{"id":"https://openalex.org/W3031069693","doi":"https://doi.org/10.1186/s13020-020-00330-0","title":"Transcriptomics- and metabolomics-based integration analyses revealed the potential pharmacological effects and functional pattern of in vivo Radix Paeoniae Alba administration","display_name":"Transcriptomics- and metabolomics-based integration analyses revealed the potential pharmacological effects and functional pattern of in vivo Radix Paeoniae Alba administration","publication_year":2020,"publication_date":"2020-05-24","ids":{"openalex":"https://openalex.org/W3031069693","doi":"https://doi.org/10.1186/s13020-020-00330-0","mag":"3031069693","pmid":"https://pubmed.ncbi.nlm.nih.gov/32489401","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7245909"},"language":"en","primary_location":{"id":"doi:10.1186/s13020-020-00330-0","doi":"https://doi.org/10.1186/s13020-020-00330-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13020-020-00330-0","pdf_url":"https://cmjournal.biomedcentral.com/track/pdf/10.1186/s13020-020-00330-0","source":{"id":"https://openalex.org/S103976430","display_name":"Chinese Medicine","issn_l":"1749-8546","issn":["1749-8546","1991-0150"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese Medicine","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W3031069693"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://cmjournal.biomedcentral.com/track/pdf/10.1186/s13020-020-00330-0","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103245288","display_name":"Sining Wang","orcid":"https://orcid.org/0000-0002-3532-2777","observed_orcids":["https://orcid.org/0000-0002-3532-2777"]},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sining Wang","raw_affiliation_strings":["Department of Pathology, School of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine, 1200 CaiLun Ave, Pudong, 201203, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, School of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine, 1200 CaiLun Ave, Pudong, 201203, Shanghai, China","institution_ids":["https://openalex.org/I4210098460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029214510","display_name":"Huihua Chen","orcid":"https://orcid.org/0000-0002-5045-6845","observed_orcids":["https://orcid.org/0000-0002-5045-6845"]},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huihua Chen","raw_affiliation_strings":["Department of Pathology, School of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine, 1200 CaiLun Ave, Pudong, 201203, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, School of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine, 1200 CaiLun Ave, Pudong, 201203, Shanghai, China","institution_ids":["https://openalex.org/I4210098460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039286429","display_name":"Yufan Zheng","orcid":"https://orcid.org/0000-0002-4827-6191","observed_orcids":["https://orcid.org/0000-0002-4827-6191"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yufan Zheng","raw_affiliation_strings":["Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, 130 DongAn Ave, Xuhui, 200032, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, 130 DongAn Ave, Xuhui, 200032, Shanghai, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100330749","display_name":"Zhenyu Li","orcid":"https://orcid.org/0000-0001-6941-5982","observed_orcids":["https://orcid.org/0000-0001-6941-5982"]},"institutions":[{"id":"https://openalex.org/I47689461","display_name":"Northeast Forestry University","ror":"https://ror.org/02yxnh564","country_code":"CN","type":"education","lineage":["https://openalex.org/I47689461"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenyu Li","raw_affiliation_strings":["College of Information and Computer Engineering, Northeast Forestry University, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Information and Computer Engineering, Northeast Forestry University, Harbin, China","institution_ids":["https://openalex.org/I47689461"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113539052","display_name":"Baiping Cui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Baiping Cui","raw_affiliation_strings":["Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, 130 DongAn Ave, Xuhui, 200032, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, 130 DongAn Ave, Xuhui, 200032, Shanghai, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031034960","display_name":"Pei Zhao","orcid":"https://orcid.org/0000-0002-8896-6701","observed_orcids":["https://orcid.org/0000-0002-8896-6701","https://orcid.org/0000-0002-6454-2592","https://orcid.org/0009-0004-8332-7531"]},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pei Zhao","raw_affiliation_strings":["Public Laboratory Platform, School of Basic Medical Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Public Laboratory Platform, School of Basic Medical Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China","institution_ids":["https://openalex.org/I4210098460"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jiali Zheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiali Zheng","raw_affiliation_strings":["Department of Pathology, School of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine, 1200 CaiLun Ave, Pudong, 201203, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, School of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine, 1200 CaiLun Ave, Pudong, 201203, Shanghai, China","institution_ids":["https://openalex.org/I4210098460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112121656","display_name":"Rong L\u00fc","orcid":"https://orcid.org/0000-0003-3040-5781","observed_orcids":["https://orcid.org/0000-0003-3040-5781"]},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Rong