{"id":"https://openalex.org/W3030967445","doi":"https://doi.org/10.3877/cma.j.issn.1674-0785.2018.03.008","title":"Delivery strategies for gene therapy of chronic heart failure","display_name":"Delivery strategies for gene therapy of chronic heart failure","publication_year":2018,"publication_date":"2018-02-01","ids":{"openalex":"https://openalex.org/W3030967445","doi":"https://doi.org/10.3877/cma.j.issn.1674-0785.2018.03.008","mag":"3030967445"},"language":"en","primary_location":{"id":"mag:3030967445","doi":"https://doi.org/10.3877/cma.j.issn.1674-0785.2018.03.008","is_oa":false,"landing_page_url":"http://rs.yiigle.com/CN119147201803/1041325.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764366365","display_name":"Zhonghua linchuang yishi zazhi","issn_l":"1674-0785","issn":["1674-0785"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4320800525","host_organization_name":"Chinese Medical Association","host_organization_lineage":["https://openalex.org/P4320800525"],"host_organization_lineage_names":["Chinese Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Chin J Clinicians(Electronic Edition)","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102946443","display_name":"Zhiqiang Yin","orcid":"https://orcid.org/0000-0002-0847-6535","observed_orcids":["https://orcid.org/0000-0002-0847-6535"]},"institutions":[{"id":"https://openalex.org/I17721919","display_name":"Shanxi Medical University","ror":"https://ror.org/0265d1010","country_code":"CN","type":"education","lineage":["https://openalex.org/I17721919"]},{"id":"https://openalex.org/I4210133678","display_name":"Second Hospital of Shanxi Medical University","ror":"https://ror.org/03tn5kh37","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133678"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiqiang Yin","raw_affiliation_strings":["Department of Cardiothoracic Surgery, the Second Hospital of Shanxi Medical University, Taiyuan 030000, China"],"raw_orcid":"https://orcid.org/0000-0002-0847-6535","affiliations":[{"raw_affiliation_string":"Department of Cardiothoracic Surgery, the Second Hospital of Shanxi Medical University, Taiyuan 030000, China","institution_ids":["https://openalex.org/I17721919","https://openalex.org/I4210133678"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027343770","display_name":"Wanhong Xing","orcid":"https://orcid.org/0009-0001-8718-3975","observed_orcids":["https://orcid.org/0009-0001-8718-3975"]},"institutions":[{"id":"https://openalex.org/I17721919","display_name":"Shanxi Medical University","ror":"https://ror.org/0265d1010","country_code":"CN","type":"education","lineage":["https://openalex.org/I17721919"]},{"id":"https://openalex.org/I4210133678","display_name":"Second Hospital of Shanxi Medical University","ror":"https://ror.org/03tn5kh37","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133678"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wanhong Xing","raw_affiliation_strings":["Department of Cardiothoracic Surgery, the Second Hospital of Shanxi Medical University, Taiyuan 030000, China"],"raw_orcid":"https://orcid.org/0009-0001-8718-3975","affiliations":[{"raw_affiliation_string":"Department of Cardiothoracic Surgery, the Second Hospital of Shanxi Medical University, Taiyuan 030000, China","institution_ids":["https://openalex.org/I17721919","https://openalex.org/I4210133678"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100604237","display_name":"Jie Ma","orcid":"https://orcid.org/0000-0002-5399-6804","observed_orcids":["https://orcid.org/0000-0002-5399-6804"]},"institutions":[{"id":"https://openalex.org/I17721919","display_name":"Shanxi Medical University","ror":"https://ror.org/0265d1010","country_code":"CN","type":"education","lineage":["https://openalex.org/I17721919"]},{"id":"https://openalex.org/I4210133678","display_name":"Second Hospital of Shanxi Medical University","ror":"https://ror.org/03tn5kh37","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133678"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Ma","raw_affiliation_strings":["Department of Cardiothoracic Surgery, the Second Hospital of Shanxi Medical University, Taiyuan 030000, China"],"raw_orcid":"https://orcid.org/0000-0002-5399-6804","affiliations":[{"raw_affiliation_string":"Department of Cardiothoracic Surgery, the Second Hospital of Shanxi Medical University, Taiyuan 030000, China","institution_ids":["https://openalex.org/I17721919","https://openalex.org/I4210133678"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100550878","display_name":"Jianxin Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17721919","display_name":"Shanxi Medical University","ror":"https://ror.org/0265d1010","country_code":"CN","type":"education","lineage":["https://openalex.org/I17721919"]},{"id":"https://openalex.org/I4210133678","display_name":"Second Hospital of Shanxi Medical University","ror":"https://ror.org/03tn5kh37","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133678"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianxin Yang","raw_affiliation_strings":["Anesthesia, the Second Hospital of Shanxi Medical University, Taiyuan 030000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anesthesia, the Second Hospital of Shanxi Medical University, Taiyuan 030000, China","institution_ids":["https://openalex.org/I17721919","https://openalex.org/I4210133678"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":"3","first_page":"160","last_page":"163"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9258000254631042,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9258000254631042,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.0348999984562397,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.00839999970048666,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-heart-failure","display_name":"chronic heart