{"id":"https://openalex.org/W3030931007","doi":"https://doi.org/10.3760/cma.j.issn.1671-0282.2016.11.009","title":"Clinical value of ganglioside combined with nalmefene on delayed encephalopathy after carbon monoxide poisoning","display_name":"Clinical value of ganglioside combined with nalmefene on delayed encephalopathy after carbon monoxide poisoning","publication_year":2016,"publication_date":"2016-11-10","ids":{"openalex":"https://openalex.org/W3030931007","doi":"https://doi.org/10.3760/cma.j.issn.1671-0282.2016.11.009","mag":"3030931007"},"language":"en","primary_location":{"id":"mag:3030931007","doi":"https://doi.org/10.3760/cma.j.issn.1671-0282.2016.11.009","is_oa":false,"landing_page_url":"http://rs.yiigle.com/CN114656201611/934781.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764945285","display_name":"Zhonghua jizhen yixue zazhi","issn_l":"1671-0282","issn":["1671-0282"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4320800525","host_organization_name":"Chinese Medical Association","host_organization_lineage":["https://openalex.org/P4320800525"],"host_organization_lineage_names":["Chinese Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhonghua jizhen yixue zazhi","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020514596","display_name":"Fantuo Kong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111381250","display_name":"Hebei Medical University","ror":"https://ror.org/04eymdx19","country_code":"CN","type":"education","lineage":["https://openalex.org/I111381250"]},{"id":"https://openalex.org/I4210137025","display_name":"Harrison International Peace Hospital","ror":"https://ror.org/03kgydk02","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210137025"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fantuo Kong","raw_affiliation_strings":["Emergency Department of Harrison International Peace Hospital Affiliated to Hebei Medical University , Hengshui 053000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emergency Department of Harrison International Peace Hospital Affiliated to Hebei Medical University , Hengshui 053000, China","institution_ids":["https://openalex.org/I111381250","https://openalex.org/I4210137025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058816006","display_name":"Guilan Zhang","orcid":"https://orcid.org/0000-0001-8788-9583","observed_orcids":["https://orcid.org/0000-0001-8788-9583"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guilan Zhang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8788-9583","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Jing Li","orcid":"https://orcid.org/0000-0001-7792-4322","observed_orcids":["https://orcid.org/0000-0001-7792-4322"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jing Li","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7792-4322","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111831633","display_name":"Lan Wang","orcid":"https://orcid.org/0009-0007-0755-5526","observed_orcids":["https://orcid.org/0009-0007-0755-5526"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lan Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100714128","display_name":"Jing Chen","orcid":"https://orcid.org/0000-0002-6227-7393","observed_orcids":["https://orcid.org/0000-0002-6227-7393","https://orcid.org/0000-0003-4390-8468"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jing Chen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6227-7393","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020635379","display_name":"Weizhan Wang","orcid":"https://orcid.org/0000-0001-5505-301X","observed_orcids":["https://orcid.org/0000-0001-5505-301X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Weizhan Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5101897218","display_name":"Yaqin Li","orcid":"https://orcid.org/0000-0002-5626-9557","observed_orcids":["https://orcid.org/0000-0002-5626-9557"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yaqin Li","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5626-9557","affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"25","issue":"11","first_page":"1400","last_page":"1405"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":0.8417999744415283,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":0.8417999744415283,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11635","display_name":"Poisoning