{"id":"https://openalex.org/W303069730","doi":"https://doi.org/10.5070/d3213024118","title":"Successful use of the excimer laser for generalized psoriasis in an ustekinumab non-responder","display_name":"Successful use of the excimer laser for generalized psoriasis in an ustekinumab non-responder","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W303069730","doi":"https://doi.org/10.5070/d3213024118","mag":"303069730","pmid":"https://pubmed.ncbi.nlm.nih.gov/25780961"},"language":"en","primary_location":{"id":"doi:10.5070/d3213024118","doi":"https://doi.org/10.5070/d3213024118","is_oa":true,"landing_page_url":"https://doi.org/10.5070/d3213024118","pdf_url":null,"source":{"id":"https://openalex.org/S166925758","display_name":"Dermatology Online Journal","issn_l":"1087-2108","issn":["1087-2108"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","medline","norway-1","oarl","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315571","host_organization_name":"University of California, Davis","host_organization_lineage":["https://openalex.org/P4310315571","https://openalex.org/P4310316177"],"host_organization_lineage_names":["University of California, Davis","University of California"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dermatology Online Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.5070/d3213024118","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010033713","display_name":"Mona Malakouti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I189273616","display_name":"Rosalind Franklin University of Medicine and Science","ror":"https://ror.org/04fegvg32","country_code":"US","type":"education","lineage":["https://openalex.org/I189273616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mona Malakouti","raw_affiliation_strings":["Chicago Medical School, Rosalind Franklin University of Medicine and Science University of California San Francisco Psoriasis Treatment Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chicago Medical School, Rosalind Franklin University of Medicine and Science University of California San Francisco Psoriasis Treatment Center","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I189273616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110040747","display_name":"Gabrielle Elena Brown","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210110664","display_name":"University of California San Francisco Medical Center","ror":"https://ror.org/01t8svj65","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210110664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gabrielle Elena Brown","raw_affiliation_strings":["University of California San Francisco Psoriasis Treatment Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California San Francisco Psoriasis Treatment Center","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210110664"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Eric Sorenson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210110664","display_name":"University of California San Francisco Medical Center","ror":"https://ror.org/01t8svj65","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210110664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric Sorenson","raw_affiliation_strings":["University of California San Francisco Psoriasis Treatment Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California San Francisco Psoriasis Treatment Center","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210110664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043197838","display_name":"Argentina Leon","orcid":"https://orcid.org/0000-0002-5227-8050","observed_orcids":["https://orcid.org/0000-0002-5227-8050"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Argentina Leon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102727788","display_name":"John Y. M. Koo","orcid":"https://orcid.org/0009-0004-1005-5221","observed_orcids":["https://orcid.org/0009-0004-1005-5221"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Koo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5087990097","display_name":"Ethan Levin","orcid":"https://orcid.org/0000-0002-7428-3168","observed_orcids":["https://orcid.org/0000-0002-7428-3168"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ethan Charles Levin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":300,"currency":"USD","value_usd":300},"apc_paid":{"value":300,"currency":"USD","value_usd":300},"fwci":0.164,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.53569748,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"21","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11811","display_name":"Cutaneous lymphoproliferative disorders research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/generalized-psoriasis","display_name":"generalized psoriasis","score":0.9419999718666077},{"id":"https://openalex.org/keywords/il-17","display_name":"IL-17","score":0.7689999938011169},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.7940000295639038},{"id":"https://openalex.org/keywords/th17-cells","display_name":"Th17 cells","score":0.8479999899864197},{"id":"https://openalex.org/keywords/th1-cells","display_name":"Th1 cells","score":0.902999997138977},{"id":"https://openalex.org/keywords/t-cell-apoptosis","display_name":"T cell apoptosis","score":0.8949999809265137},{"id":"https://openalex.org/keywords/antigen-presenting-cells","display_name":"antigen-presenting cells","score":0.7049999833106995},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.7089999914169312},{"id":"https://openalex.org/keywords/pasi-response","display_name":"PASI response","score":0.6470000147819519},{"id":"https://openalex.org/keywords/biologic-therapy-failure","display_name":"biologic failure","score":0.503000020980835}],"concepts":[{"id":"https://openalex.org/C2778975655","wikidata":"https://www.wikidata.org/wiki/Q420305","display_name":"Ustekinumab","level":4,"score":0.927842378616333},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9194336533546448},{"id":"https://openalex.org/C2780564577","wikidata":"https://www.wikidata.org/wiki/Q179945","display_name":"Psoriasis","level":2,"score":0.6301569938659668},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.5131927132606506},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5071539878845215},{"id":"https://openalex.org/C2779112978","wikidata":"https://www.wikidata.org/wiki/Q423417","display_name":"Imiquimod","level":2,"score":0.442281037569046},{"id":"https://openalex.org/C2780477314","wikidata":"https://www.wikidata.org/wiki/Q241056","display_name":"Excimer