Lu","raw_affiliation_strings":["Department of Pathology, School of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine, 1200 CaiLun Ave, Pudong, 201203, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, School of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine, 1200 CaiLun Ave, Pudong, 201203, Shanghai, China","institution_ids":["https://openalex.org/I4210098460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100406411","display_name":"Ning Sun","orcid":"https://orcid.org/0000-0002-7861-3646","observed_orcids":["https://orcid.org/0000-0002-7861-3646","https://orcid.org/0000-0002-1128-9036"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ning Sun","raw_affiliation_strings":["Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, 130 DongAn Ave, Xuhui, 200032, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, 130 DongAn Ave, Xuhui, 200032, Shanghai, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100406411","https://openalex.org/A5112121656"],"corresponding_institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210098460"],"apc_list":{"value":0,"currency":"USD","value_usd":0},"apc_paid":{"value":0,"currency":"USD","value_usd":0},"fwci":1.3895,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.80611528,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"15","issue":"1","first_page":"52","last_page":"52"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12647","display_name":"Traditional Chinese Medicine Studies","score":0.007499999832361937,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radix-paeoniae-alba","display_name":"Radix Paeoniae Alba","score":0.9990000128746033},{"id":"https://openalex.org/keywords/paeonia-lactiflora","display_name":"Paeonia lactiflora","score":0.9319999814033508},{"id":"https://openalex.org/keywords/traditional-chinese-medicine","display_name":"traditional Chinese medicine","score":0.7929999828338623},{"id":"https://openalex.org/keywords/meridian-tropism","display_name":"meridian tropism","score":0.7670000195503235},{"id":"https://openalex.org/keywords/serum-metabolomics","display_name":"serum metabolomics","score":0.6549999713897705},{"id":"https://openalex.org/keywords/hepatic-lipid-metabolism","display_name":"hepatic lipid metabolism","score":0.6359999775886536},{"id":"https://openalex.org/keywords/glycerolipid-metabolism","display_name":"glycerolipid metabolism","score":0.8809999823570251}],"concepts":[{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.6728533506393433},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5580036044120789},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.5362403392791748},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.5113312602043152},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.48662862181663513},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.46697211265563965},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4666115641593933},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45443999767303467},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.403016060590744},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3821130692958832},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3452807366847992},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3311058282852173},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.22161445021629333},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1438840925693512},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.10013875365257263}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1186/s13020-020-00330-0","doi":"https://doi.org/10.1186/s13020-020-00330-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13020-020-00330-0","pdf_url":"https://cmjournal.biomedcentral.com/track/pdf/10.1186/s13020-020-00330-0","source":{"id":"https://openalex.org/S103976430","display_name":"Chinese Medicine","issn_l":"1749-8546","issn":["1749-8546","1991-0150"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7245909","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7245909","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chin Med","raw_type":"Text"},{"id":"pmid:32489401","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32489401","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese medicine","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:95ac297dab9d423db6f907612e6b531f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/95ac297dab9d423db6f907612e6b531f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Chinese Medicine, Vol 15, Iss 1, Pp 1-13 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s13020-020-00330-0","doi":"https://doi.org/10.1186/s13020-020-00330-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13020-020-00330-0","pdf_url":"https://cmjournal.biomedcentral.com/track/pdf/10.1186/s13020-020-00330-0","source":{"id":"https://openalex.org/S103976430","display_name":"Chinese Medicine","issn_l":"1749-8546","issn":["1749-8546","1991-0150"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2708038660","display_name":null,"funder_award_id":"NO. ZY (2018-2020)-CCCX-2001-01","funder_id":"https://openalex.org/F4320325099","funder_display_name":"Shanghai Municipal Population and Family Planning Commission"}],"funders":[{"id":"https://openalex.org/F4320321851","display_name":"Fudan University","ror":"https://ror.org/013q1eq08"},{"id":"https://openalex.org/F4320325099","display_name":"Shanghai Municipal Population and Family Planning Commission","ror":"https://ror.org/03at7w331"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3031069693.pdf","grobid_xml":"https://content.openalex.org/works/W3031069693.