and overdose treatments","score":0.07599999755620956,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.014399999752640724,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gangliosides","display_name":"gangliosides","score":0.9850000143051147},{"id":"https://openalex.org/keywords/nalmefene","display_name":"nalmefene","score":0.9980000257492065},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.8009999990463257},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.878000020980835},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.8970000147819519},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.8169999718666077},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.9589999914169312},{"id":"https://openalex.org/keywords/glutathione-peroxidase","display_name":"glutathione peroxidase","score":0.9909999966621399},{"id":"https://openalex.org/keywords/nitric-oxide-synthase","display_name":"nitric oxide synthase","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cognitive-function","display_name":"cognitive function","score":0.6470000147819519},{"id":"https://openalex.org/keywords/hyperbaric-oxygen-therapy","display_name":"hyperbaric oxygen therapy","score":0.7950000166893005},{"id":"https://openalex.org/keywords/cerebral-edema-prevention","display_name":"cerebral edema prevention","score":0.7839999794960022},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.3790000081062317},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.3449999988079071}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9229211211204529},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.5627235770225525},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.5606088042259216},{"id":"https://openalex.org/C2781119925","wikidata":"https://www.wikidata.org/wiki/Q125367","display_name":"Carbon monoxide poisoning","level":3,"score":0.5338476896286011},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5310167670249939},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5193287134170532},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5176463723182678},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.46979793906211853},{"id":"https://openalex.org/C2778760513","wikidata":"https://www.wikidata.org/wiki/Q24773045","display_name":"Glutathione peroxidase","level":4,"score":0.46047747135162354},{"id":"https://openalex.org/C2778621155","wikidata":"https://www.wikidata.org/wiki/Q576349","display_name":"Encephalopathy","level":2,"score":0.4156549572944641},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.33021003007888794},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.13567611575126648},{"id":"https://openalex.org/C3017944768","wikidata":"https://www.wikidata.org/wiki/Q1450463","display_name":"Poison control","level":2,"score":0.11668801307678223},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:3030931007","doi":"https://doi.org/10.3760/cma.j.issn.1671-0282.2016.11.009","is_oa":false,"landing_page_url":"http://rs.yiigle.com/CN114656201611/934781.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764945285","display_name":"Zhonghua jizhen yixue zazhi","issn_l":"1671-0282","issn":["1671-0282"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4320800525","host_organization_name":"Chinese Medical Association","host_organization_lineage":["https://openalex.org/P4320800525"],"host_organization_lineage_names":["Chinese Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhonghua jizhen yixue zazhi","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3029354208","https://openalex.org/W2354148665","https://openalex.org/W2392825203","https://openalex.org/W2350945495","https://openalex.org/W2358899637","https://openalex.org/W2355160276","https://openalex.org/W2369799273","https://openalex.org/W2390857694","https://openalex.org/W2349848091","https://openalex.org/W2908807071"],"abstract_inverted_index":{"Objective\r\nTo":[0],"observe":[1],"the":[2,73,122,143,155,183,201,268,329,347,355,361,369,377],"effects":[3],"of":[4,20,52,63,68,96,124,158,167,177,187,207,221,284,349,363,371,379,386],"ganglioside":[5,53],"combined":[6,342],"with":[7,11,23,49,78,170,313,343],"nalmefene":[8,79,344],"on":[9],"patients":[10,22,351],"delayed":[12],"encephalopathy":[13],"after":[14,165,226,288],"carbon":[15,400],"monoxide":[16,401],"poisoning":[17],"(DEACMP).