],"stimulating":[12],"hormone":[13],"receptor(TSHR)":[14],"Fisher":[16,71],"rat":[17,72],"cells":[19,74,170],"membrane.Methods":[20],"Two":[21],"kinds":[22],"asPNA":[24,69,99,114],"which":[25],"could":[26,132,164],"hybridized":[27],"to":[28,70],"TSHR":[30,87,137,141,161,176],"mRNA":[31,88],"named":[32,49],"as":[33,50],"nuclear":[34],"localization":[35],"signal-asPNA1":[36],"(NLS-asPNA1)":[37],"and":[38,130,171],"NLS-asPNA2":[39,131],"were":[40,60,100],"designed,and":[41],"a":[42,46],"control":[43],"PNA":[44],"with":[45,146],"scramble":[47],"sequence":[48],"NLS-scrPNA":[51,152],"was":[52,75,89],"synthetized.The":[53],"cellular":[54],"uptake":[55],"acids":[59],"analyzed":[61],"by":[62,77,91,103,168],"fluorescence":[63],"microscopy,and":[64],"toxic":[66,117],"effect":[67,80,118,156],"evaluated":[76],"MTT":[78,108],"assay.The":[79],"NLS-asPNA":[82,163],"expression":[85,135,159,174],"detected":[90],"realtime":[92,124],"quantitative":[93,125],"RT-PCR.Results":[94],"Fluorescence":[95],"microscopy":[96],"indicated":[97],"that":[98,111,128],"taken":[101,166],"up":[102,167],"cells.The":[105,121],"results":[106,122],"assay":[109],"showed":[110,127],"all":[112],"had":[115,153],"no":[116,154],"RT-PCR":[126],"NLS-asPNA1":[129],"inhibit":[133],"mRNA,the":[138],"copies":[139],"cDNA":[142],"decreased":[143],"gradually":[144],"along":[145],"prolongation":[148],"culture":[150],"time.But":[151],"significant":[155],"mRNA.Conclusion":[162],"be":[165],"down-regulate":[172],"mRNA.\r\n\r\nKey":[177],"words:":[178],"\r\nPeptide":[179],"acids;\u00a0Receptors,":[181],"thyrotropin;\u00a0RNA,":[182],"messenger":[183]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2020-06-05T00:00:00"}
