{"id":"https://openalex.org/W3031183017","doi":"https://doi.org/10.3877/cma.j.issn.2095-655x.2016.01.013","title":"The serum levels of PRSS8 and their clinical significance in the patients with gastritis, esophagitis and esophageal cancer","display_name":"The serum levels of PRSS8 and their clinical significance in the patients with gastritis, esophagitis and esophageal cancer","publication_year":2016,"publication_date":"2016-02-26","ids":{"openalex":"https://openalex.org/W3031183017","doi":"https://doi.org/10.3877/cma.j.issn.2095-655x.2016.01.013","mag":"3031183017"},"language":"en","primary_location":{"id":"mag:3031183017","doi":"https://doi.org/10.3877/cma.j.issn.2095-655x.2016.01.013","is_oa":false,"landing_page_url":"http://rs.yiigle.com/CN119346201601/1074428.htm","pdf_url":null,"source":{"id":"https://openalex.org/S4306506095","display_name":"Chin J Diagnostics(Electronic Edition)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Chin J Diagnostics(Electronic Edition)","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100399875","display_name":"Kai Li","orcid":"https://orcid.org/0000-0002-3062-3618","observed_orcids":["https://orcid.org/0000-0002-3062-3618"]},"institutions":[{"id":"https://openalex.org/I4210115182","display_name":"First Affiliated Hospital of Xinxiang Medical University","ror":"https://ror.org/0278r4c85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115182"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kai Li","raw_affiliation_strings":["Department of Pathology, the First Affiliated Hospital of Xinxiang Medical University, Weihui 453100"],"raw_orcid":"https://orcid.org/0000-0002-3062-3618","affiliations":[{"raw_affiliation_string":"Department of Pathology, the First Affiliated Hospital of Xinxiang Medical University, Weihui 453100","institution_ids":["https://openalex.org/I4210115182"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101500519","display_name":"Weixing Zhao","orcid":"https://orcid.org/0000-0001-5746-3696","observed_orcids":["https://orcid.org/0000-0001-5746-3696"]},"institutions":[{"id":"https://openalex.org/I4210115182","display_name":"First Affiliated Hospital of Xinxiang Medical University","ror":"https://ror.org/0278r4c85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115182"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weixing Zhao","raw_affiliation_strings":["Department of Pathology, the First Affiliated Hospital of Xinxiang Medical University, Weihui 453100"],"raw_orcid":"https://orcid.org/0000-0001-5746-3696","affiliations":[{"raw_affiliation_string":"Department of Pathology, the First Affiliated Hospital of Xinxiang Medical University, Weihui 453100","institution_ids":["https://openalex.org/I4210115182"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110332731","display_name":"Yonghua Bao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I80626142","display_name":"Henan Medical University","ror":"https://ror.org/038hzq450","country_code":"CN","type":"education","lineage":["https://openalex.org/I80626142"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yonghua Bao","raw_affiliation_strings":["Department of Immunology, Xinxiang Medical University, Xinxiang 453003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Xinxiang Medical University, Xinxiang 453003, China","institution_ids":["https://openalex.org/I80626142"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074110801","display_name":"Wancai Yang","orcid":"https://orcid.org/0000-0001-7437-9197","observed_orcids":["https://orcid.org/0000-0001-7437-9197"]},"institutions":[{"id":"https://openalex.org/I80626142","display_name":"Henan Medical University","ror":"https://ror.org/038hzq450","country_code":"CN","type":"education","lineage":["https://openalex.org/I80626142"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wancai Yang","raw_affiliation_strings":["Department of Pathology, Xinxiang Medical University Xinxiang, 453003, China"],"raw_orcid":"https://orcid.org/0000-0001-7437-9197","affiliations":[{"raw_affiliation_string":"Department of Pathology, Xinxiang Medical University Xinxiang, 453003, China","institution_ids":["https://openalex.org/I80626142"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.37705651,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"4","issue":"1","first_page":"45","last_page":"47"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.5297999978065491,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.5297999978065491,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.27810001373291016,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.06159999966621399,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prss8","display_name":"PRSS8","score":0.9919999837875366},{"id":"https://openalex.org/keywords/serine-protease","display_name":"serine