{"id":"https://openalex.org/W3031005545","doi":"https://doi.org/10.1172/jci.insight.139388","title":"Neutrophil extracellular traps mediate articular cartilage damage and enhance cartilage component immunogenicity in rheumatoid arthritis","display_name":"Neutrophil extracellular traps mediate articular cartilage damage and enhance cartilage component immunogenicity in rheumatoid arthritis","publication_year":2020,"publication_date":"2020-06-02","ids":{"openalex":"https://openalex.org/W3031005545","doi":"https://doi.org/10.1172/jci.insight.139388","mag":"3031005545","pmid":"https://pubmed.ncbi.nlm.nih.gov/32484790","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7406272"},"language":"en","primary_location":{"id":"doi:10.1172/jci.insight.139388","doi":"https://doi.org/10.1172/jci.insight.139388","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci.insight.139388","pdf_url":"http://insight.jci.org/articles/view/139388/files/pdf","source":{"id":"https://openalex.org/S2764964142","display_name":"JCI Insight","issn_l":"2379-3708","issn":["2379-3708"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI Insight","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://insight.jci.org/articles/view/139388/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077136138","display_name":"Carmelo Carmona\u2010Rivera","orcid":"https://orcid.org/0000-0002-7706-1464","observed_orcids":["https://orcid.org/0000-0002-7706-1464"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210087962","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Carmelo Carmona-Rivera","raw_affiliation_strings":["Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland, USA"],"raw_orcid":"https://orcid.org/0000-0002-7706-1464","affiliations":[{"raw_affiliation_string":"Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081572127","display_name":"Philip M. Carlucci","orcid":"https://orcid.org/0000-0002-9729-4572","observed_orcids":["https://orcid.org/0000-0002-9729-4572"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210087962","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip M. Carlucci","raw_affiliation_strings":["Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland, USA"],"raw_orcid":"https://orcid.org/0000-0002-9729-4572","affiliations":[{"raw_affiliation_string":"Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072931739","display_name":"Rishi R. Goel","orcid":"https://orcid.org/0000-0003-1715-5191","observed_orcids":["https://orcid.org/0000-0003-1715-5191"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210087962","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rishi R. Goel","raw_affiliation_strings":["Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland, USA"],"raw_orcid":"https://orcid.org/0000-0003-1715-5191","affiliations":[{"raw_affiliation_string":"Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073087501","display_name":"Eddie A. James","orcid":"https://orcid.org/0000-0002-7217-5729","observed_orcids":["https://orcid.org/0000-0002-7217-5729"]},"institutions":[{"id":"https://openalex.org/I4391012615","display_name":"Benaroya Research Institute","ror":"https://ror.org/04j9rp686","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802797007","https://openalex.org/I4210118434","https://openalex.org/I4391012615"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eddie James","raw_affiliation_strings":["Translational Research Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Research Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington, USA","institution_ids":["https://openalex.org/I4391012615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078434832","display_name":"Stephen R. Brooks","orcid":"https://orcid.org/0000-0001-5592-5332","observed_orcids":["https://orcid.org/0000-0001-5592-5332"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210087962","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen R. Brooks","raw_affiliation_strings":["Office of the Clinical Director, Biodata Mining and Discovery Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland, USA"],"raw_orcid":"https://orcid.org/0000-0001-5592-5332","affiliations":[{"raw_affiliation_string":"Office of the Clinical Director, Biodata Mining and Discovery Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039483764","display_name":"Cliff R. Rims","orcid":"https://orcid.org/0009-0003-0342-4378","observed_orcids":["https://orcid.org/0009-0003-0342-4378"]},"institutions":[{"id":"https://openalex.org/I4391012615","display_name":"Benaroya Research Institute","ror":"https://ror.org/04j9rp686","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802797007","https://openalex.org/I4210118434","https://openalex.org/I4391012615"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cliff Rims","raw_affiliation_strings":["Translational Research Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Research Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington, USA","institution_ids":["https://openalex.org/I4391012615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087709399","display_name":"Victoria J. Hoffmann","orcid":"https://orcid.org/0000-0002-2378-9724","observed_orcids":["https://orcid.org/0000-0002-2378-9724"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210091794","display_name":"Office of the Director","ror":"https://ror.org/00fj8a872","country_code":"US","type":"other","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210091794"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victoria Hoffmann","raw_affiliation_strings":["Division of Veterinary Resources, Office of the Director, NIH, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Veterinary Resources, Office of the Director, NIH, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210091794"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025044565","display_name":"David