\r\n\r\n\r\nMethods\r\nA":[18],"total":[19,174,184],"128":[21],"DEACMP":[24,350],"treated":[25,48,77],"in":[26,84,145,200,228,238,267,275,290,300,331,338,352],"Emergency":[27],"Department":[28],"from":[29],"January":[30],"2012":[31],"to":[32,86,101,135,354],"March":[33],"2016":[34],"were":[35,47,76,99,129,197,231,241,248,293,303,309,334],"randomly":[36],"divided":[37],"into":[38],"control":[39,45,188,229,276,291,339],"group":[40,46,75,179,189,230,240,270,277,292,302,333,340],"and":[41,61,66,72,114,142,148,164,182,204,212,224,236,244,265,281,286,298,328,366,373,375],"therapy":[42,74,178,239,259,301,322,332],"group.":[43],"The":[44,218,279,382],"routine":[50,87],"treatments":[51],"0.1":[54],"g":[55],"intramuscular":[56],"injection,":[57],"hyperbaric":[58],"oxygen,":[59],"prevention":[60],"treatment":[62,159,166,227,254,269,289,316,348,357,388],"cerebral":[64],"edema":[65],"enhancement":[67],"brain":[69],"cell":[70],"metabolism,":[71],"0.3":[80],"mg":[81],"intravenous":[82],"injection":[83],"addition":[85,353],"treatment.":[88],"After":[89],"observation":[90],"for":[91,346,395],"two":[92,152,168,215],"weeks,":[93],"10":[94],"mL":[95],"venous":[97],"blood":[98],"collected":[100],"detect":[102],"malonyldialdehyde":[103],"(MDA),":[104],"superoxide":[105],"dismutase":[106],"(SOD),":[107],"glutathione":[108],"peroxidase":[109],"(GSH-PX),":[110],"nitric":[111,115],"oxide":[112,116,405],"(NO)":[113],"synthase":[117,406],"(NOS),":[118],"as":[119,121],"well":[120],"changes":[123,144,330],"mini-mental":[125],"state":[126],"examination":[127],"(MMSE)":[128],"observed.":[130],"T":[131],"test":[132],"was":[133,160,180,190,271],"used":[134,345],"compare":[136],"MMSE":[137,202,280],"score,":[138],"MDA,":[139,208,222,364],"NO":[140,223,365],"levels":[141,206,220,283,362],"SOD,":[146,210],"GSH-PX":[147,211,287],"NOS":[149,213,225],"activity":[150],"between":[151,162,214],"groups":[153,169,216],"and,":[154],"clinical":[156,396],"efficacy":[157,385],"compared":[161,312],"prior":[163],"chi":[171],"square":[172],"test.\r\n\r\n\r\nResults\r\nThe":[173],"effective":[175,185],"rate":[176,186],"84.4%,":[181],"68.8%.":[191],"(\u03c72=4.354,":[192],"P=0.037).":[193],"Before":[194],"treatment,":[195],"there":[196],"no":[198],"difference":[199],"score":[203],"plasma":[205,219,282],"NO,":[209],"(P>0.05).":[217],"(4.39\u00b11.01)\u03bcmol/L,":[232],"(60.28\u00b19.68)\u03bcmol/L,":[233],"(21.46\u00b15.53)U/mL,":[234],"respectively,":[235,246,297],"those":[237,252,266,274,299,314,337],"(3.37\u00b10.83)\u03bcmol/L,":[242],"(55.29\u00b19.57)\u03bcmol/L,":[243],"(18.71\u00b14.40)U/mL,":[245],"which":[247,308],"significantly":[249,310],"lower":[250,272],"than":[251,273,336],"before":[253,315],"[control":[255,317],"group(5.54\u00b10.96)\u03bcmol/L,":[256],"(68.42\u00b112.71)\u03bcmol/L,":[257],"(29.75\u00b16.79)U/mL;":[258],"group:":[260,318,323],"(5.48\u00b11.16)\u03bcmol/L,":[261],"(69.46\u00b116.37)\u03bcmol/L,":[262],"(30.42\u00b17.39)U/mL]":[263],"(P<0.05),":[264,327],"(P<0.05).":[278],"SOD":[285,372],"(18.30\u00b15.91),":[294],"(81.66\u00b110.75)U/mL,":[295],"(60.58\u00b19.69)U/L,":[296],"(23.85\u00b17.21),":[304],"(96.41\u00b19.64)U/mL,":[305],"(73.22\u00b19.95)U/L,":[306],"respectively":[307],"increased":[311],"(8.93\u00b12.49),":[319],"(69.58\u00b18.05)U/mL,":[320],"(49.35\u00b16.71)U/L;":[321],"(9.14\u00b12.85),":[324],"(70.41\u00b17.30)U/mL,":[325],"(48.40\u00b17.89)U/L]":[326],"higher":[335],"(P<0.05).\r\n\r\n\r\nConclusion\r\nGanglioside":[341],"conventional":[356],"could":[358],"effectively":[359],"reduce":[360],"NOS,":[367],"enhance":[368],"expression":[370],"GSH-PX,":[374],"improve":[376],"recovery":[378],"neurological":[380],"function.":[381],"clinically":[383],"therapeutic":[384],"this":[387],"is":[389],"noticeable":[390],"thus":[391],"providing":[392],"important":[393],"evidence":[394],"practice.\r\n\r\n\r\nKey":[397],"words:":[398],"\r\nAcute":[399],"poisoning;\u00a0Delayed":[402],"encephalopathy;\u00a0Ganglioside;\u00a0Nalmefene;\u00a0Oxidative":[403],"stress;\u00a0Nitric":[404]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2020-06-05T00:00:00"}