protease","score":0.6710000038146973},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.8539999723434448},{"id":"https://openalex.org/keywords/gastritis","display_name":"gastritis","score":0.9409999847412109},{"id":"https://openalex.org/keywords/esophagitis","display_name":"esophagitis","score":1.0},{"id":"https://openalex.org/keywords/esophageal-cancer","display_name":"esophageal cancer","score":0.996999979019165},{"id":"https://openalex.org/keywords/disease-diagnosis","display_name":"disease diagnosis","score":0.3919999897480011}],"concepts":[{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.8106766939163208},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7513930797576904},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7365240454673767},{"id":"https://openalex.org/C2779920096","wikidata":"https://www.wikidata.org/wiki/Q298230","display_name":"Esophagitis","level":4,"score":0.7294495701789856},{"id":"https://openalex.org/C2778677798","wikidata":"https://www.wikidata.org/wiki/Q183130","display_name":"Gastritis","level":3,"score":0.7282527685165405},{"id":"https://openalex.org/C2779742542","wikidata":"https://www.wikidata.org/wiki/Q372701","display_name":"Esophageal cancer","level":3,"score":0.7213706970214844},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.44179368019104004},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.4340824484825134},{"id":"https://openalex.org/C2780561475","wikidata":"https://www.wikidata.org/wiki/Q183130","display_name":"Chronic gastritis","level":4,"score":0.42473816871643066},{"id":"https://openalex.org/C2776409635","wikidata":"https://www.wikidata.org/wiki/Q180556","display_name":"Helicobacter pylori","level":2,"score":0.21279188990592957},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.11666449904441833},{"id":"https://openalex.org/C43270747","wikidata":"https://www.wikidata.org/wiki/Q898610","display_name":"Reflux","level":3,"score":0.053947269916534424}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:3031183017","doi":"https://doi.org/10.3877/cma.j.issn.2095-655x.2016.01.013","is_oa":false,"landing_page_url":"http://rs.yiigle.com/CN119346201601/1074428.htm","pdf_url":null,"source":{"id":"https://openalex.org/S4306506095","display_name":"Chin J Diagnostics(Electronic Edition)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Chin J Diagnostics(Electronic Edition)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2334328788","https://openalex.org/W2386463848","https://openalex.org/W2488657055","https://openalex.org/W2355166467","https://openalex.org/W2386249425","https://openalex.org/W2381558155","https://openalex.org/W2978868990","https://openalex.org/W2952015016","https://openalex.org/W2389885426","https://openalex.org/W3030613327"],"abstract_inverted_index":{"Objective\r\nTo":[0],"study":[1],"the":[2,14,28,69,74,81,87,104,108,129,133,148,164],"expression":[3,60,142],"level":[4,61,92,116],"and":[5,19,27,35,55,80,154,170],"significance":[6],"of":[7,62,93,117,166],"serum":[8,22,39,44,49,53,58,70,91,118,159],"human":[9],"protease":[10],"serine":[11],"8(PRSS8)":[12],"in":[13,95,120,147],"patient":[15],"with":[16,86,150],"gastritis,":[17,155],"esophagitis":[18,43,75,96],"esophageal":[20,33,47,77,152,168],"cancer.\r\n\r\n\r\nMethods\r\nThe":[21],"samples":[23,40,54],"from":[24,73,103,128],"healthy":[25,57,88,105,130],"subjects":[26],"patients":[29,149],"diagnosed":[30],"as":[31],"esophagitis,":[32,151,167],"cancer":[34,48,78,153,169],"gastritis":[36,52,82,121],"were":[37,84],"collected.The":[38],"included":[41],"20":[42],"samples,":[45,50],"6":[46],"60":[51],"28":[56],"samples.The":[59],"PRSS8":[63,71,94,119,141],"was":[64,99,110,124,135],"detected":[65],"by":[66],"ELISA":[67],"assay.Then":[68],"levels":[72,143],"group,":[76,89],"group":[79,83,97,106,122,131],"compared":[85],"respectively.\r\n\r\n\r\nResults\r\nThe":[90],"[(4.58\u00b11.67)\u03bcg/L]":[98],"higher":[100,125],"than":[101,126],"that":[102,127,158],"[(3.52\u00b11.49)\u03bcg/L],":[107,132],"difference":[109,134],"statistically":[111,137],"significant(LSD-t=2.59,":[112],"P":[113],"0.05).":[114],"The":[115],"[(5.39\u00b11.04)\u03bcg/L]":[123],"also":[136],"significant":[138],"(LSD-t=6.22,":[139],"P<0.05).\r\n\r\n\r\nConclusion\r\nSerum":[140],"are":[144],"obviously":[145],"increased":[146],"which":[156],"suggests":[157],"PRRS8":[160],"maybe":[161],"relate":[162],"to":[163],"development":[165],"gastritis.\r\n\r\n\r\nKey":[171],"words:":[172],"\r\nEsophagitis;\u00a0Esophageal":[173],"neoplasms;\u00a0Gastritis;\u00a0Serine":[174],"proteases;\u00a0Serum":[175]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2020-06-05T00:00:00"}