failure","score":0.8939999938011169},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.8309999704360962},{"id":"https://openalex.org/keywords/cardiac-gene-delivery","display_name":"cardiac gene delivery","score":0.9200000166893005},{"id":"https://openalex.org/keywords/gene-delivery-vectors","display_name":"gene delivery vectors","score":0.6320000290870667},{"id":"https://openalex.org/keywords/cardiac-remodeling","display_name":"cardiac remodeling","score":0.7850000262260437},{"id":"https://openalex.org/keywords/apoptosis-inhibition","display_name":"apoptosis inhibition","score":0.7139999866485596},{"id":"https://openalex.org/keywords/myocardial-contractility","display_name":"cardiac contractility","score":0.8579999804496765},{"id":"https://openalex.org/keywords/ischemic-heart-disease","display_name":"ischemic heart disease","score":0.828000009059906},{"id":"https://openalex.org/keywords/signaling-pathways","display_name":"signaling pathways","score":0.7360000014305115}],"concepts":[{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.8148659467697144},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.8083926439285278},{"id":"https://openalex.org/C135983454","wikidata":"https://www.wikidata.org/wiki/Q2790163","display_name":"Gene delivery","level":4,"score":0.7322389483451843},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6829969882965088},{"id":"https://openalex.org/C3018928802","wikidata":"https://www.wikidata.org/wiki/Q83185","display_name":"Gene transfer","level":3,"score":0.47504520416259766},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.47496554255485535},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.42374444007873535},{"id":"https://openalex.org/C2780074459","wikidata":"https://www.wikidata.org/wiki/Q389735","display_name":"Heart disease","level":2,"score":0.4192933440208435},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.40522944927215576},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.35116398334503174},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3077540397644043},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2776070237159729},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1615801453590393},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:3030967445","doi":"https://doi.org/10.3877/cma.j.issn.1674-0785.2018.03.008","is_oa":false,"landing_page_url":"http://rs.yiigle.com/CN119147201803/1041325.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764366365","display_name":"Zhonghua linchuang yishi zazhi","issn_l":"1674-0785","issn":["1674-0785"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4320800525","host_organization_name":"Chinese Medical Association","host_organization_lineage":["https://openalex.org/P4320800525"],"host_organization_lineage_names":["Chinese Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Chin J Clinicians(Electronic Edition)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2797213756","https://openalex.org/W2137572671","https://openalex.org/W2558306816","https://openalex.org/W3023577447","https://openalex.org/W2136106373","https://openalex.org/W2021209349","https://openalex.org/W2025119360","https://openalex.org/W4386865301","https://openalex.org/W395376242","https://openalex.org/W2080318306"],"abstract_inverted_index":{"Chronic":[0],"heart":[1,33,124,146,189,192,234],"failure":[2,125,147,193,235],"(CHF)":[3],"is":[4,49,54,159],"still":[5],"the":[6,20,35,45,70,78,86,111,164,169,172,197,213],"leading":[7],"cause":[8],"of":[9,37,72,88,144,154,201],"morbidity":[10],"and":[11,41,85,97,135,167,191,195,199],"mortality":[12,31],"worldwide,":[13],"causing":[14],"a":[15,26,140,220],"great":[16],"economic":[17],"burden":[18],"to":[19,56,77,128,160],"society.":[21],"Although":[22],"conventional":[23],"therapy":[24,64,100,122,143,156],"has":[25,117,148],"substantial":[27],"role":[28],"in":[29,43,67,81,94,187,204],"reducing":[30],"from":[32],"failure,":[34],"efficacy":[36],"novel":[38],"pharmacologic":[39],"agents":[40],"surgery":[42,215,226],"extending":[44],"5-year":[46],"survival":[47],"rate":[48],"not":[50],"satisfactory.":[51],"Therefore,":[52],"it":[53],"necessary":[55],"develop":[57],"new":[58],"therapies":[59],"for":[60,108,123,157],"this":[61,178],"disease.":[62],"Gene":[63],"was":[65],"introduced":[66],"1970s":[68],"with":[69,126,209,216,227],"development":[71],"recombinant":[73],"DNA":[74],"technology.":[75],"Thanks":[76],"recent":[79],"progress":[80],"myocardial":[82],"metabolism":[83],"research":[84,116],"application":[87],"vector":[89],"based":[90],"gene":[91,99,121,142,155,184,207],"transfer":[92,185],"strategies":[93,203],"animal":[95],"models":[96],"humans,":[98],"would":[101],"probably":[102],"be":[103],"an":[104],"ideal":[105],"treatment":[106],"alternative":[107],"CHF.":[109],"Over":[110],"last":[112],"two":[113],"decades,":[114],"much":[115],"been":[118],"done":[119],"about":[120],"regard":[127],"different":[129,131,136],"genes,":[130],"signal":[132],"transduction":[133],"pathways,":[134],"delivery":[137,218,230],"methods.":[138],"As":[139],"result,":[141],"advanced":[145],"become":[149],"possible.":[150],"The":[151],"main":[152],"goal":[153],"CHF":[158],"inhibit":[161],"apoptosis,":[162],"reduce":[163],"undesirable":[165],"remodeling,":[166],"increase":[168],"contractility":[170],"through":[171],"most":[173],"efficient":[174],"cardiomyocyte":[175],"transfection.":[176],"In":[177],"paper,":[179],"we":[180],"will":[181],"review":[182],"various":[183],"technologies":[186],"ischemic":[188],"disease":[190],"models,":[194],"discuss":[196],"advantages":[198],"disadvantages":[200],"these":[202],"vector-mediated":[205],"cardiac":[206,214],"delivery,":[208],"emphasis":[210],"put":[211],"on":[212],"recirculating":[217,228],"system,":[219],"high":[221],"efficiency":[222],"approach.\r\n\r\n\r\nKey":[223],"words:":[224],"\r\nCardiac":[225],"delivery;\u00a0Gene":[229],"methods;\u00a0Gene":[231],"therapy,":[232],"Cardiac;\u00a0Chronic":[233]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-06-05T00:00:00"}