laser","level":3,"score":0.44074100255966187},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4016857445240021},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.18305617570877075},{"id":"https://openalex.org/C520434653","wikidata":"https://www.wikidata.org/wiki/Q38867","display_name":"Laser","level":2,"score":0.1475418508052826},{"id":"https://openalex.org/C2777138892","wikidata":"https://www.wikidata.org/wiki/Q415264","display_name":"Infliximab","level":3,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069549","descriptor_name":"Ustekinumab","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000279","descriptor_name":"Administration, Cutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002117","descriptor_name":"Calcitriol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002990","descriptor_name":"Clobetasol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003879","descriptor_name":"Dermatologic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009824","descriptor_name":"Ointments","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011565","descriptor_name":"Psoriasis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D017211","descriptor_name":"Treatment Failure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054018","descriptor_name":"Lasers, Excimer","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.5070/d3213024118","doi":"https://doi.org/10.5070/d3213024118","is_oa":true,"landing_page_url":"https://doi.org/10.5070/d3213024118","pdf_url":null,"source":{"id":"https://openalex.org/S166925758","display_name":"Dermatology Online Journal","issn_l":"1087-2108","issn":["1087-2108"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","medline","norway-1","oarl","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315571","host_organization_name":"University of California, Davis","host_organization_lineage":["https://openalex.org/P4310315571","https://openalex.org/P4310316177"],"host_organization_lineage_names":["University of California, Davis","University of California"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dermatology Online Journal","raw_type":"journal-article"},{"id":"pmid:25780961","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25780961","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dermatology online journal","raw_type":"Case Reports"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt76m221mt","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/76m221mt","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dermatology Online Journal, vol 21, iss 3","raw_type":"article"},{"id":"pmh:qt76m221mt","doi":null,"is_oa":true,"landing_page_url":"http://www.escholarship.org/uc/item/76m221mt","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Malakouti, Mona; Brown, Gabrielle Elena; Sorenson, Eric; Leon, Argentina; Koo, John; &amp; Levin, Ethan Charles. (2015). Successful use of the excimer laser for generalized psoriasis in an ustekinumab non-responder. Dermatology Online Journal, 21(3). Retrieved from: http://www.escholarship.org/uc/item/76m221mt","raw_type":"article"}],"best_oa_location":{"id":"doi:10.5070/d3213024118","doi":"https://doi.org/10.5070/d3213024118","is_oa":true,"landing_page_url":"https://doi.org/10.5070/d3213024118","pdf_url":null,"source":{"id":"https://openalex.org/S166925758","display_name":"Dermatology Online Journal","issn_l":"1087-2108","issn":["1087-2108"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","medline","norway-1","oarl","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315571","host_organization_name":"University of California, Davis","host_organization_lineage":["https://openalex.org/P4310315571","https://openalex.org/P4310316177"],"host_organization_lineage_names":["University of California, Davis","University of California"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dermatology Online Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8600000143051147}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1575168223","https://openalex.org/W1925381594","https://openalex.org/W2024911140","https://openalex.org/W2037742343","https://openalex.org/W2040164730","https://openalex.org/W2088771904","https://openalex.org/W2092537789","https://openalex.org/W2115627739","https://openalex.org/W2116956799","https://openalex.org/W2119330427","https://openalex.org/W2129777700","https://openalex.org/W2149484663","https://openalex.org/W2168488015","https://openalex.org/W2294166638","https://openalex.org/W2333396611","https://openalex.org/W2464005302","https://openalex.org/W4248269869","https://openalex.org/W4248543376","https://openalex.org/W6637806584","https://openalex.org/W6660495038"],"related_works":["https://openalex.org/W2765688020","https://openalex.org/W2182887296","https://openalex.org/W2358890932","https://openalex.org/W1547091693","https://openalex.org/W3006152446","https://openalex.org/W2055166812","https://openalex.org/W2465675780","https://openalex.org/W4255768555","https://openalex.org/W2056122008","https://openalex.org/W2021330306"],"abstract_inverted_index":{"Effective":[0],"treatments":[1,12],"for":[2,169],"moderate":[3],"to":[4,42,69,157],"severe":[5],"psoriasis":[6],"are":[7,13],"phototherapy":[8,152],"and":[9,77,118,139,163],"biologics.":[10],"These":[11],"similar":[14],"in":[15,95,104,112,124,143],"that":[16,97],"they":[17],"both":[18,122],"decrease":[19],"cutaneous":[20],"immune":[21,154],"system":[22],"hyperactivity":[23],"yet":[24],"do":[25],"so":[26],"via":[27],"different":[28],"mechanisms.":[29],"Our":[30],"patient,":[31],"a":[32,39,64,92,101],"63":[33],"year":[34],"old":[35],"Asian":[36],"male":[37],"had":[38,91],"rapid":[40],"response":[41,172],"treatment":[43,53,84],"with":[44,54,85],"the":[45,86,89,105,113,119,130,148,158,170],"high":[46],"dose":[47],"excimer":[48,87,120,131],"laser,":[49,88],"having":[50],"previously":[51],"failed":[52],"28":[55],"weeks":[56],"of":[57,63,74,107,127,136,151,161],"ustekinumab":[58,117,166],"therapy.":[59],"A":[60],"pre-treatment":[61],"biopsy":[62],"psoriatic":[65],"plaque":[66],"was":[67,98],"found":[68,111],"contain":[70],"relatively":[71],"low":[72],"levels":[73,126],"IFN-\u03b3":[75],"(Th1)":[76],"IL-17":[78],"(Th17)":[79],"secreting":[80],"T":[81,109,137],"cells.":[82,146],"Following":[83],"patient":[90],"quick":[93],"improvement":[94],"PASI":[96],"reflected":[99],"by":[100,165],"3-fold":[102],"reduction":[103],"number":[106],"live":[108],"cells":[110,138,155],"post-treatment":[114],"biopsy.":[115],"Although":[116],"laser":[121,132],"result":[123],"decreased":[125],"these":[128],"cytokines,":[129],"directly":[133],"causes":[134],"apoptosis":[135],"induces":[140],"DNA":[141],"damage":[142],"antigen":[144],"presenting":[145],"Thus,":[147],"broader":[149],"effects":[150],"on":[153],"compared":[156],"targeted":[159],"inhibition":[160],"IL-12":[162],"IL-23":[164],"likely":[167],"account":[168],"superior":[171],"observed.":[173]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