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1889456003","https://openalex.org/W1906327883","https://openalex.org/W1974450480","https://openalex.org/W1993150720","https://openalex.org/W2002311481","https://openalex.org/W2024866955","https://openalex.org/W2032181284","https://openalex.org/W2032569321","https://openalex.org/W2035618305","https://openalex.org/W2066025317","https://openalex.org/W2072916675","https://openalex.org/W2077372011","https://openalex.org/W2085237567","https://openalex.org/W2113136577","https://openalex.org/W2131456076","https://openalex.org/W2255840627","https://openalex.org/W2395705836","https://openalex.org/W2561810583","https://openalex.org/W2565611885","https://openalex.org/W2581210481","https://openalex.org/W2585787843","https://openalex.org/W2614851485","https://openalex.org/W2741509806","https://openalex.org/W2796566168","https://openalex.org/W2803664483","https://openalex.org/W2805047884","https://openalex.org/W2905155342","https://openalex.org/W2916310167","https://openalex.org/W2921984723","https://openalex.org/W2938800717","https://openalex.org/W2945822375","https://openalex.org/W2947531822","https://openalex.org/W2972112856"],"related_works":["https://openalex.org/W6976834736","https://openalex.org/W6901849010","https://openalex.org/W6958409239","https://openalex.org/W6958347182","https://openalex.org/W6902027170","https://openalex.org/W6901971048","https://openalex.org/W6920879041","https://openalex.org/W6920667821","https://openalex.org/W6901912432","https://openalex.org/W3134272388"],"abstract_inverted_index":{"BACKGROUND:":[0],"Radix":[1],"Paeoniae":[2],"Alba":[3],"(RPA)":[4],"and":[5,13,27,77,83,98,117,130,147,152,213,236,276,300,304,350,357,365],"other":[6],"natural":[7,41],"medicines":[8,42],"have":[9],"remarkable":[10],"curative":[11],"effects":[12,48],"are":[14],"widely":[15],"used":[16,343],"in":[17,43,73,91,136,178,181,189,227,250],"traditional":[18,286],"Chinese":[19],"Medicine":[20],"(TCM).":[21],"However,":[22],"due":[23],"to":[24,33,66,103,318,344,351],"their":[25,46,131],"multi-component":[26],"multi-target":[28],"characteristics,":[29],"it":[30,311],"is":[31,51],"difficult":[32],"study":[34,63,67,293,334],"the":[35,61,68,79,104,113,123,143,160,163,173,179,198,228,232,237,244,251,285,295,320,327,331,337,346,362],"detailed":[36],"pharmacological":[37],"mechanisms":[38,70],"for":[39,306,326,361],"those":[40],"vivo.":[44],"Therefore,":[45],"real":[47],"on":[49,142,243,336],"organisms":[50],"still":[52],"uncertain.":[53],"METHODS:":[54],"RPA":[55,72,89,139,166,185,221,259,282,299],"was":[56,64,162,260],"selected":[57],"as":[58,203,231],"research":[59,355],"object,":[60],"present":[62],"designed":[65],"complex":[69],"of":[71,95,106,115,125,150,175,197,258,298,324,348],"vivo":[74],"by":[75,192,281],"integrating":[76],"interpreting":[78],"transcriptomic":[80],"based":[81,85,242,335],"RNA-seq":[82],"metabolomic":[84],"NMR":[86],"spectrum":[87],"after":[88,138],"administration":[90],"mice.":[92],"A":[93],"variety":[94],"dimension-reduction":[96],"algorithms":[97],"classifier":[99],"models":[100],"were":[101,119,133,240,278],"applied":[102],"processing":[105],"high-throughput":[107,338],"data.":[108],"RESULTS:":[109],"Among":[110],"serum":[111],"metabolites,":[112],"contents":[114,124],"PC":[116],"glucose":[118],"significantly":[120,134],"increased,":[121],"while":[122],"various":[126],"amino":[127],"acids,":[128],"lipids":[129],"metabolites":[132],"decreased":[135],"mice":[137],"administration.":[140],"Based":[141],"Gene":[144],"Ontology":[145],"(GO)":[146],"Kyoto":[148],"Encyclopedia":[149],"Genes":[151],"Genomes":[153],"(KEGG)":[154],"databases,":[155],"differential":[156],"analysis":[157],"showed":[158],"that":[159,220,274],"liver":[161,275],"site":[164],"where":[165],"exerted":[167],"a":[168,187,264,269,314,353],"significant":[169],"effect,":[170],"which":[171,272],"confirmed":[172],"rationality":[174],"\"meridian":[176],"tropism\"":[177],"theory":[180,347],"TCM.":[182],"In":[183,330],"addition,":[184],"played":[186],"role":[188],"lipid":[190],"metabolism":[191,200],"regulating":[193],"genes":[194],"encoding":[195],"enzymes":[196],"glycerolipid":[199],"pathway,":[201,235],"such":[202,230,333],"1-acyl-sn-glycerol-3-phosphate":[204],"acyltransferase":[205],"(Agpat),":[206],"phosphatidate":[207],"phosphatase":[208,211],"(Lpin),":[209],"phospholipid":[210],"(Plpp)":[212],"endothelial":[214],"lipase":[215],"(Lipg).":[216],"We":[217],"also":[218,312],"found":[219,273],"regulates":[222],"several":[223],"substance":[224],"addiction":[225,234],"pathways":[226],"brain,":[229],"cocaine":[233],"related":[238],"targets":[239,303],"predicted":[241],"sequencing":[245],"data":[246,339],"from":[247],"pathological":[248],"model":[249,271,317,356],"GEO":[252],"database.":[253],"The":[254],"overall":[255,321],"effective":[256,322],"pattern":[257,323],"intuitively":[261],"presented":[262],"with":[263,284],"multidimensional":[265],"radar":[266],"map":[267],"through":[268],"self-designed":[270],"brain":[277],"mainly":[279],"regulated":[280],"compared":[283],"meridian":[287],"tropism":[288],"theory.":[289],"CONCLUSIONS:":[290],"Overall":[291],"this":[292],"expanded":[294],"potential":[296],"application":[297],"provided":[301],"possible":[302],"directions":[305],"further":[307],"mechanism":[308],"study,":[309],"meanwhile,":[310],"established":[313],"multi-dimensional":[315],"evaluation":[316],"represent":[319],"TCM":[325,349,363],"first":[328],"time.":[329],"future,":[332],"sets":[340],"can":[341],"be":[342],"interpret":[345],"provide":[352],"valuable":[354],"clinical":[358],"medication":[359],"reference":[360],"researchers":[364],"doctors.":[366]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2020-06-05T00:00:00"}