A. Fox","orcid":"https://orcid.org/0000-0002-0230-6607","observed_orcids":["https://orcid.org/0000-0002-0230-6607"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Fox","raw_affiliation_strings":["Division of Rheumatology and Clinical Autoimmunity Center of Excellence, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology and Clinical Autoimmunity Center of Excellence, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019862484","display_name":"Jane Hoyt Buckner","orcid":"https://orcid.org/0000-0002-9005-1885","observed_orcids":["https://orcid.org/0000-0002-9005-1885"]},"institutions":[{"id":"https://openalex.org/I4391012615","display_name":"Benaroya Research Institute","ror":"https://ror.org/04j9rp686","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802797007","https://openalex.org/I4210118434","https://openalex.org/I4391012615"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jane H. Buckner","raw_affiliation_strings":["Translational Research Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Research Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington, USA","institution_ids":["https://openalex.org/I4391012615"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010407321","display_name":"Mariana J. Kaplan","orcid":"https://orcid.org/0000-0003-2968-0815","observed_orcids":["https://orcid.org/0000-0003-2968-0815"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210087962","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mariana J. Kaplan","raw_affiliation_strings":["Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5010407321","https://openalex.org/A5077136138"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210087962"],"apc_list":{"value":4100,"currency":"USD","value_usd":4100},"apc_paid":{"value":4100,"currency":"USD","value_usd":4100},"fwci":8.2504,"has_fulltext":true,"cited_by_count":193,"citation_normalized_percentile":{"value":0.98599748,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"5","issue":"13","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.8744999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.8744999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.06679999828338623,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.012299999594688416,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neutrophil-extracellular-traps","display_name":"neutrophil extracellular traps","score":0.9739999771118164},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9729999899864197},{"id":"https://openalex.org/keywords/articular-cartilage-injury","display_name":"articular cartilage damage","score":0.9210000038146973},{"id":"https://openalex.org/keywords/neutrophil-elastase","display_name":"neutrophil elastase","score":0.9829999804496765},{"id":"https://openalex.org/keywords/synovial-fibroblasts","display_name":"synovial fibroblasts","score":0.9160000085830688},{"id":"https://openalex.org/keywords/pad2","display_name":"PAD2","score":0.949999988079071},{"id":"https://openalex.org/keywords/protein-citrullination","display_name":"citrullination","score":0.9459999799728394},{"id":"https://openalex.org/keywords/macrophage-activation","display_name":"macrophage activation","score":0.8999999761581421},{"id":"https://openalex.org/keywords/immune-complexes","display_name":"immune complexes","score":0.8140000104904175},{"id":"https://openalex.org/keywords/hla-drb1-04-01","display_name":"HLA-DRB1*0401","score":0.9570000171661377},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.9300000071525574},{"id":"https://openalex.org/keywords/synovitis","display_name":"synovitis","score":0.8880000114440918}],"concepts":[{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.8548693060874939},{"id":"https://openalex.org/C134897094","wikidata":"https://www.wikidata.org/wiki/Q7003141","display_name":"Neutrophil extracellular traps","level":3,"score":0.7958693504333496},{"id":"https://openalex.org/C2776317360","wikidata":"https://www.wikidata.org/wiki/Q14905648","display_name":"Neutrophil elastase","level":3,"score":0.6320204734802246},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.6008081436157227},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5802416801452637},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.5719767212867737},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.55810546875},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.5434468388557434},{"id":"https://openalex.org/C2781044401","wikidata":"https://www.wikidata.org/wiki/Q418897","display_name":"Elastase","level":3,"score":0.5311815738677979},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5055937767028809},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4465503394603729},{"id":"https://openalex.org/C2779663596","wikidata":"https://www.wikidata.org/wiki/Q2741512","display_name":"Synovial joint","level":5,"score":0.44379955530166626},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.44005492329597473},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.4233558177947998},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41079461574554443},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3500177264213562},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.2814592123031616},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20804879069328308},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.20691582560539246},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.1547306478023529},{"id":"https://openalex.org/C3020332539","wikidata":"https://www.wikidata.org/wiki/Q2014564","display_name":"Articular cartilage","level":4,"score":0.1395561397075653},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.08736667037010193},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001324","descriptor_name":"Autoantigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000293","qualifier_name":"injuries","is_major_topic":true},{"descriptor_ui":"D002956","descriptor_name":"Citrulline","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065206","descriptor_name":"Extracellular Traps","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1172/jci.insight.139388","doi":"https://doi.org/10.1172/jci.insight.139388","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci.insight.139388","pdf_url":"http://insight.jci.org/articles/view/139388/files/pdf","source":{"id":"https://openalex.org/S2764964142","display_name":"JCI Insight","issn_l":"2379-3708","issn":["2379-3708"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI Insight","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7406272","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7406272","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI Insight","raw_type":"Text"},{"id":"pmid:32484790","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32484790","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI insight","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1172/jci.insight.139388","doi":"https://doi.org/10.1172/jci.insight.139388","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci.insight.139388","pdf_url":"http://insight.jci.org/articles/view/139388/files/pdf","source":{"id":"https://openalex.org/S2764964142","display_name":"JCI Insight","issn_l":"2379-3708","issn":["2379-3708"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI Insight","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7952112274","display_name":null,"funder_award_id":"AR041199","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G9000865007","display_name":"Systemic Autoimmunity","funder_award_id":"ZIAAR041199","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3031005545.pdf","grobid_xml":"https://content.openalex.org/works/W3031005545.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W201632791","https://openalex.org/W1498945885","https://openalex.org/W1506260673","https://openalex.org/W1950911242","https://openalex.org/W1973390579","https://openalex.org/W1973481438","https://openalex.org/W2015865604","https://openalex.org/W2017268676","https://openalex.org/W2019642817","https://openalex.org/W2045553984","https://openalex.org/W2048758989","https://openalex.org/W2050257369","https://openalex.org/W2078836325","https://openalex.org/W2086420062","https://openalex.org/W2087958138","https://openalex.org/W2114100604","https://openalex.org/W2115959782","https://openalex.org/W2121134187","https://openalex.org/W2127631759","https://openalex.org/W2141522272","https://openalex.org/W2157234417","https://openalex.org/W2164903899","https://openalex.org/W2167481892","https://openalex.org/W2274704536","https://openalex.org/W2288622561","https://openalex.org/W2410322647","https://openalex.org/W2438262092","https://openalex.org/W2486272166","https://openalex.org/W2587650072","https://openalex.org/W2607154592","https://openalex.org/W2795101963","https://openalex.org/W2899116898","https://openalex.org/W2902102863","https://openalex.org/W2920885032","https://openalex.org/W2971609950","https://openalex.org/W2998322151"],"related_works":["https://openalex.org/W3037298845","https://openalex.org/W2607154592","https://openalex.org/W4390680495","https://openalex.org/W2330679614","https://openalex.org/W4313351570","https://openalex.org/W3185431319","https://openalex.org/W4416676630","https://openalex.org/W2038863881","https://openalex.org/W2149374372","https://openalex.org/W4250703375"],"abstract_inverted_index":{"Rheumatoid":[0],"arthritis":[1],"(RA)":[2],"is":[3],"characterized":[4],"by":[5,60,74,84],"synovial":[6,41,154],"joint":[7,177],"inflammation,":[8],"cartilage":[9,52,65,99,118,123,131,151],"damage,":[10],"and":[11,36,67,86,120,138,153,160,169],"dysregulation":[12],"of":[13,33,40,70,126],"the":[14,31,38],"adaptive":[15],"immune":[16,95],"system.":[17],"While":[18],"neutrophil":[19,139,158],"extracellular":[20],"traps":[21],"(NETs)":[22],"have":[23,163],"been":[24],"proposed":[25],"to":[26,89,104],"play":[27,145],"a":[28,57,164],"role":[29,166],"in":[30,37,51,142,149,167,170],"generation":[32],"modified":[34],"autoantigens":[35],"activation":[39],"fibroblasts,":[42],"it":[43],"remains":[44],"unknown":[45],"whether":[46],"NETs":[47,113,137,161],"are":[48,80],"directly":[49],"involved":[50],"damage.":[53,124,132,178],"Here,":[54],"we":[55],"report":[56],"new":[58],"mechanism":[59],"which":[61],"NET-derived":[62,127],"elastase":[63,128,140,159],"disrupts":[64],"matrix":[66],"induces":[68],"release":[69,105],"membrane-bound":[71],"peptidylarginine":[72],"deiminase-2":[73],"fibroblast-like":[75],"synoviocytes":[76],"(FLSs).":[77],"Cartilage":[78],"fragments":[79],"subsequently":[81],"citrullinated,":[82],"internalized":[83],"FLSs,":[85],"then":[87],"presented":[88],"antigen-specific":[90],"CD4+":[91],"T":[92],"cells.":[93],"Furthermore,":[94],"complexes":[96],"containing":[97],"citrullinated":[98,117],"components":[100],"can":[101],"activate":[102],"macrophages":[103],"proinflammatory":[106],"cytokines.":[107],"HLA-DRB1*04:01":[108],"transgenic":[109],"mice":[110],"immunized":[111],"with":[112,175],"develop":[114],"autoantibodies":[115],"against":[116],"proteins":[119],"display":[121],"enhanced":[122],"Inhibition":[125],"rescues":[129],"NET-mediated":[130],"These":[133],"results":[134],"show":[135],"that":[136],"externalized":[141],"these":[143],"structures":[144],"fundamental":[146],"pathogenic":[147],"roles":[148],"promoting":[150],"damage":[152],"inflammation.":[155],"Strategies":[156],"targeting":[157],"could":[162],"therapeutic":[165],"RA":[168],"other":[171],"inflammatory":[172,176],"diseases":[173],"associated":[174]},"counts_by_year":[{"year":2026,"cited_by_count":28},{"year":2025,"cited_by_count":32},{"year":2024,"cited_by_count":36},{"year":2023,"cited_by_count":37},{"year":2022,"cited_by_count":25},{"year":2021,"cited_by_count":28},{"year":2020,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-06-05T00:00:00"}
